{"product_id":"asymmetric-synthesis-of-drugs-and-natural-products-9781138033610","title":"Asymmetric Synthesis of Drugs and Natural","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThis book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eChapter 1 Basic Stereochemical Approaches to Natural Products and Drugs.\u003c\/p\u003e\u003cp\u003e1.1Basic concept of Chirality.\u003c\/p\u003e\u003cp\u003e1.2 Meso compounds.\u003c\/p\u003e\u003cp\u003e1.3 Tautomerism and Valance Tautomerism. \u003c\/p\u003e\u003cp\u003e1.4 Conformation.Fischer Projection and Absolute Configuration.\u003c\/p\u003e\u003cp\u003e1.5 Chiral Resolution. \u003c\/p\u003e\u003cp\u003eApplication of Enantiomers in Drugs and Natural Products\u003c\/p\u003e\u003cp\u003e1.7. References\u003c\/p\u003e\u003cp\u003eProblems and answers \u003c\/p\u003e\u003cp\u003eChapter- 2: Diastereoselective Addition of Organometallic Reagents to Chiral Carbonyl Compounds\u003c\/p\u003e\u003cp\u003e2.1. Introduction\u003c\/p\u003e\u003cp\u003e2.2. Models for Asymmetric carbonyl compounds addition\u003c\/p\u003e\u003cp\u003e2.3 Models for 1,3 Asymmetric carbonyl addition\u003c\/p\u003e\u003cp\u003e2.4. Addition reactions of achiral reagent\u003c\/p\u003e\u003cp\u003e2.5. Addition of aldehyde\u003c\/p\u003e\u003cp\u003e2.6. Addition of Chiral ketones\u003c\/p\u003e\u003cp\u003e2.7. Conclusion\u003c\/p\u003e\u003cp\u003e2.8. References\u003c\/p\u003e\u003cp\u003eChapter- 3: Enantiomerically Pure Compounds by Enantioselective Synthetic Chiral Metal Complexes\u003c\/p\u003e\u003cp\u003e3.1.Introduction\u003c\/p\u003e\u003cp\u003e3.2 History\u003c\/p\u003e\u003cp\u003e3.3. Mechanism of Dirhodium(II) – catalysed cycloprpanation reactions\u003c\/p\u003e\u003cp\u003e3.4.Electronic modifications4.1.2.Steric modifications\u003c\/p\u003e\u003cp\u003e3.5.Dirhodium ( II) carboxylate complexes\u003c\/p\u003e\u003cp\u003e3.6.Dirhodium(II) catalysts-derived from chiral N-protected amino acid ligands\u003c\/p\u003e\u003cp\u003e3.7.Dirhodium(II) catalysts derived from substituted cyclopropane carboxylate ligands\u003c\/p\u003e\u003cp\u003e3.8.Dirhodium (II) carboxamidates complexes\u003c\/p\u003e\u003cp\u003e3.9.Effects of axial ligands on Enantioselectivity \u003c\/p\u003e\u003cp\u003e3.10. Conclusion \u003c\/p\u003e\u003cp\u003e3.11. References\u003c\/p\u003e\u003cp\u003eChapter – 4: Chirality Organization of Peptide and -Conjugated Polyanilines\u003c\/p\u003e\u003cp\u003e4.1. Introduction\u003c\/p\u003e\u003cp\u003e4.2 Chirality Organization of Peptides\u003c\/p\u003e\u003cp\u003e4.2.1 Chirality Organization of Peptides by Using Organic Molecular Scaffold\u003c\/p\u003e\u003cp\u003e4.2.2 Chirality Organization of Peptides by Using Organometallic Molecular Scaffold\u003c\/p\u003e\u003cp\u003e4.3 Synthesis of Optically Active Polyanilines\u003c\/p\u003e\u003cp\u003e4.3.1 Polymerization of Anilines in the Presence of a Chiral Acid\u003c\/p\u003e\u003cp\u003e4.3.2 Doping of Emeraldine Bases with a Chiral Acid\u003c\/p\u003e\u003cp\u003e4.3.3 Introduction of Chiral Groups into Polyanilines\u003c\/p\u003e\u003cp\u003e4.4 Chiral Complexation of Emeraldine Bases with Chiral Complexes\u003c\/p\u003e\u003cp\u003e4.5 Application of Optically Active Polyanilines\u003c\/p\u003e\u003cp\u003e4.6. Conclusion\u003c\/p\u003e\u003cp\u003e4.7.Reference\u003c\/p\u003e\u003cp\u003eChapter -5: Diastereoselective Syntheses of Iminosugars\u003c\/p\u003e\u003cp\u003e5.0. Introduction\u003c\/p\u003e\u003cp\u003e5.1. Syntheses from the Chiral Pool\u003c\/p\u003e\u003cp\u003e5.2. Bio-catalyzed syntheses.\u003c\/p\u003e\u003cp\u003e5.3. Asymmetric Syntheses\u003c\/p\u003e\u003cp\u003e5.4. Conclusion and Future Directions\u003c\/p\u003e\u003cp\u003e5.5. References\u003c\/p\u003e\u003cp\u003eChaptere-6: The use of specific new artificial or semisynthetic bio-catalysts for synthesis of regio- and enantioselective compounds\u003c\/p\u003e\u003cp\u003e6.1. Introduction\u003c\/p\u003e\u003cp\u003e6.2. Regioselective preparation of monodeprotected esters \u003c\/p\u003e\u003cp\u003e6.3. Refrences\u003c\/p\u003e\u003cp\u003eChapter – 7: Bioactive Natural Products and Their Structure-Activity Relationships Studies\u003c\/p\u003e\u003cp\u003e7.1 Introduction\u003c\/p\u003e\u003cp\u003e7.2 Anti-Microbial Natural Products\u003c\/p\u003e\u003cp\u003e7.3 Glutathione S-Transferase Inhibitors\u003c\/p\u003e\u003cp\u003e7.4 Acetylcholinesterase Inhibitors\u003c\/p\u003e\u003cp\u003e7.5.-Glucosidase Inhibitors\u003c\/p\u003e\u003cp\u003e7.6 Anti-Renin Natural Products\u003c\/p\u003e\u003cp\u003e7.7. References\u003c\/p\u003e\u003cp\u003eChapter-8: Asymmetric Biocatalysis in Organic synthesis of Natural Products\u003c\/p\u003e\u003cp\u003e8.1.Introduction\u003c\/p\u003e\u003cp\u003e8.2.Prochirality. meso compounds\u003c\/p\u003e\u003cp\u003e8.3.The enzymatic desymmetrization\u003c\/p\u003e\u003cp\u003e8.4.Factors affecting an enzymatic reaction enantioselectivity\u003c\/p\u003e\u003cp\u003e8.5.Hydrolases\u003c\/p\u003e\u003cp\u003e8.6.Application of esterases and proteases in enzymatic desymmetrization of symmetrical compounds\u003c\/p\u003e\u003cp\u003e8.7.Application of lipases in enzymatic desymmetrization of symmetrical compounds\u003c\/p\u003e\u003cp\u003e8.8.Oxidoreductases \u003c\/p\u003e\u003cp\u003e8.9. Application of dehydrogenases in enzymatic reduction of symmetrical compounds\u003c\/p\u003e\u003cp\u003e8.10. Application of ene-reductases in enzymatic reduction of symmetrical compounds\u003c\/p\u003e\u003cp\u003e8.11.Application of oxidases in enzymatic oxidation reactions of symmetrical compounds\u003c\/p\u003e\u003cp\u003e8.12.Application of peroxidases in enzymatic oxidation reactions of symmetrical compounds \u003c\/p\u003e\u003cp\u003e8.13. References\u003c\/p\u003e\u003cp\u003eCHAPTER -9: Asymmetric Synthesis Of Biaryls And Axially Chiral Natural Products\u003c\/p\u003e\u003cp\u003e9.1. Introduction\u003c\/p\u003e\u003cp\u003e9.2.Chirality in biaryl compounds\u003c\/p\u003e\u003cp\u003e9.3.Bridged and nonbridged biaryl compounds\u003c\/p\u003e\u003cp\u003e9.4.Selective construction of biaryl axes\u003c\/p\u003e\u003cp\u003e9.5.Oxidative homocoupling in the presence of chiral additives\u003c\/p\u003e\u003cp\u003e9.6.Redox-neutral cross-coupling catalyzed by chiral metal complexes\u003c\/p\u003e\u003cp\u003e9.7.Transformations of stable but achiral biaryls and conformationally unstable but chiralbiaryls\u003c\/p\u003e\u003cp\u003e9.8.Desymmetrization of prostereogenicbiaryl compounds\u003c\/p\u003e\u003cp\u003e9.9.Conversion of axially chiral but conformationally unstable biaryl compounds - introduction of additional substituent in the ortho position\u003c\/p\u003e\u003cp\u003e9.10.Conversion of axially chiral but conformationally unstable biaryl compounds -bridge formation\u003c\/p\u003e\u003cp\u003e9.11.Conversion of axially chiral but conformationally unstable biaryl compounds -cleavage of a bridge\u003c\/p\u003e\u003cp\u003e9.12.Asymmetric axially chiral biarylsynthesis by construction of an aromatic ring\u003c\/p\u003e\u003cp\u003e9.13.References\u003c\/p\u003e\u003cp\u003eCHAPTER-10: Palladium-Catalyzed Asymmetric Transformations Of Natural Products And Drug Molecules\u003c\/p\u003e\u003cp\u003e10.1. Introduction\u003c\/p\u003e\u003cp\u003e10.2. Palladium-catalyzed asymmetric allylic alkylations\u003c\/p\u003e\u003cp\u003e10.3. Asymmetric Intramolecular cyclization reactions\u003c\/p\u003e\u003cp\u003e10.4. Palladium-catalyzed carbonylation reactions\u003c\/p\u003e\u003cp\u003e10.5. Conclusion and Future Perspectives\u003c\/p\u003e\u003cp\u003e10.6.Reference\u003c\/p\u003e\u003cp\u003eChapter-11: Enantioselective Organocatalysis from Concepts to Applications in the Synthesis of Natural Products and Pharmaceuticals\u003c\/p\u003e\u003cp\u003e11.1.Introduction\u003c\/p\u003e\u003cp\u003e11.2. Enamine Chemistry\u003c\/p\u003e\u003cp\u003e11.3.Modes of activation: iminium catalysis\u003c\/p\u003e\u003cp\u003e11.4.Cascade reactions based on iminium\/enamine chemistry\u003c\/p\u003e\u003cp\u003e11.5 Application in total synthesis of organocascade reactions: Synthesis of Strychnine\u003c\/p\u003e\u003cp\u003e11.6.Conclusions\u003c\/p\u003e\u003cp\u003e11.7.References\u003c\/p\u003e\u003cp\u003eChapter-12: Chiral Building Blocks for Drugs Synthesis via Biotransformations\u003c\/p\u003e\u003cp\u003e12.1. Introduction\u003c\/p\u003e\u003cp\u003e12.2. Anticancer Drugs\u003c\/p\u003e\u003cp\u003e12.3 Small molecules\u003c\/p\u003e\u003cp\u003e12.4 Antidiabetic Drugs.\u003c\/p\u003e\u003cp\u003e12.5. Anti-inflammatory Drugs: Profens\u003c\/p\u003e\u003cp\u003e12.6. Drugs for treatment of Cardiovascular diseases\u003c\/p\u003e\u003cp\u003e12.7. Anticholesterol drugs\u003c\/p\u003e\u003cp\u003e12.8 Antihypertensive drugs\u003c\/p\u003e\u003cp\u003e12.8.1 β-BLOCKERS\u003c\/p\u003e\u003cp\u003e12.9 ACE inhibitors\u003c\/p\u003e\u003cp\u003e12.10 Calcium channel blockers\u003c\/p\u003e\u003cp\u003e12.11. Conclusion\u003c\/p\u003e\u003cp\u003e12.12.References\u003c\/p\u003e\u003cp\u003eChapter-13: Chiral Medicines\u003c\/p\u003e\u003cp\u003e13.1 Introduction\u003c\/p\u003e\u003cp\u003e13.2. Sitagliptin \u003c\/p\u003e\u003cp\u003e13.3. Aprepitant \u003c\/p\u003e\u003cp\u003e13.4. Simvastatin \u003c\/p\u003e\u003cp\u003e13.5. Paroxetine \u003c\/p\u003e\u003cp\u003e13.6. Levetiracetam \u003c\/p\u003e\u003cp\u003e13.7 Pregabalin \u003c\/p\u003e\u003cp\u003e13.8. Sertraline \u003c\/p\u003e\u003cp\u003e13.9. Conclusions \u003c\/p\u003e\u003cp\u003e13.10. References \u003c\/p\u003e\u003cp\u003eChapter -14: Drug Delivery Systems\u003c\/p\u003e\u003cp\u003e14.1. Introduction\u003c\/p\u003e\u003cp\u003e14.2. Classification of drugs \u003c\/p\u003e\u003cp\u003e14.3. Prodrug \u003c\/p\u003e\u003cp\u003e14.4.Mode of action of drug\u003c\/p\u003e\u003cp\u003e14.5. Sites of Drug Action\u003c\/p\u003e\u003cp\u003e14.6.Goal of Drug delivery \u003c\/p\u003e\u003cp\u003e14.7. Safety considerations\u003c\/p\u003e\u003cp\u003e14.8.Drug Distribution\u003c\/p\u003e\u003cp\u003e14.9.Further reading\u003c\/p\u003e\u003cp\u003eProblems to be solved\u003c\/p\u003e","brand":"CRC Press","offers":[{"title":"Default Title","offer_id":50577800134999,"sku":"9781138033610","price":199.5,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781138033610.jpg?v=1746096761","url":"https:\/\/bookcurl.com\/products\/asymmetric-synthesis-of-drugs-and-natural-products-9781138033610","provider":"Book Curl","version":"1.0","type":"link"}