{"product_id":"analogue-based-drug-discovery-9783527312573","title":"Analogue-based Drug Discovery","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds. \u003cbr\u003e Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them.\u003cbr\u003e The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"This book is eminently  capable of educating both newcomers and experienced practitioners to the fields of medicinal chemistry and pharmacology, and it is highly recommended as an addition to the personal collection of the practicing drug designer and as a reference volume for institutional use as well.\"\u003cbr\u003e Journal of Medicinal Chemistry\u003cbr\u003e \u003cbr\u003e \"Overall the book is of interest for medicinal chemists who already have a sound knowledge of aspects of analogue-based drug design.\" ChemMedChem\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eIntroduction\u003cbr\u003e GENERAL ASPECTS OF ANALOGUE-BASED DRUG DISCOVERY\u003cbr\u003e Analogues as a Means of Discovering New Drugs\u003cbr\u003e Drug Likeness and Analogue-Based Drug Discovery\u003cbr\u003e Privileged Structures and Analog-Based Drug Discovery\u003cbr\u003e SELECTED EXAMPLES FROM THE ANALOGUE-BASED DRUG DISCOVERIES\u003cbr\u003e Development of Anti-Ulcer H2-Receptor Histamine Antagonists\u003cbr\u003e Esomeprazole in the Framework of Proton-Pump Inhibitor Development\u003cbr\u003e The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole\u003cbr\u003e Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors\u003cbr\u003e Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers\u003cbr\u003e Optimizing Antihypertensive Therapy by Angiotensin-Converting Enzyme Inhibitors\u003cbr\u003e Case Study of Lacidipine in the Research of New Calcium Antagonists\u003cbr\u003e Selective Beta-Adrenergic Receptor-Blocking Agents\u003cbr\u003e Case Study: \"Esmolol Stat\" [1]\u003cbr\u003e Development of Organic Nitrates for Coronary Heart Disease\u003cbr\u003e Development of Opioid Receptor Ligands\u003cbr\u003e Stigmines\u003cbr\u003e Structural Analogues of Clozapine\u003cbr\u003e Quinolone Antibiotics: The Development of Moxifloxacin\u003cbr\u003e The Development of Bisphosphonates as Drugs\u003cbr\u003e Cisplatin and its Analogs for Cancer Chemotherapy\u003cbr\u003e The History of Drospirenone\u003cbr\u003e Histamine H1 Blockers: From Relative Failures to Blockbusters Within Series of Analogues\u003cbr\u003e Corticosteroids: From Natural Products to Useful Analogues","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":53196945621335,"sku":"9783527312573","price":213.26,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/analogue-based-drug-discovery-9783527312573","provider":"Book Curl","version":"1.0","type":"link"}