{"product_id":"bio-and-multifunctional-polymer-architectures-9781118158913","title":"Bio and Multifunctional Polymer Architectures","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis reference\/text addresses concepts and synthetic techniques for the preparation of polymers for state-of-the-art usein biomedicine, synthetic biology, and bionanotechnology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eAcknowledgments xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 What makes Polymers so Interesting? 1\u003c\/p\u003e \u003cp\u003e1.2 Macromolecular Engineering and Nanostructure Formation 4\u003c\/p\u003e \u003cp\u003e1.3 Specific Needs in Bionanotechnology and Biomedicine 5\u003c\/p\u003e \u003cp\u003eReference 6\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Terminology 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Polymer Architectures 7\u003c\/p\u003e \u003cp\u003e2.2 Multifunctionality 11\u003c\/p\u003e \u003cp\u003e2.3 Bioconjugates 12\u003c\/p\u003e \u003cp\u003e2.4 Biocompatibility 12\u003c\/p\u003e \u003cp\u003e2.5 Biodegradation 14\u003c\/p\u003e \u003cp\u003e2.6 Bioactivity 14\u003c\/p\u003e \u003cp\u003e2.7 Multivalency 15\u003c\/p\u003e \u003cp\u003e2.8 Bionanotechnology 17\u003c\/p\u003e \u003cp\u003eReferences 18\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Preparation Methods and Tools 19\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 General Aspects of Polymer Synthesis 19\u003c\/p\u003e \u003cp\u003e3.1.1 Chain Growth Polymerizations 20\u003c\/p\u003e \u003cp\u003e3.1.2 Step Growth Polymerizations 23\u003c\/p\u003e \u003cp\u003e3.1.3 Modification of Polymers 25\u003c\/p\u003e \u003cp\u003e3.2 Controlled Polymer Synthesis 25\u003c\/p\u003e \u003cp\u003e3.2.1 Anionic Polymerization 26\u003c\/p\u003e \u003cp\u003e3.2.2 Cationic Polymerization 30\u003c\/p\u003e \u003cp\u003e3.2.3 Controlled Radical Polymerization 34\u003c\/p\u003e \u003cp\u003e3.2.4 Metal‐Catalyzed Polymerization 37\u003c\/p\u003e \u003cp\u003e3.2.5 Chain Growth Condensation Polymerization 41\u003c\/p\u003e \u003cp\u003e3.3 Effective Polymer Analogous Reactions 43\u003c\/p\u003e \u003cp\u003e3.4 Pegylation 47\u003c\/p\u003e \u003cp\u003e3.5 Bioconjugation 51\u003c\/p\u003e \u003cp\u003e3.5.1 Polynucleotide Conjugates 53\u003c\/p\u003e \u003cp\u003e3.5.2 Protein Conjugates 55\u003c\/p\u003e \u003cp\u003e3.5.3 Polysaccharide Conjugates 57\u003c\/p\u003e \u003cp\u003e3.6 Enzymatic Polymer Synthesis 59\u003c\/p\u003e \u003cp\u003e3.7 Solid Phase Synthesis and Biotechnological Approaches 63\u003c\/p\u003e \u003cp\u003e3.7.1 Solid Phase Synthesis 63\u003c\/p\u003e \u003cp\u003e3.7.2 Biotechnology Approaches in the Synthesis of Biopolymers 75\u003c\/p\u003e \u003cp\u003e3.8 Hydrogels and Hydrogel Scaffolds 81\u003c\/p\u003e \u003cp\u003e3.8.1 Hydrogels 81\u003c\/p\u003e \u003cp\u003e3.8.2 Hydrogels as Scaffold Materials 84\u003c\/p\u003e \u003cp\u003e3.9 Surface Modification and Film Preparation 92\u003c\/p\u003e \u003cp\u003e3.9.1 Self‐Assembled Monolayers 93\u003c\/p\u003e \u003cp\u003e3.9.2 Langmuir–Blodgett Films 95\u003c\/p\u003e \u003cp\u003e3.9.3 Layer‐by‐Layer Deposition 96\u003c\/p\u003e \u003cp\u003e3.9.4 Immobilization by Chemical Binding to Substrates 97\u003c\/p\u003e \u003cp\u003e3.9.5 Low‐Pressure Plasma 99\u003c\/p\u003e \u003cp\u003e3.9.6 Electron Beam Treatment 101\u003c\/p\u003e \u003cp\u003e3.10 Microengineering of Polymers and Polymeric Surfaces 102\u003c\/p\u003e \u003cp\u003eReferences 107\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Analytical Methods 113\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Molecular Structure and Molar Mass Determination of Polymers and Biohybrids 113\u003c\/p\u003e \u003cp\u003e4.1.1 Structural Characterization 114\u003c\/p\u003e \u003cp\u003e4.1.2 Determination of Molar Mass and Molar Mass Distribution 132\u003c\/p\u003e \u003cp\u003e4.2 Characterization of Aggregates and Assemblies 137\u003c\/p\u003e \u003cp\u003e4.2.1 Dynamic Light Scattering 138\u003c\/p\u003e \u003cp\u003e4.2.2 Pulsed Field Gradient and Electrophoretic Nuclear Magnetic Resonance 139\u003c\/p\u003e \u003cp\u003e4.2.3 Field‐Flow Fractionation 142\u003c\/p\u003e \u003cp\u003e4.2.4 UV–Vis Spectroscopy and Fluorescence Spectroscopy 144\u003c\/p\u003e \u003cp\u003e4.2.5 Electron Microscopy 145\u003c\/p\u003e \u003cp\u003e4.3 Characterization of Hydrogel Networks 147\u003c\/p\u003e \u003cp\u003e4.3.1 Network Structure of Hydrogels 148\u003c\/p\u003e \u003cp\u003e4.3.2 Swelling Degree 148\u003c\/p\u003e \u003cp\u003e4.3.3 Mechanical Properties 150\u003c\/p\u003e \u003cp\u003e4.3.4 Deriving Microscopic Network Parameters from Macroscopic Hydrogel Properties 153\u003c\/p\u003e \u003cp\u003e4.4 Surface Characterization 154\u003c\/p\u003e \u003cp\u003e4.4.1 X‐Ray Photoelectron Spectroscopy 154\u003c\/p\u003e \u003cp\u003e4.4.2 Contact Angle Measurements by Axisymmetric Drop Shape Analysis 157\u003c\/p\u003e \u003cp\u003e4.4.3 Electrokinetic Measurements 158\u003c\/p\u003e \u003cp\u003e4.4.4 Spectroscopic Ellipsometry 159\u003c\/p\u003e \u003cp\u003e4.4.5 Quartz Crystal Microbalance with Dissipation Monitoring 160\u003c\/p\u003e \u003cp\u003e4.4.6 Surface Plasmon Resonance 161\u003c\/p\u003e \u003cp\u003e4.4.7 Scanning Force Techniques 162\u003c\/p\u003e \u003cp\u003e4.4.8 Environmental Scanning Electron Microscopy 164\u003c\/p\u003e \u003cp\u003e4.5 Biophysical Characterization and Biocompatibility 166\u003c\/p\u003e \u003cp\u003e4.5.1 Biophysical Characterization 167\u003c\/p\u003e \u003cp\u003e4.5.2 Biocompatibility 175\u003c\/p\u003e \u003cp\u003eReferences 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Multifunctional Polymer Architectures 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Multifunctional (Block) Copolymers 187\u003c\/p\u003e \u003cp\u003e5.1.1 Multifunctionality through Copolymerization 187\u003c\/p\u003e \u003cp\u003e5.1.2 Multifunctionality by Polymer Analogous Reactions 189\u003c\/p\u003e \u003cp\u003e5.1.3 Spatially Defined Multifunctionality by Phase Separation and Self‐Assembly of Segmented Copolymers 190\u003c\/p\u003e \u003cp\u003e5.2 Dendritic Polymers 196\u003c\/p\u003e \u003cp\u003e5.2.1 Synthesis of Dendrimers and Hyperbranched Polymers 198\u003c\/p\u003e \u003cp\u003e5.2.2 Properties and Applications 200\u003c\/p\u003e \u003cp\u003e5.3 Glycopolymers 203\u003c\/p\u003e \u003cp\u003e5.3.1 Linear Glycopolymers 205\u003c\/p\u003e \u003cp\u003e5.3.2 Globular Glycomacromolecules 207\u003c\/p\u003e \u003cp\u003e5.4 Peptide‐Based Structures 212\u003c\/p\u003e \u003cp\u003e5.4.1 Hierarchical Self‐Assembly of Peptide Molecules 214\u003c\/p\u003e \u003cp\u003e5.4.2 General Design Concepts for Peptide‐Based Structural Materials 215\u003c\/p\u003e \u003cp\u003e5.4.3 Noncanonical Amino Acids in Peptide\/Protein Engineering 217\u003c\/p\u003e \u003cp\u003e5.4.4 Peptide‐Based Materials Inspired by Naturally Occurring Structural Proteins 217\u003c\/p\u003e \u003cp\u003e5.4.5 Polypeptide Materials Based on other Naturally Occurring or De Novo Designed Self‐Assembling Domains such as Coiled Coils 221\u003c\/p\u003e \u003cp\u003e5.4.6 Self‐Assembly of Short Peptide Derivates and Peptide‐Based Amphiphilic Molecules 222\u003c\/p\u003e \u003cp\u003e5.5 Biohybrid Hydrogels 224\u003c\/p\u003e \u003cp\u003e5.5.1 Composition Basic Principles and Formation of Biohybrids 225\u003c\/p\u003e \u003cp\u003e5.5.2 Polynucleotide Biohybrids 228\u003c\/p\u003e \u003cp\u003e5.5.3 Polypeptide or Protein Biohybrids 231\u003c\/p\u003e \u003cp\u003e5.5.4 Polysaccharide Biohybrids 232\u003c\/p\u003e \u003cp\u003eReferences 235\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Functional Materials and Applied Systems 241\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Organic Nanoparticles and Aggregates for Drug and Gene Delivery 241\u003c\/p\u003e \u003cp\u003e6.1.1 Polymeric Micelles Polymersomes and Nanocapsules 241\u003c\/p\u003e \u003cp\u003e6.1.2 Polymeric Beads and Micro\/Nanogels Based on Dendritic Structures 254\u003c\/p\u003e \u003cp\u003e6.1.3 Polyplexes for Gene Delivery 263\u003c\/p\u003e \u003cp\u003e6.2 Polymer Therapeutics and Targeting Approaches 264\u003c\/p\u003e \u003cp\u003e6.2.1 Current Status of Polymer Therapeutics 264\u003c\/p\u003e \u003cp\u003e6.2.2 Implications and Rationale for Effective Delivery Systems 266\u003c\/p\u003e \u003cp\u003e6.2.3 Cellular Uptake and Targeting 267\u003c\/p\u003e \u003cp\u003e6.3 Multi‐ and Polyvalent Polymeric Architectures 271\u003c\/p\u003e \u003cp\u003e6.3.1 Polyvalent Interactions on Biological Interfaces 272\u003c\/p\u003e \u003cp\u003e6.3.2 Prospects for Multivalent Drugs 277\u003c\/p\u003e \u003cp\u003e6.4 Bioresponsive Networks 280\u003c\/p\u003e \u003cp\u003e6.4.1 Active Principle 280\u003c\/p\u003e \u003cp\u003e6.4.2 Homeostatic Regulation of Blood Coagulation 281\u003c\/p\u003e \u003cp\u003e6.4.3 Insulin Release in Response to Glucose Concentration 282\u003c\/p\u003e \u003cp\u003e6.4.4 Urate‐Responsive Release of Urate Oxidase 283\u003c\/p\u003e \u003cp\u003e6.4.5 Cell‐Responsive Degradation of Hydrogel Networks 284\u003c\/p\u003e \u003cp\u003e6.5 Biofunctional Surfaces 284\u003c\/p\u003e \u003cp\u003e6.5.1 Concepts and Aims of Biofunctional Material Surfaces 284\u003c\/p\u003e \u003cp\u003e6.5.2 Biofunctional Surfaces for the Prevention of Biofouling 287\u003c\/p\u003e \u003cp\u003e6.5.3 Anticoagulant Coatings for Blood‐Contacting Devices 292\u003c\/p\u003e \u003cp\u003eReferences 295\u003c\/p\u003e \u003cp\u003eAbbreviations 303\u003c\/p\u003e \u003cp\u003eIndex 309\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default 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