{"title":"Medical toxicology Books","description":"","products":[{"product_id":"uninformed-consent-the-hidden-dangers-in-dental-care-9781571741172","title":"Uninformed Consent: The Hidden Dangers in Dental","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Hampton Roads Publishing Co","offers":[{"title":"Default Title","offer_id":48740512039255,"sku":"9781571741172","price":17.09,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781571741172.jpg?v=1720054901"},{"product_id":"poisonous-tales-a-forensic-examination-of-poisons-in-fiction-9781839161438","title":"Poisonous Tales: A Forensic Examination of","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDangerous, dark and difficult to detect, poisons have been a common character in literature from ancient times to the modern day. Their ability to perform deadly deeds at a distance is a common device for creating dramatic tension and playing on our real life fears. But what is fact and what is pure fiction?   From Shakespeare and Dickens to Hugo and Poe, the macabre world of literary poisonings is as large as it is fascinating. Utilising real forensic science Poisonous Tales explores the real science inspiring the toxins and tinctures in our favourite works. Could a poison really mimic death in Romeo and Juliet? What is the cause of the mad Hatter’s malady in Alice in Wonderland? And could a stone from the stomach of a goat really have been used as an antidote in Harry Potter and the Half-Blood Prince? Through these and many more ‘cases’ we discover the captivating truth in the texts and how real-life tragedies can replicate themselves in fiction.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eUseful Herb or Dreadful Poison;The Cry of Death;A Ghostly Encounter with Poison;The Flattering Truth of Sleep;The Queen of Poisons;Outfoxed by Digitalis;Poison for a Broken Heart;The Power to Heal as well as Harm;Beautiful but Deadly;Nature’s Toxic Gift;Mad as a Hatter;The Silent Killer","brand":"Royal Society of Chemistry","offers":[{"title":"Default Title","offer_id":48741984305495,"sku":"9781839161438","price":22.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781839161438.jpg?v=1720059563"},{"product_id":"marine-mammal-ecotoxicology-9780128121443","title":"Marine Mammal Ecotoxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePART 1. Legacy and emerging contaminants in marine mammal populations 1. Organochlorine contaminants and reproductive implication in cetaceans: A case study of the common dolphin  2. Feeding ecology tools to assess contaminant exposure in coastal mammals  3. The toxicological effects of oil exposure on cetaceans  4.  Legacy contamination in estuarine dolphin species from the South American coast  5. Poly- and Perfluoroalkyl Substances in Marine Mammals 6. Marine debris interaction with marine mammals  7. Persistent organic pollutants in cetaceans living in a hotspot area: the Mediterranean sea 8. Pollutants in tropical marine mammals of the Galapagos Islands, Ecuador: An Ecotoxicological Quest to the Last Eden    PART 2. Effects of toxicological and cumulative stress on marine mammal health 9. Field sampling techniques and ecotoxicological Biomarkers in cetaceans  10. Ecotoxicological biomarkers and accumulation of contaminants in pinnipeds  11. New technologies for monitoring marine mammal health  12. Immunotoxic effects of environmental pollutants in marine mammals 13. Ecotoxicological stress in Arctic marine mammals - with particular focus on polar bears 14. Toxicological Risks and Considerations Associated with Lipophilic Contaminant Burdens of Mysticetes in Antarctic Ecosystems  15. Emerging pathogens and stress syndromes of cetaceans in European waters: cumulative effects 16. Ecotoxicology of the Sirenia in the Twenty-First Century    PART 3. Implication for monitoring and conservation of marine mammals 17. Marine mammals and multiple stressors, implications for conservation and policy","brand":"Elsevier Science Publishing Co Inc","offers":[{"title":"Default Title","offer_id":48864163561815,"sku":"9780128121443","price":90.0,"currency_code":"GBP","in_stock":true}]},{"product_id":"clarkes-analysis-of-drugs-and-poisons-9780853697114","title":"Clarkes Analysis of Drugs and Poisons","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eClarke's Analysis of Drugs and Poisons is the definitive source of analytical data for drugs and poisons.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"This continues to be an invaluable reference for pharmaceutical scientists, clinical and forensic toxicologists and environmental chemists...Both the number of substances discussed in the monograph section and the depth of information presented are quite impressive.\"   Randall C. Baselt, Ph.D., Journal of Forensic Science, 2011. -- Randall C. Baselt * Journal of Forensic Science *\u003cbr\u003e\"Pathologists, clinicians, lawyers and students will find the new Clarke engaging, systematic in its approach and daunting in the massive amount of information provided. It is not until you become accustomed with the layout and logical style of the book that one appreciates the thought that has gone into producing this excellent and essential reference. No toxicologist should be without one!\" Dimitri Gerostamoulos, TIAFT Bulletin 41(2), 2011. -- Dimitri Gerostamoulos * TIAFT Bulletin *\u003cbr\u003e\"The work provides a compilation and easy access to analytical data for numerous compounds that can give an overview without the need of an extensive database search. This is especially true for data of older compounds that cannot be easily found elsewhere...the reader is provided with substantial information making the work an incomparable reference book in drug analysis.\"  Gerhard K.E. Scriba, Department of Pharmaceutical Chemistry, University of Jena, Chromatographia, 10 July 2011. -- Gerhard K.E. Scriba * Chromatographia *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eVolume one, part one: methodology and analytical techniques - Contains 44 chapters by leading international scientists covering the practice areas and analytical procedures used in toxicology. Volume two, parts two and three: analytical and toxicological data. Contains 2111 drug and poison monographs detailing physical properties, analytical methods, pharmacokinetic data and toxicity data. Part four: Indexes to analytical data. This part contains indexes of analytical data, including all data for colour tests, chromatography, ultraviolet spectrophotometry, infrared spectrometry and mass spectrometry.","brand":"Pharmaceutical Press","offers":[{"title":"Default Title","offer_id":48866059092311,"sku":"9780853697114","price":481.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780853697114.jpg?v=1722276849"},{"product_id":"goldfranks-clinical-manual-of-toxicologic-emergencies-second-edition-9781260474992","title":"Goldfranks Clinical Manual of Toxicologic","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eDerived from the definitive guide to medical toxicology, this hands-on companion provides accurate information for diagnosing and treating poisoned patients on the spot\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eA Doody's Core Title for 2024!\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eAfter more than a decade on the market,\u003ci\u003e Goldfrankâs Toxicologic Emergencies\u003c\/i\u003e has established itself as the go-to reference for medical toxicologyâand this companion manual distills the most important information into a portable, easy-to-navigate resource.\u003c\/p\u003e\u003cp\u003e\u003ci\u003eGoldfrankâs Manual of Toxicologic Emergencies\u003c\/i\u003e distills critical information into short summaries and synopses, so you can use it to treat patients in clinical settings or for quick review of critical topics. Fully updated to ensure all information is completely current, this new edition is filled with tables, figures, images, and other visuals to make finding the right answers quick and easy. Each chapter is a direct distillation of the corresponding chapter in \u003ci\u003eGoldfrankâs Toxicologic Eme\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eThe table of contents (below) will mirror the main text, both for completeness and ease of cross-referencing. \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eHistorical Principles and Perspectives\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e          \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eToxicologic Misfortunes and Catastrophes in History\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e           \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePART A\u003c\/p\u003e\n\u003cp\u003eTHE GENERAL APPROACH TO THE PATIENT\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eInitial Evaluation of the Patient: Vital Signs and Toxic Syndromes\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e          \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePrinciples of Managing the Acutely Poisoned or Overdosed Patient \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eSC1.    Principles of Antidote Stocking\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eDecontamination Principles: Prevention of Gastrointestinal Absorption\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eSC2.    Decontamination Principles: Prevention of Dermal, ophthalmic and inhalational  Absorption \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eA1.      Activated Charcoal\u003c\/p\u003e\u003cp\u003e          \u003c\/p\u003e\u003cp\u003e    A2.      Whole-Bowel Irrigation and Other Intestinal Evacuants\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003ePrinciples and Techniques Applied to Enhance Elimination\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eLaboratory Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePrinciples of Diagnostic Imaging\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePharmacokinetic and Toxicokinetic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePART B\u003c\/p\u003e\n\u003cp\u003eTHE FUNDAMENTAL PRINCIPLES OF MEDICALTOXICOLOGY\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e     SECTION I\u003c\/p\u003e\u003cp\u003e   BIOCHEMICAL AND MOLECULAR CONCEPTS\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eChemical Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eBiochemical and Metabolic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eFluid, Electrolyte, and Acid–Base Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eNeurotransmitters and Neuromodulators\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eWithdrawal Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSECTION II\u003c\/p\u003e\u003cp\u003ePATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eCardiologic Principles I: Electrophysiologic and Electrocardiographic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eCardiologic Principles II: Hemodynamics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eDermatologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e     SC3.    Transdermal Toxicology\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eGastrointestinal Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eGenitourinary Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eHematologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eHepatic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eNeurologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eOncologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eOphthalmic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eOtolaryngologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003ePsychiatric Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSC4.    patient violence\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eRespiratory Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eThermoregulatory Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSECTION III\u003c\/p\u003e\u003cp\u003eSPECIAL POPULATIONS\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eReproductive and Perinatal Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003ePediatric Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eGeriatric Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePART C\u003c\/p\u003e\n\u003cp\u003eTHE CLINICAL BASIS OF MEDICAL TOXICOLOGY\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSECTION I\u003c\/p\u003e\n\u003cp\u003eA. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAcetaminophen\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e                                                                                          \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e    A3.      N-Acetylcysteine\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eColchicine, Podophyllin, and the Vinca Alkaloids\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eNonsteroidal Antiinflammatory Drugs\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eOpioids\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e     A4.      Opioid antagonists\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSC5.    Internal Concealment of Xenobiotics \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSC6.    Harm Reduction for Opioid Overdose \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eSalicylates\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eA5. Sodium bicarbonate\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eB. Food, Diet, and Nutrition\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eBotulism\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eA6.      botulinum antitoxin\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003e   Food Poisoning\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eDieting Xenobiotics and Regimens\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAthletic Performance Enhancers\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eEssential Oils\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePlantand Animal-Derived Dietary Supplements\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e   Vitamins\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eIron\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e     A7.      deferoxamine\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003eC. pharmaceuticals\u003cp\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003ePharmaceutical Additives\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAntidiabetics and Hypoglycemics\/Antiglycemics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eA8.      Dextrose(d-Glucose)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eA9.      octreotide\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntiepileptics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eA10.    l-carnitine\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntihistamines and Decongestants\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eA11.    physostigmine salicylate\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eChemotherapeutics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eMethotrexate,5-Flourouracil, and Capecitabine \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eA12.    folates :leucovorin (Folinic acid) and Folic Acid \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eA13.    glucarpidase(carboxypeptidase g2)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eA14.    uridine triacetate\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSC7.   Inadvertent Intrathecal Administration of Xenobiotics \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSC8.    Extravasation of Chemotherapeutics\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntimigraine Medications\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eThyroidand Antithyroid Medications\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eD. Antimicrobials\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntibacterials, Antifungals, and Antivirals\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAntimalarials\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntituberculous Medications\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e           \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e     A15.    pyridoxine\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eE. Cardiopulmonary Medications\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eCASE STUDY 4\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntidysrhythmics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eA16.    Magnesium Sulfate\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntithrombotics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eA17.    Protein Complex Concentrate and Novel Antithrombotic Antidotes \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eA18.    Vitamin k1\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eA19.    protamine\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003cp\u003eβ-Adrenergic Antagonists\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eA20.    Glucagon\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e","brand":"McGraw-Hill Education","offers":[{"title":"Default Title","offer_id":48866493858135,"sku":"9781260474992","price":89.09,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781260474992.jpg?v=1722278925"},{"product_id":"a-is-for-arsenic-9781472911322","title":"A is for Arsenic","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eShortlisted for the BMA Book Awards and Macavity Awards 2016\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e\u003cbr\u003eFourteen novels. Fourteen poisons. Just because it''s fiction doesn't mean it''s all made-up ...\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eAgatha Christie revelled in the use of poison to kill off unfortunate victims in her books; indeed, she employed it more than any other murder method, with the poison itself often being a central part of the novel. Her choice of deadly substances was far from random  the characteristics of each often provide vital clues to the discovery of the murderer. With gunshots or stabbings the cause of death is obvious, but this is not the case with poisons. How is it that some compounds prove so deadly, and in such tiny amounts?\u003cbr\u003e\u003cbr\u003eChristie''s extensive chemical knowledge provides the backdrop for \u003ci\u003eA is for Arsenic\u003c\/i\u003e, in which Kathryn Harkup investigates the poisons used by the murderer in fourteen classic Agatha Christie mysteries. It looks at why certain chemicals kill, how they interact with the bo\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eA is for Arsenic: The Poisons of Agatha Christie \u003c\/i\u003ehas lethal charm. Harkup leads every chapter with a literary quote, then proceeds to tell us what the poison is, how and under what circumstances it kills, some real-life instances of its use and what role it plays in the Christie plot ... good fun. * The Washington Post *\u003cbr\u003eThis book is fascinating, and anyone who is interested in the myriad painful and unpleasant ways in which people can be killed will relish it. * The Times *\u003cbr\u003eHarkup superbly captures the texture of Christie's books, the sunshine and the surreptitious villainy. * Daily Mail *\u003cbr\u003eA cracking compendium of Christie's poisonings ... \u003ci\u003eA Is For Arsenic\u003c\/i\u003e will appeal to any fan of Christie's work, but as a potted history of poisons, antidotes and medicines it has much wider reach than that. * BBC Focus *\u003cbr\u003eFact and fun packed, \u003ci\u003eA is for Arsenic \u003c\/i\u003elooks at why certain chemicals kill, how they interact with th body, and the feasibility of obtaining, administering and detecting these poisons. * Agatha Christie Website *\u003cbr\u003eAn enjoyable, alphabetical overview of the renowned mystery writer's frequent weapon of choice. * Washington Independent Review of Books *\u003cbr\u003eA knockout analysis of poisons used in Christie's novels and short stories … Each chapter gives riveting information on the poison's chemical makeup, how it kills, whether there's an antidote, its history and its use in Christie's works and in real life ... This is an absolutely bravura chemical compound. * Booklist *\u003cbr\u003eIf you are coming to Agatha Christie's work for the first time, an avid fan, have an interest in crime or toxicology, or just like being taken on an adventure through time, \u003ci\u003eA is for Arsenic \u003c\/i\u003eis a must read. * Chemistry World *\u003cbr\u003eA killing read that combines scientific expertise with fan-based knowledge. * Saga *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Dame Agatha’s Deadly Dispensary 2. A is for Arsenic – Murder is Easy 3. B is for Belladonna – The Labours of Hercules 4. C is for Cyanide – Sparkling Cyanide     5. D is for Digitalis – Appointment with Death 6. E is for Eserine – Crooked House 7. H is for Hemlock – Five Little Pigs 8. M is for Monkshood – 4:50 from Paddington 9. N is for Nicotine – Three Act Tragedy 10. O is for Opium – Sad Cypress         11. P is for Phosphorus – Dumb Witness 12. R is for Ricin – Partners in Crime 13. S is for Strychnine – The Mysterious Affair at Styles 14. T is for Thallium – The Pale Horse 15. V is for Veranol – Lord Edgware Dies  Appendix Glossary Bibliography\u003c\/p\u003e","brand":"Bloomsbury Publishing PLC","offers":[{"title":"Default Title","offer_id":48867226091863,"sku":"9781472911322","price":10.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781472911322.jpg?v=1722282303"},{"product_id":"toxic-legacy-how-the-weedkiller-glyphosate-is-destroying-our-health-and-the-environment-9781645021872","title":"Toxic Legacy: How the Weedkiller Glyphosate Is","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eNamed a ‘Best Book of the Year’ by \u003cem\u003eKirkus Reviews\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003e‘Urgent and eye-opening, the book serves as a loud-and-clear alarm.’ – \u003cem\u003eThe Boston Globe\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eFrom an MIT scientist, mounting evidence that the active ingredient in the world’s most commonly used weedkiller is contributing to skyrocketing rates of chronic disease.\u003c\/strong\u003e\u003c\/p\u003e  \u003cp\u003eGlyphosate is the active ingredient in Roundup, the most commonly used weedkiller in the world. Over 300 million pounds of glyphosate-based herbicide are sprayed on farms – and food – every year.\u003c\/p\u003e  \u003cp\u003eAgrochemical companies claim that glyphosate is safe for humans, animals and the environment. But emerging scientific research on glyphosate’s deadly disruption of the gut microbiome, its crippling effect on protein synthesis and its impact on the body’s ability to use and transport sulfur – not to mention several landmark legal cases – tells a very different story.\u003c\/p\u003e  \u003cp\u003eIn \u003cem\u003eToxic Legacy\u003c\/em\u003e, senior research scientist Stephanie Seneff, PhD, delivers compelling evidence based on countless published, peer-reviewed studies – all in frank, illuminating and always accessible language.\u003c\/p\u003e  \u003cp\u003eAs Rachel Carson did with DDT in the 1960’s with \u003cem\u003eSilent Spring\u003c\/em\u003e, Seneff sounds the alarm on glyphosate, giving you guidance on simple changes you can make right now and essential information you need to protect your health, your family’s health and the planet on which we all depend. \u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003e‘A game-changer that we would be foolish to ignore.’ – \u003cem\u003eKirkus Reviews \u003c\/em\u003e(starred)\u003c\/strong\u003e\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003e‘\u003cem\u003eToxic Legacy\u003c\/em\u003e will stand shoulder to shoulder with Rachel Carson’s \u003cem\u003eSilent Spring\u003c\/em\u003e. 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And for this we owe her incalculable gratitude. \u003cem\u003eToxic Legacy\u003c\/em\u003e will stand shoulder to shoulder with Rachel Carson’s \u003cem\u003eSilent Spring\u003c\/em\u003e, not just defining the pervasive threat to us and future generations, but more importantly, articulating what we can do right now to change our destiny. Unquestionably, one of the most important books of our time.”\u003cstrong\u003e—David Perlmutter, MD, #1 \u003cem\u003eNew York Times\u003c\/em\u003e bestselling author of \u003cem\u003eGrain Brain\u003c\/em\u003e and \u003cem\u003eBrain Wash\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“A highly readable, fascinating look at how man-made chemicals invade the air we breathe, the water we drink, and the food we eat. \u003cem\u003eToxic Legacy\u003c\/em\u003e is both a scientific exposé and an inspiring call to action. In revealing the diabolical mechanisms by which glyphosate damages human health, Dr. Seneff’s work will change the way we all think about food.”\u003cstrong\u003e—Mark Hyman, MD, founder and director, The UltraWellness Center; Head of Strategy and Innovation, Cleveland Clinic Center for Functional Medicine; and a thirteen-time \u003cem\u003eNew York Times\u003c\/em\u003e bestselling author\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Anyone who wants to understand a root cause of the massive epidemics of chronic diseases we are experiencing—from autism to non-alcoholic fatty liver and 30+ other devastating diseases rampant in today’s society—can find the answers in \u003cem\u003eToxic Legacy\u003c\/em\u003e. Dr. Seneff is to be complimented in her comprehensive, in-depth connection of the dots from glyphosate through the myriad biochemical and physiological processes altered, to the tragic consequences from the indiscriminate application of the Roundup and other glyphosate-based herbicides. The complex chemical perturbations are presented in an easily-understood manner, and the systems are well documented. Her ‘relaxed’ writing style makes for easy reading and ready comprehension of this important information.”\u003cstrong\u003e—Don M. Huber, professor emeritus, Purdue University and retired colonel, US Army, Medical Intel\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Dr. Seneff is a senior scientist at MIT. She not only understands molecular biology at a deep level but also has the unique ability to translate extremely complex technical concepts into easy-to-understand language. This is a must-read book to help you comprehend one of the most significant toxic threats unleashed on the world. \u003cem\u003eToxic Legacy\u003c\/em\u003e is the modern-day equivalent of Rachel Carson’s \u003cem\u003eSilent Spring\u003c\/em\u003e from 1962—one of the greatest science books of all time.”\u003cstrong\u003e—Dr. Joseph Mercola, founder, mercola.com, the most visited natural health site for eighteen years\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Monsanto knew for decades that glyphosate causes cancer and a deadly retinue of other devastating illnesses. Instead of warning its customers and consumers about those risks, Monsanto manipulated the science, defrauded regulators, bribed prominent researchers, transformed the EPA pesticide division into a cesspool of corruption, and promoted propaganda worldwide, systematically lying to the public that the deadly pesticide was safe. This company injured public health, destroyed our soils, exterminated species, wiped out small farmers, and deprived the public of their fundamental civil right of informed consent. Monsanto made a special project of discrediting and destroying scientists, advocates, and reformers who exposed its corrupt cover-up. Among the most prominent of these was heroic MIT researcher Dr. Stephanie Seneff. In 2018, I was fortunate enough to be a part of the legal team that finally brought Monsanto to justice. We relied heavily on Dr. Seneff’s research to achieve this victory.”\u003cstrong\u003e—Robert F. Kennedy, Jr.\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Glyphosate (the active ingredient in Roundup) and the other toxic chemicals and GMOs of industrial agriculture are the primary drivers of the chronic disease epidemic that has degenerated public health and the environment. Until we drive these poisons off the market and make the transition to organic and regenerative farming practices, our health, the health of our children, and the health of the planet are at risk. Glyphosate is the DDT of the twenty-first century, and \u003cem\u003eToxic Legacy\u003c\/em\u003e is essential reading for everyone who cares about food and health.”\u003cstrong\u003e—Ronnie Cummins, Organic Consumers Association; author of \u003cem\u003eGrassroots Rising\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Seneff takes us on a shocking biochemical journey through the deleterious effects of glyphosate on the environment and humans. The author clearly explains the ever-growing body of scientific evidence of the insidious consequences of its continued, massive application across the world. As Seneff shows, the herbicide is the common denominator to a swath of environmental and human health problems, from obesity to autism to toad die-offs. The herbicide disrupts the uptake of minerals by plants and kills the bacteria, fungi, and other organisms that have symbiotic relationships with plants for mutual health. The direct effect on humans is dire, as glyphosate damages the gut microorganisms our bodies use to synthesize the amino acids that build body proteins. This affects everything from liver and kidney functions to fertility and autoimmunity. Seneff is precise about the biochemistry involved, but she is a genial, attentive guide. “I know this is technical but stay with me,” she writes. When she ventures into new, even controversial work, she is diligent in her analysis but candid about such territory: ‘I propose . . . ,’ ‘may be damaging . . . ,’ ‘Autism is not due to glyphosate exposure alone. . . .’ The two most salient—and devastating—points that Seneff highlights: First, glyphosate, which shows up in our soil, water, and even air, is disturbingly pervasive . . . ubiquitous . . . ‘nearly impossible for even the most diligent person to avoid.’ Second, the agricultural industry, taking a page from the tobacco industry’s playbook, does everything it can to hide the dangers: Monsanto and other companies censor research and proliferate junk science, raking in profits by turning a blind eye to the chronic illnesses resulting from glyphosate use. Comparisons will be made to Rachel Carson’s \u003cem\u003eSilent Spring\u003c\/em\u003e—and they should be. We can only hope Seneff’s work goes on to rival Carson’s in reach and impact.”\u003cstrong\u003e—Kirkus Reviews (starred)\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“At last, a scientist with impeccable credentials has painstakingly assembled, categorized, and presented the growing body of evidence that highlights the negative impacts of the most widely used pesticide in the world.\u003c\/p\u003e  \u003cp\u003e“Stephanie’s forensic analysis demonstrates beyond reasonable doubt that the use of Roundup and its active ingredient glyphosate is not only poisoning the planet but also its human population.\u003c\/p\u003e  \u003cp\u003e“Everyone should read this book. It’s about our future health and the health of the planet. What issue could be more important than that? As an organization that has been highlighting these potential harms for more than a decade, The Sustainable Food Trust hopes that this milestone publication gets the publicity it needs and deserves.”\u003cstrong\u003e—Patrick Holden, founder and chief executive, Sustainable Food Trust\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Stephanie Seneff’s \u003cem\u003eToxic Legacy\u003c\/em\u003e continues on the path laid by Rachel Carson in \u003cem\u003eSilent Spring\u003c\/em\u003e. Seneff provides the scientific evidence of how, by disrupting our bodies’ metabolic pathways, glyphosate is at the root of multiple metabolic, neurological, autoimmune diseases that have taken epidemic form. More significantly, Seneff’s book introduces us to the complex, sophisticated, metabolic processes of life, from the soil to our gut microbiome. It is a book for governments who want to ban glyphosate. It is a book for every citizen who seeks to regenerate the health of the planet and people.”\u003cstrong\u003e—Dr. Vandana Shiva, director, Navdanya; coauthor of \u003cem\u003eOneness vs. the 1%\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“There is nothing more important than the health of our current and future generations. There is nothing more costly than jeopardizing the physical and mental health of generations of our populations. Without our health, we cannot effectively combat climate change, homelessness, poverty, racial injustice, addiction, or other daunting issues. This book unlocks why we should and how we can resolve a myriad of skyrocketing health issues plaguing society. If heeded, the result of banning glyphosate would put us in the direction of recovering our health and the future of human life on this planet.”\u003cstrong\u003e—Zen Honeycutt, founding executive director, Moms Across America\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Dr. Stephanie Seneff, established and out-of-the-box critical thinker\/researcher, lays down the foundation of our understanding of the toxicity from glyphosate, in a clear and concise format, from the practical to the molecular mechanisms on how glyphosate does harm. Although Dr. Seneff leans heavily on the biochemical basis of glyphosate’s modes of action, her information is understandable and carefully cited for the more investigative readers. She carefully describes the blueprint for the myriad of chronic diseases now prevalent globally and how they are created around the ubiquitous glyphosate. Her book is not only an analytic reference treasure, but a call to action to denounce and reverse our self-imposed toxic legacy.”\u003cstrong\u003e—Michelle Perro, MD; coauthor of \u003cem\u003eWhat’s Making our Children Sick?\u003c\/em\u003e; executive director and cofounder, GMO Science\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“While I’d always intuited that glyphosate exposure—with all of its other deleterious effects—is a contributor to the stark rise in autoimmunity, Dr. Seneff presents unequivocal evidence of this truth.”\u003cstrong\u003e—Jill McLaughlin (Grunewald), HNC, FMCHC, bestselling author of \u003cem\u003eThe Essential Thyroid Cookbook\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“I’ve long been impressed with Dr. Stephanie Seneff’s published work on neurological damage, environmental toxins, and chronic disease. She’s a brave and meticulous scientific researcher. She’s also one of the smartest people I know.”\u003cstrong\u003e—Paul Thomas, MD, #1 Amazon bestselling author of \u003cem\u003eThe Vaccine-Friendly Plan\u003c\/em\u003e and \u003cem\u003eThe Addiction Spectrum\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“For the last decade, while ‘science’ and ‘health’ journalists were gleefully content to repeat the limited corporate talking points about glyphosate’s safety, Dr. Seneff was on the hunt for deeper truths. \u003cem\u003eToxic Legacy\u003c\/em\u003e may be one of the most important literary journeys, weaving in a bounty of irrefutable evidence, essential science, and the personal journey of one of the most treasured scientific researchers of our time.”\u003cstrong\u003e—Jefferey Jaxen, investigative health reporter\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Stephanie Seneff is one of the most important, original, and brilliant scientific researchers of our time.”\u003cstrong\u003e—Jennifer Margulis, PhD, award-winning journalist and author\u003c\/strong\u003e\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e “Dr. Stephanie Seneff’s deep dive into the science of glyphosate helps us as consumers make choices that protect ourselves, our families, and the environment.”\u003cstrong\u003e—Kate Hanley, author of \u003cem\u003eHow to Be a Better Person\u003c\/em\u003e and host, \u003cem\u003eHow to Be a Better Person\u003c\/em\u003e podcast\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“Glyphosate has become a bit like sugar, used by everyone for everything, everywhere. It has spread, largely invisibly, across farms and gardens and parks and so, too, into our food, bodies, and lives. This book lays out, in expert technical detail by a scientist with huge and broad knowledge, what this ubiquitous and ‘uniquely diabolical’ chemical and its formulations could be doing. And how the deeply worrying, chronic consequences this may have for our health are only being recognized—from affecting our critically important gut microbes to causing hormone disruption and DNA damage. It’s also an intriguing, if complex, lesson on the dense web of interconnected bodily functions, structures, enzymes, and chemicals. Glyphosate has also allowed a kind of sterilization of farming with even wider consequences for the ecosystems on which we all depend. Dr. Seneff shows clearly how we need to act fast to curb its use and so change our diets, our green spaces, and how we farm.”\u003cstrong\u003e—Vicki Hird, MSc, FRES, food and environmental writer and campaigner; author of \u003cem\u003eRebugging the Planet\u003c\/em\u003e \u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“I am so thankful for Stephanie Seneff’s work, which is invaluable in protecting the health of generations to come. I did a toxin screen on my three children a few years back and found they were all high in glyphosate even though we used organic products for our home and garden and tried our best to eat organic food! Dr. Seneff’s work is spreading much-needed awareness so our children and our children’s children can grow up less toxic.”\u003cstrong\u003e—Cammy Benton, MD, founder, Benton Integrative Medicine\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e“It’s crucial we all understand the harm environmental toxins are doing to people and the planet. Like Rachel Carson who blew the whistle in her book \u003cem\u003eSilent Spring\u003c\/em\u003e, Stephanie Seneff is educating us about current poisons. There’s no question in my mind that she is \u003cem\u003ethe scientist\u003c\/em\u003e to help us open our eyes.”\u003cstrong\u003e—Vera Sharav, president, Alliance for Human Research Protection and Holocaust survivor\u003c\/strong\u003e\u003c\/p\u003e","brand":"Chelsea Green Publishing Co","offers":[{"title":"Default Title","offer_id":48867949936983,"sku":"9781645021872","price":13.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781645021872.jpg?v=1722285747"},{"product_id":"study-guide-for-goldfranks-toxicologic-emergencies-11th-edition-9781260475029","title":"Study Guide for Goldfranks Toxicologic","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eThe hands-on study companion for the most respected, rigorous medical toxicology text available\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003ci\u003eGoldfrank's Toxicologic Emergencies\u003c\/i\u003e has long been the go-to guide for accurately diagnosing and effectively treating poisoned and overdosed patients. Now, this practical companion provides everything you need to get even more out of Goldfrankâs.\u003c\/p\u003e\u003cp\u003e\u003ci\u003eStudy Guide for Goldfrank's Toxicologic Emergencies\u003c\/i\u003e provides 1,400 questions with answers for testing your knowledgeâa process that increases information retention and serves as invaluable practice for board exams. Each chapter has its own question set using both general factual and case-based questions. The guide is ideal for students, nurses, pharmacists, and physicians.\u003c\/p\u003e\u003cp\u003e\u003ci\u003eStudy Guide for Goldfrank's Toxicologic Emergencies\u003c\/i\u003e covers:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eGeneral approaches to the poisoned patient\u003c\/li\u003e\n\u003cli\u003ePrinciples of medical toxicology\u003c\/li\u003e\n\u003cli\u003eClinical basis of medical toxicology\u003c\/li\u003e\n\u003cli\u003ePoison prevention and edu\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003col\u003e\u003cli\u003e\u003cp\u003e\u003c\/p\u003e\u003c\/li\u003e\u003c\/ol\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eHistorical Principles and Perspectives\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e          \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eToxicologic Misfortunes and Catastrophes in History\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e           \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePART A\u003c\/p\u003e\n\u003cp\u003eTHE GENERAL APPROACH TO THE PATIENT\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eInitial Evaluation of the Patient: Vital Signs and Toxic Syndromes\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e          \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePrinciples of Managing the Acutely Poisoned or Overdosed Patient \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eSC1.    Principles of Antidote Stocking\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eDecontamination Principles: Prevention of Gastrointestinal Absorption\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eSC2.    Decontamination Principles: Prevention of Dermal, ophthalmic and inhalational  Absorption \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA1.      Activated Charcoal\u003c\/p\u003e\n\u003cp\u003e          \u003c\/p\u003e\n\u003cp\u003e    A2.      Whole-Bowel Irrigation and Other Intestinal Evacuants\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003ePrinciples and Techniques Applied to Enhance Elimination\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eLaboratory Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePrinciples of Diagnostic Imaging\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePharmacokinetic and Toxicokinetic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePART B\u003c\/p\u003e\n\u003cp\u003eTHE FUNDAMENTAL PRINCIPLES OF MEDICALTOXICOLOGY\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e     SECTION I\u003c\/p\u003e\n\u003cp\u003e   BIOCHEMICAL AND MOLECULAR CONCEPTS\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eChemical Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eBiochemical and Metabolic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eFluid, Electrolyte, and Acid–Base Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eNeurotransmitters and Neuromodulators\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eWithdrawal Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSECTION II\u003c\/p\u003e\n\u003cp\u003ePATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eCardiologic Principles I: Electrophysiologic and Electrocardiographic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eCardiologic Principles II: Hemodynamics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eDermatologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e     SC3.    Transdermal Toxicology\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eGastrointestinal Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eGenitourinary Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eHema tologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eHepatic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eNeurologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eOncologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eOphthalmic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eOtolaryngologic Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003ePsychiatric Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eSC4.    patient violence\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eRespiratory Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eThermoregulatory Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSECTION III\u003c\/p\u003e\n\u003cp\u003eSPECIALPOPULATIONS\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eReproductive and Perinatal Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003ePediatric Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eGeriatric Principles\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePART C\u003c\/p\u003e\n\u003cp\u003eTHE CLINICAL BASIS OF MEDICAL TOXICOLOGY\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSECTION I\u003c\/p\u003e\n\u003cp\u003eA. ANALGESICS ANDANTIINFLAMMATORY MEDICATIONS\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAcetaminophen\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e                                                                                          \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e    A3.      N-Acetylcysteine\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eColchicine, Podophyllin, and the Vinca Alkaloids\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eNonsteroidal Antiinflammatory Drugs\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eOpioids\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e     A4.      opioid antagonists\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSC5.    Internal Concealment of Xenobiotics \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSC6.    Harm Reduction for Opioid Overdose \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eSalicylates\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eA5.      sodium bicarbonate\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eB. Food, Diet, and Nutrition\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eBotulism\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA6.      botulinum antitoxin\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003e   Food Poisoning\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eDieting Xenobiotics and Regimens\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAthletic Performance Enhancers\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eEssential Oils\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003ePlant and Animal-Derived Dietary Supplements\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e   Vitamins\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eIron\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e     A7.      deferoxamine\u003c\/p\u003e\n\u003cp\u003eMary Ann Howland\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eC. pharmaceuticals\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003ePharmaceutical Additives\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAntidiabetics and Hypoglycemics\/Antiglycemics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eA8.      Dextrose(d-Glucose)\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA9.      octreotide\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntiepileptics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eA10.    l-carnitine\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntihistamines and Decongestants\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eA11.    physostigmine salicylate\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eChemotherapeutics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eMethotrexate,5-Flourouracil, and Capecitabine \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eA12.    folates: leucovorin (Folinic acid) and Folic Acid \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA13.    glucarpidase(carboxypeptidase g2)\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA14.    uridine triacetate\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSC7.   Inadvertent Intrathecal Administration of Xenobiotics \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSC8.    Extravasation of Chemotherapeutics\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntimigraine Medications\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eThyroid and Antithyroid Medications\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eD. Antimicrobials\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntibacterials, Antifungals, and Antivirals\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eAntimalarials\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntituberculous Medications\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e           \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e     A15.    pyridoxine\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eE. Cardiopulmonary Medications\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eCASE STUDY 4\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntidysrhythmics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eA16.    Magnesium Sulfate\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eAntithrombotics\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\u003c\/ol\u003e\n\u003cp\u003eA17.    Protein Complex Concentrate and Novel Antithrombotic Antidotes \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA18.    Vitamin k1\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA19.    protamine\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003col\u003e\u003cli\u003e\n\u003cp\u003eβ-Adrenergic Antagonists\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eA20.    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Introduction2. Rodent Models for Toxicity Testing and Biomarkers3. The Göttingen Minipig as large animal model in toxicology4. Nonhuman primates in preclinical research5. Biomarkers of toxicity in zebrafish6. Mechanistic Toxicology Biomarkers in Caenorhabditis elegans7. Drosophila melanogaster, Eisenia fetida, and Daphnia magna for toxicity testing and Biomarkers 8. Alternative animal toxicity testing and biomarkers9. Adverse outcome pathways and biomarkers   Part II. Systems Toxicity Biomarkers10. Central nervous system toxicity biomarkers11. Peripheral nervous system toxicity biomarkers12. Cardiovascular toxicity biomarkers13. Respiratory toxicity biomarkers14. Hepatic toxicity biomarkers15. Conventional and emerging renal biomarkers16. Gastrointestinal toxicity biomarkers17. Reproductive toxicity biomarkers18. Biomarkers of toxicity in human placenta19. Early Biomarkers of Acute and Chronic Pancreatitis20. Skeletal muscle toxicity biomarkers21. Ocular biomarkers in diseases and toxicities22. Biomarkers of Ototoxicity23. Blood and bone marrow toxicity biomarkers24. Immunotoxicity biomarkers   Part III. Chemical Agents, Solvents and Gases Toxicity Biomarkers25. Bisphenol A (BPA) Biomarkers and Biomonitoring26. Insecticides27. Herbicides and fungicides28. Polychlorinated biphenyls, polybrominated biphenyls, and brominated flame retardants29. Polycyclic aromatic hydrocarbons30. Metals31. Melamine 32. Biomarkers of petroleum products toxicity 33. Biomarkers of chemical mixture toxicity34. Biomarkers of toxic solvents and gases   Part IV. Biotoxins Biomarkers35. Freshwater cyanotoxins 36. Mycotoxins37. Poisonous plants: biomarkers for diagnosis   Part V. Pharmaceuticals and Nutraceuticals Biomarkers38. Biomarkers of drug toxicity and safety evaluation 39. Risk Assessment, Regulation and the Role of Biomarkers for the Evaluation of Dietary Ingredients present in Dietary Supplements40. Nutriphenomics in rodent models: Impact of dietary choices on toxicological biomarkers   Part VI. Nanomaterials and Radiation41. Engineered nanomaterials: Biomarkers of exposure and effect42. Biomarkers of Exposure and Responses to Ionizing Radiation   Part VII. Carcinogens Biomonitoring and Cancer Biomarkers43. Biomonitoring exposures to carcinogens44. Genotoxicity biomarkers: Molecular basis of genetic variability and susceptibility45. Epigenetic biomarkers in toxicology46. Breast cancer biomarkers47. Pancreatic and ovarian cancer biomarkers48. Prostate cancer biomarkers   Part VIII. Disease Biomarkers49. Biomarkers of Alzheimer’s disease50. Biomarkers of Parkinson’s disease51. Biomarkers for drugs of abuse and neuropsychiatric disorders: Models and mechanisms52. Osteoarthritis biomarkers53. Pathological biomarkers in toxicology54. Oral pathology biomarkers   Part IX. Special Topics55. Biomarkers of mitochondrial dysfunction and toxicity 56. Biomarkers of blood-brain barrier dysfunction57. Biomarkers of oxidative\/nitrosative stress and neurotoxicity58. Cytoskeletal disruption as a biomarker of developmental neurotoxicity59. Membrane transporters and transporter substrates as biomarkers for drug pharmacokinetics, pharmacodynamics, and toxicity\/adverse events60. Citrulline: Pharmacological perspectives and role as a biomarker in diseases and toxicities   Part X. Applications of Biomarkers in Toxicology61. Analysis of toxin- and toxicant-induced biomarker signatures using microarrays62. Biomarkers detection for toxicity testing using metabolomics63. Transcriptomic biomarkers in safety and risk assessment of chemicals64. Percellome toxicogenomics project as a source of biomarkers of chemical toxicity65. Proteomics in biomarkers of chemical toxicity66. Biomarkers for Testing Toxicity and Monitoring Exposure to Xenobiotics67. Biomarkers in epidemiology, risk assessment and regulatory toxicology","brand":"Elsevier Science Publishing Co Inc","offers":[{"title":"Default Title","offer_id":49399836639575,"sku":"9780128146552","price":215.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780128146552.jpg?v=1730468867"},{"product_id":"handbook-of-toxicology-of-chemical-warfare-agents-9780128190906","title":"Handbook of Toxicology of Chemical Warfare Agents","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eSection I: Historical Perspective and Epidemiology  1. History of Toxicology: From Killers to Healers; 2. Historical Perspective of Chemical Warfare Agents; 3. Global Impact of Chemical Warfare Agents Used Before and After 1945; 4. Sarin Attacks in Japan: Acute and Delayed Health Effects in Survivors; 5. 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Acute Cyanide Toxicity and its Treatment: The Body is Dead and Maybe Red but Does Not Stay Red for Long; 26. Methyl Isocyanate: The Bhopal Gas; 27. Other Toxic Chemicals as Potential Chemical Warfare Agents; 28. Ricin; 29. Botulinum Toxin; 30. Onchidal and Fasciculins; 31. Cyanobacterial (Blue-Green Algae) Toxins   Section III: Target Organ Toxicity 32. Chemical Warfare Agents and the Nervous System; 33. Behavioral Toxicity of Nerve Agents; 34. The Respiratory Toxicity of Chemical Warfare Agents; 35. Cardiovascular System as a Target of Chemical Warfare Agents; 36. Ocular Toxicity of Chemical Warfare Agents; 37. Skeletal Muscle; 38. Dermal Toxicity of Sulfur Mustard; 39. Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents; 40. Liver Toxicity of Chemical Warfare Agents; 41. Renal System; 42. Impact of Chemical Warfare Agents on the Immune System   Section IV: Special Topics 43. Health Effects of Nuclear Weapons and Releases of Radioactive Materials; 44. Clinical and Cellular Aspects of Traumatic Brain Injury; 45. Neurological Effects and Mechanisms of Blast Overpressure Injury; 46. Genomics and Proteomics in Brain Complexity in Relation to Chemically-Induced PTSD; 47. Excitotoxicity, Oxidative Stress, and Neuronal Injury; 48. Blood–Brain Barrier Damage and Dysfunction by Chemical Toxicity; 49. The Effects of Organophosphates in the Early Stages of Human Skeletal Muscle Regeneration; 50. Experimental modeling for delayed effects of organophosphates; 51. Alternative Animal Toxicity Testing of Chemical Warfare Agents   Section V: Toxicokinetics, Toxicodynamics and Physiologically-Based Pharmacokinetics 52. Toxicokinetic Aspects of Nerve Agents and Vesicants; 53. Toxicokinetics and Toxicodynamics of DFP; 54. Physiologically Based Pharmacokinetic Modeling of Chemical Warfare Agents; 55. Biotransformation of Warfare Nerve Agents   Section VI: Analytical Methods, Biosensors and Biomarkers 56. Laboratory Analysis of Chemical Warfare Agents, Adducts, and Metabolites in Biomedical Samples; 57. On-Site Detection of Chemical Warfare Agents; 58. Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed Neuropathic Agents; 59. The crosslinking action of organophosphorus poisons; implications for chronic neurotoxicity; 60. Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents   Section VII: Risks to Animals and Wildlife 61. Potential Agents That Can Cause Contamination of Animal Feed stuff and Terror; 62. Chemical Warfare Agents and Risks to Animal Health; 63. Threats to Wildlife by Chemical and Warfare Agents   Section VIII: Emergency Preparedness, Prophylactic, Therapeutic and Countermeasures 64. Pharmacological Prophylaxis Against Nerve Agent Poisoning: Experimental Studies and Practical Implications;  65. Prophylactic and Therapeutic Measures in Nerve Agents Poisoning; 66. Physiologically Based Pharmacokinetic\/Pharmacodynamic Modeling of Countermeasures to Nerve Agents; 67. Research on Medical Countermeasures for Chemical Attacks on Civilians; 68. Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds; 69. Novel Cholinesterase Reactivators; 70. Paraoxonase (PON1), detoxication of nerve agents, and modulation of their toxicity; 71. The role of carboxylesterases in therapeutic interventions of nerve agent poisoning; 72. Catalytic bioscavengers: the new generation of bioscavenger-based medical countermeasures   Section IX: Decontamination and Detoxification 73. 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Carcinogenicity Assessment   Part 2. Product-Specific Practices for Safety Assessment    6. Protein Therapeutics   7. Nucleic Acid Pharmaceutical Agents   8. Gene Therapy and Gene Editing   9. Vaccines   10. Stem Cells and Other Cell Therapies    Part 3: Data Interpretation and Communication    11. Biomedical Materials and Devices   12. Safety Assessment of Agricultural and Bulk Chemicals   13. Preparation of the Anatomic Pathology Report for Toxicity Studies   14. Interpretation of Clinical Pathology Results in Nonclinical Toxicity Testing    15. Assigning Adversity to Toxicologic Outcomes   16. Risk Assessment   17. Risk Management and Communication: Building Trust and Credibility with the Public","brand":"Elsevier Science Publishing Co Inc","offers":[{"title":"Default Title","offer_id":49399839195479,"sku":"9780128210475","price":175.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780128210475.jpg?v=1730468875"},{"product_id":"haschek-and-rousseauxs-handbook-of-toxicologic-pathology-volume-4-toxicologic-pathology-of-organ-systems-9780128210468","title":"Haschek and Rousseauxs Handbook of Toxicologic","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":49399839228247,"sku":"9780128210468","price":184.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780128210468.jpg?v=1730468875"},{"product_id":"the-poisoners-handbook-murder-and-the-birth-of-forensic-medicine-in-jazz-age-new-york-9780143118824","title":"The Poisoners Handbook Murder and the Birth of","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eEqual parts true crime, twentieth-century history, and science thriller, \u003ci\u003eThe Poisoner's Handbook\u003c\/i\u003e is a vicious, page-turning story that reads more like Raymond Chandler than Madame Curie. —\u003c\/b\u003e\u003ci\u003e\u003cb\u003eThe New York Observer\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/i\u003e\u003cb\u003e“The Poisoner’s Handbook breathes deadly life into the Roaring Twenties.” —\u003ci\u003eFinancial Times\u003cbr\u003e\u003cbr\u003e\u003c\/i\u003e“Reads like science fiction, complete with suspense, mystery and foolhardy guys in lab coats tipping test tubes of mysterious chemicals into their own mouths.”\u003c\/b\u003e\u003ci\u003e\u003cb\u003e \u003ci\u003e—NPR: What We're Reading\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/i\u003eA fascinating Jazz Age tale of chemistry and detection, poison and murder, \u003ci\u003eThe Poisoner's Handbook\u003c\/i\u003e is a page-turning account of a forgotten era. In early twentieth-century New York, poisons offered an easy path to the perfect crime. Science had no place in the Tammany Hall-controlled coroner's office, and corruption ran rampant. However, with the appointment","brand":"Penguin Putnam Inc","offers":[{"title":"Default Title","offer_id":49399865508183,"sku":"9780143118824","price":16.2,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780143118824.jpg?v=1730468963"},{"product_id":"the-alchemy-of-disease-9780231191661","title":"The Alchemy of Disease","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn \u003ci\u003eThe Alchemy of Disease\u003c\/i\u003e, John Whysner offers an accessible and compelling history of toxicology and its key findings. He details the experiments and discoveries that revealed the causal connections between chemical exposures and diseases.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThe field of toxicology has become increasingly sophisticated as our knowledge of biology continues to evolve. As a scientist, it is enjoyable to read how John Whysner presents the information, and I have no doubt that the general public and students will find it equally enjoyable and informative. -- Samuel M. Cohen, Havlik-Wall Professor of Oncology, University of Nebraska Medical Center\u003cbr\u003eI often tell students in the biological sciences that the best way to learn about a topic is not just to learn what knowledge has been discovered, but rather how the discoveries were made.  Whysner’s scholarly yet reader-friendly book reads like a series of fascinating stories derived from his lifetime of experience in the world of toxicology and public health, and what a storyteller he is! The book shows him to be a remarkable science historian as each link between chemical exposures and human diseases is placed in a captivating historical context. The extent to which Whysner has been intimately involved in major discoveries is absolutely mind-boggling. -- Joseph H. Graziano, Mailman School of Public Health, Columbia University\u003cbr\u003eWhysner provides an honest evaluation of the science of toxicology, engaging readers with fascinating, well-paced narratives of subjects such as chronic arsenic poisoning. -- Katherine Watson, Oxford Brookes University\u003cbr\u003eWhysner's book is a valuable addition to the history of toxicology and allied fields, as it benefits from the institutional knowledge of a professional working in the field of toxicology for five decades. The author brings to light technical aspects of the science that some may not be aware of, especially concepts of risk assessment, dose response, and links between cancer rates and the reality of the state of the science.\u003ci\u003e  \u003c\/i\u003e -- Dale A. Stirling, Consultant in Environmental \u0026amp; Public Health History and author of \u003ci\u003eThe Nanotechnology Revolution: A Global Bibliographic Perspective\u003c\/i\u003e and \u003ci\u003eA Bibliographic Guide to North American Industry: History, Health \u0026amp; Hazardous Waste\u003c\/i\u003e\u003cbr\u003eWhysner ... delivers an illuminating overview of the history of toxicology. Serious students of medical history will appreciate this detailed, historical account of toxicology’s contributions to better health. * Publisher's Weekly *\u003cbr\u003eWe all have only so much time on this Earth and so much to learn.  This fine book presents an efficient and highly enjoyable way to learn the principles and history of the monumental subject of toxicology. -- Judge Lawrence P. Riff * Los Angeles Daily Journal *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eAcknowledgments\u003cbr\u003eIntroduction\u003cbr\u003e\u003cb\u003ePart I: Why Do We Need Toxicology?\u003c\/b\u003e\u003cbr\u003e1\u003cb\u003e.\u003c\/b\u003e Cancer Clusters: Truth Can Be Obscure\u003cbr\u003e2. Death from Arsenic and Venoms: Truth Can Be Obvious\u003cbr\u003e3. Paracelsus: The Alchemist at Work\u003cbr\u003e4. Mining and the Beginnings of Occupational Medicine\u003cbr\u003e5. The Chemical Age\u003cbr\u003e6. The Bioassay Boom\u003cbr\u003e\u003cb\u003ePart II: How Do We Study Toxicology, and What Have We Learned?\u003c\/b\u003e\u003cbr\u003e7\u003cb\u003e.\u003c\/b\u003e Lead: A Heavy Metal Weighing Down the Brain\u003cbr\u003e8. Rachel Carson: Silent Spring Is Now Noisy Summer\u003cbr\u003e9. The Study of Cancer\u003cbr\u003e10. How Are Carcinogens Made?\u003cbr\u003e11. Some Carcinogens Directly Affect Genes\u003cbr\u003e12. Cancer Caused by Irritation\u003cbr\u003e13. Cigarette Smoking: Black, Tarry Lungs\u003cbr\u003e14. What Causes Cancer?\u003cbr\u003e\u003cb\u003ePart III: How Do We Use Toxicology?\u003c\/b\u003e\u003cbr\u003e15\u003cb\u003e.\u003c\/b\u003e Protecting Workers from Chemical Diseases\u003cbr\u003e16. The Importance of Having a Good Name\u003cbr\u003e17. Can We Accurately Regulate Chemicals?\u003cbr\u003e18. The Dose Makes the Poison\u003cbr\u003e19. Are We Ready to Clean Up the Mess?\u003cbr\u003e20. Legal Battles\u003cbr\u003e21. The Toxicology of War\u003cbr\u003e\u003cb\u003ePart IV: The Unfinished Business of Toxicology\u003c\/b\u003e\u003cbr\u003e22\u003cb\u003e.\u003c\/b\u003e Opiates and Politics\u003cbr\u003e23. The Toxicology of Climate Change\u003cbr\u003e24. Animal Models for Human Disease\u003cbr\u003e25. Are Animal Cancer Bioassays Reliable?\u003cbr\u003e26. Hormone Mimics and Disrupters\u003cbr\u003e27. Building Better Tools for Testing\u003cbr\u003e28. An Ounce of Prevention Is Worth a Pound of Cure\u003cbr\u003eNotes\u003cbr\u003eIndex","brand":"Columbia University Press","offers":[{"title":"Default Title","offer_id":49400339398999,"sku":"9780231191661","price":27.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780231191661.jpg?v=1730470433"},{"product_id":"sittigs-handbook-of-toxic-and-hazardous-chemicals-and-carcinogens-9780323389686","title":"Sittigs Handbook of Toxic and Hazardous Chemicals","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":49401734562135,"sku":"9780323389686","price":408.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780323389686.jpg?v=1730478366"},{"product_id":"brenner-and-stevens-pharmacology-9780323758987","title":"Brenner and Stevens Pharmacology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eSection I: Principles of Pharmacology   Chapter 1 Introduction to Pharmacology   Chapter 2 Pharmacokinetics   Chapter 3 Pharmacodynamics   Chapter 4 Drug Development and Safety   Chapter 5 Toxicology and the Treatment of Poisoning    Section II: Autonomic and Neuromuscular Pharmacology   Chapter 6 Peripheral Neuropharmacology and Acetylcholine Agonists   Chapter 7 Acetylcholine Receptor Antagonists   Chapter 8 Sympathetic Neurotransmission and Adrenoceptor Agonists   Chapter 9 Adrenoceptor Antagonists    Section III: Cardiovascular, Renal, and Hematologic Pharmacology   Chapter 10 Antihypertensive Drugs   Chapter 11 Antianginal Drugs   Chapter 12 Drugs for Heart Failure   Chapter 13 Diuretics   Chapter 14 Drugs for Cardiac Dysrhythmia   Chapter 15 Drugs for Hyperlipidemia   Chapter 16 Antithrombotic and Thrombolytic Drugs   Chapter 17 Hematopoietic Drugs    Section IV: Central Nervous System Pharmacology   Chapter 18 Introduction to Central Nervous System Pharmacology   Chapter 19 Sedative-Hypnotic and Anxiolytic Drugs   Chapter 20 Antiepileptic Drugs   Chapter 21 Local and General Anesthetics   Chapter 22 Psychotherapeutic Drugs   Chapter 23 Opioid Analgesics and Antagonists   Chapter 24 Drugs for Neurodegenerative Diseases   Chapter 25 Drugs of Abuse    Section V: Pharmacology of Respiratory and Other Systems   Chapter 26 Autacoid Drugs   Chapter 27 Respiratory Pharmacology   Chapter 28 Gastrointestinal Pharmacology    Chapter 29 Drugs for Headache Disorders   Chapter 30 Drugs for Pain, Inflammation, and Arthritic Disorders    Section VI: Endocrine Pharmacology   Chapter 31 Hypothalamic and Pituitary Drugs   Chapter 32 Thyroid Drugs   Chapter 33 Adrenal Steroids and Related Drugs   Chapter 34 Drugs Affecting Fertility and Reproduction   Chapter 35 Drugs for Diabetes   Chapter 36 Drugs Affecting Calcium and Bone    Section VII: Chemotherapy   Chapter 37 Principles of Antimicrobial Chemotherapy   Chapter 38 Inhibitors of Bacterial Cell Wall Synthesis   Chapter 39 Inhibitors of Bacterial Protein Synthesis   Chapter 40 Quinolones, Antifolate Drugs, and Other Antimicrobial Agents   Chapter 41 Antimycobacterial Drugs   Chapter 42 Antifungal Drugs   Chapter 43 Antiviral Drugs   Chapter 44 Antiparasitic Drugs   Chapter 45 Antineoplastic Drugs   Chapter 46 Immunotherapeutic Agents","brand":"Elsevier - Health Sciences Division","offers":[{"title":"Default Title","offer_id":49401763496279,"sku":"9780323758987","price":54.14,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780323758987.jpg?v=1730478446"},{"product_id":"cyanobacterial-toxins-of-drinking-water-supplies-9780415318792","title":"Cyanobacterial Toxins of Drinking Water Supplies","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe contamination of both drinking and recreational water supplies by cyanobacteria is increasingly a cause for concern worldwide. While contamination causes livestock deaths with relative frequency, acute poisoning is rare in humans. However, there is growing apprehension over the possible role of cylindrospermopsins and microcystins in gastrointestinal and liver cancer.  \u003cp\u003e\u003cb\u003eCyanobacterial Toxins of Drinking Water Supplies\u003c\/b\u003e provides an articulate account of the biology, chemistry, toxicology, and human health implications of cylindrospermopsins and microcystins, and their occurrence in water supplies. It discusses effective methods of prevention, mitigation, and remediation of cyanobacterial blooms in reservoirs. The book presents novel and traditional approaches to water treatment for the elimination of these toxins. Written by a renowned expert who plays an instrumental role in revising the World Health Organization's drinking water guidelines for cyanotoxins, the book uses th\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e“This book covers the biology, chemistry, toxicology, and human health implications of cylindro-spermopsins and microcystins, as well as their occurrence in water supplies. Written by an expert in the field, the book discusses effective methods of prevention, mitigation, and remediation of cyanobacterial blooms in reservoirs and presents both new and traditional approaches for treating water to eliminate these toxins. … ” \u003cbr\u003e — In \u003ci\u003eJournal of The Awwa\u003c\/i\u003e, June 2007\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eIntroduction. Toxic cyanobacteria and their identification. Toxin chemistry and biosynthesis. Cyanobacterial ecology. Cyanobacterial poisoning of livestock and mankind. Cylindrospermopsin toxicity. Microcystin toxicity. Risk and safety from drinking water. Monitoring of reservoirs for toxic cyanobacteria and analysis of nutrients in water. Detection and analysis of cylindrospermopsins and microcystins. Prevention, mitigation and remediation of cyanobacterial blooms in reservoirs. Water treatment. Emerging issues. Index.","brand":"Taylor \u0026 Francis Ltd","offers":[{"title":"Default Title","offer_id":49402091700567,"sku":"9780415318792","price":199.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780415318792.jpg?v=1730479387"},{"product_id":"haschek-and-rousseauxs-handbook-of-toxicologic-pathology-volume-3-environmental-toxicologic-pathology-and-major-toxicant-classes-9780443161537","title":"Haschek and Rousseauxs Handbook of Toxicologic","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePart 1. Toxicologic Pathology in Environment and Food Protection   1. Environmental Toxicologic Pathology and Human Health   2. Food and Toxicologic Pathology   3. Nutrition and Toxicologic Pathology   Part 2. Selected Toxicant Classes   21. Herbal Remedies   22. Phycotoxins   23. Mycotoxins   24. Poisonous Plants   25. Animal Toxins   26. Bacterial Toxins   27. Metals    28. Agrochemicals   29. New Frontiers in Endocrine Disruptor Research   30. Nanoparticulate   31. Radiation and Other Physical Agents","brand":"Elsevier Science Publishing Co Inc","offers":[{"title":"Default Title","offer_id":49402197377367,"sku":"9780443161537","price":175.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780443161537.jpg?v=1730479682"},{"product_id":"chromatographic-methods-in-clinical-chemistry-and-toxicology-9780470023099","title":"Chromatographic Methods in Clinical Chemistry and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eChromatographic Methods in Clinical Chemistry and Toxicology fills the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts that focus almost exclusively on clinical relevance and applications.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Quality Assurance, Quality Control and Method Validation in Chromatographic Applications 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMichele L. Merves and Bruce A. Goldberger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 History 1\u003c\/p\u003e \u003cp\u003e1.3 Definition of Quality Assurance and Quality Control 3\u003c\/p\u003e \u003cp\u003e1.4 Professional Organizations 4\u003c\/p\u003e \u003cp\u003e1.5 Internal Quality Assurance and Control 5\u003c\/p\u003e \u003cp\u003e1.5.1 Standard operating procedure manual 5\u003c\/p\u003e \u003cp\u003e1.5.2 Method development 5\u003c\/p\u003e \u003cp\u003e1.5.3 Method validation 6\u003c\/p\u003e \u003cp\u003e1.5.4 Accuracy 7\u003c\/p\u003e \u003cp\u003e1.5.5 Precision 7\u003c\/p\u003e \u003cp\u003e1.5.6 Recovery 7\u003c\/p\u003e \u003cp\u003e1.5.7 Lower limits of detection (sensitivity) and quantitation 8\u003c\/p\u003e \u003cp\u003e1.5.8 Range of linearity 8\u003c\/p\u003e \u003cp\u003e1.5.9 Specificity 9\u003c\/p\u003e \u003cp\u003e1.5.10 Stability 9\u003c\/p\u003e \u003cp\u003e1.5.11 Carryover 9\u003c\/p\u003e \u003cp\u003e1.5.12 Ruggedness 9\u003c\/p\u003e \u003cp\u003e1.5.13 Selection of a reference standard 10\u003c\/p\u003e \u003cp\u003e1.5.14 Selection of an internal standard and standard addition 10\u003c\/p\u003e \u003cp\u003e1.5.15 Selection of derivatization agent 10\u003c\/p\u003e \u003cp\u003e1.5.16 Selection of ions for selected-ion monitoring or full-scan analysis 11\u003c\/p\u003e \u003cp\u003e1.5.17 Chromatographic performance 11\u003c\/p\u003e \u003cp\u003e1.5.18 Statistical evaluation of quality control 11\u003c\/p\u003e \u003cp\u003e1.6 External Quality Assurance 13\u003c\/p\u003e \u003cp\u003eReferences 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Liquid Chromatographic-Mass Spectrometric Measurement of Anabolic Steroids 15\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDon H. Catlin, Yu-Chen Chang, Borislav Starcevic and Caroline K. Hatton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 15\u003c\/p\u003e \u003cp\u003e2.2 LC-MS Analysis of Synthetic Steroids or Animal Samples 16\u003c\/p\u003e \u003cp\u003e2.3 LC-MS Analysis of Natural Androgens in Human Samples 19\u003c\/p\u003e \u003cp\u003e2.4 Conclusion 29\u003c\/p\u003e \u003cp\u003eReferences 29\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. High-performance Liquid Chromatography in the Analysis of Active Ingredients in Herbal Nutritional Supplements 33\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAmitava Dasgupta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 33\u003c\/p\u003e \u003cp\u003e3.2 St John’s Wort 35\u003c\/p\u003e \u003cp\u003e3.2.1 Drug interactions with St John’s wort 35\u003c\/p\u003e \u003cp\u003e3.2.2 Measurement of active ingredients of St John’s wort using HPLC 36\u003c\/p\u003e \u003cp\u003e3.2.3 Analysis of St John’s wort extract with other analytical techniques 38\u003c\/p\u003e \u003cp\u003e3.2.4 Measurement of hypericin and hyperforin in human plasma using HPLC 38\u003c\/p\u003e \u003cp\u003e3.3 Herbal Supplements with Digoxin-like Immunoreactivity 39\u003c\/p\u003e \u003cp\u003e3.3.1 Use of HPLC for the determination of chan su, danshen and ginsengs 40\u003c\/p\u003e \u003cp\u003e3.4 Herbal Remedies and Abnormal Liver Function Tests 41\u003c\/p\u003e \u003cp\u003e3.4.1 Use of GC-MS and HPLC for the measurement of active components 43\u003c\/p\u003e \u003cp\u003e3.5 Ginkgo Biloba 43\u003c\/p\u003e \u003cp\u003e3.5.1 Analysis of components of ginkgo biloba by HPLC 44\u003c\/p\u003e \u003cp\u003e3.6 Echinacea 45\u003c\/p\u003e \u003cp\u003e3.6.1 Analysis of active components of echinacea by HPLC 45\u003c\/p\u003e \u003cp\u003e3.7 Valerian 46\u003c\/p\u003e \u003cp\u003e3.7.1 Analysis of components of valerian by HPLC 46\u003c\/p\u003e \u003cp\u003e3.8 Feverfew 46\u003c\/p\u003e \u003cp\u003e3.8.1 Analysis of parthenolide by HPLC 47\u003c\/p\u003e \u003cp\u003e3.9 Garlic 47\u003c\/p\u003e \u003cp\u003e3.9.1 Measurement of components of garlic by HPLC 48\u003c\/p\u003e \u003cp\u003e3.10 Ephedra (Ma Huang) and Related Drugs 48\u003c\/p\u003e \u003cp\u003e3.10.1 Analysis of active components of ephedra-containing products 49\u003c\/p\u003e \u003cp\u003e3.11 Conclusions 50\u003c\/p\u003e \u003cp\u003eReferences 50\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Measurement of Plasma L-DOPA and L-Tyrosine by High-Performance Liquid Chromatography as a Tumor Marker in Melanoma 56\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eThierry Le Bricon, Sabine Letellier, Konstantin Stoitchkov and Jean-Pierre Garnier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 56\u003c\/p\u003e \u003cp\u003e4.2 Melanogenesis 57\u003c\/p\u003e \u003cp\u003e4.2.1 Overview of the pathway 57\u003c\/p\u003e \u003cp\u003e4.2.2 Potential tumor markers 58\u003c\/p\u003e \u003cp\u003e4.3 L-DOPA Alone 59\u003c\/p\u003e \u003cp\u003e4.3.1 Urine analysis 59\u003c\/p\u003e \u003cp\u003e4.3.2 Blood (plasma or serum) analysis 59\u003c\/p\u003e \u003cp\u003e4.4 L-DOPA\/L-Tyrosine Ratio 60\u003c\/p\u003e \u003cp\u003e4.4.1 Technical aspects 60\u003c\/p\u003e \u003cp\u003e4.4.2 Clinical results 61\u003c\/p\u003e \u003cp\u003e4.4.3 Future directions 63\u003c\/p\u003e \u003cp\u003e4.5 Conclusion 64\u003c\/p\u003e \u003cp\u003eReferences 65\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Hypersensitive Measurement of Proteins by Capillary Isoelectric Focusing and Liquid Chromatography-Mass Spectrometry 67\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eFeng Zhou and Murray Johnston\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 67\u003c\/p\u003e \u003cp\u003e5.2 A Robust CIEF-RPLC Interface 69\u003c\/p\u003e \u003cp\u003e5.3 First-Generation CIEF-RPLC-MS System for Proteins 71\u003c\/p\u003e \u003cp\u003e5.4 Second-Generation CIEF-RPLC-MS System 76\u003c\/p\u003e \u003cp\u003e5.5 Future Improvements 83\u003c\/p\u003e \u003cp\u003eAcknowledgment 83\u003c\/p\u003e \u003cp\u003eReferences 83\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Chromatographic Measurement of Transferrin Glycoforms for Detecting Alcohol Abuse and Congenital Disorders of Glycosylation 87\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnders Helander\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 87\u003c\/p\u003e \u003cp\u003e6.2 Transferrin Microheterogeneity 88\u003c\/p\u003e \u003cp\u003e6.3 Carbohydrate-deficient Transferrin (CDT) 89\u003c\/p\u003e \u003cp\u003e6.4 Congenital Disorders of Glycosylation (CDG) 89\u003c\/p\u003e \u003cp\u003e6.5 Analytical Methods for Transferrin Microheterogeneity 90\u003c\/p\u003e \u003cp\u003e6.6 Chromatographic Methods for CDT 91\u003c\/p\u003e \u003cp\u003e6.6.1 HPLC conditions and potential interferences 91\u003c\/p\u003e \u003cp\u003e6.6.2 Chromatographic separation of transferrin glycoforms 92\u003c\/p\u003e \u003cp\u003e6.6.3 Genetic transferrin variants and glycoform types 94\u003c\/p\u003e \u003cp\u003e6.6.4 Sensitivity and reproducibility 94\u003c\/p\u003e \u003cp\u003e6.7 Chromatographic Methods for CDG 94\u003c\/p\u003e \u003cp\u003e6.7.1 HPLC testing for CDG 95\u003c\/p\u003e \u003cp\u003e6.7.2 LC-MS testing for CDG 95\u003c\/p\u003e \u003cp\u003e6.8 Summary and Conclusions 96\u003c\/p\u003e \u003cp\u003eReferences 97\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Chromatographic Measurements of Catecholamines and Metanephrines 101\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEric C. Y. Chan and Paul C. L. Ho\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Background 101\u003c\/p\u003e \u003cp\u003e7.1.1 Total or individual assays 104\u003c\/p\u003e \u003cp\u003e7.2 Analytical Measurements of Catecholamines and Metanephrines 105\u003c\/p\u003e \u003cp\u003e7.3 Early Methods 105\u003c\/p\u003e \u003cp\u003e7.3.1 Catecholamines 105\u003c\/p\u003e \u003cp\u003e7.3.2 Metanephrines 106\u003c\/p\u003e \u003cp\u003e7.4 Current Chromatographic Methods 106\u003c\/p\u003e \u003cp\u003e7.4.1 Chemistry of catecholamines 106\u003c\/p\u003e \u003cp\u003e7.4.2 Specimen preparation 107\u003c\/p\u003e \u003cp\u003e7.4.3 Fluorescence detection 109\u003c\/p\u003e \u003cp\u003e7.4.4 Electrochemical detection 110\u003c\/p\u003e \u003cp\u003e7.4.5 Chemiluminescence detection 112\u003c\/p\u003e \u003cp\u003e7.4.6 Mass spectrometry 115\u003c\/p\u003e \u003cp\u003e7.5 Practical Considerations for the Stability of Urinary Catecholamines and Metanephrines During Storage 117\u003c\/p\u003e \u003cp\u003e7.6 Future Developments 118\u003c\/p\u003e \u003cp\u003eDedication 119\u003c\/p\u003e \u003cp\u003eReferences 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Chromatographic Measurement of Volatile Organic Compounds (VOCs) 127\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLarry A. Broussard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 127\u003c\/p\u003e \u003cp\u003e8.2 General Considerations 127\u003c\/p\u003e \u003cp\u003e8.3 Intended Use 128\u003c\/p\u003e \u003cp\u003e8.4 Volatility of Compounds 128\u003c\/p\u003e \u003cp\u003e8.5 Sample Collection, Handling and Storage 129\u003c\/p\u003e \u003cp\u003e8.6 Headspace Gas Chromatographic Methods 129\u003c\/p\u003e \u003cp\u003e8.7 Columns and Detectors 130\u003c\/p\u003e \u003cp\u003e8.8 Identification, Quantitation and Confirmation 130\u003c\/p\u003e \u003cp\u003e8.9 Ethanol and Other Volatile Alcohols 131\u003c\/p\u003e \u003cp\u003e8.10 Inhalants and Screening for Multiple VOCs 132\u003c\/p\u003e \u003cp\u003e8.11 Interpretation 134\u003c\/p\u003e \u003cp\u003e8.12 Conclusion 136\u003c\/p\u003e \u003cp\u003eReferences 136\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Chromatographic Techniques for Measuring Organophosphorus Pesticides 139\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eH. Wollersen and F. Musshoff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 139\u003c\/p\u003e \u003cp\u003e9.2 Organophosphorus Pesticides (OPs) 141\u003c\/p\u003e \u003cp\u003e9.2.1 Mechanism of action 141\u003c\/p\u003e \u003cp\u003e9.2.2 Intoxication 141\u003c\/p\u003e \u003cp\u003e9.2.3 Progression of intoxication and longer term risks 145\u003c\/p\u003e \u003cp\u003e9.2.4 Therapy 146\u003c\/p\u003e \u003cp\u003e9.2.5 Analytical procedures 146\u003c\/p\u003e \u003cp\u003e9.3 Conclusion 163\u003c\/p\u003e \u003cp\u003eReferences 164\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Chromatographic Analysis of Nerve Agents 170\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJeri D. Ropero-Miller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 170\u003c\/p\u003e \u003cp\u003e10.2 Neuromuscular Blockers 170\u003c\/p\u003e \u003cp\u003e10.2.1 Background and uses 170\u003c\/p\u003e \u003cp\u003e10.2.2 Classification, mechanism and duration of action 171\u003c\/p\u003e \u003cp\u003e10.2.3 Effects and toxicity 173\u003c\/p\u003e \u003cp\u003e10.2.4 Analysis 173\u003c\/p\u003e \u003cp\u003e10.3 Paralytic Shellfish Poisoning: Saxitoxin 185\u003c\/p\u003e \u003cp\u003e10.3.1 Background 185\u003c\/p\u003e \u003cp\u003e10.3.2 Toxicity 187\u003c\/p\u003e \u003cp\u003e10.3.3 Analysis 188\u003c\/p\u003e \u003cp\u003e10.4 Summary 191\u003c\/p\u003e \u003cp\u003eReferences 195\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. History and Pharmacology of c-Hydroxybutyric Acid 197\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLaureen Marinetti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 197\u003c\/p\u003e \u003cp\u003e11.2 History of Illicit Use of GHB 198\u003c\/p\u003e \u003cp\u003e11.3 Clinical Use of GHB in Humans 200\u003c\/p\u003e \u003cp\u003e11.4 History of Illicit Use of GBL and 1,4BD 200\u003c\/p\u003e \u003cp\u003e11.5 Distribution and Pharmacokinetics of GHB, GBL and 1,4BD 202\u003c\/p\u003e \u003cp\u003e11.6 GHB Interpretation Issues and Post-mortem Production 204\u003c\/p\u003e \u003cp\u003e11.7 Analysis for GHB, GBL and 1,4BD 208\u003c\/p\u003e \u003cp\u003eReferences 213\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection for Element Speciation: Clinical and Toxicological Applications 217\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKatarzyna Wrobel, Kazimierz Wrobel and Joseph A. Caruso\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 217\u003c\/p\u003e \u003cp\u003e12.2 Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection 218\u003c\/p\u003e \u003cp\u003e12.3 Analytical Applications of Clinical and Toxicological Relevance 219\u003c\/p\u003e \u003cp\u003e12.3.1 Arsenic 219\u003c\/p\u003e \u003cp\u003e12.3.2 Iodine 234\u003c\/p\u003e \u003cp\u003e12.3.3 Mercury 234\u003c\/p\u003e \u003cp\u003e12.3.4 Platinum 240\u003c\/p\u003e \u003cp\u003e12.3.5 Selenium 245\u003c\/p\u003e \u003cp\u003e12.4 Conclusions and Future Trends 260\u003c\/p\u003e \u003cp\u003e12.5 Abbreviations 260\u003c\/p\u003e \u003cp\u003eReferences 262\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Applications of Gas Chromatography-Mass Spectrometry to the Determination of Toxic Metals 274\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSuresh K. Aggarwal, Robert L. Fitzgerald and David A. Herold\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 274\u003c\/p\u003e \u003cp\u003e13.2 Instrumentation 275\u003c\/p\u003e \u003cp\u003e13.3 Experimental Procedure 276\u003c\/p\u003e \u003cp\u003e13.3.1 Preparation of internal standard solutions 276\u003c\/p\u003e \u003cp\u003e13.3.2 Digestion of biological sample 276\u003c\/p\u003e \u003cp\u003e13.3.3 Preparation of metal chelate 277\u003c\/p\u003e \u003cp\u003e13.4 GC-MS Studies 278\u003c\/p\u003e \u003cp\u003e13.4.1 Memory effect evaluation 278\u003c\/p\u003e \u003cp\u003e13.4.2 Precision and accuracy in measuring isotope ratios 281\u003c\/p\u003e \u003cp\u003e13.4.3 Results of concentration determination of toxic metals in biological samples 283\u003c\/p\u003e \u003cp\u003e13.5 Conclusions 284\u003c\/p\u003e \u003cp\u003eReferences 284\u003c\/p\u003e \u003cp\u003eIndex 287\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402259997015,"sku":"9780470023099","price":134.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470023099.jpg?v=1730479865"},{"product_id":"immunotoxicology-strategies-for-pharmaceutical-safety-assessment-9780470122389","title":"Immunotoxicology Strategies for Pharmaceutical","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis core reference explains current strategies for immunotoxicology pharmaceutical safety assessments, which can reduce drug candidate attrition and streamline the development process.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"I would recommend this book to toxicologists wishing to develop their knowledge in the specialised field of immunotoxicology. The book provides extremely clear indication on the assessment of immunotoxicology and contains many recent references at the end of each chapter.\" (\u003ci\u003eBTS Newsletter\u003c\/i\u003e, Summer 2009)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003eIntroduction to Immunotoxicology xvii\u003cbr\u003e\u003ci\u003eJack H. Dean\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Current Regulatory Expectations For Immunotoxicity Evaluation Of Pharmaceuticals 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Current Regulatory Expectations for Immunotoxicity Evaluation of Pharmaceuticals 3\u003cbr\u003e\u003ci\u003eKenneth L. Hastings\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Weight of Evidence Review: A New Strategy In Immunotoxicology 11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Clinical Pathology as Crucial Insight into Immunotoxicity Testing 13\u003cbr\u003e\u003ci\u003eEllen Evans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.2 Histomorphology of the Immune System: A Basic Step in Assessing Immunotoxicity 27\u003cbr\u003e\u003ci\u003ePatrick Haley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.3 Need for Specialized Immunotoxicity Tests 45\u003cbr\u003e\u003ci\u003eKazuichi Nakamura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.4 Specific Drug-Induced Immunotoxicity: Immune-Mediated Hemolytic Anemia 55\u003cbr\u003e\u003ci\u003eRaj Krishnaraj\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Nonclinical Core Immunotoxicity Testing In Drug Development 65\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1.1 T Cell-Dependent Antibody Response Tests 67\u003cbr\u003e\u003ci\u003eJoseph R. Piccotti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1.2 Natural Killer Cell Assay and Other Innate Immunity Tests 77\u003cbr\u003e\u003ci\u003eLisa Plitnick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1.3 Cellular Immune Response in Delayed-Type Hypersensitivity Test 87\u003cbr\u003e\u003ci\u003eKaren Price\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.2 Evaluation of Drug Effects on Immune Cell Phenotypes 103\u003cbr\u003e\u003ci\u003eLaurie Iciek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Extended Immunotoxicology Assessment: \u003ci\u003eEx Vivo \u003c\/i\u003eModels 125\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Functional Cellular Responses and Cytokine Profiles 127\u003cbr\u003e\u003ci\u003eElizabeth R. Gore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.2 Application of Flow Cytometry in Drug Development 141\u003cbr\u003e\u003ci\u003ePadma Narayanan, Renold J. Capocasale, Nianyu Li, and Peter J. Bugelski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Extended Immunotoxicology Assessment: \u003ci\u003eIn Vivo \u003c\/i\u003eModels 161\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Animal Models of Host Resistance 163\u003cbr\u003e\u003ci\u003eGary R. Burleson and Florence G. Burleson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.2 Approaches to Evaluation of Autoimmunity 179\u003cbr\u003e\u003ci\u003eDanuta J. Herzyk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI Immunotoxicity Testing In Biopharmaceutical Development 189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Differentiation between Desired Immunomodulation and Potential Immunotoxicity 191\u003cbr\u003e\u003ci\u003eJeanine L. Bussiere and Barbara Mounho\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.2 Relevant Immune Tests across Different Species and Surrogate Models 199\u003cbr\u003e\u003ci\u003eJeanine L. Bussiere\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.3 Antidrug Antibody Responses in Nonclinical Studies and Their Implications 209\u003cbr\u003e\u003ci\u003eBarbara Mounho\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VII Development of Vaccines 217\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Pharmacological Immunogenicity and Adverse Responses to Vaccines 219\u003cbr\u003e\u003ci\u003eMary Kate Hart, Mark Bolanowski, and Robert V. House\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.2 Immunotoxicological Concerns for Vaccines and Adjuvants 229\u003cbr\u003e\u003ci\u003eCatherine Kaplanski, Jose Lebron, Jayanthi Wolf, and Brian Ledwith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VIII Testing For Drug Hypersensitivity 239\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Systemic Hypersensitivity 241\u003cbr\u003e\u003ci\u003eRaymond Pieters\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.2 Nonclinical Models to Assess Respiratory Hypersensitivity Potential 257\u003cbr\u003e\u003ci\u003eCurtis C. Maier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IX Testing For Developmental Immunotoxicity 271\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Developmental Immunotoxicity in Rodents 273\u003cbr\u003e\u003ci\u003eRodney R. Dietert and Leigh Ann Burns-Naas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.2 Developmental Immunotoxicity in Nonhuman Primates 299\u003cbr\u003e\u003ci\u003ePauline L. Martin and Eberhard Buse\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart X New Methods In Assessing Immunomodulation, Immunotoxicity, and Immunogenicity 319\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Alternative Animal Models for Immunomodulation and Immunotoxicity 321\u003cbr\u003e\u003ci\u003ePeter J. Bugelski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.2 Animal Models for Preclinical Comparative Immunogenicity Testing 345\u003cbr\u003e\u003ci\u003eDaniel Wierda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.3 T Cell Epitopes and Minimization of Immunogenicity 361\u003cbr\u003e\u003ci\u003eHarald Kropshoffer and Thomas Singer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart XI Bridging Immunotoxicology To Clinical Drug Development 373\u003cbr\u003e\u003cbr\u003e\u003c\/b\u003e11 Bridging Immunotoxicology to Clinical Drug Development 375\u003cbr\u003e\u003ci\u003eIan Gourley and Jacques Descotes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 385\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402291093847,"sku":"9780470122389","price":125.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470122389.jpg?v=1730479963"},{"product_id":"a-textbook-of-modern-toxicology-9780470462065","title":"A Textbook of Modern Toxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eToxicology is a multi-faceted field that requires a keen analytical eye.  A Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with an insightful overview of this discipline.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"The book assumes a good knowledge of general toxicology and some knowledge of specialist areas, and would be a useful aid if studying for a higher degree where basic understanding has been.\" (British Toxicology Society, Winter 2010)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePREFACE TO THE FOURTH EDITION xxi\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I INTRODUCTION 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Introduction to Toxicology 3\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Definition and Scope 3\u003c\/p\u003e \u003cp\u003e1.2 Relationship to Other Sciences 9\u003c\/p\u003e \u003cp\u003e1.3 A Brief History of Toxicology 10\u003c\/p\u003e \u003cp\u003e1.4 Dose–Response Relationships 11\u003c\/p\u003e \u003cp\u003e1.5 Sources of Toxic Compounds 12\u003c\/p\u003e \u003cp\u003e1.6 Movement of Toxicants in the Environment 12\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 13\u003c\/p\u003e \u003cp\u003eSample Questions 14\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Introduction to Biochemical and Molecular Methods in Toxicology 15\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson, Gerald A. Leblanc, Sharon A. Meyer, and Robert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 15\u003c\/p\u003e \u003cp\u003e2.2 Cell Culture Techniques 15\u003c\/p\u003e \u003cp\u003e2.3 Molecular Techniques 19\u003c\/p\u003e \u003cp\u003e2.4 Immunochemical Techniques 23\u003c\/p\u003e \u003cp\u003e2.5 Proteomics 26\u003c\/p\u003e \u003cp\u003e2.6 Metabolomics 26\u003c\/p\u003e \u003cp\u003e2.7 Bioinformatics 26\u003c\/p\u003e \u003cp\u003e2.8 Summary and Conclusions 27\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 27\u003c\/p\u003e \u003cp\u003eSample Questions 27\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II CLASSES OF TOXICANTS 29\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Exposure Classes, Toxicants in Air, Water, Soil, Domestic, and Occupational Settings 31\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eW. Gregory Cope\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Air Pollutants 31\u003c\/p\u003e \u003cp\u003e3.2 Water and Soil Pollutants 38\u003c\/p\u003e \u003cp\u003e3.3 Occupational Toxicants 42\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 46\u003c\/p\u003e \u003cp\u003eAir Pollutants 46\u003c\/p\u003e \u003cp\u003eWater and Soil Pollutants 47\u003c\/p\u003e \u003cp\u003eOccupational Toxicants 47\u003c\/p\u003e \u003cp\u003eSample Questions 47\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Classes of Toxicants: Use Classes 49\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eW. Gregory Cope and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 49\u003c\/p\u003e \u003cp\u003e4.2 Metals 49\u003c\/p\u003e \u003cp\u003e4.3 Agricultural Chemicals (Pesticides) 55\u003c\/p\u003e \u003cp\u003e4.4 Food Additives and Contaminants 65\u003c\/p\u003e \u003cp\u003e4.5 Toxins 66\u003c\/p\u003e \u003cp\u003e4.6 Solvents 71\u003c\/p\u003e \u003cp\u003e4.7 Therapeutic Drugs 71\u003c\/p\u003e \u003cp\u003e4.8 Drugs of Abuse 72\u003c\/p\u003e \u003cp\u003e4.9 Combustion Products 72\u003c\/p\u003e \u003cp\u003e4.10 Cosmetics 74\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 74\u003c\/p\u003e \u003cp\u003eGeneral 74\u003c\/p\u003e \u003cp\u003eMetals 74\u003c\/p\u003e \u003cp\u003ePesticides 75\u003c\/p\u003e \u003cp\u003eToxins 75\u003c\/p\u003e \u003cp\u003eSolvents 75\u003c\/p\u003e \u003cp\u003eTherapeutic Drugs 75\u003c\/p\u003e \u003cp\u003eSample Questions 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III TOXICANT PROCESSING IN VIVO 77\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Absorption and Distribution of Toxicants 79\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRonald E. Baynes and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 79\u003c\/p\u003e \u003cp\u003e5.2 Cell Membranes 80\u003c\/p\u003e \u003cp\u003e5.3 Mechanisms of Transport 82\u003c\/p\u003e \u003cp\u003e5.4 Physicochemical Properties Relevant to Diffusion 87\u003c\/p\u003e \u003cp\u003e5.5 Routes of Absorption 90\u003c\/p\u003e \u003cp\u003e5.6 Toxicant Distribution 99\u003c\/p\u003e \u003cp\u003e5.7 Toxicokinetics 108\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 112\u003c\/p\u003e \u003cp\u003eSample Questions 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Metabolism of Toxicants 115\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Randy L. Rose\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 115\u003c\/p\u003e \u003cp\u003e6.2 Phase I Reactions 116\u003c\/p\u003e \u003cp\u003e6.3 Phase II Reactions 143\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 154\u003c\/p\u003e \u003cp\u003eSample Questions 155\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Reactive Metabolites 157\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Randy L. Rose\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 157\u003c\/p\u003e \u003cp\u003e7.2 Activation Enzymes 158\u003c\/p\u003e \u003cp\u003e7.3 Nature and Stability of Reactive Metabolites 160\u003c\/p\u003e \u003cp\u003e7.4 Fate of Reactive Metabolites 161\u003c\/p\u003e \u003cp\u003e7.5 Factors Affecting Toxicity of Reactive Metabolites 162\u003c\/p\u003e \u003cp\u003e7.6 Reactive Oxygen Species 163\u003c\/p\u003e \u003cp\u003e7.7 Examples of Activating Reactions 164\u003c\/p\u003e \u003cp\u003e7.8 Summary and Conclusions 170\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 171\u003c\/p\u003e \u003cp\u003eSample Questions 171\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Chemical and Physiological Effects on Xenobiotic Metabolism 173\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrew D. Wallace and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 173\u003c\/p\u003e \u003cp\u003e8.2 Nutritional Effects 173\u003c\/p\u003e \u003cp\u003e8.3 Physiological Effects 176\u003c\/p\u003e \u003cp\u003e8.4 Comparative and Genetic Effects 182\u003c\/p\u003e \u003cp\u003e8.5 Chemical Effects 191\u003c\/p\u003e \u003cp\u003e8.6 Environmental Effects 207\u003c\/p\u003e \u003cp\u003e8.7 Summary and Conclusions 209\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 210\u003c\/p\u003e \u003cp\u003eSample Questions 211\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Elimination of Toxicants 213\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 213\u003c\/p\u003e \u003cp\u003e9.2 Transport 215\u003c\/p\u003e \u003cp\u003e9.3 Renal Elimination 216\u003c\/p\u003e \u003cp\u003e9.4 Hepatic Elimination 217\u003c\/p\u003e \u003cp\u003e9.5 Respiratory Elimination 220\u003c\/p\u003e \u003cp\u003e9.6 Conclusion 221\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 221\u003c\/p\u003e \u003cp\u003eSample Questions 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV TOXIC ACTION 223\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Acute Toxicity 225\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 225\u003c\/p\u003e \u003cp\u003e10.2 Acute Exposure and Effect 225\u003c\/p\u003e \u003cp\u003e10.3 Dose–Response Relationships 227\u003c\/p\u003e \u003cp\u003e10.4 Nonconventional Dose–Response Relationships 229\u003c\/p\u003e \u003cp\u003e10.5 Alternative Methods 230\u003c\/p\u003e \u003cp\u003e10.6 Mechanisms of Acute Toxicity 231\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 236\u003c\/p\u003e \u003cp\u003eSample Questions 236\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Chemical Carcinogenesis and Mutagenesis 237\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRobert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 DNA Damage and Mutagenesis 237\u003c\/p\u003e \u003cp\u003e11.2 General Aspects of Cancer 239\u003c\/p\u003e \u003cp\u003e11.3 Human Cancer 242\u003c\/p\u003e \u003cp\u003e11.4 Classes of Agents That Are Associated with Carcinogenesis 251\u003c\/p\u003e \u003cp\u003e11.5 General Aspects of Chemical Carcinogenesis 254\u003c\/p\u003e \u003cp\u003e11.6 Oncogenes 259\u003c\/p\u003e \u003cp\u003e11.7 Tumor Suppressor Genes 262\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 264\u003c\/p\u003e \u003cp\u003eSample Questions 264\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Teratogenesis 265\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJill A. Barnes and Ida M. Washington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 265\u003c\/p\u003e \u003cp\u003e12.2 Overview of Embryonic Development 266\u003c\/p\u003e \u003cp\u003e12.3 Principles of Teratogenesis 268\u003c\/p\u003e \u003cp\u003e12.4 Mechanisms of Teratogenesis 268\u003c\/p\u003e \u003cp\u003e12.5 Future Considerations 272\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 272\u003c\/p\u003e \u003cp\u003eSample Questions 272\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V ORGAN TOXICITY 275\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Hepatotoxicity 277\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrew D. Wallace and Sharon A. Meyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 277\u003c\/p\u003e \u003cp\u003e13.2 Susceptibility of the Liver 279\u003c\/p\u003e \u003cp\u003e13.3 Types of Liver Injury 279\u003c\/p\u003e \u003cp\u003e13.4 Mechanisms of Hepatotoxicity 283\u003c\/p\u003e \u003cp\u003e13.5 Examples of Hepatotoxicants 285\u003c\/p\u003e \u003cp\u003e13.6 Metabolic Activation of Hepatotoxicants 288\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 289\u003c\/p\u003e \u003cp\u003eSample Questions 289\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Nephrotoxicity 291\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJoan B. Tarloff and Andrew D. Wallace\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 291\u003c\/p\u003e \u003cp\u003e14.2 Factors Contributing to Nephrotoxicity 292\u003c\/p\u003e \u003cp\u003e14.3 Examples of Nephrotoxicants 293\u003c\/p\u003e \u003cp\u003e14.4 Summary 301\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 301\u003c\/p\u003e \u003cp\u003eSample Questions 302\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. Toxicology of the Nervous System 303\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eBonita L. Blake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 303\u003c\/p\u003e \u003cp\u003e15.2 The Nervous System 303\u003c\/p\u003e \u003cp\u003e15.3 Toxicant Effects on the Nervous System 312\u003c\/p\u003e \u003cp\u003e15.4 Neurotoxicity Testing 317\u003c\/p\u003e \u003cp\u003e15.5 Summary 321\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 322\u003c\/p\u003e \u003cp\u003eSample Questions 322\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16. Reproductive System 323\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHeather Patisaul\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 323\u003c\/p\u003e \u003cp\u003e16.2 The Hypothalamic-Pituitary-Gonadal Axis 324\u003c\/p\u003e \u003cp\u003e16.3 Male Reproductive Physiology 326\u003c\/p\u003e \u003cp\u003e16.4 Disruption of Male Reproduction By Toxicants 330\u003c\/p\u003e \u003cp\u003e16.5 Female Reproductive Physiology 332\u003c\/p\u003e \u003cp\u003e16.6 Disruption of Female Reproduction by Toxicants 335\u003c\/p\u003e \u003cp\u003e16.7 Summary 341\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 341\u003c\/p\u003e \u003cp\u003eSample Questions 343\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17. Endocrine Toxicology 345\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 345\u003c\/p\u003e \u003cp\u003e17.2 Endocrine System 345\u003c\/p\u003e \u003cp\u003e17.3 Endocrine Disruption 352\u003c\/p\u003e \u003cp\u003e17.4 Incidents of Endocrine Toxicity 358\u003c\/p\u003e \u003cp\u003e17.5 Conclusion 361\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 362\u003c\/p\u003e \u003cp\u003eSample Questions 362\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18. Respiratory Toxicology 363\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJames C. Bonner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 363\u003c\/p\u003e \u003cp\u003e18.2 Anatomy and Function of the Respiratory Tract 363\u003c\/p\u003e \u003cp\u003e18.3 Toxicant-Induced Lung Injury, Remodeling, and Repair 373\u003c\/p\u003e \u003cp\u003e18.4 Occupational and Environmental Lung Diseases 380\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 385\u003c\/p\u003e \u003cp\u003eSample Questions 385\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19. Immune System 387\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMaryJane K. Selgrade\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 387\u003c\/p\u003e \u003cp\u003e19.2 The Immune System 388\u003c\/p\u003e \u003cp\u003e19.3 Immune Suppression 391\u003c\/p\u003e \u003cp\u003e19.4 Classification of Immune-Mediated Injury (Hypersensitivity) 396\u003c\/p\u003e \u003cp\u003e19.5 Effects of Chemicals on Allergic Disease 398\u003c\/p\u003e \u003cp\u003e19.6 Other Issues: Autoimmunity and the Developing\u003c\/p\u003e \u003cp\u003eImmune System 403\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 404\u003c\/p\u003e \u003cp\u003eSample Questions 404\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VI APPLIED TOXICOLOGY 407\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20. Toxicity Testing 409\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Helen Cunny\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction 409\u003c\/p\u003e \u003cp\u003e20.2 Experimental Administration of Toxicants 412\u003c\/p\u003e \u003cp\u003e20.3 Chemical and Physical Properties 414\u003c\/p\u003e \u003cp\u003e20.4 Exposure and Environmental Fate 414\u003c\/p\u003e \u003cp\u003e20.5 In Vivo Tests 415\u003c\/p\u003e \u003cp\u003e20.6 In Vitro and Other Short-Term Tests 442\u003c\/p\u003e \u003cp\u003e20.7 Ecological Effects 451\u003c\/p\u003e \u003cp\u003e20.8 Risk Analysis 453\u003c\/p\u003e \u003cp\u003e20.9 The Future of Toxicity Testing 453\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 454\u003c\/p\u003e \u003cp\u003eSample Questions 455\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21. Forensic and Clinical Toxicology 457\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSharon A. Meyer and Bonita L. Blake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction 457\u003c\/p\u003e \u003cp\u003e21.2 Forensic Toxicology 457\u003c\/p\u003e \u003cp\u003e21.3 Clinical Toxicology 462\u003c\/p\u003e \u003cp\u003e21.4 Analytical Methods in Forensic and Clinical Toxicology 469\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 472\u003c\/p\u003e \u003cp\u003eSample Questions 473\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22. Prevention of Toxicity 475\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction 475\u003c\/p\u003e \u003cp\u003e22.2 Legislation and Regulation 475\u003c\/p\u003e \u003cp\u003e22.3 Prevention in Different Environments 482\u003c\/p\u003e \u003cp\u003e22.4 Education 485\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 486\u003c\/p\u003e \u003cp\u003eSample Questions 487\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23. Human Health Risk Assessment 489\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRonald E. Baynes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23.1 Introduction 489\u003c\/p\u003e \u003cp\u003e23.2 Risk Assessment Methods 490\u003c\/p\u003e \u003cp\u003e23.3 Noncancer Risk Assessment 493\u003c\/p\u003e \u003cp\u003e23.4 Cancer Risk Assessment 500\u003c\/p\u003e \u003cp\u003e23.5 PBPK Modeling 503\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 504\u003c\/p\u003e \u003cp\u003eSample Questions 505\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VII ENVIRONMENTAL TOXICOLOGY 507\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24. Toxicant Analysis: Analytical Methods and Quality Assurance 509\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChris Hofelt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24.1 Introduction 509\u003c\/p\u003e \u003cp\u003e24.2 Environmental Sample Collection Methods 510\u003c\/p\u003e \u003cp\u003e24.3 Analytical Techniques 514\u003c\/p\u003e \u003cp\u003e24.4 Quantifi cation, QA, and QC 525\u003c\/p\u003e \u003cp\u003e24.5 Summary 528\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 528\u003c\/p\u003e \u003cp\u003eSample Questions 529\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25. Basics of Environmental Toxicology 531\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc and David B. Buchwalter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25.1 Introduction 531\u003c\/p\u003e \u003cp\u003e25.2 Environmental Persistence 532\u003c\/p\u003e \u003cp\u003e25.3 Bioaccumulation 535\u003c\/p\u003e \u003cp\u003e25.4 Toxicity 539\u003c\/p\u003e \u003cp\u003e25.5 Conclusion 546\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 547\u003c\/p\u003e \u003cp\u003eSample Questions 547\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26. Transport and Fate of Toxicants in the Environment 549\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eDamian Shea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26.1 Introduction 549\u003c\/p\u003e \u003cp\u003e26.2 Sources of Toxicants to the Environment 550\u003c\/p\u003e \u003cp\u003e26.3 Transport Processes 553\u003c\/p\u003e \u003cp\u003e26.4 Equilibrium Partitioning 557\u003c\/p\u003e \u003cp\u003e26.5 Transformation Processes 560\u003c\/p\u003e \u003cp\u003e26.6 Environmental Fate Models 567\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 569\u003c\/p\u003e \u003cp\u003eSample Questions 569\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27. Environmental Risk Assessment 571\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eDamian Shea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27.1 Introduction 571\u003c\/p\u003e \u003cp\u003e27.2 Formulating the Problem 573\u003c\/p\u003e \u003cp\u003e27.3 Analyzing Exposure and Effects Information 578\u003c\/p\u003e \u003cp\u003e27.4 Characterizing Risk 582\u003c\/p\u003e \u003cp\u003e27.5 Managing Risk 587\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 588\u003c\/p\u003e \u003cp\u003eSample Questions 589\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VIII NEW APPROACHES IN TOXICOLOGY 591\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28. Perspectives on Informatics in Toxicology 593\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSeth W. Kullman, Carolyn J. Mattingly, Joel N. Meyer, and Andrew Whitehead\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28.1 Introduction 593\u003c\/p\u003e \u003cp\u003e28.2 Transcriptomics 594\u003c\/p\u003e \u003cp\u003e28.3 Annotation Resources 595\u003c\/p\u003e \u003cp\u003e28.4 Genome Sequencing, Resequencing and Genotyping 597\u003c\/p\u003e \u003cp\u003e28.5 Epigenomic Profi ling 598\u003c\/p\u003e \u003cp\u003e28.6 Computational Toxicology 599\u003c\/p\u003e \u003cp\u003e28.7 Informatics Tools in Toxicology 601\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 602\u003c\/p\u003e \u003cp\u003eSample Question 605\u003c\/p\u003e \u003cp\u003e\u003cb\u003e29. Future Considerations 607\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29.1 Introduction 607\u003c\/p\u003e \u003cp\u003e29.2 Risk Assessment 609\u003c\/p\u003e \u003cp\u003e29.3 Risk Management 613\u003c\/p\u003e \u003cp\u003e29.4 Risk Communication 613\u003c\/p\u003e \u003cp\u003e29.5 In Vivo Toxicity 614\u003c\/p\u003e \u003cp\u003e29.6 In Vitro Toxicity 614\u003c\/p\u003e \u003cp\u003e29.7 Molecular and Biochemical Toxicology 614\u003c\/p\u003e \u003cp\u003e29.8 Development of Selective Toxicants 615\u003c\/p\u003e \u003cp\u003e29.9 Summary and Conclusions 616\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 616\u003c\/p\u003e \u003cp\u003eSample Questions 617\u003c\/p\u003e \u003cp\u003eGLOSSARY 619\u003c\/p\u003e \u003cp\u003eINDEX 638\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402337722711,"sku":"9780470462065","price":97.16,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470462065.jpg?v=1730480108"},{"product_id":"the-ah-receptor-in-biology-and-toxicology-9780470601822","title":"The Ah Receptor in Biology and Toxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface.  \u003cp\u003e\u003cb\u003eA. Historical background.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. History of Research on the AHR (\u003ci\u003eThomas A. Gasiewocz and Ellen C. Henry\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eB. AHR as a ligand-activated transcription factor.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2. Overview of AHR functional domains and the classical signaling pathway: induction of drug-metabolizing enzymes (\u003ci\u003eQiang Ma\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3. Role of chaperone proteins in AHR function (\u003ci\u003eIain A. Murray and Gary H. Perdew\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4. AHR Ligands: Promiscuity in Binding and Diversity in Response (\u003ci\u003eDanica DeGroot, Guochun He, Domenico Fraccalvieri, Laura Bonati, Allesandro Pandin and Michael S. Denison\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5. Dioxin response elements and regulation of gene transcription (\u003ci\u003eHollie Swanson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6. The AHR\/ARNT dimer and transcriptional coactivators (\u003ci\u003eOliver Hankinson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7. Regulation of AHR by the AHR repressor (AHRR) (\u003ci\u003eYoshiaki Fujii-Kuriyama and Kaname Kawajiri\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8. Influence of HIF-1α and Nrf2 signaling on AHR-mediated gene expression, toxicity and biological functions (\u003ci\u003eThomas Haarmann-Stemmann and Josef Abel\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9. Functional interactions of AHR with other receptors (\u003ci\u003eSara Brunnberg, Elin Swedenborg and Jan-Åke Gustafsson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10. The E3 ubiquitin ligase activity of transcription factor AHR permits non-genomic regulation of biological pathways (\u003ci\u003eFumiaki Ohtake and Shigeaki Kato\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11. Epigenetic mechanisms in AHR function (\u003ci\u003eChia-I Ko and Alvaro Puga\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eC. AHR as a mediator of xenobiotic toxicities: dioxins as a key example.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12. Role of the AHR and its structure in TCDD toxicity (\u003ci\u003eRaimo Pohjanvirta, Merja Korkalainen, Ivy D. Moffat, Paul C. Boutros, Allan B. Okey\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13. Nongenomic route of action of TCDD: Identity, characteristics and toxicological significance (\u003ci\u003eFumio Matsumura\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14. Inter-species heterogeneity in the hepatic transcriptomic response to AHR activation by dioxin (\u003ci\u003ePaul Boutros\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15. Dioxin-activated AHR: toxic responses and the induction of oxidative stress (\u003ci\u003eSidney J. Stohs and Ezdihar A. Hassoun\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16. Dioxin-activated AHR and cancer in laboratory animals (\u003ci\u003eDieter Schrenk and Martin Chopra\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17. Teratogenic impact of dioxin-activated AHR in laboratory animals (\u003ci\u003eBarbara D. Abbott\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18. The developmental toxicity of dioxin to the developing male reproductive system in the rat; relevance of the AHR for risk assessment (\u003ci\u003eDavid R. Bell\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e19. TCDD, AHR and immune regulation (\u003ci\u003eNancy I. Kerkvliet\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20. Effects of dioxins on teeth and bone: the role of AHR (\u003ci\u003eMatti Viluksela, Hanna M. Miettinen and Merja Korkalainen\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21. Impacts of dioxin-activated AHR signaling in fish and birds (\u003ci\u003eMichael T. Simonich and Robert L. Tangray\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e22. Adverse Health Outcomes Caused By Dioxin-Activated AHR in Humans (\u003ci\u003eSally S. White, Suzanne E. Fenton, and Linda S. Birnbaum\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e23. The toxic equivalency principle and its application in dioxin risk assessment (\u003ci\u003eJouko Tuomisto\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e24. AHR-active compounds in the human diet (\u003ci\u003eStephen Safe, Gayathri Chadalapaka and Indira Jutooru\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e25. Modulation of AHR function by heavy metals and disease states (\u003ci\u003eAnwar Anwar-Mohammed and Ayman O.S. El-Kadi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e26. Transgenic mice with a constitutively active AHR: a model for human exposure to dioxin an other AHR ligands (\u003ci\u003ePatrik Andersson, Sara Brunnberg, Carolina Wejheden, Lorenz Poellinger and Annika Hanberg\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eD. AHR as a physiological regulator.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e27. Structural and functional diversification of AHRs during metazoan evolution (\u003ci\u003eMark E. Hahn and Sibel I. Karchner\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e28. Invertebrate AHR homologs: Ancestral functions in sensory systems (\u003ci\u003eJo Anne Powell-Coffman and Hongtao Qin\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e29. Role of AHR in the development of the liver and blood vessels (\u003ci\u003eSahoko Ichihara\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e30. Involvement of the AHR in cardiac function and regulation of blood pressure (\u003ci\u003eJason A. Scott and Mary K. Walker\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e31. Involvement of the AHR in development and functioning of the female and male reproductive systems (\u003ci\u003eBethany N. Karman, Isabel Hernández-Ochoa, Ayelet Ziv-Gal, Jodi A. Fl\u003c\/i\u003eaws).\u003c\/p\u003e \u003cp\u003e32. The AHR in the control of cell cycle and apoptosis (\u003ci\u003eCornelia Dietrich\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e33. The AHR regulates cell adhesion and migration by interacting with oncogene and growth factor-dependent signaling (\u003ci\u003eAngel Carlos Roman, Jose M. Carvajal-Gonzalez, Sonia Mulero-Navarro, Aurea Gomez-Duran, Eva M. Rico-Leo and Pedro M. Fernandez-Salguero\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e34. The physiological role of AHR in the mouse immune system (\u003ci\u003eCharlotte Esser\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e35. AHR and the circadian clock (\u003ci\u003eShelley A. Tischkau\u003c\/i\u003e). \u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402377240919,"sku":"9780470601822","price":134.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470601822.jpg?v=1730480209"},{"product_id":"antimicrobial-resistance-in-the-environment-9780470905425","title":"Antimicrobial Resistance in the Environment","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e*          Offers textbook level introductions into basic microbiology as it relates to human and ecological risk assessment of antibiotics and antibiotic resistance genes.          *          The unique multidisciplinary platform is intended to integrate environmental microbiology into human and ecological risk assessment.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e“This is an excellent publication, including primary data and detailed explanations of specific studies and techniques as well as review chapters. As both an introduction to a research area and a call for greater study and thought into how we regulate antimicrobial use in all spheres of society to limit further resistance, I highly recommend Antimicrobial resistance in the environment.”  (\u003ci\u003ePhenotype\u003c\/i\u003e, 1 February 2013) \u003c\/p\u003e \u003cp\u003e“This book will be an ideal read for anyone seeking a comprehensive introduction to the many reservoirs and routes a resistance gene may pass through before or after its appearance in a clinical setting. Even experts in the field stand to gain knowledge regarding the complex web that is the issue of antibiotic resistance in the environment.”  (\u003ci\u003eThe Quarterly Review of Biology\u003c\/i\u003e, 1 December 2012)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePREFACE xi  \u003cp\u003eCONTRIBUTORS xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I SOURCES 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Introduction 3\u003cbr\u003e \u003ci\u003eStuart B. Levy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 2 Path to Resistance 7\u003cbr\u003e \u003ci\u003eVivian Miao, Dorothy Davies, and Julian Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 3 Antibiotic Resistome: A Framework Linking the Clinic and the Environment 15\u003cbr\u003e \u003ci\u003eGerard D. Wright\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 4 Ecological and Clinical Consequences of Antibiotic Subsistence by Environmental Microbes 29\u003cbr\u003e \u003ci\u003eGautam Dantas and Morten O. A. Sommer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 5 Importance of Adaptive and Stepwise Changes in the Rise and Spread of Antimicrobial Resistance 43\u003cbr\u003e \u003ci\u003eLucia Fernandez, Elena B. M. Breidenstein, and Robert E. W. Hancock\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 6 Environmental Reservoirs of Resistance Genes in Antibiotic-Producing Bacteria and Their Possible Impact on the Evolution of Antibiotic Resistance 73\u003cbr\u003e \u003ci\u003eParis Laskaris, William H. Gaze and Elizabeth M. H. Wellington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 7 Mechanisms of Bacterial Antibiotic Resistance and Lessons Learned from Environmental Tetracycline-Resistant Bacteria 93\u003cbr\u003e \u003ci\u003eMarilyn C. Roberts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 8 Environmental Antibiotic Resistome: New Insights from Culture-Independent Approaches 123\u003cbr\u003e \u003ci\u003eIsabel S. Henriques, Artur Alves, Maria Jose´ Saavedra, Mark H. M. M. Montforts, and Anto´nio Correia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II FATE 149\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 9 Environmental Pollution by Antibiotic Resistance Genes 151\u003cbr\u003e \u003ci\u003eJose Luis Martinez and Jorge Olivares\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 10 Quantifying Anthropogenic Impacts on Environmental Reservoirs of Antibiotic Resistance 173\u003cbr\u003e \u003ci\u003eAmy Pruden and Mazdak Arabi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 11 Antibiotic Resistance in Swine-Manure-Impacted Environments 203\u003cbr\u003e \u003ci\u003eJoanne Chee-Sanford, Scott Maxwell, Kristy Tsau, Kelly Merrick, and Rustam Aminov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 12 Antimicrobial-Resistant Indicator Bacteria in Manure and the Tracking of Indicator Resistance Genes 225\u003cbr\u003e \u003ci\u003eChristina S. Ho¨lzel and Karin Schwaiger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 13 Municipal Wastewater as a Reservoir of Antibiotic Resistance 241\u003cbr\u003e \u003ci\u003eTimothy Lapara and Tucker Burch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 14 Strategies to Assess and Minimize the Biological Risk of Antibiotic Resistance in the Environment 251\u003cbr\u003e \u003ci\u003eThomas Schwartz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 15 Antibiotic Resistance in Animals—The Australian Perspective 265\u003cbr\u003e \u003ci\u003eOlasumbo Ndi and Mary Barton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III ANTIMICROBIAL SUBSTANCES AND RESISTANCE 291\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 16 Detection and Occurrence of Antibiotics and Their Metabolites in Pig Manure in Bavaria (Germany) 293\u003cbr\u003e \u003ci\u003eKatrin Harms and Johann Bauer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 17 Fate and Transport of Antibiotics in Soil Systems 309\u003cbr\u003e \u003ci\u003eAlistair B. A. Boxall\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 18 Antibiotics in the Aquatic Environment 325\u003cbr\u003e \u003ci\u003eKlaus Ku¨mmerer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 19 Residues of Veterinary Drugs in Wild Fish 337\u003cbr\u003e \u003ci\u003eThomas Heberer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 20 Role of Quaternary Ammonium Compounds on Antimicrobial Resistance in the Environment 349\u003cbr\u003e \u003ci\u003eUlas Tezel and Spyros G. Pavlostathis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV EFFECTS AND RISKS 389\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 21 Human Health Importance of use of Antimicrobials in Animals and Its Selection of Antimicrobial Resistance 391\u003cbr\u003e \u003ci\u003eScott A. McEwen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 22 Antimicrobial Resistance Associated with Salmonid Farming 423\u003cbr\u003e \u003ci\u003eClaudio D. Miranda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 23 Effect of Veterinary Medicines Introduced via Manure into Soil on the Abundance and Diversity of Antibiotic Resistance Genes on Their Transferability 453\u003cbr\u003e \u003ci\u003eHolger Heuer, Christoph Kopmann, Ute Zimmerling, Ellen Kro¨gerrecklenfort, Kristina Kleineidamm, Michael Schloter, Eva M. Top and Kornelia Smalla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 24 Tracking Antibiotics and Antibiotic Resistance Genes through the Composting Process and Field Distribution of Poultry Waste: Lessons Learned 465\u003cbr\u003e \u003ci\u003ePatricia L. Keen and Nancy De With\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 25 Environmental Microbial Communities Living Under Very High Antibiotic Selection Pressure 483\u003cbr\u003e \u003ci\u003eAnders Janzon, Erik Kristiansson, and D. G. Joakim Larsson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 26 Antibiotic Use During an Influenza Pandemic: Downstream Ecological Effects and Antibiotic Resistance 503\u003cbr\u003e \u003ci\u003eAndrew C. Singer and Heike Schmitt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 27 Use of Veterinary Antibacterial Agents in Europe and the United States 539\u003cbr\u003e \u003ci\u003eIngeborg M. van Geijlswijk, Nico Bondt, Linda F. Puister-Jansen, and Dik J. Mevius\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 28 Regulatory Research on Antimicrobial Resistance in the Environment 549\u003cbr\u003e \u003ci\u003eEmily A. McVey and Mark H. M. M. Montforts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 569\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49402456441175,"sku":"9780470905425","price":121.46,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470905425.jpg?v=1730480453"},{"product_id":"chemical-exposures-2e-low-levels-and-high-stakes-9780471292401","title":"Chemical Exposures 2e Low Levels and High Stakes","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eChemical Exposures: Low Levels and High Stakes explains how day-to-day variations in chemical exposure may cause unusual and seemingly unpredictable symptoms, including many that have been termed psychosomatic in the past.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eDEFINING CHEMICAL SENSITIVITY.\u003cbr\u003e \u003cbr\u003e Chemical Exposures and Sensitive Populations.\u003cbr\u003e \u003cbr\u003e Key Terms and Concepts.\u003cbr\u003e \u003cbr\u003e Origins of Multiple Chemical Sensitivity and Effects on Health.\u003cbr\u003e \u003cbr\u003e MECHANISMS, DIAGNOSIS, AND TREATMENT.\u003cbr\u003e \u003cbr\u003e Mechanisms of Multiple Chemical Sensitivities.\u003cbr\u003e \u003cbr\u003e Diagnosis and Treatment.\u003cbr\u003e \u003cbr\u003e RESPONDING TO THE PROBLEM.\u003cbr\u003e \u003cbr\u003e Needs, Concerns, and Recommendations.\u003cbr\u003e \u003cbr\u003e UPDATE SINCE THE FIRST EDITION.\u003cbr\u003e \u003cbr\u003e Recent Developments.\u003cbr\u003e \u003cbr\u003e Key Research Findings Since the First Edition.\u003cbr\u003e \u003cbr\u003e Reviews, Commentaries, and Polemics.\u003cbr\u003e \u003cbr\u003e Research and Medical Needs.\u003cbr\u003e \u003cbr\u003e Epilogue.\u003cbr\u003e \u003cbr\u003e Appendices.\u003cbr\u003e \u003cbr\u003e Bibliography.\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402554810711,"sku":"9780471292401","price":105.26,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471292401.jpg?v=1730480742"},{"product_id":"demography-in-ecotoxicology-ecological-environmental-toxicology-series-9780471490029","title":"Demography in Ecotoxicology Ecological","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDemography in Ecotoxicology focuses on the interface between toxicology, life history and demographic theory. This comprehensive book examines the different ways of adequately assessing the potential impact of toxic stress on populations and discusses how to obtain an insight into the underlying physiological and genetic mechanisms.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"this book will be valuable to ecotoxicologists, ecologists and wildlife conservationists...\" --Water 21, February 2001\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eList of Contributors.\u003cbr\u003e Series Foreword\u003cbr\u003e Preface\u003cbr\u003e Introduction\u003cbr\u003e Demographic Approaches in Ecotoxicology: State of the Art (J. Kammenga R. Laskowski)\u003cbr\u003e The Toxicologists' and Ecologists' Point of View-Unification through a Demographic Approach (J. Stark J. Banks)\u003cbr\u003e Demographic Changes\u003cbr\u003e Dynamic Effects of Compounds on Animal Energetics and Their Population Consequences (B. Kooijman J. Bedaux)\u003cbr\u003e Life Table Response Experiments in Ecotoxicology (H. Caswell)\u003cbr\u003e Stochastic and Density-dependent Models in Ecotoxicology (R. Laskowski)\u003cbr\u003e Effects of Heavy Metals on the Badger Meles meles: Interaction between Habitat Quality and Fragmentation (C. Klok, et al.)\u003cbr\u003e Cadmium and Zinc Accumulation and Its Demographic Effects in Invertebrates (P. Kramarz)\u003cbr\u003e Small Mammal Response at Population and Community Level to Heavy Metal Pollution (Pb, Cd, Tl) (K. Dmowski, et al.)\u003cbr\u003e Evolution in Polluted Environments\u003cbr\u003e Evolution in Toxic Environments: Quantitative Versus Major Gene Approaches (R. Woods A. Hoffmann)\u003cbr\u003e Review of Experimental Evidence for Physiological Costs of Tolerance to Toxicants (N. van Straalen A. Hoffmann)\u003cbr\u003e Multi-generation Effects at the Population Level: Fitness Maximisation and Optimal Allocation in a Nematode (J. Kammenga, et al.)\u003cbr\u003e Optimal Allocation, Life History and Heavy Metal Accumulation: a Dynamic Programming Model (M. Janczur, et al.)\u003cbr\u003e Preadapted Populations in Metal-polluted Environments (A. Rozen)\u003cbr\u003e Relationships between Enzymatic Response and Animal Population Demography in Polluted Environments (P. Migula)\u003cbr\u003e Tissue Changes in Animals and Their Population Effects (R. wiergosz)\u003cbr\u003e Open Problems and Recommendations for Risk Assessment\u003cbr\u003e Demographic Approaches in Ecotoxicology-Open Problems (J. Kammenga R. Laskowski)\u003cbr\u003e Implications for Ecological Risk Assessment: The Risk Quotient Life-cycle Approach (J. Kammenga)\u003cbr\u003e Index","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402609992023,"sku":"9780471490029","price":218.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471490029.jpg?v=1730480948"},{"product_id":"biomolecular-free-radical-toxicity-9780471490760","title":"Biomolecular Free Radical Toxicity","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eBiomolecular injury is damage inflicted by a reactive molecule on a biological molecule. This work presents up-to-date and wide-ranging information in a user-friendly format for research scientists specializing in food and nutrition-based toxicology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eMACROMOLECULAR MECHANISMS OF INJURY AND THE ROLE OF ANTIOXIDANTS.\u003cbr\u003e \u003cbr\u003e Membrane Lipid and Lipoprotein Injury: Prevention by Antioxidants (H. Wiseman \u0026amp; T. Ridgway).\u003cbr\u003e \u003cbr\u003e DNA Injury: Prevention by Antioxidants (R. Hambly).\u003cbr\u003e \u003cbr\u003e Protein Injury: Prevention by Antioxidants (B. Evans \u0026amp; J. Woodward).\u003cbr\u003e \u003cbr\u003e GENE EXPRESSION AND CELL MEDIATED MECHANISMS OF TOXICITY EXPRESSION.\u003cbr\u003e \u003cbr\u003e Xenobiotic Metabolism and Bioactivation by Cytochromes P-450 (C. Ioannides).\u003cbr\u003e \u003cbr\u003e Apoptosis Triggered by Free Radicals: Role in Human Diseases (G. Kass, et al.).\u003cbr\u003e \u003cbr\u003e HUMAN AND ENVIRONMENTAL HEALTH EFFECTS.\u003cbr\u003e \u003cbr\u003e Dietary Phytoestrogens, Oestrogens and Tamoxifen: Mechanisms of Action in Modulation of Breast Cancer Risk and Prevention of Heart Disease (H. Wiseman).\u003cbr\u003e \u003cbr\u003e Strategies for the Removal of Ecotoxicants: Environmental Oestrogens and Oestrogen-Mimics (T. Ridgway \u0026amp; H. Wiseman).\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402610647383,"sku":"9780471490760","price":228.56,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471490760.jpg?v=1730480955"},{"product_id":"pesticide-toxicology-and-international-regulation-1-current-toxicology-9780471496441","title":"Pesticide Toxicology and International Regulation","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAims to bring together key features of toxicology and occupational hazards of pesticides and the way their use is regulated in trading regions of the world. This book also covers fungicides and herbicides, as well as specialised agents such as microbial pesticides.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"Toxicologists, toxicologic pathologists, and others involved in the manufacture, use, and regulation of pesticides would be interested in this reference…\" (\u003ci\u003eVeterinary Pathology\u003c\/i\u003e, July 2005)  \u003cp\u003e\"...a good account of [the] properties and the effects of exposure...a superb bibliography...\" (Bulletin of the Royal College of Pathologists, July 2004)\u003c\/p\u003e \u003cp\u003e\"...impressed with the scope of the book...very up-to-date...an invaluable reference source...\" (The British Toxicological Society, No. 24, Summer 2004)\u003c\/p\u003e \u003cp\u003e“…well researched and well organised.” (Applied Organometallic Chemistry, Vol 18 No 8 August 2004) \u003c\/p\u003e \u003cp\u003e“…an excellent resource for chemists and toxicologists in the pesticide industry, academia, pesticide regulators and regulatory affairs professionals.” (Chemistry and Industry, 18\u003csup\u003eth\u003c\/sup\u003e October 2004)   \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface.\u003cbr\u003e \u003cbr\u003e List of Contributors.\u003cbr\u003e \u003cbr\u003e Frequently Used Abbreviations.\u003cbr\u003e \u003cbr\u003e Toxicity Classifications and Hazard Ratings.\u003cbr\u003e \u003cbr\u003e 1. Pesticides: An Overview of Fundamentals (Bryan Ballantyne \u0026amp; Timothy Marrs).\u003cbr\u003e \u003cbr\u003e PART I: INSECTICIDES.\u003cbr\u003e \u003cbr\u003e 2. Toxicology of Organochlorine Insecticides (Andrew G. Smith).\u003cbr\u003e \u003cbr\u003e 3. Anticholinesterase Insecticides (Charles M. Thompson and Rudy J. Richardson ).\u003cbr\u003e \u003cbr\u003e 4. Toxicology of Pyrethrins and Synthetic Pyrethroids (David E. Ray).\u003cbr\u003e \u003cbr\u003e 5. Toxicology of miscellaneous insecticides (Roland Solecki).\u003cbr\u003e \u003cbr\u003e PART II: FUNGICIDES, HERBICIDESM AND GROWTH REGULATORS.\u003cbr\u003e \u003cbr\u003e 6. Toxicology of Fungicides (Bryan Ballantyne).\u003cbr\u003e \u003cbr\u003e 7. Toxicology of Herbicides (Timothy C. Marrs).\u003cbr\u003e \u003cbr\u003e PART III: SPECIAL TYPES OF PESTICIDE.\u003cbr\u003e \u003cbr\u003e 8. Microbial Pesticides (Ian C. Dewhurst).\u003cbr\u003e \u003cbr\u003e 9. Biocides (Bryan Ballantyne and Susan L. Jordan).\u003cbr\u003e \u003cbr\u003e PART IV: RESIDUES.\u003cbr\u003e \u003cbr\u003e 10. Variability of Residues in Unprocessed Food Items and its Impact on Consumer Risk Assessment (Caroline A. Harris and Alan R. C. Hill).\u003cbr\u003e \u003cbr\u003e PART V: HUMAN ASPECTS.\u003cbr\u003e \u003cbr\u003e 11. Occupational Aspects of Pesticide Toxicity in Humans (Angelo Moretto).\u003cbr\u003e \u003cbr\u003e 12. Treatment of Pesticide Poisoning (Gregory P. Wedin and Blaine E. Benson).\u003cbr\u003e \u003cbr\u003e PART VI: REGULATION.\u003cbr\u003e \u003cbr\u003e 13. Regulation of Pesticides and Biocides in the European Union (Deborah J. Hussey and Graham M. Bell).\u003cbr\u003e \u003cbr\u003e 14. Regulation in NAFTA (Cheryl E. A. Chaffey and Virginia A. Dobozy).\u003cbr\u003e \u003cbr\u003e 15. The Regulatory System in Japan (Kannosuke Fujimori).\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402615988567,"sku":"9780471496441","price":197.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471496441.jpg?v=1730480982"},{"product_id":"t-lymphocytes-subpopulations-in-immunotoxicology-9780471971948","title":"T Lymphocytes Subpopulations in Immunotoxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eT Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and\/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and \u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eT Lymphocyte Subpopulations in Immunotoxicology: An Introduction (I. Kimber \u0026amp; M. Selgrade).\u003cbr\u003e \u003cbr\u003e Functional Subpopulations of CD4¯+ T Lymphocytes (L. Krishnan \u0026amp; T. Mosmann).\u003cbr\u003e \u003cbr\u003e Functional Subpopulations of CD8¯+ T Lymphocytes (D. Kemeny, et al.).\u003cbr\u003e \u003cbr\u003e T Lymphocyte Subpopulations and TCDD Immunotoxicity (N. Kerkvliet).\u003cbr\u003e \u003cbr\u003e T Lymphocyte Subpopulations and Immunotoxicology of Drugs of Abuse (M. Holsapple, et al.).\u003cbr\u003e \u003cbr\u003e Oxidative Stress and Heavy Metal Modification of T Lymphocyte Subsets (J. Krieger, et al.).\u003cbr\u003e \u003cbr\u003e The Effect of UV Exposure on the Activation of T-Cell Subsets (S. Ullrich).\u003cbr\u003e \u003cbr\u003e T Helper Cell Clones and In Vitro Assessment of Immunotoxicity (B. Lawrence \u0026amp; N. Kerkvliet).\u003cbr\u003e \u003cbr\u003e Influence of the Sympathetic Nervous System on T Helper Cell Function (V. Sanders, et al.).\u003cbr\u003e \u003cbr\u003e Endocrine Regulation of T Lymphocyte Subpopulations (G. Rook, et al.).\u003cbr\u003e \u003cbr\u003e T Lymphocyte Subpopulations and Immune Responses to Chemical Allergens (I. Kimber \u0026amp; R. Dearman).\u003cbr\u003e \u003cbr\u003e T Lymphocyte Subpopulations in Human Allergic Disease (M. Schuyler \u0026amp; J. Wilder).\u003cbr\u003e \u003cbr\u003e Modulation of T Lymphocyte Responses by Air Pollutants (M. Gilmour \u0026amp; M. Selgrade).\u003cbr\u003e \u003cbr\u003e T Lymphocyte Subpopulations in Autoimmune Responses to Chemicals and Drugs (D. Oliveira \u0026amp; J. Coleman).\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402702004567,"sku":"9780471971948","price":252.86,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471971948.jpg?v=1730481282"},{"product_id":"laboratory-animal-endocrinology-9780471972624","title":"Laboratory Animal Endocrinology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe complex and fascinating subject of endocrinology can often seem rather daunting for non-specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies'' differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much-needed support for the interpolation of endocrine data from one test species to a\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eOrganisation of Endocrine Systems.\u003cbr\u003e \u003cbr\u003e Endocrine Evolution.\u003cbr\u003e \u003cbr\u003e The Hypothalamus.\u003cbr\u003e \u003cbr\u003e The Pituitary.\u003cbr\u003e \u003cbr\u003e Thyroid and Parathyroid Hormones.\u003cbr\u003e \u003cbr\u003e The Adrenal Glands.\u003cbr\u003e \u003cbr\u003e Atrial Natriuretic Factor.\u003cbr\u003e \u003cbr\u003e The Endocrine Pancreas.\u003cbr\u003e \u003cbr\u003e Gastrointestinal Hormones.\u003cbr\u003e \u003cbr\u003e Reproductive Hormones.\u003cbr\u003e \u003cbr\u003e Endothelin.\u003cbr\u003e \u003cbr\u003e Erythropoietin.\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402702168407,"sku":"9780471972624","price":362.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471972624.jpg?v=1730481282"},{"product_id":"minamata-9780674007857","title":"Minamata","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe outbreak of the “Minamata Disease” in 1950s Japan remains one of the most horrific examples of environmental poisoning in history. Based on primary documents and interviews, this book describes responses to this incidence of mercury poisoning, focusing on the efforts of its victims and their supporters to secure redress.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis is the first account, in any language, which covers the controversies surrounding the infamous mercury poisoning in Minamata in southern Kyushu over the time frame of ninety years, from the founding of the factory which caused the pollution, up to the settlement for compensation reached in 1995… George’s monograph provides an excellent point of departure for further inquiries. -- Anja Osiander * Social Science Journal *","brand":"Harvard University, Asia Center","offers":[{"title":"Default Title","offer_id":49403514847575,"sku":"9780674007857","price":22.46,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780674007857.jpg?v=1730483696"},{"product_id":"essentials-of-kumar-and-clarks-clinical-medicine-9780702082795","title":"Essentials of Kumar and Clarks Clinical Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eFrom customer reviews of the previous edition: 2018 BMA Awards: Winner, Internal Medicine   \"This book is amazing helpful. It goes through every core condition you need and is simply written and to the point but has all the information that is needed. As a medical student this book has been great for my studies\"   \"Great book, small enough to take on the wards, full of information on the go. I love it.\"   \"Excellent little companion book.\"   \"Good book. It has all the basics that student needs to revise, write assignments etc\"\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1 Ethics and Communication 2 Infectious Diseases 3 Gastroenterology and Nutrition 4 Liver, Biliary Tract, and Pancreatic Disease 5 Haematological Disease 6 Malignant Disease 7 Rheumatology 8 Water, Electrolytes, and Acid-Base Balance 9 Renal Disease 10 Cardiovascular Disease 11 Respiratory Disease 12 Critical Care Medicine 13 Clinical Pharmacology and Toxicology 14 Endocrine Disease 15 Diabetes Mellitus and Other Disorders of Metabolism 16 The Special Senses 17 Neurology 18 Dermatology 19 Elderly Medicine and Frailty","brand":"Elsevier Health Sciences","offers":[{"title":"Default Title","offer_id":49404016165207,"sku":"9780702082795","price":30.39,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780702082795.jpg?v=1730485173"},{"product_id":"the-venomous-reptiles-of-the-western-hemisphere-9780801441417","title":"The Venomous Reptiles of the Western Hemisphere","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eAn essential, 2-volume reference for everyone interested in herpetology—professional herpetologists and their students conducting research in the classroom, at the zoo, and in the field, as well as amateurs.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThe discussion of envenomation identification, grading, and treatment is fascinating and clinically valuable. I was very impressed with the organization and readability of the text. I nearly forgot to mention the wonderful color photographs.... The amount of information packed into these two volumes is truly mindboggling. This is a 'must have' reference for anyone interested in these creatures.\u003c\/p\u003e -- Grady Calhoun * \"The Forked Tongue,\" The Monthly Newsletter of the Greater Cincinnati Herpetological Society *\u003cbr\u003e\u003cp\u003eThe information available is overwhelming, yet it is presented in scholarly and clearly understandable fashion, utilizing every available form of still documentation.... The two volumes are indeed a masterful compilation and overview of the venomous reptiles in this geographic region. The volumes are well-produced and published, with sturdy binding, easily readable font size and style, and excellent quality printing of illustrations, colored figures, and the abundant colored photographic plates.... The chapter on 'Venom Poisoning by North American Reptiles' and the following contribution entitled 'Snake Bites in Central and South America: Epidemiology Clinical Features and Clinical Management' offers abundant experiences, observations, and recommendations that often support those currently used by toxicologists and emergency room physicians in North America, yet are diverse enough to highlight some of the controversies and continuing debates on what is most appropriate when and how!... One could easily spend many hours reviewing the clinical recommendations made and observing the excellent documented color photographs of effects and the good-and-bad results from various management procedures.... Just to skim through the illustrations and accompanying text for elaboration opens up a new world for students, herpetologists, zoologists, and veterinary and human toxicologists conducting research in the field or at the zoo, or managing envenomated patients.\u003c\/p\u003e * Veterinary and Human Toxicology *","brand":"Cornell University Press","offers":[{"title":"Default Title","offer_id":49405127590231,"sku":"9780801441417","price":131.75,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780801441417.jpg?v=1730488795"},{"product_id":"indoor-air-pollution-9780801841255","title":"Indoor Air Pollution","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eContributors including epidemiologists, clinicians, risk assessors, experts in air monitoring, microbiologists, and engineers discuss methodologies used in measuring exposures to pollution, strategies for improving indoor air quality, and other issues. They also assess the health effects of specific\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eHarmful of toxic substances enter the body through the air we breathe, through food or water ingested, or through the skin. This book by two prominent epidemiologists explores the relationship between air pollution and health. The book is well documented and well illustrated and provides a wealth of useful information including epidemiologic results and standards or requirements that influence air quality-both indoor and out. the 17 edited contributions are divided into discussions of (1) sources, (2) health effects, and (3) control and legal aspects. Each chapter is a detailed but readable review, of excellent quality and reliability. Particularly strong are the chapters on indoor air pollution, nitrogen dioxide, wood smoke, formaldehyde, and radon. Worldwide in coverage, this volume successfully provides a review for policy makers, engineers, lawyers, and health professionals, and for students in these disciplines, undergraduate and graduate. M.Gochfeld, Robert Wood Johnson Medical School\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eContributors\u003cbr\u003ePreface\u003cbr\u003eAckowledgments\u003cbr\u003eChapter 1. A Perspective on Indoor and Outdoor Air Pollution\u003cbr\u003e\u003cb\u003ePart I. Sources, Concentrations, and Exposure\u003c\/b\u003e\u003cbr\u003eChapter 2. Sources and Concentrations of Indoor Air Pollution\u003cbr\u003eChapter 3. Building Dynamics and INdoor Air Quality\u003cbr\u003eChapter 4. Assessment of Indoor Air Quality\u003cbr\u003eChapter 5. Personal Exposure to Indoor Air Pollution\u003cbr\u003e\u003cb\u003ePart II. Health Efects\u003c\/b\u003e\u003cbr\u003eChapter 6. Environmental Tobacco Smoke\u003cbr\u003eChapter 7. Nitrogen Dioxide\u003cbr\u003eChapter 8. Carbon Monoxide\u003cbr\u003eChapter 9. Wood Smoke\u003cbr\u003eChapter 10. Formaldehyde\u003cbr\u003eChapter 11. Volatile Organic Compounds\u003cbr\u003eChapter 12. Indoor Air Pollution and Infectious Diseases\u003cbr\u003eChapter 13. Biological Agents and Allergic Diseases\u003cbr\u003eChapter 14. Building-related Illnesses\u003cbr\u003eChapter 15. Radon\u003cbr\u003e\u003cb\u003ePart III. Control and Legal Aspects\u003c\/b\u003e\u003cbr\u003eChapter 16. COntrol Strategies\u003cbr\u003eChapter 17. Legal Aspects of Indoor Air Pollution\u003cbr\u003eIndex\u003c\/p\u003e","brand":"Johns Hopkins University Press","offers":[{"title":"Default Title","offer_id":49405184573783,"sku":"9780801841255","price":31.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780801841255.jpg?v=1730489027"},{"product_id":"pharmaceutical-toxicology-9780853695936","title":"Pharmaceutical Toxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eCovering areas of drug toxicity which address the major issues including registration requirements of new drugs and pharmacovigilance, this book provides an overview of the methodology and requirements of pre-clinical safety assessment of new medicines. It discusses mechanisms by which drugs cause toxic effects in living organisms.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e'The text is well written, concise and easy to understand with informative and helpful illustrations, figures and tables...it serves as an excellent companion to pharmacology textbooks, dealing with the issues relevant for assessing the safety of new drugs...a good starting point for the novice toxicologist, ambitious undergraduate student or graduate students working in the pharmaceutical sciences.' Irish Pharmacy Journal, November 2006, p418\u003c\/p\u003e * Irish Pharmacy Journal *\u003cbr\u003e\u003cp\u003e'...this is a great little book...the text is aimed primarily at new PHD students in the pharmaceutical and related sciences but could equally well serve taught postgraduate students on toxicology, clinical pharmacology, drug development and safety or similar courses. The book 'does exactly what it says on the tin' and will definitely whet the appetite of enthusiastic young researchers for toxicology.' Heather M Wallace, Summer 2007 issue of the British Toxicology Society Newsletter\u003c\/p\u003e -- Heather M Wallace * British Toxicology Society Newsletter *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. General toxicology; 2. Drug metabolism: inactivation and bioactivation of xenobioptics; 3. Molecular and cellular mechanisms of toxicity; 4. Teratology; 5. Genotoxicity; 6. Carcinogenicity of drugs; 7. Liver toxicity; 8. Kidney toxicity; 9. Toxicology in the respiratory system; 10. Immunotoxicity; 11. Clinical toxicology; 12. Safety assessment of pharmaceuticals: regulatory aspects; 13. Pharmacovigilance.","brand":"Pharmaceutical Press","offers":[{"title":"Default Title","offer_id":49406262575447,"sku":"9780853695936","price":38.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780853695936.jpg?v=1730495149"},{"product_id":"clarkes-analytical-forensic-toxicology-9780857110541","title":"Clarkes Analytical Forensic Toxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis second edition of Clarke's Analytical Forensic Toxicology offers a fresh perspective on the drugs and poisons that you are most likely to encounter in forensic toxicology, with a focus on collection, extraction and analysis.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"...a useful reference for students both undergraduate and postgraduate, as well as toxicologists who are relatively new to this discipline...There are many chapters from experienced toxicologists (many who are familiar to us) and the book is well structured and follows a consistent approach to understanding the essentials of forensic toxicology...There is a comprehensive number of chapters on techniques (extraction and analysis) and the major chromatographic approaches are covered well by recognised authors with considerable expertise...So if you have the 4th edition of Clarke's Analysis of Drugs and Poisons would you also buy this volume as well? Yes I would because the book is geared to a more novice readership - students, researchers and inexperienced toxicologists.\" Dimitri Gerostamoulos, TIAFT Bulletin 43(2), July 2013. -- Dimitri Gerostamoulos * TIAFT Bulletin *\u003cbr\u003e\"This new edition is based on content in volume 1 of Clarke's Analysis of Drugs and Poisons, and modified for student use...this volume is full of useful information that will allow students to become familiar with the field. Summing up: Recommended. Upper-division undergraduates and graduate students.\" J. Allison, The College of New Jersey, CHOICE (51:3) November 2013. -- J. Allison * CHOICE *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e1. Introduction to Forensic Toxicology 2. Pharmacokinetics and Metabolism 3. Drugs of Abuse 4. Other Poisons 5. Workplace Drug Testing 6. Alternative Specimens 7. Postmortem Toxicology 8. Clinical Toxicology 9. Drug Abuse in Sport 10. Drug-Facilitated Sexual Assault 11. Alcohol, Drugs and Driving 12. Forensic Chemistry \u0026amp; Solid Dosage Form Identification 13. Sampling, Storage and Stability 14. Extraction 15. Colour Tests and Thin-Layer Chromatography 16. Immunoassays 17. Ultraviolet, Visible and Fluorescence Spectrophotometry 18. Infrared Spectroscopy 19. Gas Chromatography 20. High-Performance Liquid Chromatography 21. Mass Spectrometry 22. Quality Control and Assessment\u003c\/p\u003e","brand":"Pharmaceutical Press","offers":[{"title":"Default Title","offer_id":49406278009175,"sku":"9780857110541","price":61.75,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780857110541.jpg?v=1730495206"},{"product_id":"acute-toxicology-testing-9780936923062","title":"Acute Toxicology Testing","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAcute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and models. For each test, applicable U.S. and international guidelines are also presented, and the formulation and selection of vehicles, dosages, and test animals are addressed.","brand":"Telford Press","offers":[{"title":"Default Title","offer_id":49406535598423,"sku":"9780936923062","price":175.75,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780936923062.jpg?v=1730496193"},{"product_id":"the-toxic-microbiome-9781032065120","title":"The Toxic Microbiome","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eGut microbiomes are dynamic communities varying from population to population and throughout life. In Western societies, a toxic metabolic shift of gut microbiomes is a driver and underestimated risk factor for the development of many noncommunicable chronic pathologies. This book identifies the root cause of these deleterious microbial changes. During the last several decades, increased consumption of animal products, coinciding and correlating with global climate change, has been a contributing cause of undesirable gut microbiome changes.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eKey Features\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eEstablishes a connection between poor gut microbiome health and chronic disease and cancer development\u003c\/li\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eDemonstrates how animal products and low-fiber diet patterns induce a detrimental metabolic transition of the gut microbiome from a human health-maintaining towards a disease-promoting state\u003c\/li\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eDiscusses the opportunity of a toxic microbial metabolic signat\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eTable of Contents\u003c\/p\u003e\n\u003cp\u003eDedication \u003c\/p\u003e\n\u003cp\u003ePreface\u003c\/p\u003e\n\u003cp\u003eIntroduction\u003c\/p\u003e\n\u003cp\u003eChapter 1: Diet related chronic diseases are the most critical health problem of modern societies – how did that happen?\u003c\/p\u003e\n\u003cp\u003eChapter 2: The \"industrialized\" microbiome - a caution label for a global epidemic\u003c\/p\u003e\n\u003cp\u003eMissing microbes - does it matter?\u003c\/p\u003e\n\u003cp\u003eChapter 3: The subtle problems of microbiome research\u003c\/p\u003e\n\u003cp\u003eIs the microbiome \"oversold\"?\u003c\/p\u003e\n\u003cp\u003eIs microbiome science heading in the wrong direction?\u003c\/p\u003e\n\u003cp\u003eChapter 4: The gut microbiome: a new perspective\u003c\/p\u003e\n\u003cp\u003eOur microbiome is a metabolic organ\u003c\/p\u003e\n\u003cp\u003eFunctional \u003ci\u003eomes\u003c\/i\u003e: metabolites over species\u003c\/p\u003e\n\u003cp\u003eFinding a new definition for a \"healthy\" microbiome and \"dysbiosis\"\u003c\/p\u003e\n\u003cp\u003eChapter 5: Shaping the microbial behavior\u003c\/p\u003e\n\u003cp\u003eDiet: the master educator of the gut microbiome\u003c\/p\u003e\n\u003cp\u003eStarving the microbial self: a foundation for developing a chronic disease\u003c\/p\u003e\n\u003cp\u003eChapter 6: The toxic microbiome\u003c\/p\u003e\n\u003cp\u003e\"It’s not the fiber, it’s the animal protein\"\u003c\/p\u003e\n\u003cp\u003eProtein fermentation\u003c\/p\u003e\n\u003cp\u003eFat toxicity\u003c\/p\u003e\n\u003cp\u003eSecondary bile acids\u003c\/p\u003e\n\u003cp\u003eHeme iron\u003c\/p\u003e\n\u003cp\u003eTMAO: the way to a man’s heart is through his gut microbiota\u003c\/p\u003e\n\u003cp\u003eToxicomicrobiomics\u003c\/p\u003e\n\u003cp\u003eA toxic microbiome: useful for predicting chronic diseases?\u003c\/p\u003e\n\u003cp\u003eChapter 7: How to build a healthy gut microbiome and prevent chronic diseases\u003c\/p\u003e\n\u003cp\u003eThe \"true\" human diet: are humans really omnivores?\u003c\/p\u003e\n\u003cp\u003e\"The Paleo diet is a myth\"\u003c\/p\u003e\n\u003cp\u003eProtein concerns: Do we get enough on plants?\u003c\/p\u003e\n\u003cp\u003eFeeding microbes for disease prevention and treatment\u003c\/p\u003e\n\u003cp\u003eChapter 8: \"Fixing\" the microbiome - Can we restore a healthy microbiome by other means than diet?\u003c\/p\u003e\n\u003cp\u003eProbiotics – hype or hope?\u003c\/p\u003e\n\u003cp\u003eFecal microbial transplantation or \"The Power of Poop\"\u003c\/p\u003e\n\u003cp\u003eThe \"Wild West\" of microbiome science: drugging the microbiome and personalized nutrition\u003c\/p\u003e\n\u003cp\u003eGlossary\u003c\/p\u003e\n\u003cp\u003eAbbreviations\u003c\/p\u003e\n\u003cp\u003eLiterature\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Taylor \u0026 Francis Ltd","offers":[{"title":"Default Title","offer_id":49406658412887,"sku":"9781032065120","price":39.99,"currency_code":"GBP","in_stock":true}]},{"product_id":"highthroughput-screening-assays-in-toxicology-9781071622124","title":"HighThroughput Screening Assays in Toxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cdiv\u003eThis second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models. This volume also covers the application of artificial intelligence (AI) and data science to curate, manage, and use HTS data. Written in the highly successful \u003ci\u003eMethods in Molecular Biology\u003c\/i\u003e series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. \u003c\/div\u003e\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\u003cdiv\u003eCutting-edge and thorough, \u003ci\u003eHigh Throughput Screening Assays in Modern Toxicology, Second Edition\u003c\/i\u003e is a valuable resource for scientists pursuing chemical toxicology research. This book will aid scientists and researchers in translating new HTS techniques into standardized chemical toxicology assessment tools that can refine, re\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eAcknowledgement…Preface…Table of Contents…Contributing Authors…\u003cbr\u003ePart I In Vitro Toxicological High Throughput Screening Methods\u003cbr\u003e1. Cell-Based Assays to Identify ERR and ERR\/PGC ModulatorsCaitlin Lynch, Jinghua Zhao, and Menghang Xia\u003cbr\u003e2. Mitochondrial Membrane Potential AssaySrilatha Sakamuru, Jinghua Zhao, Matias S. Attene-Ramos, and Menghang Xia\u003cbr\u003e3. Cell-Based hERG Inhibition Assay in a High-Throughput FormatJinghua Zhao, and Menghang Xia \u003cbr\u003e4. Identifying CAR Modulators Utilizing a Reporter Gene AssayCaitlin Lynch, Jinghua Zhao, Hongbing Wang, and Menghang Xia\u003cbr\u003e5. Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 CellsYitong Liu\u003cbr\u003e6. Acetylcholinesterase Inhibition Assays for High-Throughput ScreeningShuaizhang Li, Andrew J. Li, Michael F. Santillo, and Menghang Xia\u003cbr\u003e7. Cell-Based Assays to Identify Modulators of Nrf2\/ARE PathwayZhengxi Wei, Jinghua Zhao, Li Zhang, and Menghang Xia\u003cbr\u003ePart II In Vitro Toxicological High Content Screening Methods\u003cbr\u003e8. Cell-Based Imaging Assay for Detection of PhospholipdosisLi Zhang, Shuaizhang Li, and Menghang Xia\u003cbr\u003e9. GFP-LC3 High-Content Assay for Screening Autophagy ModulatorsLi Zhang, Jinghua Zhao, Wen-Xing Ding, and Menghang Xia\u003cbr\u003ePart III Three-Dimensional Cell System for Toxicological High Throughput Screening\u003cbr\u003e10. Generation of iPSC-Derived Brain Organoids for Drug Testing and Toxicological EvaluationHa Nam Nguyen\u003cbr\u003ePart IV In Vivo Toxicological High Throughput Screening Methods\u003cbr\u003e11. Zebrafish Behavioral Assays in ToxicologySubham Dasgupta, Michael T. Simonich, and Robert L. Tanguay\u003cbr\u003ePart V In Silico High Throughput Screening Toxicity Data Analysis\u003cbr\u003e12. High Throughput Screening Assay Profiling for Large Chemical DatabasesDaniel P. Russo and Hao Zhu\u003cbr\u003e13. A Quantitative High Throughput Screening Data Analysis Pipeline for Activity ProfilingRuili Huang\u003cbr\u003e14. CurveP Method for Rendering High Throughput Screening Dose-Response Data into Digital FingerprintsAlexander Sedykh\u003cbr\u003e15. Accounting for Artifacts in High Throughput Toxicity AssaysJui-Hua Hsieh\u003cbr\u003e16. Automatic Quantitative Structure-Activity Relationship Modeling to Fill Data Gaps in High-Throughput ScreeningHeather L. Ciallella, Elena Chung, Daniel P. Russo, and Hao Zhu\u003cbr\u003e17. Use In Silico and In Vitro Methods to Screen Hepatotoxic Chemicals and CYP450 Enzyme InhibitorsYitong Liu\u003cbr\u003eSubject Index List…\u003cbr\u003e\n\u003c\/div\u003e","brand":"Springer-Verlag New York Inc.","offers":[{"title":"Default Title","offer_id":49406772183383,"sku":"9781071622124","price":125.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781071622124.jpg?v=1730497056"},{"product_id":"highthroughput-screening-methods-in-toxicity-testing-9781118065631","title":"HighThroughput Screening Methods in Toxicity","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eExplores the benefits and limitations of the latest high-throughput screening methods\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWith its expert coverage of high-throughput \u003ci\u003ein vitro\u003c\/i\u003e screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council''s Toxicity Testing in the 21st Century: A Vision and Strategy and the E.U.''s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eHigh-Throughput Screening Methods in Toxicity Testing\u003c\/i\u003e is divided into five parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eGeneral aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling\u003c\/li\u003e \u003cli\u003eAssessing different cytotoxic\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I GENERAL ASPECTS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling 3\u003cbr\u003e \u003ci\u003eKeith A. Houck, Ann M. Richard, Richard S. Judson, Matthew T. Martin, David M. Reif, and Imran Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 High-Throughput Toxicity Testing in Drug Development: Aims, Strategies, and Novel Trends 33\u003cbr\u003e \u003ci\u003eWillem G.E.J. Schoonen, Walter M.A. Westerink, Femke M. van de Water, and Horbach G. Jean\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Incorporating Human Dosimetry and Exposure Information with High-Throughput Screening Data in Chemical Toxicity Assessment 77\u003cbr\u003e \u003ci\u003eBarbara A. Wetmore and Russell S. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 The Use of Human Embryonic Stem Cells in High-Throughput Toxicity Assays 97\u003cbr\u003e \u003ci\u003eXin Huang, Dan-yan Zhu, and Yi-jia Lou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II HIGH-THROUGHPUT ASSAYS TO ASSESS DIFFERENT CYTOTOXICITY ENDPOINTS\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e 5 High-Throughput Screening Assays for the Assessment of Cytotoxicity 109\u003cbr\u003e \u003ci\u003eAndrew L. Niles, Richard A. Moravec, Tracy J. Worzella, Nathan J. Evans, and Terry L. Riss\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 High-Throughput Flow Cytometry Analysis of Apoptosis 129\u003cbr\u003e Francesca de Giorgi and Franc¸ois Ichas\u003c\/p\u003e \u003cp\u003e7 High Content Imaging-Based Screening for Cellular Toxicity Pathways 143\u003cbr\u003e \u003ci\u003eBram Herpers and Bob van de Water\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 The Keratinosens Assay: A High-Throughput Screening Assay to Assess Chemical Skin Sensitization 159\u003cbr\u003e \u003ci\u003eAndreas Natsch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 High-Throughput Screening Assays to Assess Chemical Phototoxicity 177\u003cbr\u003e \u003ci\u003eSatomi Onoue, Yoshiki Seto, and Shizuo Yamada\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III HIGH-THROUGHPUT ASSAYS TO ASSESS DNA DAMAGE AND CARCINOGENESIS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 Ames IITM and Ames Liquid Format Mutagenicity Screening Assays 193\u003cbr\u003e \u003ci\u003eKamala Pant\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 High-Throughput Bacterial Mutagenicity Testing: VitotoxTM Assay 213\u003cbr\u003e \u003ci\u003eLuc Verschaeve\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Genotoxicity and Carcinogenicity: Regulatory and Novel Test Methods 233\u003cbr\u003e \u003ci\u003eWalter M.A. Westerink, Joe C.R. Stevenson, G. Jean Horbach, Femke M. van de Water, Beppy van de Waart, and Willem G.E.J. Schoonen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 High-Throughput Genotoxicity Testing: The Greenscreen Assay 271\u003cbr\u003e \u003ci\u003eJorg Blumel and Nadine Krause\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 High-Throughput Assays to Quantify the Formation of DNA Strand Breaks 285\u003cbr\u003e \u003ci\u003eMarýa Moreno-Villanueva and Alexander Burkle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 High-Throughput Versions of the Comet Assay 295\u003cbr\u003e \u003ci\u003eIrene Witte and Andre Stang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Automated Soft Agar Colony Formation Assay for the High-Throughput Screening of Malignant Cell Transformation 309\u003cbr\u003e \u003ci\u003ePablo Steinberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 High-Throughput Quantification of Morphologically Transformed Foci in Bhas 42 Cells (v-Ha-ras Transfected BALB\/c 3T3) Using Spectrophotometry 317\u003cbr\u003e \u003ci\u003eKiyoshi Sasaki, Ayako Sakai, and Noriho Tanaka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV HIGH-THROUGHPUT ASSAYS TO ASSESS REPRODUCTIVE TOXICITY, CARDIOTOXICITY,\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eAND HAEMATOTOXICITY\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 ReProGlo: A New Stem-Cell-Based High-Throughput Assay to Predict the Embryotoxic Potential of Chemicals 343\u003cbr\u003e \u003ci\u003eFrederik Uibel and Michael Schwarz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Embryonic Stem Cell Test (EST): Molecular Endpoints Toward High-Throughput Analysis of Chemical Embryotoxic Potential 357\u003cbr\u003e \u003ci\u003ePeter T. Theunissen, Esther de Jong, Joshua F. Robinson, and Aldert H. Piersma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Zebrafish Development: High-Throughput Test Systems to Assess Developmental Toxicity 371\u003cbr\u003e \u003ci\u003eStephanie Padilla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Single Cell Imaging Cytometry-Based High-Throughput Analysis of Drug-Induced Cardiotoxicity 385\u003cbr\u003e \u003ci\u003eMin Jung Kim and Joon Myong Song\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 High-Throughput Screening Assays to Evaluate the Cardiotoxic Potential of Drugs 403\u003cbr\u003e \u003ci\u003eCarl-Fredrik Mandenius and Thomas Meyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 High-Throughput Screening Assays to Evaluate the Hematotoxic Potential of Drugs 421\u003cbr\u003e \u003ci\u003eCaroline Haglund, Rolf Larsson, and Martin Hoglund\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V HIGH-THROUGHPUT ASSAYS TO ASSESS DRUG METABOLISM AND RECEPTOR-RELATED TOXICITY\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e24 High-Throughput Enzyme Biocolloid Systems for Drug Metabolism and Genotoxicity Profiling Using LC–MS\/MS 433\u003cbr\u003e \u003ci\u003eJames F. Rusling and John Schenkman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Higher-Throughput Screening Methods to Identify Cytochrome P450 Inhibitors and Inducers: Current Applications and Practice 453\u003cbr\u003e \u003ci\u003eDavid M. Stresser and George Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 High-Throughput Yeast-Based Assays to Study Receptor-Mediated Toxicity 479\u003cbr\u003e Johanna Rajasarkka and Marko Virta\u003c\/p\u003e \u003cp\u003e27 Evaluating the Peroxisomal Phenotype in High Content Toxicity Profiling 501\u003cbr\u003e \u003ci\u003eJonathan Z. Sexton and Kevin P. Williams\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 A Panel of Quantitative Calux R  Reporter Gene Assays for Reliable High-Throughput Toxicity Screening of Chemicals and Complex Mixtures 519\u003cbr\u003e \u003ci\u003eBart van der Burg, Sander van der Linden, Hai-yen Man, Roos Winter, Lydia\u003c\/i\u003e \u003ci\u003eJonker, Barbara van Vugt-Lussenburg, and Abraham Brouwer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 DR-Calux R  : A High-Throughput Screening Assay for the Detection of Dioxin and Dioxin-Like Compounds in Food and Feed 533\u003cbr\u003e \u003ci\u003eBarbara van Vugt-Lussenburg, Harrie T. Besselink, Bart van der Burg, and\u003c\/i\u003e \u003ci\u003eAbraham Brouwer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 547\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406825562455,"sku":"9781118065631","price":128.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118065631.jpg?v=1730497244"},{"product_id":"molecular-and-cellular-toxicology-9781119952060","title":"Molecular and Cellular Toxicology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eOver the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional (some might say old-fashioned) methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e“Overall, we consider that this book is a useful summary of current and emerging techniques in molecular toxicology.”  (\u003ci\u003eBTS Newsletter\u003c\/i\u003e, 1 March 2015)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eForeword xiii  \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003eAcknowledgements xvii\u003c\/p\u003e \u003cp\u003eAbbreviations xix\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Background to Molecular and Cellular Toxicology 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 What do we mean by molecular and cellular toxicology? 1\u003c\/p\u003e \u003cp\u003e1.2 Tissues and their maintenance 2\u003c\/p\u003e \u003cp\u003e1.2.1 Stem cells 3\u003c\/p\u003e \u003cp\u003e1.3 Tissue damage 4\u003c\/p\u003e \u003cp\u003e1.3.1 Consequences of tissue injury 4\u003c\/p\u003e \u003cp\u003e1.3.2 Reversible changes in cells and tissues 6\u003c\/p\u003e \u003cp\u003e1.3.3 Irreversible changes in cells and tissues 7\u003c\/p\u003e \u003cp\u003e1.4 Tissue responses to injury 7\u003c\/p\u003e \u003cp\u003e1.4.1 Oxidative stress 7\u003c\/p\u003e \u003cp\u003e1.4.2 Necrosis and apoptosis 10\u003c\/p\u003e \u003cp\u003e1.4.3 Neoplasia 13\u003c\/p\u003e \u003cp\u003e1.4.4 The initiation–promotion paradigm 13\u003c\/p\u003e \u003cp\u003e1.5 Key concepts in toxicology 23\u003c\/p\u003e \u003cp\u003e1.5.1 Risk and hazard 23\u003c\/p\u003e \u003cp\u003e1.5.2 Variability and uncertainty 25\u003c\/p\u003e \u003cp\u003e1.5.3 Threshold and non-threshold dose responses 26\u003c\/p\u003e \u003cp\u003e1.5.4 The regulatory context 28\u003c\/p\u003e \u003cp\u003e1.5.5 Limitations of whole animal studies 29\u003c\/p\u003e \u003cp\u003e1.5.6 Use of human tissues in toxicology 31\u003c\/p\u003e \u003cp\u003e1.6 Summing up 33\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 33\u003c\/p\u003e \u003cp\u003eBackground Reading 34\u003c\/p\u003e \u003cp\u003eReferences 34\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Individual Susceptibility to Toxic Chemicals 37\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 37\u003c\/p\u003e \u003cp\u003e2.2 Toxicogenetics and toxicogenomics 38\u003c\/p\u003e \u003cp\u003e2.3 Genotyping and phenotyping 39\u003c\/p\u003e \u003cp\u003e2.3.1 Genotyping 40\u003c\/p\u003e \u003cp\u003e2.3.2 Phenotyping 43\u003c\/p\u003e \u003cp\u003e2.3.3 Correlating genotype and phenotype 44\u003c\/p\u003e \u003cp\u003e2.4 Polymorphic xenobiotic metabolism 45\u003c\/p\u003e \u003cp\u003e2.4.1 Polymorphic xenobiotic metabolising enzymes 49\u003c\/p\u003e \u003cp\u003e2.4.2 The role of xenobiotic metabolising polymorphisms in susceptibility to toxic agents 50\u003c\/p\u003e \u003cp\u003e2.5 Study numbers and effect size 60\u003c\/p\u003e \u003cp\u003e2.6 Recent developments 62\u003c\/p\u003e \u003cp\u003e2.6.1 Genome-wide association studies 62\u003c\/p\u003e \u003cp\u003e2.6.2 Collaborative programmes 64\u003c\/p\u003e \u003cp\u003e2.7 The UK Biobank 69\u003c\/p\u003e \u003cp\u003e2.8 Conclusions 71\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 72\u003c\/p\u003e \u003cp\u003eBackground Reading 72\u003c\/p\u003e \u003cp\u003eReferences 73\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 ‘Omics Techniques 79\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 ‘Omics and bioinformatics 79\u003c\/p\u003e \u003cp\u003e3.2 Transcriptomics 80\u003c\/p\u003e \u003cp\u003e3.2.1 Methodology 80\u003c\/p\u003e \u003cp\u003e3.2.2 Proof of principle 89\u003c\/p\u003e \u003cp\u003e3.2.3 Hepatotoxicity 91\u003c\/p\u003e \u003cp\u003e3.2.4 Extrahepatic toxicity 96\u003c\/p\u003e \u003cp\u003e3.3 Proteomics 97\u003c\/p\u003e \u003cp\u003e3.3.1 Methodology 98\u003c\/p\u003e \u003cp\u003e3.4 Metabolomics\/metabonomics 101\u003c\/p\u003e \u003cp\u003e3.4.1 MS-based metabolomics 102\u003c\/p\u003e \u003cp\u003e3.4.2 NMR-based metabolomics 106\u003c\/p\u003e \u003cp\u003e3.5 Integrating different types of ‘omics data 107\u003c\/p\u003e \u003cp\u003e3.5.1 ‘Omics in drug discovery 108\u003c\/p\u003e \u003cp\u003e3.5.2 ‘Omics profiles as biomarkers of toxicity 109\u003c\/p\u003e \u003cp\u003e3.6 Remaining issues with ‘omics approaches 111\u003c\/p\u003e \u003cp\u003e3.7 Conclusions 112\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 113\u003c\/p\u003e \u003cp\u003eBackground Reading 113\u003c\/p\u003e \u003cp\u003eReferences 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 In Vitro Methods for Predicting In Vivo Toxicity 117\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 In vitro toxicology 117\u003c\/p\u003e \u003cp\u003e4.2 Tissue culture 117\u003c\/p\u003e \u003cp\u003e4.2.1 Primary cell cultures 122\u003c\/p\u003e \u003cp\u003e4.2.2 Established cell lines 125\u003c\/p\u003e \u003cp\u003e4.3 Acute toxicity in vitro 127\u003c\/p\u003e \u003cp\u003e4.3.1 Cytotoxicity testing 127\u003c\/p\u003e \u003cp\u003e4.3.2 Choice of cell line 129\u003c\/p\u003e \u003cp\u003e4.3.3 Liver 131\u003c\/p\u003e \u003cp\u003e4.3.4 Skin 133\u003c\/p\u003e \u003cp\u003e4.3.5 Eye 141\u003c\/p\u003e \u003cp\u003e4.4 Repeated dose toxicity 144\u003c\/p\u003e \u003cp\u003e4.5 Reproductive toxicity 147\u003c\/p\u003e \u003cp\u003e4.6 Stem cell-derived systems 149\u003c\/p\u003e \u003cp\u003e4.7 Conclusions 151\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 151\u003c\/p\u003e \u003cp\u003eBackground Reading 152\u003c\/p\u003e \u003cp\u003eReferences 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 In Vitro Methods for Absorption, Distribution, Metabolism and Excretion 159\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Why study ADME in vitro? 159\u003c\/p\u003e \u003cp\u003e5.2 Absorption 160\u003c\/p\u003e \u003cp\u003e5.2.1 Dermal penetration 160\u003c\/p\u003e \u003cp\u003e5.2.2 Gastrointestinal absorption 164\u003c\/p\u003e \u003cp\u003e5.3 Distribution 171\u003c\/p\u003e \u003cp\u003e5.3.1 Protein binding 172\u003c\/p\u003e \u003cp\u003e5.3.2 Blood-brain barrier 172\u003c\/p\u003e \u003cp\u003e5.3.3 Other protective barriers 176\u003c\/p\u003e \u003cp\u003e5.4 Metabolism 176\u003c\/p\u003e \u003cp\u003e5.4.1 Skin 177\u003c\/p\u003e \u003cp\u003e5.4.2 Gastrointestinal tract 179\u003c\/p\u003e \u003cp\u003e5.4.3 Liver 179\u003c\/p\u003e \u003cp\u003e5.5 Excretion 189\u003c\/p\u003e \u003cp\u003e5.5.1 Biliary excretion 190\u003c\/p\u003e \u003cp\u003e5.5.2 Renal clearance 191\u003c\/p\u003e \u003cp\u003e5.6 Conclusions 191\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 192\u003c\/p\u003e \u003cp\u003eReferences 192\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 In Silico Methods and Structure–Activity Relationships 199\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Why in silico? 199\u003c\/p\u003e \u003cp\u003e6.2 Predicting the ADME characteristics of xenobiotics 200\u003c\/p\u003e \u003cp\u003e6.2.1 Absorption 200\u003c\/p\u003e \u003cp\u003e6.2.2 Distribution 206\u003c\/p\u003e \u003cp\u003e6.2.3 Metabolism 207\u003c\/p\u003e \u003cp\u003e6.2.4 Excretion 212\u003c\/p\u003e \u003cp\u003e6.3 Physiologically based biokinetic modelling 212\u003c\/p\u003e \u003cp\u003e6.4 Toxicity 221\u003c\/p\u003e \u003cp\u003e6.4.1 Exposure modelling 222\u003c\/p\u003e \u003cp\u003e6.4.2 Prediction of toxicity 223\u003c\/p\u003e \u003cp\u003e6.5 Conclusions 233\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 235\u003c\/p\u003e \u003cp\u003eReferences 235\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Transgenic Animal Models for ADME and Systemic Toxicity 241\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Transgenic models and their use in toxicology 241\u003c\/p\u003e \u003cp\u003e7.2 ADME models 242\u003c\/p\u003e \u003cp\u003e7.2.1 Nuclear receptor models 244\u003c\/p\u003e \u003cp\u003e7.2.2 Xenobiotic metabolism models 251\u003c\/p\u003e \u003cp\u003e7.2.3 Drug transporter models 259\u003c\/p\u003e \u003cp\u003e7.3 Reporter models 264\u003c\/p\u003e \u003cp\u003e7.3.1 LacZ-based models 264\u003c\/p\u003e \u003cp\u003e7.3.2 Green fluorescent protein-based models 267\u003c\/p\u003e \u003cp\u003e7.3.3 Luciferase-based models 268\u003c\/p\u003e \u003cp\u003e7.3.4 Evaluation 273\u003c\/p\u003e \u003cp\u003e7.4 Conclusions 273\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 274\u003c\/p\u003e \u003cp\u003eBackground Reading 274\u003c\/p\u003e \u003cp\u003eReferences 274\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Genotoxicity and its Measurement 281\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Genotoxicity testing 281\u003c\/p\u003e \u003cp\u003e8.2 Core in vitro tests 282\u003c\/p\u003e \u003cp\u003e8.2.1 The Ames test 282\u003c\/p\u003e \u003cp\u003e8.2.2 In vitro gene mutation tests using mammalian cells 283\u003c\/p\u003e \u003cp\u003e8.2.3 The in vitro chromosome aberration test 284\u003c\/p\u003e \u003cp\u003e8.2.4 The in vitro micronucleus assay 287\u003c\/p\u003e \u003cp\u003e8.3 Assessment of genotoxicity for regulatory purposes 291\u003c\/p\u003e \u003cp\u003e8.4 Novel in vitro methods 292\u003c\/p\u003e \u003cp\u003e8.4.1 GreenScreen HC 292\u003c\/p\u003e \u003cp\u003e8.4.2 The Reconstructed Skin MicroNucleus assay 293\u003c\/p\u003e \u003cp\u003e8.5 Novel in vivo assays for gene mutations 294\u003c\/p\u003e \u003cp\u003e8.5.1 The Pig-A assay 294\u003c\/p\u003e \u003cp\u003e8.5.2 In vivo assays using transgenic mouse models 295\u003c\/p\u003e \u003cp\u003e8.6 DNA damage and its repair 300\u003c\/p\u003e \u003cp\u003e8.6.1 DNA damage 300\u003c\/p\u003e \u003cp\u003e8.6.2 DNA repair 305\u003c\/p\u003e \u003cp\u003e8.7 Thresholds 308\u003c\/p\u003e \u003cp\u003e8.8 Conclusions 310\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 310\u003c\/p\u003e \u003cp\u003eReferences 311\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Oncogenes and the Identification of Human Carcinogens 317\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 317\u003c\/p\u003e \u003cp\u003e9.2 Identification of human carcinogens 317\u003c\/p\u003e \u003cp\u003e9.2.1 The lifetime carcinogenicity bioassay 317\u003c\/p\u003e \u003cp\u003e9.2.2 The National Toxicology Program 2-year bioassay 318\u003c\/p\u003e \u003cp\u003e9.3 Genetic changes in cancer 321\u003c\/p\u003e \u003cp\u003e9.3.1 Methods for detecting activated oncogenes 324\u003c\/p\u003e \u003cp\u003e9.3.2 In vitro transformation assays 324\u003c\/p\u003e \u003cp\u003e9.3.3 Ras oncogene activation during tumour development 326\u003c\/p\u003e \u003cp\u003e9.3.4 Non-ras oncogenes 328\u003c\/p\u003e \u003cp\u003e9.3.5 Evaluation 329\u003c\/p\u003e \u003cp\u003e9.4 Non-genotoxic carcinogenesis 329\u003c\/p\u003e \u003cp\u003e9.4.1 Non-receptor-mediated mechanisms 330\u003c\/p\u003e \u003cp\u003e9.4.2 Receptor-mediated mechanisms 331\u003c\/p\u003e \u003cp\u003e9.4.3 When is a genotoxic carcinogen not a genotoxic carcinogen? 333\u003c\/p\u003e \u003cp\u003e9.5 Transgenic models for short-term carcinogenicity bioassays 335\u003c\/p\u003e \u003cp\u003e9.5.1 RasH2 335\u003c\/p\u003e \u003cp\u003e9.5.2 Tg.AC 337\u003c\/p\u003e \u003cp\u003e9.5.3 p53 models 338\u003c\/p\u003e \u003cp\u003e9.5.4 XPC−¨M−, XPA−¨M− and XPA−¨M−\/p53+¨M− null mouse models 340\u003c\/p\u003e \u003cp\u003e9.5.5 Comparative evaluation of models 340\u003c\/p\u003e \u003cp\u003e9.5.6 Regulatory status 341\u003c\/p\u003e \u003cp\u003e9.5.7 Limitations of the assays 343\u003c\/p\u003e \u003cp\u003e9.5.8 Evaluation 344\u003c\/p\u003e \u003cp\u003e9.6 Conclusions 345\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 346\u003c\/p\u003e \u003cp\u003eReferences 346\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Emerging Techniques 351\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 What’s next? 351\u003c\/p\u003e \u003cp\u003e10.2 Novel model organisms 351\u003c\/p\u003e \u003cp\u003e10.2.1 The zebrafish 352\u003c\/p\u003e \u003cp\u003e10.2.2 Evaluation 358\u003c\/p\u003e \u003cp\u003e10.3 Less invasive methods 359\u003c\/p\u003e \u003cp\u003e10.3.1 Use of biomarkers 359\u003c\/p\u003e \u003cp\u003e10.3.2 Liver 359\u003c\/p\u003e \u003cp\u003e10.3.3 Kidney 367\u003c\/p\u003e \u003cp\u003e10.3.4 Circulating mRNA biomarkers 371\u003c\/p\u003e \u003cp\u003e10.3.5 Evaluation 373\u003c\/p\u003e \u003cp\u003e10.4 The systems biology approach 373\u003c\/p\u003e \u003cp\u003e10.4.1 Systems biology in toxicology 376\u003c\/p\u003e \u003cp\u003e10.5 Collaborative programmes 381\u003c\/p\u003e \u003cp\u003e10.5.1 Europe 381\u003c\/p\u003e \u003cp\u003e10.5.2 USA 383\u003c\/p\u003e \u003cp\u003e10.5.3 Evaluation 384\u003c\/p\u003e \u003cp\u003e10.6 Final word 385\u003c\/p\u003e \u003cp\u003eSelf-assessment questions 385\u003c\/p\u003e \u003cp\u003eReferences 385\u003c\/p\u003e \u003cp\u003eIndex 391\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49407192957271,"sku":"9781119952060","price":52.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119952060.jpg?v=1730498503"}],"url":"https:\/\/bookcurl.com\/collections\/medical-toxicology.oembed?page=4","provider":"Book Curl","version":"1.0","type":"link"}