{"product_id":"a-handbook-for-dnaencoded-chemistry-9781118487686","title":"A Handbook for DNAEncoded Chemistry","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eThis book comprehensively describes the development and practice of DNA-encoded library synthesis technology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTogether, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eProvides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry\u003c\/li\u003e \u003cli\u003eHelps chemists generate and screen novel chemical libraries of large size and quality\u003c\/li\u003e \u003cli\u003eBridges interdisciplinary areas of DNA-encoded combinatorial chemistry  synthetic and analytical chemistry, molecular biology, informatics, and biochemistry\u003c\/li\u003e \u003cli\u003eShows medicinal and pharmaceutical chemists how to efficiently broaden available chemical space for drug discovery\u003c\/li\u003e \u003cli\u003eProvides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eAcknowledgments ix\u003c\/p\u003e \u003cp\u003eIntroductory Comments xi\u003c\/p\u003e \u003cp\u003eContributors xxiii\u003c\/p\u003e \u003cp\u003e1 Just enough knowledge… 1\u003cbr\u003e\u003ci\u003eAgnieszka Kowalczyk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry 19\u003cbr\u003e\u003ci\u003eRobert A. Goodnow, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 A brief history of DNA-encoded chemistry 45\u003cbr\u003e\u003ci\u003eAnthony D. Keefe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 DNA-Compatible Chemistry 67\u003cbr\u003e\u003ci\u003eKin-Chun Luk and Alexander Lee Satz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Foundations of a DNA-encoded library (DEL) 99\u003cbr\u003e\u003ci\u003eAlexander Lee Satz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Exercises in the Synthesis of DNA-encoded Libraries 123\u003cbr\u003e\u003ci\u003eSteffen P. Creaser and Raksha A. Acharya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The DNA Tag: A Chemical gene designed for DNA-encoded libraries 153\u003cbr\u003e\u003ci\u003eAndrew W. Fraley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Analytical challenges for DNA-encoded library systems 171\u003cbr\u003e\u003ci\u003eGeorge L. Perkins and G. John Langley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Informatics: Functionality and architecture for DNA-encoded library production and screening 201\u003cbr\u003e\u003ci\u003eJohn A. Feinberg and Zhengwei Peng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Theoretical considerations of the application of DNA-encoded libraries to drug discovery 213\u003cbr\u003e\u003ci\u003eCharles Wartchow\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Begin with the End in Mind: The hit-to-lead process 231\u003cbr\u003e\u003ci\u003eJohn Proudfoot\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Enumeration and Visualization of Large Combinatorial Chemical Libraries 247\u003cbr\u003e\u003ci\u003eSung-Sau So\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Screening Large Compound Collections 281\u003cbr\u003e\u003ci\u003eStephen P. Hale\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Reported applications of DNA-encoded library chemistry 319\u003cbr\u003e\u003ci\u003eJohannes Ottl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Dual-Pharmacophore DNA-encoded Chemical Libraries 349\u003cbr\u003e\u003ci\u003eJörg Scheuermann and Dario Neri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Hit Identification and Hit Follow-up 357\u003cbr\u003e\u003ci\u003eYixin Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding 377\u003cbr\u003e\u003ci\u003eLynn M. McGregor and David R. Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 The changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches 417\u003cbr\u003e\u003ci\u003eRobert A. Goodnow, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Keeping the promise? An outlook on DNA chemical library technology 427\u003cbr\u003e\u003ci\u003eSamu Melkko and Johannes Ottl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 435\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406878482775,"sku":"9781118487686","price":97.16,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118487686.jpg?v=1730497424","url":"https:\/\/bookcurl.com\/products\/a-handbook-for-dnaencoded-chemistry-9781118487686","provider":"Book Curl","version":"1.0","type":"link"}