{"product_id":"an-introduction-to-statistics-in-early-phase-trials-9780470059852","title":"An Introduction to Statistics in Early Phase","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis guide offers an overview of the most common types of trial undertaken in early clinical development. The coverage discusses the different methodologies and the impact of new technologies, both clinical and statistical, on clinical development.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"An Introduction to Statistics in Early Phase Trials\" is an admirably concise and practical guide to the pertinent context, principles and formulae for statisticians inexpert in the application of their discipline to Phase I and II clinical research\". (Journal of Clinical Research Best Practices, 1 March 2011)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e“\u003ci\u003eAn Introduction to Statistics in Early Phase Trials\u003c\/i\u003e provides concise descriptions of many early phase trial designs, along with the statistical equations necessary to gather and analyze the data”  (\u003ci\u003eAnnals of Pharmacotherapy, 2010\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e\"I enjoyed reading the work of Dr. Julious, Tan, and Machin,found it quite useful, and recommend it to others teaching about, working with, or considering work in the learning phase of drug development.\" (\u003ci\u003eJournal of Biopharmaceutical Statistics\u003c\/i\u003e, \u003ci\u003e2011\u003c\/i\u003e)\u003c\/p\u003e \u003cbr\u003e \u003cbr\u003e  \u003cbr\u003e \u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eChapter 1 Early phase trials 1\u003c\/p\u003e \u003cp\u003eChapter 2 Introduction to pharmacokinetics 13\u003c\/p\u003e \u003cp\u003eChapter 3 Sample size calculations for clinical trials 37\u003c\/p\u003e \u003cp\u003eChapter 4 Crossover trial basics 55\u003c\/p\u003e \u003cp\u003eChapter 5 Multi-period crossover trials 71\u003c\/p\u003e \u003cp\u003eChapter 6 First time into man 87\u003c\/p\u003e \u003cp\u003eChapter 7 Bayesian and frequentist methods 113\u003c\/p\u003e \u003cp\u003eChapter 8 First-time-into-new-population studies 125\u003c\/p\u003e \u003cp\u003eChapter 9 Bioequivalence studies 139\u003c\/p\u003e \u003cp\u003eChapter 10 Other Phase I trials 169\u003c\/p\u003e \u003cp\u003eChapter 11 Phase II trials: general issues 187\u003c\/p\u003e \u003cp\u003eChapter 12 Dose–response studies 197\u003c\/p\u003e \u003cp\u003eChapter 13 Phase II trials with toxic therapies 211\u003c\/p\u003e \u003cp\u003eChapter 14 Interpreting and applying early phase trial results 223\u003c\/p\u003e \u003cp\u003eChapter 15 Go\/No-Go criteria 231\u003c\/p\u003e \u003cp\u003eAppendix 245\u003c\/p\u003e \u003cp\u003eReferences 251\u003c\/p\u003e \u003cp\u003eIndex 257\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":51037067051351,"sku":"9780470059852","price":80.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470059852.jpg?v=1750934235","url":"https:\/\/bookcurl.com\/products\/an-introduction-to-statistics-in-early-phase-trials-9780470059852","provider":"Book Curl","version":"1.0","type":"link"}