{"product_id":"applied-bioengineering-innovations-and-future-directions-9783527340750","title":"Applied Bioengineering: Innovations and Future Directions","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eA comprehensive overview of the topic, highlighting recent developments, ongoing research trends and future directions.\u003c\/b\u003e\u003cbr\u003e Experts from Europe, Asia and the US cover five core areas of imminent importance to the food, feed, pharmaceutical and water treatment industries in terms of sustainable and innovative processing and production. In the field of enzyme engineering, they summarize historic developments and provide an overview of molecular enzyme engineering, while also discussing key principles of microbial process engineering, including chapters on process development and control. Further sections deal with animal and plant cell culture engineering. The final section of the book deals with environmental topics and highlights the application of bioengineering principles in waste treatment and the recovery of valuable resources.\u003cbr\u003e With its cutting-edge visions, extensive discussions and unique perspectives, this is a ready reference for biotechnologists, bioengineers, bioengineers, biotechnological institutes, and environmental chemists.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors XIX\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eToshiomi Yoshida\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Enzyme Technology 2\u003c\/p\u003e \u003cp\u003e1.3 Microbial Process Engineering 2\u003c\/p\u003e \u003cp\u003e1.4 Plant Cell Culture 5\u003c\/p\u003e \u003cp\u003e1.5 Animal Cell Culture 5\u003c\/p\u003e \u003cp\u003e1.6 Environmental Bioengineering 6\u003c\/p\u003e \u003cp\u003e1.7 Composition of the Volume 7\u003c\/p\u003e \u003cp\u003eReferences 7\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Enzyme Technology 11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Enzyme Technology: History and Current Trends 13\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKlaus Buchholz and Uwe T. Bornscheuer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 The Early Period up to 1890 13\u003c\/p\u003e \u003cp\u003e2.2 The Period from 1890 to 1940 16\u003c\/p\u003e \u003cp\u003e2.3 A New Biocatalyst Concept – Immobilized Enzymes 19\u003c\/p\u003e \u003cp\u003e2.4 Expanding Enzyme Application after the 1950s 24\u003c\/p\u003e \u003cp\u003e2.5 Recombinant Technology –A New Era in Biocatalysis and Enzyme Technology 27\u003c\/p\u003e \u003cp\u003e2.6 Current Strategies for Biocatalyst Search and Tailor Design 32\u003c\/p\u003e \u003cp\u003e2.7 Summary and Conclusions 39\u003c\/p\u003e \u003cp\u003eAcknowledgment 40\u003c\/p\u003e \u003cp\u003eAbbreviations 40\u003c\/p\u003e \u003cp\u003eReferences 40\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Molecular Engineering of Enzymes 47\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMaria Elena Ortiz-Soto and Jürgen Seibel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 47\u003c\/p\u003e \u003cp\u003e3.2 Protein Engineering: An Expanding Toolbox 48\u003c\/p\u003e \u003cp\u003e3.3 High-Throughput Screening Systems 56\u003c\/p\u003e \u003cp\u003e3.4 Engineered Enzymes for Improved Stability and Asymmetric Catalysis 58\u003c\/p\u003e \u003cp\u003e3.5 De Novo Design of Catalysts: Novel Activities within Common Scaffolds 65\u003c\/p\u003e \u003cp\u003e3.6 Conclusions 69\u003c\/p\u003e \u003cp\u003eReferences 69\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Biocatalytic Process Development 81\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn M.Woodley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 A Structured Approach to Biocatalytic Process Development 83\u003c\/p\u003e \u003cp\u003e4.2 Process Metrics 83\u003c\/p\u003e \u003cp\u003e4.3 Technologies for Implementation of Biocatalytic Processes 87\u003c\/p\u003e \u003cp\u003e4.4 Industrial Development Examples 91\u003c\/p\u003e \u003cp\u003e4.5 Future Outlook 95\u003c\/p\u003e \u003cp\u003e4.6 Concluding Remarks 96\u003c\/p\u003e \u003cp\u003eReferences 96\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Development of Enzymatic Reactions in Miniaturized Reactors 99\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eTakeshi Honda, Hiroshi Yamaguchi, and Masaya Miyazaki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 99\u003c\/p\u003e \u003cp\u003e5.2 Fundamental Techniques for Enzyme Immobilization 100\u003c\/p\u003e \u003cp\u003e5.3 Novel Techniques for Enzyme Immobilization 150\u003c\/p\u003e \u003cp\u003e5.4 Conclusions and Future Perspectives 155\u003c\/p\u003e \u003cp\u003eAbbreviations 156\u003c\/p\u003e \u003cp\u003eReferences 157\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Microbial Process Engineering 167\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Bioreactor Development and Process Analytical Technology 169\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eToshiomi Yoshida\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 169\u003c\/p\u003e \u003cp\u003e6.2 Bioreactor Development 170\u003c\/p\u003e \u003cp\u003e6.3 Monitoring and Process Analytical Technology 196\u003c\/p\u003e \u003cp\u003e6.4 Conclusion 203\u003c\/p\u003e \u003cp\u003eAbbreviations 204\u003c\/p\u003e \u003cp\u003eReferences 204\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Omics-Integrated Approach for Metabolic State Analysis of Microbial Processes 213\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHiroshi Shimizu, Chikara Furusawa, Takashi Hirasawa, Katsunori Yoshikawa, Yoshihiro Toya, Tomokazu Shirai, and Fumio Matsuda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 General Introduction 213\u003c\/p\u003e \u003cp\u003e7.2 Transcriptome Analysis of Microbial Status in Bioprocesses 214\u003c\/p\u003e \u003cp\u003e7.3 Analysis of Metabolic State Based on Simulation in a Genome-Scale Model 219\u003c\/p\u003e \u003cp\u003e7.4 13C-Based Metabolic Flux Analysis of Microbial Processes 223\u003c\/p\u003e \u003cp\u003e7.5 Comprehensive Phenotypic Analysis of Genes Associated with Stress Tolerance 227\u003c\/p\u003e \u003cp\u003e7.6 Multi-Omics Analysis and Data Integration 230\u003c\/p\u003e \u003cp\u003e7.7 Future Aspects for Developing the Field 231\u003c\/p\u003e \u003cp\u003eAcknowledgments 233\u003c\/p\u003e \u003cp\u003eReferences 233\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Control of Microbial Processes 237\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKazuyuki Shimizu, Hiroshi Shimizu, and Toshiomi Yoshida\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 237\u003c\/p\u003e \u003cp\u003e8.2 Monitoring 238\u003c\/p\u003e \u003cp\u003e8.3 Bioprocess Control 242\u003c\/p\u003e \u003cp\u003e8.4 Recent Trends in Monitoring and Control Technologies 250\u003c\/p\u003e \u003cp\u003e8.5 Concluding Remarks 253\u003c\/p\u003e \u003cp\u003eAbbreviations 254\u003c\/p\u003e \u003cp\u003eReferences 254\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Plant Cell Culture and Engineering 259\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Contained Molecular Farming Using Plant Cell and Tissue Cultures 261\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eStefan Schillberg, Nicole Raven, Rainer Fischer, Richard M. Twyman, and Andreas Schiermeyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Molecular Farming –Whole Plants and Cell\/Tissue Cultures 261\u003c\/p\u003e \u003cp\u003e9.2 Plant Cell and Tissue Culture Platforms 263\u003c\/p\u003e \u003cp\u003e9.3 Comparison ofWhole Plants and In Vitro Culture Platforms 265\u003c\/p\u003e \u003cp\u003e9.4 Technical Advances on the Road to Commercialization 267\u003c\/p\u003e \u003cp\u003e9.5 Regulatory and Industry Barriers on the Road to Commercialization 271\u003c\/p\u003e \u003cp\u003e9.6 Outlook 273\u003c\/p\u003e \u003cp\u003eAcknowledgments 275\u003c\/p\u003e \u003cp\u003eReferences 275\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Bioprocess Engineering of Plant Cell Suspension Cultures 283\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGregory R. Andrews and Susan C. Roberts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 283\u003c\/p\u003e \u003cp\u003e10.2 Culture Development and Maintenance 286\u003c\/p\u003e \u003cp\u003e10.3 Choice of Culture System 288\u003c\/p\u003e \u003cp\u003e10.4 Engineering Considerations 291\u003c\/p\u003e \u003cp\u003e10.5 Bioprocess Parameters 294\u003c\/p\u003e \u003cp\u003e10.6 Operational Modes 296\u003c\/p\u003e \u003cp\u003e10.7 Bioreactors for Plant Cell Suspensions 297\u003c\/p\u003e \u003cp\u003e10.8 Downstream Processing 303\u003c\/p\u003e \u003cp\u003e10.9 Yield Improvement Strategies 306\u003c\/p\u003e \u003cp\u003e10.10 Case Studies 310\u003c\/p\u003e \u003cp\u003e10.11 Conclusion 315\u003c\/p\u003e \u003cp\u003eReferences 316\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 The Role of Bacteria in Phytoremediation 327\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eZhaoyu Kong and Bernard R. Glick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 The Problem 327\u003c\/p\u003e \u003cp\u003e11.2 Defining Phytoremediation and Its Components 329\u003c\/p\u003e \u003cp\u003e11.3 Role of Bacteria in Phytoremediation 330\u003c\/p\u003e \u003cp\u003e11.4 Examples of Phytoremediation in Action 342\u003c\/p\u003e \u003cp\u003e11.5 Summary and Perspectives 343\u003c\/p\u003e \u003cp\u003eReferences 344\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Animal Cell Cultures 355\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Cell Line Development for Biomanufacturing Processes 357\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMugdha Gadgil andWei-Shou Hu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 357\u003c\/p\u003e \u003cp\u003e12.2 Host Cell 359\u003c\/p\u003e \u003cp\u003e12.3 Vector Components 360\u003c\/p\u003e \u003cp\u003e12.4 Transfection 365\u003c\/p\u003e \u003cp\u003e12.5 Integration of Foreign DNA into Host Chromosome 366\u003c\/p\u003e \u003cp\u003e12.6 Amplification 369\u003c\/p\u003e \u003cp\u003e12.7 Single-Cell Cloning 370\u003c\/p\u003e \u003cp\u003e12.8 Selecting the Production Clone 373\u003c\/p\u003e \u003cp\u003e12.9 Clone Stability 376\u003c\/p\u003e \u003cp\u003e12.10 Conclusion 376\u003c\/p\u003e \u003cp\u003eAcknowledgments 377\u003c\/p\u003e \u003cp\u003eReferences 377\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Medium Design, Culture Management, and the PAT Initiative 383\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eZiomara P. Gerdtzen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Historical Perspective on Culture Medium 383\u003c\/p\u003e \u003cp\u003e13.2 Cell Growth Environment 384\u003c\/p\u003e \u003cp\u003e13.3 Media Types 386\u003c\/p\u003e \u003cp\u003e13.4 Medium Components 387\u003c\/p\u003e \u003cp\u003e13.5 High MolecularWeight and Complex Supplements 400\u003c\/p\u003e \u003cp\u003e13.6 Medium for Industrial Production 407\u003c\/p\u003e \u003cp\u003e13.7 Conclusions 411\u003c\/p\u003e \u003cp\u003eReferences 412\u003c\/p\u003e \u003cp\u003eFurther Reading\/Resources 416\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Advanced Bioprocess Engineering: Fed-Batch and Perfusion Processes 417\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSarika Mehra, Vikas Chandrawanshi, and Kamal Prashad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Primary Modes of Bioreactor Operation 417\u003c\/p\u003e \u003cp\u003e14.2 Fed-Batch Mode of Operation 419\u003c\/p\u003e \u003cp\u003e14.3 Perfusion Mode of Bioreactor Operation 435\u003c\/p\u003e \u003cp\u003e14.4 Use of Disposables in Cell Culture Bioprocesses 447\u003c\/p\u003e \u003cp\u003e14.5 Analytical Methods to Monitor Key Metabolites and Parameters 450\u003c\/p\u003e \u003cp\u003e14.6 Concluding Remarks 453\u003c\/p\u003e \u003cp\u003eNomenclature 455\u003c\/p\u003e \u003cp\u003eReferences 456\u003c\/p\u003e \u003cp\u003eFurther Reading\/Resources 468\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Environmental Bioengineering 469\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Treatment of Industrial and Municipal Wastewater: An Overview about Basic and Advanced Concepts 471\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJyoti K. Kumar, Parag R. Gogate, and Aniruddha B. Pandit\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Types ofWastewater 471\u003c\/p\u003e \u003cp\u003e15.2 Biological Treatment 471\u003c\/p\u003e \u003cp\u003e15.3 Wastewater Regulations 473\u003c\/p\u003e \u003cp\u003e15.4 Biological Treatment Processes 473\u003c\/p\u003e \u003cp\u003e15.5 Aerobic Techniques 475\u003c\/p\u003e \u003cp\u003e15.6 Anaerobic Techniques 488\u003c\/p\u003e \u003cp\u003e15.7 Aerobic–Anaerobic Processes 495\u003c\/p\u003e \u003cp\u003e15.8 Modified Biological Processes 496\u003c\/p\u003e \u003cp\u003e15.9 Overall Conclusions 511\u003c\/p\u003e \u003cp\u003eList of Acronyms\/Abbreviations 512\u003c\/p\u003e \u003cp\u003eList of Variables and Coefficients 513\u003c\/p\u003e \u003cp\u003eReferences 514\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Treatment of SolidWaste 521\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMichael Nelles, Gert Morscheck, Astrid Lemke, and Ayman El Naas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Biological Treatment of Source Segregated Bio-Waste 522\u003c\/p\u003e \u003cp\u003e16.2 Mechanical–Biological Treatment of Mixed Municipal Solid Waste 538\u003c\/p\u003e \u003cp\u003e16.3 Biological Treatment of AgriculturalWaste 542\u003c\/p\u003e \u003cp\u003e16.4 Conclusion 542\u003c\/p\u003e \u003cp\u003eReferences 542\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Energy Recovery from Organic Waste 545\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eYutaka Nakashimada and Naomichi Nishio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Advantage of Methane Fermentation for Energy Recovery from Organic Matter 545\u003c\/p\u003e \u003cp\u003e17.2 Basic Knowledge of Methane Fermentation of OrganicWastes 546\u003c\/p\u003e \u003cp\u003e17.3 Conventional Methane Fermentation Process 549\u003c\/p\u003e \u003cp\u003e17.4 Advanced Methane Fermentation Processes 551\u003c\/p\u003e \u003cp\u003e17.5 Hydrogen Production from OrganicWastes 555\u003c\/p\u003e \u003cp\u003e17.6 Upgrading of Biogas from OrganicWastes Based on Biological Syngas Platform 561\u003c\/p\u003e \u003cp\u003e17.7 Conclusions 564\u003c\/p\u003e \u003cp\u003eReferences 565\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Microbial Removal and Recovery of Metals from Wastewater 573\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMichihiko Ike,Mitsuo Yamashita, and Masashi Kuroda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Microbial Reactions Available for Metal Removal\/Recovery 574\u003c\/p\u003e \u003cp\u003e18.2 Selenium Recovery by Pseudomonas stutzeri NT-I 583\u003c\/p\u003e \u003cp\u003e18.3 Future Prospects 587\u003c\/p\u003e \u003cp\u003e18.4 Conclusions 590\u003c\/p\u003e \u003cp\u003eReferences 590\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Sustainable Use of Phosphorus Through Bio-Based Recycling 597\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHisao Ohtake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 597\u003c\/p\u003e \u003cp\u003e19.2 Microbiological Basis 598\u003c\/p\u003e \u003cp\u003e19.3 Bio-Based P Recycling 600\u003c\/p\u003e \u003cp\u003e19.4 Other Options for P Recycling 604\u003c\/p\u003e \u003cp\u003e19.5 Conclusions 607\u003c\/p\u003e \u003cp\u003eReferences 609\u003c\/p\u003e \u003cp\u003eIndex 613\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":53196949717335,"sku":"9783527340750","price":153.85,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/applied-bioengineering-innovations-and-future-directions-9783527340750","provider":"Book Curl","version":"1.0","type":"link"}