{"product_id":"airway-smooth-muscle-in-asthma-and-copd-biology-and-pharmacology-9780470060667","title":"Airway Smooth Muscle in Asthma and COPD Biology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e“Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management.” (\u003ci\u003eDoody's Reviews\u003c\/i\u003e, March 2009)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSteven S. An and Jeffrey J. Fredberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Airway hyperresponsiveness 2\u003c\/p\u003e \u003cp\u003e1.3 Classical behaviour of airway smooth muscle and the balance of static forces 6\u003c\/p\u003e \u003cp\u003e1.4 Shortening velocity and other manifestations of muscle dynamics 8\u003c\/p\u003e \u003cp\u003e1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture? 10\u003c\/p\u003e \u003cp\u003e1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle 14\u003c\/p\u003e \u003cp\u003e1.7 Recent observations 18\u003c\/p\u003e \u003cp\u003e1.8 Future directions 20\u003c\/p\u003e \u003cp\u003eReferences 20\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction 31\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eWenwu Zhang and Susan J. Gunst\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 31\u003c\/p\u003e \u003cp\u003e2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell 33\u003c\/p\u003e \u003cp\u003e2.3 Cytoskeletal dynamics and airway smooth muscle contraction 38\u003c\/p\u003e \u003cp\u003eReferences 43\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Airway smooth muscle: role in airway constrictor hyperresponsiveness 53\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMelanie Brown and Julian Solway\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 What is airway constrictor hyperresponsiveness (AHR)? 53\u003c\/p\u003e \u003cp\u003e3.2 Is AHR ever good? 55\u003c\/p\u003e \u003cp\u003e3.3 Potential mechanisms leading to airflow obstruction 55\u003c\/p\u003e \u003cp\u003e3.4 Potential abnormalities of airway smooth muscle (ASM) 60\u003c\/p\u003e \u003cp\u003e3.5 If ASM is dysfunctional, how did it get that way? 63\u003c\/p\u003e \u003cp\u003e3.6 Summary 64\u003c\/p\u003e \u003cp\u003eAcknowledgements 64\u003c\/p\u003e \u003cp\u003eReferences 64\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Airway smooth muscle phenotypic and functional plasticity 71\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrew J. Halayko, Reinoud Gosens and Thai Tran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 71\u003c\/p\u003e \u003cp\u003e4.2 Historical perspective: smooth muscle phenotype plasticity 72\u003c\/p\u003e \u003cp\u003e4.3 Features of phenotype plasticity 74\u003c\/p\u003e \u003cp\u003e4.4 Mechanisms for phenotypic plasticity 76\u003c\/p\u003e \u003cp\u003e4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis 80\u003c\/p\u003e \u003cp\u003e4.6 Concluding remarks 84\u003c\/p\u003e \u003cp\u003eReferences 84\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 89\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eReynold A. Panettieri, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences 89\u003c\/p\u003e \u003cp\u003e5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation 91\u003cbr\u003eReferences 99\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Airway smooth muscle bidirectional interactions with extracellular matrix 105\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJane E. Ward and Stuart J. Hirst\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Overview 105\u003c\/p\u003e \u003cp\u003e6.2 Introduction 106\u003c\/p\u003e \u003cp\u003e6.3 Airway extracellular matrix (ECM) in health and disease 108\u003c\/p\u003e \u003cp\u003e6.4 Integrins 110\u003c\/p\u003e \u003cp\u003e6.5 Airway smooth muscle (ASM) as a modulator of airway ECM 111\u003c\/p\u003e \u003cp\u003e6.6 Airway ECM as modulator of ASM function 113\u003c\/p\u003e \u003cp\u003e6.7 Impact of anti-asthma therapy on ASM–ECM interactions 118\u003c\/p\u003e \u003cp\u003e6.8 Conclusions 120\u003c\/p\u003e \u003cp\u003eAcknowledgements 121\u003c\/p\u003e \u003cp\u003eReferences 121\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Airway smooth muscle interaction with mast cells 127\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRoger Marthan, Patrick Berger, Pierre-Olivier Girodet and J. Manuel Tunon-de-Lara\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 127\u003c\/p\u003e \u003cp\u003e7.2 Mast cell mediators alter smooth muscle function 129\u003c\/p\u003e \u003cp\u003e7.3 Smooth muscle cells induce mast cell chemotaxis 132\u003c\/p\u003e \u003cp\u003e7.4 Mast cells can adhere to airway smooth muscle 134\u003c\/p\u003e \u003cp\u003e7.5 Conclusion 135\u003c\/p\u003e \u003cp\u003eAcknowledgements 136\u003c\/p\u003e \u003cp\u003eReferences 136\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Airway smooth muscle synthesis of inflammatory mediators 141\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAlison E. John, Deborah L. Clarke, Alan J. Knox and Karl Deacon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 141\u003c\/p\u003e \u003cp\u003e8.2 Lipid mediators 142\u003c\/p\u003e \u003cp\u003e8.3 Chemokines 146\u003c\/p\u003e \u003cp\u003e8.4 Growth and remodelling factors 149\u003c\/p\u003e \u003cp\u003e8.5 Conclusions 152\u003c\/p\u003e \u003cp\u003eReferences 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Airway smooth muscle in experimental models 159\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnne-Marie Lauzon and James G. Martin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 159\u003c\/p\u003e \u003cp\u003e9.2 Methods of assessment of airway smooth muscle (ASM) function 160\u003c\/p\u003e \u003cp\u003e9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness 161\u003c\/p\u003e \u003cp\u003e9.4 Experimental models 164\u003c\/p\u003e \u003cp\u003e9.5 Conclusion 173\u003c\/p\u003e \u003cp\u003eAcknowledgement 173\u003c\/p\u003e \u003cp\u003eReferences 173\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Altered properties of airway smooth muscle in asthma 181\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJudith Black, Janette Burgess, Brian Oliver and Lyn Moir\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 181\u003c\/p\u003e \u003cp\u003e10.2 The extracellular matrix (ECM) and the airway smooth muscle (ASM) 182\u003c\/p\u003e \u003cp\u003e10.3 ASM and integrins 190\u003c\/p\u003e \u003cp\u003e10.4 The ASM cell and inflammation 191\u003c\/p\u003e \u003cp\u003e10.5 The ASM cell and infection 193\u003c\/p\u003e \u003cp\u003eReferences 194\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 The airway smooth muscle in chronic obstructive pulmonary disease (COPD) 201\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMaria B. Sukkar and Kian Fan Chung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 201\u003c\/p\u003e \u003cp\u003e11.2 Definition and assessment of COPD 202\u003c\/p\u003e \u003cp\u003e11.3 Pathological features of COPD 203\u003c\/p\u003e \u003cp\u003e11.4 COPD mechanisms 206\u003c\/p\u003e \u003cp\u003e11.5 Conclusion 220\u003c\/p\u003e \u003cp\u003eReferences 220\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Glucocorticoid actions on airway smooth muscle 235\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eIan M. Adcock, Loukia Tsaprouni and Pank Bhavsar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 235\u003c\/p\u003e \u003cp\u003e12.2 Airway smooth muscle (ASM) in airways disease 236\u003c\/p\u003e \u003cp\u003e12.3 Gene induction by glucocorticoid receptors (GR) 240\u003c\/p\u003e \u003cp\u003e12.4 Actions of β2-agonists and glucocorticoids on growth, proliferation, and migration of ASM 245\u003c\/p\u003e \u003cp\u003e12.5 Summary and conclusions 248\u003c\/p\u003e \u003cp\u003eAcknowledgements 248\u003c\/p\u003e \u003cp\u003eReferences 248\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 β2-Adrenergic receptors: effects on airway smooth muscle 255\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMalcolm Johnson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 The β2-adrenoceptor 255\u003c\/p\u003e \u003cp\u003e13.2 β2-Receptor activation 257\u003c\/p\u003e \u003cp\u003e13.3 β2-Receptor signalling pathways 257\u003c\/p\u003e \u003cp\u003e13.4 Effects in airway smooth muscle (ASM) 258\u003c\/p\u003e \u003cp\u003e13.5 β2-Receptor desensitization 260\u003c\/p\u003e \u003cp\u003e13.6 Influence of polymorphisms of the β2-adrenoceptor in ASM 262\u003c\/p\u003e \u003cp\u003e13.7 Non-bronchodilator effects of β2-agonists in ASM 264\u003c\/p\u003e \u003cp\u003e13.8 Conclusion 271\u003c\/p\u003e \u003cp\u003eReferences 271\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Asthma treatments: effects on the airway smooth muscle 277\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKian Fan Chung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 277\u003c\/p\u003e \u003cp\u003e14.2 Role and abnormalities of airway smooth muscle (ASM) in asthma and COPD 279\u003c\/p\u003e \u003cp\u003e14.3 Treatment of asthma 283\u003c\/p\u003e \u003cp\u003e14.4 Conclusion 293\u003c\/p\u003e \u003cp\u003eReferences 293\u003c\/p\u003e \u003cp\u003eIndex 303\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49525364031831,"sku":"9780470060667","price":151.95,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470060667.jpg?v=1731860235","url":"https:\/\/bookcurl.com\/products\/airway-smooth-muscle-in-asthma-and-copd-biology-and-pharmacology-9780470060667","provider":"Book Curl","version":"1.0","type":"link"}