{"title":"Medical genetics Books","description":"","products":[{"product_id":"hacking-the-code-of-life-how-gene-editing-will-rewrite-our-futures-9781785786259","title":"Hacking the Code of Life: How gene editing will","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003e'An excellent, brisk guide to what is likely to happen as opposed to the fantastically remote.' - \u003ci\u003eLos Angeles Review of Books\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eIn 2018 the world woke up to gene editing with a storm of controversy over twin girls born in China with genetic changes deliberately introduced by scientists - changes they will pass on to their own offspring. \u003cbr\u003e\u003cbr\u003eGenetic modification (GM) has been with us for 45 years now, but the new system known as CRISPR or gene editing can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago. \u003cbr\u003e\u003cbr\u003eBut is it ethical to change the genetic material of organisms in a way that might be passed on to future generations? If a person is suffering from a lethal genetic disease, is it unethical to deny them this option? Who controls the application of this technology, when it makes 'biohacking' - perhaps of one's own genome - a real possibility?\u003cbr\u003e\u003cbr\u003eNessa Carey's book is a thrilling and timely snapshot of a cutting-edge technology that will radically alter our futures and the way we prevent disease.\u003cbr\u003e\u003cbr\u003e\u003cb\u003e'A focused snapshot of a brave new world.' - \u003ci\u003eNature\u003c\/i\u003e \u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003e'A brisk, accessible primer on the fast-moving field, a clear-eyed look at a technology that is already driving major scientific advances - and raising complex ethical questions.' - Emily Anthes, \u003ci\u003eUndark\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eCarey's trawl of potential applications - such as high-yield rice varieties, therapies for sickle-cell disease and germline gene editing - is edifying. A focused snapshot of a brave new world. * Nature *\u003cbr\u003e[A]n excellent, brisk guide to what is likely to happen as opposed to the fantastically remote. * Los Angeles Review of Books *\u003cbr\u003eA brisk, accessible primer on the fast-moving field, a clear-eyed look at a technology that is already driving major scientific advances - and raising complex ethical questions. -- Emily Anthes * Undark *","brand":"Icon Books","offers":[{"title":"Default Title","offer_id":47851264672087,"sku":"9781785786259","price":8.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781785786259.jpg?v=1710631715"},{"product_id":"sapolsky-r-monkeyluv-9780099474555","title":"Sapolsky R Monkeyluv","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eDescribed by Oliver Sacks as ''one of the best scientist-writers of our time'', Robert M. Sapolsky here presents the human animal in all its quirkiness and diversity.\u003cbr\u003e\u003cbr\u003eIn these remarkable essays, Sapolsky once again deploys his compassion and insights into the human condition to tell us who, why and how we are. \u003ci\u003eMonkeyluv \u003c\/i\u003etouches on themes such as sexuality, aggression, love, parenting, religion, ageing, and mental illness. He ponders such topics as our need to seek out beauty; why our preferences in food become fixed; why we are sexually attracted to one another; why Alzheimer''s disease tends to be a post-menopausal phenomenon; and why grandmothers buying groceries for their grandchildren are part of nature''s Darwinian logic.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThe prose is perfectly pitched: Sapolsky writes in a jocular, entertaining style without ever pandering to the presumed ignorance of his readers. And he expresses infectious enthusiasm, especially when he is reporting on new experiments performed by colleagues in his field -- Steven Poole * Guardian *\u003cbr\u003eSapolsky, who has a weakness for Martian jokes, is a bona fide boffin, but he looks beyond the lab for his case studies, assembling a cast that includes Sandra Bullock and a love-struck baboon named Jonathan. This highly readable book will both inform and enlarge your appreciation of the mystery of existence * Mail on Sunday *\u003cbr\u003eThe author of \u003ci\u003eMonkeyluv\u003c\/i\u003e, an entertaining collection of essays about humans and animals, is also a luminary among that rare breed - the funny scientist. These essays on genetic wars between men and women, dreams, bad moods, ambiguity and stress are...a combination of Oliver Sacks and David Foster Wallace * Los Angeles Times *\u003cbr\u003eSapolsky gives us these and many more intriguing gene factoids, but he also explains the elaborate nature\/nurture interactions in which they are embedded...the book is a witty blend of anecdote and analysis -- Rita Carter * Daily Mail *\u003cbr\u003eFascinating * Sunday Times *","brand":"Vintage Publishing","offers":[{"title":"Default Title","offer_id":48732240314711,"sku":"9780099474555","price":10.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780099474555.jpg?v=1719996100"},{"product_id":"genes-a-very-short-introduction-very-short-introductions-9780192856708","title":"Genes A Very Short Introduction Very Short","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eVery Short Introductions\u003cb\u003e: Brilliant, Sharp, Inspiring \u003c\/b\u003eIn this exploration of the concept of the gene, Jonathan Slack looks at the discovery, nature, and role of genes in both evolution and development. By explaining the nature of genetic variation in the human population, how hereditary factors were identified as molecules of DNA, and how certain specific mutations can lead to disease, Slack highlights how DNA variants are used to trace human ancestry and migration, and can also be used by forensic scientists to identify individuals in crime. He also explores issues such as the role of genetic heritability and IQ as well as the changes that occur in the genes of populations during evolution.An ideal guide for anyone curious about what genes are and how genetics can be put to use, this Very Short Introduction demonstrates the ways in which the gene concept has been understood and used by molecular biologists, population biologists, and social scientists around the world. This second edition has been fully updated and contains new sections on the CRISPR method for targeted genetic modification, on DNA profiling, and developments in our understanding of human ancestry using ancient DNA.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis is a concise and accurate account of genes and what they are in a readable and convenient format. * Sir Paul Nurse, Director, Francis Crick Institute *\u003cbr\u003eUnlike the genetic material itself, this book is short, sharp, and to the point. * Steve Jones, University College London *\u003cbr\u003eWe all need to know what genes are. Slack tells us with authority, clarity and grace. * Armand Leroi, Imperial College, London *\u003cbr\u003eThe essential guide for getting up to speed with the ever-changing and crazily complex science of genetics. * Adam Rutherford, University College London *\u003cbr\u003eWith more heat than light in many areas surrounding genetics, it is refreshing to have such a concise, precise and matter-of-fact introduction to the field. This is strongly recommended to anyone with even a passing interest in a field set to dominate our lives. * Laurence Hurst, Director of The Milner Centre for Evolution, University of Bath *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface List of illustrations 1: Genes before 1944 2: Genes as DNA 3: Mutations and gene variants 4: Genes as markers 5: Genes of small effect 6: Genes in evolution Conclusion: the varied concepts of the gene Further reading Glossary Index\u003c\/b\u003e","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732600172887,"sku":"9780192856708","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"genomics-9780198786207","title":"Genomics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eGenomics has transformed the biological sciences. From epidemiology and medicine to evolution and forensics, the ability to determine an organism''s complete genetic makeup has changed the way science is done and the questions that can be asked of it. Its most celebrated achievement was the Human Genome Project, a technologically challenging endeavor that took thousands of scientists around the world 13 years and over 3 billion US dollars to complete. In this Very Short Introduction John Archibald explores the science of genomics and its rapidly expanding toolbox. Sequencing a human genome now takes only a few days and costs as little as $1,000. The genomes of simple bacteria and viruses can be sequenced in a matter of hours on a device that fits in the palm of your hand. The resulting sequences can be used to better understand our biology in health and disease and to ''personalize'' medicine. Archibald shows how the field of genomics is on the cusp of another quantum leap; the implications for science and society are profound.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eGenomics does an amazingly good job of covering the gist and gestalt of arguably the most wide-ranging and fastest developing of the biological sciences. * CHOICE Reviews *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: What is genomics? 2: How to read the book of life 3: Making sense of genes and genomes 4: The human genome in biology and medicine 5: Evolutionary genomics 6: Genomics and the microbial world 7: The future of genomics Further Reading Index","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732783477079,"sku":"9780198786207","price":9.49,"currency_code":"GBP","in_stock":true}]},{"product_id":"genetics-in-medicine-9780198841555","title":"Genetics in Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eWritten primarily for students embarking on an undergraduate bioscience degree, this primer will review the essential biological concepts that underpin any programme of more advanced study and give early-stage undergraduates the opportunity to review topics about which they may feel under-prepared or less confident.Genetic medicine has entered an era of rapid expansion. It is no longer just relevant to families affected by rare congenital disorders, but has the potential to affect the diagnosis and treatment of most common complex diseases.The successful application of new genetic science in the decades ahead will depend on the next generation of undergraduates or university applicants, who are now planning their careers as Biologists and Clinicians.This primer explores core concepts about heredity and genome analysis, illustrates current clinical practice with case-histories, and discusses the potentials and pitfalls of personalised medicine.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: Nucleic Acids, Genes, and Genomes 2: Mutations and Genetic Variation 3: Laboratory Techniques and the Sequencing Revolution 4: The Application of Genetic Medicine in Childhood 5: Genetic Medicine for Adult Onset Disease 6: Pharmacogenetics and Personalised Medicine","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732808053079,"sku":"9780198841555","price":24.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198841555.jpg?v=1719998485"},{"product_id":"can-precision-medicine-be-personal-can-personalized-medicine-be-precise-9780198863465","title":"Can precision medicine be personal Can","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision\/personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science.","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732820111703,"sku":"9780198863465","price":43.69,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198863465.jpg?v=1719998539"},{"product_id":"principles-of-evolutionary-medicine-9780199663934","title":"Principles of Evolutionary Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eA new updated edition of the first integrated and comprehensive textbook to explain the principles of evolutionary biology from a medical perspective and to focus on how medicine and public health might utilise evolutionary biology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis volume will appeal to a broad readership of students and faculty in a variety of disciplines ... I recommend this book highly as a clear and accessible introduction to the growing field of evolution, medicine, and public health. * Robert Perlman, The Quarterly Review of Biology *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePART 1: FUNDAMENTALS OF EVOLUTIONARY BIOLOGY; PART 2: EVOLUTION IN HEALTH AND DISEASE","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732878569815,"sku":"9780199663934","price":40.84,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780199663934.jpg?v=1719998783"},{"product_id":"the-compatibility-gene-9780241956755","title":"The Compatibility Gene","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eShort-listed for the Society of Biology Book Award 2014 \u003c\/b\u003e\u003cbr\u003e\u003cb\u003eLong-listed for the Royal Society Winton prize for science books 2014\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eIn \u003ci\u003eThe Compatibility Gene\u003c\/i\u003e, leading scientist Daniel M Davis tells the story of the crucial genes that define our relationships, our health and our individuality. \u003cbr\u003e\u003cbr\u003eWe each possess a similar set of around 25,000 human genes. Yet a tiny, distinctive cluster of these genes plays a disproportionately large part in how our bodies work. These few genes, argues Davis, hold the key to who we are as individuals and our relationship to the world: how we combat disease, how our brains are wired, how attractive we are, even how likely we are to reproduce.\u003cbr\u003e\u003cbr\u003e\u003ci\u003eThe Compatibility Gene \u003c\/i\u003efollows the remarkable history of these genes'' discovery. From the British scientific pioneers who struggled to understand the mysteries of transplants to the Swiss zoologist who devised a new method of assessing potential couples'' compatibility based on the smell of worn T-shirts, Davis traces a true scientific revolution in our understanding of the human body: a global adventure spanning some sixty years.\u003cbr\u003e\u003cbr\u003e''Unusual results, astonishing implications and ethical dilemmas'' \u003ci\u003eThe Times\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e''Packed with an insider''s knowledge'' \u003ci\u003eNew York Times\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e''He makes immunology as fascinating to popular science readers as cosmology, consciousness, and evolution'' Steven Pinker\u003cbr\u003e\u003cbr\u003e''An elegantly written, unexpectedly gripping account'' Bill Bryson \u003ci\u003eGuardian, Books of the Year\u003c\/i\u003e \u003cbr\u003e\u003cbr\u003eDaniel M Davis is director of research at the University of Manchester''s Collaborative Centre for Inflammation Research and a visiting professor at Imperial College, London. He has published over 100 academic articles, including papers in \u003ci\u003eNature\u003c\/i\u003e and \u003ci\u003eScience\u003c\/i\u003e, and \u003ci\u003eScientific American\u003c\/i\u003e. He has won the Oxford University Press Science Writing Prize and given numerous interviews for national and international media. He was elected a Fellow of the Academy of Medical Sciences in 2011.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eWho am I? What makes me different from everyone else? Daniel Davis recounts the remarkable science that has answered one version of these questions -- Steven Pinker\u003cbr\u003eOstensibly about a set of genes that we all have and need, this book is really about the men and women who discovered them and worked out what they do.  It's a search for the essence of scientific greatness by a scientist who is headed that way himself -- Armand Marie Leroi, author of 'Mutants'\u003cbr\u003e\u003ci\u003eThe Compatibility Gene\u003c\/i\u003e cuts through the complexity to reveal the startling truth about perhaps the most important section of the molecule that defines what it means to be human -- Steve Jones, author of 'Almost Like A Whale'\u003cbr\u003eDavis weaves a warm biographical thread through his tale of scientific discovery, revealing the drive and passion of those in the vanguard of research * The Times *\u003cbr\u003eDavis makes the twists and turns all count * Guardian *\u003cbr\u003eDavis ranges energetically through the research. Cultural references and anecdotes abound * Nature *\u003cbr\u003eA fascinating, expertly told story -- Michael Brooks * New Statesman *\u003cbr\u003eThe genes that make you a true individual ... Davis provides a well-written and easy-to-read account of the sometimes complicated biology behind the crucial genes that affect our lives so profoundly * New Scientist *\u003cbr\u003eWonderful pen-portraits of the many scientists involved in this fast-moving field ... 5 out of 5 stars -- Henry Gee * BBC Focus magazine *\u003cbr\u003eDr. Davis's readable and informative book takes the reader into unexpectedly interesting corners of both the immune system and the lives of immunologists. It is packed with an insider's knowledge - not just of the field, but of where its bodies are buried -- Nicholas Wade * New York Times *\u003cbr\u003eAn elegantly written, unexpectedly gripping account of how scientists painstakingly unravelled the way in which a small group of genes ... crucially influence, and unexpectedly interconnect, various aspects of our lives... Lab work has rarely been made to seem more interesting or heroic -- Bill Bryson * Guardian, Books of the Year 2013 *","brand":"Penguin Books Ltd","offers":[{"title":"Default Title","offer_id":48733379920215,"sku":"9780241956755","price":13.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780241956755.jpg?v=1719999969"},{"product_id":"connections-9780241985816","title":"Connections","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e'I find myself at a loss for how to describe this remarkable work. Just as Karl has, through his laboratory, reimagined, and literally redefined how we view the human brain, \u003cb\u003ehe has reimagined and redefined what literary non-fiction can be, with great elegance. \u003c\/b\u003eFor all of us who write about science for the public, this will be a tough act to follow. \u003cb\u003eIt's poetic, mind-stretching, and through it all, deeply human'\u003c\/b\u003e -- Daniel Levitin\u003cbr\u003e\u003cb\u003e'Revelatory \u003c\/b\u003e... it recalls the case histories of Oliver Sacks, at times the sweep of Yuval Harari's \u003ci\u003eSapiens\u003c\/i\u003e. \u003cb\u003eHe writes with an evident love of words - but also, with a lucid line of scientific enquiry'\u003c\/b\u003e -- Richard Godwin * Guardian *\u003cbr\u003e'There are some books that you read and forget. There are others that you read and think about occasionally. \u003cb\u003eThen there are rare gems like \u003ci\u003eConnections\u003c\/i\u003e that you read, read again and find that the way you think has been irreversibly changed. Incredibly powerful'\u003c\/b\u003e -- Sue Black, author of All That Remains\u003cbr\u003e\u003cb\u003e'Karl Deisseroth is a master storyteller. \u003c\/b\u003eArmed with an abundance of compassion and curiosity, he takes us on a spellbinding tour of the mysteries of the human mind through a series of fascinating case studies. His graceful prose weaves a tapestry of complex ideas into memorable stories, each illuminated by cutting-edge science. \u003cb\u003eA delight from the opening paragraph to the stunning conclusion, this book is an invitation to reverence for the complexity of the human brain and its relationship to the mind: a ticket to a state of wonder at the essence of our selves' \u003c\/b\u003e -- Kathryn Mannix, author of With the End in Mind\u003cbr\u003e'Deisseroth is \u003cb\u003ea talented writer \u003c\/b\u003e... It is in his encounters with distressed patients that his talent for marrying science and the imagination becomes most apparent and that his writing comes truly alive. \u003cb\u003e\u003ci\u003eConnections \u003c\/i\u003ewarrants comparison with books such as \u003ci\u003eDo No Harm\u003c\/i\u003e by Henry Marsh\u003c\/b\u003e and \u003ci\u003eBrainstorm \u003c\/i\u003eby Suzanne Sullivan . . . \u003cb\u003eDeisseroth achieves the difficult feat of moving and enlightening the reader at the same time ... [this is] \u003c\/b\u003e\u003cb\u003ea book that is beautiful to read and packed with cutting edge science'\u003c\/b\u003e -- Mark Honigsbaum * Observer *\u003cbr\u003e\u003cb\u003e\u003ci\u003e'\u003c\/i\u003e\u003c\/b\u003eThis hybrid memoir, by an emergency-room psychiatrist and professor of psychiatry and bioengineering, \u003cb\u003eprobes the evolutionary origins of human emotions'\u003c\/b\u003e * New Yorker *\u003cbr\u003e\u003cb\u003e'Essential...tinged with a profound humility built over years of interactions with patients\u003c\/b\u003e... this is big' * Psychology Today *\u003cbr\u003e'Deisseroth is a genuine pioneer, whose prize-winning research is re-defining our understanding of the brain... \u003cb\u003ea stunning work from a relatively young man set on revealing the threads connecting our most pressing personal concerns with our timeless biological inheritance... Deisseroth has the imagination and literary gift to make it speak to all of us'\u003c\/b\u003e * Literary Review *\u003cbr\u003e\u003cb\u003e'Karl Deisseroth's imaginative narrative flows effortlessly... \u003c\/b\u003eThere is a first love of reading and writing and hints of a literary imagination that draws on James Joyce and Toni Morrison... Deisseroth endeavors to find an emotive language for the psychiatric patients he meets. He accomplishes this by weaving together... psychiatric knowledge, technology, and imagination. These together free him to write poetically... \u003cb\u003eHis narratives are always sensitive... an admixture of fact and fiction, reality and imagination, damage and desire'\u003c\/b\u003e * Science *\u003cbr\u003e'[Deisseroth's] \u003cb\u003escintillating and moving analysis of the human brain and emotions\u003c\/b\u003e, based on observations of his patients, proves he is not exaggerating. It is also \u003cb\u003ea great read'\u003c\/b\u003e * Nature *\u003cbr\u003e'I've known Karl as a colleague, a scientist whose discoveries in the lab have been breathtaking and revolutionary. Maybe I shouldn't be surprised to discover \u003cb\u003ehe's also a stunning writer, his words guiding us to a profound understanding of the nature of human emotions\u003c\/b\u003e, seamlessly invoking Ovid and optogenetics, Borges and basal ganglia as he takes on this journey. \u003cb\u003e\u003ci\u003eProjections \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003eis a tour de force'\u003c\/b\u003e -- Abraham Verghese, author of Cutting for Stone\u003cbr\u003e'Karl Deisseroth intertwines neuroscience and human stories in a way that is altogether new: \u003cb\u003etechnical, lyrical, and deeply compassionate all at once\u003c\/b\u003e\u003cb\u003e.\u003c\/b\u003e Through sharing what he's learned as a groundbreaking scientist and a psychiatrist caring for patients with severe illness, he reveals glimmer of what makes us human. \u003cb\u003eThis is a crucial book for anyone who loves science, anyone who loves someone suffering from a disorder of the brain, or anyone who, like so many of us, loves both'\u003c\/b\u003e -- Lucy Kalanithi\u003cbr\u003e\u003cb\u003e'The writing in this exploration of what causes human emotion at a cellular level is \u003c\/b\u003e\u003cb\u003eextraordinarily good\u003c\/b\u003e, inviting comparisons with the work of Oliver Sacks and Henry Marsh' (Editor's Choice) * Bookseller *\u003cbr\u003e'Deisseroth, professor of psychiatry at Stanford University, melds the personal with the clinical in his \u003cb\u003emasterful debut \u003c\/b\u003eon how the human mind works and what can be learned when it goes awry ... \u003cb\u003ew\u003c\/b\u003e\u003cb\u003eriting with abundant empathy, \u003c\/b\u003eDeisseroth brings his patients' struggles to life as he educates about both neuroscience and humanity. \u003cb\u003eThis is a must-read'\u003c\/b\u003e * Publishers Weekly *\u003cbr\u003e\u003cb\u003e'Unique and utterly riveting\u003c\/b\u003e, \u003ci\u003eProjections\u003c\/i\u003e braids together three skeins from Karl Deisseroth's life: his painstaking clinical experience as a psychiatrist, dedicated to helping patients; his ingenious inventions in biotechnology that have ushered in waves of new insights into how brains work; and his life as a humble and caring social human being with \u003cb\u003ea gift for crafting a spellbinding chronicle. This is a masterpiece written for each and every one of us'\u003c\/b\u003e -- Patricia Churchland, author of Conscience\u003cbr\u003e'Karl Deisseroth is already known around the world as a groundbreaking scientist who has pioneered dazzling new techniques for investigating the brain. In this \u003cb\u003eenthralling masterpiece of a book\u003c\/b\u003e, he demonstrates that he is also a perceptive psychiatrist, as well as a spellbinding writer who \u003cb\u003ebeautifully connects the inner feelings within all human beings to deep insights from modern psychiatry and neuroscience'\u003c\/b\u003e -- Robert Lefkowitz, Nobel Laureate and author of A Funny Thing Happened on the Way to Stockholm\u003cbr\u003e'We are living during a revolution in our understanding of the human brain, and Karl Deisseroth has been at the forefront of these advances. \u003cb\u003eThis magisterial work\u003ci\u003e \u003c\/i\u003eshows that not only is he one of our leading scientists, but also a gifted writer and storyteller. With precise yet luminous prose, he merges stories of cutting-edge neuroscience with a deep reverence for his patients' humanity'\u003c\/b\u003e -- Neil Shubin, author of Some Assembly Required\u003cbr\u003e'Deisseroth writes of heartbreaking and desperate medical cases with a doctor's knowledge, and a novelist's skill for narrative. \u003cb\u003eI could not put this book down'\u003c\/b\u003e -- May-Britt Moser, Nobel Laureate","brand":"Penguin Books Ltd","offers":[{"title":"Default Title","offer_id":48733430874455,"sku":"9780241985816","price":10.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780241985816.jpg?v=1720000048"},{"product_id":"the-book-of-genes-and-genomes-9780387709154","title":"The Book of Genes and Genomes","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eForward -- A Brave New World., Chapter 1.  From Genes to Genomes:  What's It All About?  ([Author's Note: Introduction; include short genetics history]., Chapter 2.  My Family's Medical History (and why it's important for me to know)., Chapter 3.  A Savior Sibling [Author's Note:  Preimplantation genetic diagnosis\/Selection]., Chapter 4. Too Few, Too Many [Author's Note: Aneuploidy\/Copy Number Variation]., Chapter 5. You've Probably Already Had a Genetic Test (But no one told you):   Newborn Screening., Chapter 6. Sweet Blood (Genetics and Diabetes)., Chapter 7.  Will this Drug Work for You? [Author's Note:  Pharmacogenetics\/Creating a Drug Just for You]., Chapter 8.  No Two Cancers Are the Same [Author's Note:  Microarrays and Disease sub-classification]., Chapter 9.  Can We Fix our Faulty Genes? [Author's Note: Gene Therapy\/Genome Editing-CRISPR]., Chapter 1\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eForward -- A Brave New World\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e\u003cb\u003e[Part I -- Introduction]\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003eChapter 1.  From Genes to Genomes:  What’s It All About?  ([Author’s Note: Introduction; include short genetics history]\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e[Part II – Medical Applications]\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003eChapter 2.  My Family’s Medical History (and why it’s important for me to know)\u003c\/p\u003e  \u003cp\u003eChapter 3.  A Savior Sibling [Author’s Note:  Preimplantation genetic diagnosis\/Selection] \u003c\/p\u003e  Chapter 4. Too Few, Too Many [Author’s Note: Aneuploidy\/Copy Number Variation] \u003cp\u003e\u003c\/p\u003e  \u003cp\u003eChapter 5. You’ve Probably Already Had a Genetic Test (But no one told you):   Newborn Screening \u003c\/p\u003e  \u003cp\u003eChapter 6. Sweet Blood (Genetics and Diabetes)\u003c\/p\u003e  \u003cp\u003eChapter 7.  Will this Drug Work for You? [Author’s Note:  Pharmacogenetics\/Creating a Drug Just for You] \u003c\/p\u003e  \u003cp\u003eChapter 8.  No Two Cancers Are the Same [Author’s Note:  Microarrays and Disease sub-classification] \u003c\/p\u003e  \u003cp\u003eChapter 9.  Can We Fix our Faulty Genes? [Author’s Note: Gene Therapy\/Genome Editing-CRISPR] \u003c\/p\u003e  \u003cp\u003eChapter 10.  Hunting the Invisible Bugs through DNA (Author’s Note:  Infectious disease\/MRSA story) \u003c\/p\u003e  \u003cp\u003eChapter 11. Can Genes Explain Behavior? (Note: Behavioral Genetics\/Gene x Environment)\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e[Part III – Non-medical Applications]\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003eChapter 12. The Not So Golden Age of Golden Rice {alternative title: Tastier (and Healthier) Foods through Genetic Technology} \u003c\/p\u003e  \u003cp\u003eChapter 13.  Cleaning up the Environment:  New Ways to Detect Land Mines and Digest Oil \u003c\/p\u003e  Chapter 14. Genetics and the Crime Scene:  Just like TV?\u003cp\u003e\u003c\/p\u003e  \u003cp\u003eChapter 15. Are We Related to Cavemen? [Alternative Title:  Ancient Ancestors] [Author’s Note:  Neanderthal\/woolly mammoth\/Population history\/Redefining Race] \u003c\/p\u003e  \u003cp\u003eChapter 16.     Creating New Life [Alternative Title:  Bringing back Extinct Species] \u003c\/p\u003e  \u003cp\u003eChapter 17.     Genetic Testing Without A Physician – A Brave New World [Author’s Note: Direct to Consumer Marketing] [move this to Part II?] \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003c\/p\u003e","brand":"Springer-Verlag New York Inc.","offers":[{"title":"Default Title","offer_id":48733726277975,"sku":"9780387709154","price":22.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780387709154.jpg?v=1720001398"},{"product_id":"fungal-pathology-9780792363705","title":"Fungal Pathology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book brings together twelve chapters on fungal pathogens with the goal of presenting an overview of the current areas of activity and the common themes that pervade research on these important organisms. The timing of the book is appropriate because we have gained sufficient insight from molecular genetic analyses to begin to make some comparisons between different fungal pathogens and to discuss the key advances that have been made. The chapters provide a broad survey of the important topics in fungal pathogenesis including morphogenesis, virulence, avirulence, and signaling. The reader also will fmd clear discussions of parasitism, mutualism, symbiosis, evolution, phylogeny and ecology for those fungi where these issues are especially important. Finally, many of the chapters in this book illustrate the fact that we are on the verge of a revolution in our understanding of fungal pathogens because of the application of genomics to these organisms and their hosts. The fungi include\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cstrong\u003e`\u003c\/strong\u003eThis book provides a broad spectrum of information. It  is of special interest and can indeed be recommended for a readership  from senior undergraduates to senior investigators working on fungal  plant pathology.\u003cstrong\u003e'\u003c\/strong\u003e\u003cbr\u003e  \u003cstrong\u003eJournal of Plant Physiology, 158:7 (2000)\u003c\/strong\u003e\u003cbr\u003e  \u003cstrong\u003e`\u003c\/strong\u003e...the volume can be recommended to the scientific community in  plant pathology and especially to those interested in molecular  aspects of host-pathogen interactions\u003cstrong\u003e'\u003c\/strong\u003e\u003cbr\u003e  \u003cstrong\u003eJournal of Phytopathology, 149:7\/8 (2001)\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Aspergillus Fumigatus; C. D'Enfert. 2.  Infection Strategies of Botrytis cinerea and Related  Necrotrophic Pathogens; T.W. Prins, et al. 3.  Cladosporium fulvum, Cause of Leaf Mould of Tomato; R.P.  Oliver, et al. 4. Evolution of Host Specific Virulence in  Cochliobolus heterostrophus; B.G. Turgeon, S.-W. Lu.  5. Colletotrichum; M.B. Dickman. 6.  Hypovirulence and Chestnut Blight: From the Field to the Laboratory;  D.L. Nuss. 7. Insect Pathogenic Fungi: From Genes to  Populations; M.J. Bidochka, et al. 8. Pathogenesis and  Genome Organization of the Rice Blast Fungus; S. Kang, et al.  9. Phytophthora; S. Kamoun. 10. The Rust  Fungi: Cytology, Physiology and Molecular Biology of Infection; M.  Hahn. 11. Symbiotic Parasites and Mutualistic Pathogens;  C.L. Schardl. 12. Ustilago maydis, the Causative  Agent of Corn Smut Disease; R. Kahmann, et al. Index.","brand":"Springer","offers":[{"title":"Default Title","offer_id":48737281966423,"sku":"9780792363705","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"textbook-of-human-reproductive-genetics-9781009197724","title":"Textbook of Human Reproductive Genetics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eA basic understanding of human genetics is vital for all those working in the field of assisted human reproduction. Genetic makeup can hamper reproduction and insight into this is making genetic diagnosis and counselling increasingly important. This fully updated textbook continues the clear structure of the original edition, beginning with a chapter on the basics of genetics and cytogenetics. Genetic causes of infertility and the effect of epigenetics and transposons on fertility are discussed in detail. Several new chapters are included in this edition, reflecting the advances of the field, including preconception genetic analysis and screening in IVF and mitochondrial genetics. Combining genetics, reproductive biology and medicine, this is an essential text for practitioners in reproductive medicine and geneticists involved in the field looking to improve their knowledge of the subject and provide outstanding patient care.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e'Recommended.' D. Schulman, Choice\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Basic genetics and cytogenetics: a brief reminder Karen Sermon; 2. Application of whole-genome technologies to ART Elia Fernandez Gallardo, Thomas Lefevre, Koen Theunis, and Thierry Voet; 3. Meiosis: how to get a good start in life Ursula Eichenlaub-Ritter; 4. Chromosomes in early human embryo development: incidence of chromosomal abnormalities, underlying mechanisms, and consequences for development Esther B. Baart, Effrosyni Chavli, and Diane Van Opstal; 5. DNA is not the whole story: transgenerational epigenesis and imprinting Ashwini Balakrishnan and J. Richard Challiet; 6. Genes are not the whole story: retrotransposons as new determinants of male fertility Patricia Fauque and Deborah Bourc'his; 7. Chromosomal causes of infertility: the story continues Svetlana A. Yatsenko and Aleksandar Rajkovic; 8. Genetics of human male infertility Stephane Viville and Ozlem Okutman; 9. Genetics of human female infertility Svetlana A. Yatsenko and Aleksandar Rajkovic; 10. Preconception genetics analysis and screening in IVF Juan Jose Guillen and Rita Vassena; 11. Genetic counseling in ART Christine De Die-Smulders and Ron van Golde; 12. Mitochondrial genetics in reproductive medicine Claudia Spits and Filippo Zambelli; 13. Preimplantation genetic diagnosis Jan Traeger-Synodinos and Carmen Rubio Lluesa; 14. Epigenetics and ART Aafke P. A. van Montfoort; 15. Ethical considerations in human reproductive genetics Guido de Vert and Wybo Dondorp.","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":48738010300759,"sku":"9781009197724","price":56.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781009197724.jpg?v=1723811679"},{"product_id":"rebel-cell-9781474609319","title":"Rebel Cell","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eA fresh and fascinating investigation into cancer and how genetics holds the key to overcoming it.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis book is packed with big ideas about life. Every chapter has something in it which made me think wow. Having worked in a major cancer charity for many years, Arney writes with genuine in-depth understanding and is a perfect guide. * Daniel M. Davis, author of The Beautiful Cure *\u003cbr\u003eRebel Cell is a bright, engaging read, fizzing with energy and metaphor. Kat Arney is a science writer for all of us - a powerful and talented story teller. * Stephen McGann *\u003cbr\u003eKat's book is Dynamite. A crystal clear reappraisal of the story behind that word we fear to mention. * Dallas Campbell, author of Ad Astra: An Illustrated Guide to Leaving the Planet *\u003cbr\u003eForget magic bullets and much hyped miracle cures, to improve the chances of cancer patients we need revolutionary new thinking.  And that new thinking, Arney forcefully argues, is evolutionary.  She not only places cancer in its evolutionary context but shows how understanding a cancer as an evolving entity leads to new therapeutic approaches that work.   This lively, scholarly and accessible book should be essential reading. * Professor Laurence D Hurst, President of the Genetics Society *\u003cbr\u003eBetter than just a history or scientific rundown of cancer, Kat Arney presents a philosophy for how to think about cancer. * Zach Weinersmith author of Soonish: Ten Emerging Technologies That Will Improve and\/or Ruin Everything *\u003cbr\u003eKat Arney does it again: taking the complex and making it easy to grasp, demystifying the mysterious, asking the right questions and finding the surprising answers - and all with rollicking good humour and bonhomie. The war on cancer would itself be far more advanced if its practitioners knew how to communicate with us and each other as well as Kat does in this mind-thrilling page turner. * Mark Stevenson, Futurist and Author of We Do Things Differently: the outsiders rebooting our world *\u003cbr\u003eA lively study of the Big C, which makes the case that cancer is the price we pay for our marvellously complicated bodies. * The Times *","brand":"Orion Publishing Co","offers":[{"title":"Default Title","offer_id":48739604693335,"sku":"9781474609319","price":10.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781474609319.jpg?v=1720052717"},{"product_id":"cardiovascular-genomics-methods-and-protocols-9781607612469","title":"Cardiovascular Genomics: Methods and Protocols","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eAs two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In \u003cem\u003eCardiovascular Genomics: Methods and Protocols\u003c\/em\u003e, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful \u003cem\u003eMethods in Molecular Biology™\u003c\/em\u003e series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.\u003c\/p\u003e \u003cp\u003eCutting-edge and easy-to-use, \u003cem\u003eCardiovascular Genomics: Methods and Protocols\u003c\/em\u003e will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eFrom the reviews:  “The book appears to provide a practical guide on a number of laboratory-based molecular methods that are likely to be useful in carrying out human and animal experiments to generate data and information for … complex cardiovascular conditions. …  Although this book is well produced with excellent layout, it will probably find a … place on any researcher’s book shelf. … laboratories may consider keeping a copy in the library for quick reference and useful in teaching and training of young investigators in molecular genomics.” (Dhavendra Kumar, Human Genetics, Vol. 127, 2010)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Modes of Defining Atherosclerosis in Mouse Models: Relative Merits and Evolving Standards Alan Daugherty, Hong Lu, Deborah A. Howatt, and Debra L. Rateri  2. Evaluating Micro- and Macro-Vascular Disease, the End Stage of Atherosclerosis, in Rat Models James C. Russell  3. Non-Invasive Blood Pressure Measurement in Mice Minjie Feng and Keith DiPetrillo  4. Direct Blood Pressure Monitoring in Laboratory Rodents via Implantable Radio Telemetry Daniel A. Huetteman and Heather Bogie  5. Measuring Kidney Function in Conscious Mice  David L. Mattson  6. Ischemic Stroke in Mice and Rats Aysan Durukan and Turgut Tatlisumak  7. Mouse Surgical Models in Cardiovascular Research Oleg Tarnavski  8. Echocardiographic Examination in Rats and Mice Jing Liu and Dean F. Rigel  9. QTL Mapping in Intercross and Backcross Populations  Fei Zou  10. Quantitative Trait Locus Analysis Using J\/qtl Randy Smith, Keith Sheppard, Keith DiPetrillo, and Gary Churchill  11. Computing Genetic Imprinting Expressed by Haplotypes Yun Cheng, Arthur Berg, Song Wu, Yao Li, and Rongling Wu  12. Haplotype Association Mapping in Mice Shirng-Wern Tsaih and Ron Korstanje  13. Candidate Gene Association Analysis Jonathan B. Singer  14. Genome-Wide Association Study in Humans J. Gustav Smith and Christopher Newton-Cheh  15. Bioinformatics Analysis of Microarray Data Yunyu Zhang, Joseph Szustakowski, and Martina Schinke  16. eQTL Analysis in Mice and Rats Bruno M. Tesson and Ritsert C. Jansen  17. eQTL Analysis in Humans Lude Franke and Ritsert C. Jansen  18. A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation Paul Fisher, Harry Noyes, Stephen Kemp, Robert Stevens, and Andrew Brass","brand":"Humana Press Inc.","offers":[{"title":"Default Title","offer_id":48740604936535,"sku":"9781607612469","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"uprooted-family-trauma-unknown-origins-and-the-secretive-history-of-artificial-insemination-9781626349070","title":"Uprooted: Family Trauma, Unknown Origins, and the","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHow a journey of self-discovery unearthed the scandalous evolution of artificial insemination.  By his forties, Peter J. Boni was an accomplished CEO, with a specialty in navigating high-tech companies out of hot water. Just before his fiftieth birthday, Peter’s seventy-five-year-old mother unveiled a bombshell: His deceased father was not biological. Peter was conceived in 1945 via an anonymous sperm donor. The emotional upheaval upon learning that he was “misattributed” rekindled traumas long past and fueled his relentless research to find his genealogy. Over two decades, he gained an encyclopedic knowledge of the scientific, legal, and sociological history of reproductive technology as well as its practices, advances, and consequences. Through twenty-first century DNA analysis, Peter finally quenched his thirst for his origin.  In Uprooted, Peter J. Boni intimately shares his personal odyssey and acquired expertise to spotlight the free market methods of gamete distribution that conceives dozens, sometimes hundreds, of unknowing half-siblings from a single donor. This thought-provoking book reveals the inner workings—and secrets—of the multibillion-dollar fertility industry, resulting in a richly detailed account of an ethical aspect of reproductive science that, until now, has not been so thoroughly explored.","brand":"Greenleaf Book Group LLC","offers":[{"title":"Default Title","offer_id":48740682760535,"sku":"9781626349070","price":19.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781626349070.jpg?v=1720055342"},{"product_id":"fundamentals-of-rna-structure-and-function-9783030902131","title":"Fundamentals of RNA Structure and Function","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThis highly illustrated textbook provides an essential overview on RNA architecture and function, it offers insights into the RNA basics and also explains novel RNA technologies, such as CRISPR-Cas and their applications. In addition, the mRNA based vaccine technology, which has long been tested, also before the COVID-19 pandemic, is discussed and students receive a basic understanding of this important medical application.\u003c\/p\u003e\u003cp\u003eThe textbook is written by Prof. Grover in collaboration with her students and has an easily accessible style.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003eThe book provides a great tool for young researchers and students in biology, biomedical engineering or biochemistry, looking for a compact introduction or refresher work on RNA, including the newest findings and technologies. It is an ideal starter to learn about several RNA specific topics and to research them further.\u003cb\u003e\u003c\/b\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e1. RNA-Composition and Base Pairing.- 2. Architecture of RNA.- 3. Small Catalytic RNA.- 4. The Spliceosome: A Large Catalytic RNA.- 5. A Genomic Perspective on RNA.- 6. The mRNA and the New Vaccines.- 7. Riboswitches: Sensors and Regulators.- 8. Small Non-Coding RNA, miRNA in Gene Regulation.- 9. CRISPR-Cas Systems, The science and ethics of gene manipulation.- 10. Transcription.\u003c\/p\u003e\u003cbr\u003e  \u003cp\u003e\u003c\/p\u003e            \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e    \u003cp\u003e\u003c\/p\u003e                \u003cp\u003e\u003c\/p\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743056998743,"sku":"9783030902131","price":58.11,"currency_code":"GBP","in_stock":true}]},{"product_id":"applied-rna-bioscience-9789811083716","title":"Applied RNA Bioscience","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThe focus of this book is to introduce up-to-date information on applications and practical use of RNA for agriculture, biotechnology and medicine. It provides unique ideas, tools, and methods in detail from a variety of scientific and technical disciplines.  RNA science has progressed enormously in recent decades, and vast amounts of information on RNA functions and their regulatory mechanisms are becoming available. Such a progress opened the door to an age of practical application of RNA in many fields including agriculture, plant science, medical science, brewing and fermentation technology, and material production. This book inspires its readership and contributes to not only expansion in application of RNA but also to basic research. \u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003ci\u003eList of titles and authors (as of 24 Aug 2016)\u003c\/i\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e1. Gene expression system that can escape from translational repression caused by brewing-related stress\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Shingo IZAWA\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e2. Bacterial cellular engineering through interspecies exchange of 16S rRNA in \u003ci\u003eEscherichia coli \u003c\/i\u003eribosome.\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Kentaro MIYAZAKI\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e3. Development and application of the excellent protein synthesis technique with riboswitches in microorganisms\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Takahiro YAMAUCHI and Naoki SUGIMOTO\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e4. Cell Reprogramming by Lactic Acid Bacteria.\u003c\/b\u003e\u003c\/p\u003e    Kunimasa OHTA\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e5. \u003c\/b\u003e\u003cb\u003eNovel detection system of mycotoxin using aptamer\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Yuji MORITA\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e6. \u003c\/b\u003e\u003cb\u003eRational design of artificial riboswitches\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Atsushi OGAWA\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e7. mRNA engineering as a tool for controlling mammalian cells in medical applications\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Kei ENDO and Hirohide SAITO\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e8. \u003c\/b\u003e\u003cb\u003eModulation of abnormal splicing by small chemical compounds in RNA diseases\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Naoyuki KATAOKA\u003c\/p\u003e  \u003cb\u003e \u003c\/b\u003e\u003cb\u003e9. Protein production system by innovating mRNA export\u003c\/b\u003e\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e  Seiji MASUDA\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e10. PPR protein and the engineering\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Takahiro NAKAMURA\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e11. Long noncoding RNAs and their applications\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Tomohiro YAMAZAKI \u003c\/p\u003e  \u003cp\u003e \u003cb\u003e12\u003c\/b\u003e. \u003cb\u003eLong non-coding RNA as new diagnostic and therapeutic targets\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e   Eleonora LEUCCI\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e13. Riboswitches and ribozymes as RNA-based modular tools to control gene expression\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e   Yoshiya IKAWA and Shigeyoshi Matsumura\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e14.\u003c\/b\u003e\u003cb\u003e Applications of CRISPR\/Cas9 genome editing for functional characterization of RNA helicases\u003c\/b\u003e\u003c\/p\u003e     Jerry PELLETIER\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e15. Application of systemic TGS on p\u003c\/b\u003e\u003c\/p\u003elant breeding\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e   Songling BAI\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e16. Theoretical and applied epigenetics in plants\u003c\/b\u003e\u003c\/p\u003e     Yuhya WAKASA, Taiji KAWAKATSU, and Fumio TAKAIWA","brand":"Springer Verlag, Singapore","offers":[{"title":"Default Title","offer_id":48743275168087,"sku":"9789811083716","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"10-human-how-your-bodys-microbes-hold-the-key-to-health-and-happiness-9780007584055","title":"10 Human How Your Bodys Microbes Hold the Key to","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eObesity, autism, mental health problems, IBS, allergies, auto-immunity, cancer. Does the answer to the modern epidemic of Western' diseases lie in our gut?You are 10% human. For every one of your cells, there are nine impostors hitching a ride. You are not just flesh and bone, but also bacteria and fungi. And you are more them' than you are you'.Your gut alone hosts 100 trillion of them and until recently we thought that our microbes didn't matter. This is all set to change as the latest scientific research tells a very different story, one where microbes run our bodies and becoming healthy is impossible without them.In this ground-breaking book, biologist Alanna Collen reveals how our personal colony of microbes influence our weight, immune system, mental health and even our choice of partner. This is a new way of understanding modern diseases  obesity, autism, mental health problems, gut disorders, allergies, auto-immunity and even cancer  as she argues they have their root in our fa\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e‘A fascinating study of the intertwined lives of microbes and humans, ‘10% Human’, is a manual for the new,\u003cbr\u003ehealthy way of being dirty … Read it, and you will learn to love your microbiota’ Newsweek\u003c\/p\u003e           \u003cp\u003e‘A welcome antidote to the simplistic \"boost your health with probiotics\" books and articles posing as science (but serving mostly commerce), Collen dares to tell the messy truth about what science knows – and doesn't know – about the microbes that live in us, live with us, and in some ways even become us … [Collen] is clearly an expert in the field … fascinating … Everything you wanted to know about microbes but were afraid to ask’ Kirkus, *Starred* Review\u003c\/p\u003e","brand":"HarperCollins Publishers","offers":[{"title":"Default Title","offer_id":48863873794391,"sku":"9780007584055","price":10.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780007584055.jpg?v=1722269410"},{"product_id":"thompson-thompson-genetics-and-genomics-in-medicine-9780323547628","title":"Thompson  Thompson Genetics and Genomics in","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eCHAPTER 1 Introduction CHAPTER 2 Introduction to the Human Genome CHAPTER 3 The Human Genome: Gene Structure and Function CHAPTER 4 Human Genetic Diversity: Genomic Variation CHAPTER 5 Principles of Clinical Cytogenetics and Genome Analysis CHAPTER 6 The Chromosomal and Genomic Basis of Disease: Disorders of the Autosomes and Sex Chromosomes CHAPTER 7 Patterns of Single-Gene Inheritance CHAPTER 8 Principles of Clinical Epigenetics CHAPTER 9 Complex Inheritance of Common Multifactorial Disorders CHAPTER 10 Population Genetics for Genomic Medicine CHAPTER 11 Identifying the Genetic Basis for Human Disease CHAPTER 12 The Molecular Basis of Genetic Disease CHAPTER 13 The Molecular, Biochemical, and Cellular Basis of Genetic Disease CHAPTER 14 The Treatment of Genetic Disease CHAPTER 15 Developmental Genetics and Birth Defects CHAPTER 16 Cancer Genetics and Genomics CHAPTER 17 Genetic Counseling and Risk Assessment CHAPTER 18 Preconception and Prenatal Screening and Diagnosis CHAPTER 19 Application of Genomics to Medicine and Individualized Health Care CHAPTER 20 Ethical and Social Issues in Genetics and Genomics Clinical Case Studies Illustrating Genetic Principles Glossary Answers to Problems Index","brand":"Elsevier - Health Sciences Division","offers":[{"title":"Default Title","offer_id":48864424788311,"sku":"9780323547628","price":48.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780323547628.jpg?v=1722271880"},{"product_id":"an-introduction-to-forensic-genetics-9780470710197","title":"An Introduction to Forensic Genetics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis is a completely revised edition of a comprehensive and popular introduction to the fast moving area of Forensic Genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field.  \u003cp\u003e \u003cb\u003eKey Features:\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eGreater in-depth coverage of kinship problems now covered in two separate chapters: one dealing with relationships between living individuals and the other covering identification of human remains. \u003c\/li\u003e \u003cli\u003eNew chapter on non-human forensic genetics, including identification of bacteria and viruses, animals and plants. \u003c\/li\u003e \u003cli\u003eSelf assessment questions to aid student understanding throughout t\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eForeword ix\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003ePreface to first edition xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction to forensic genetics 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eForensic genetics 1\u003c\/p\u003e \u003cp\u003eA brief history of forensic genetics 2\u003c\/p\u003e \u003cp\u003eReferences 6\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 DNA structure and the genome 11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDNA structure 11\u003c\/p\u003e \u003cp\u003eOrganization of DNA into chromosomes 11\u003c\/p\u003e \u003cp\u003eThe structure of the human genome 13\u003c\/p\u003e \u003cp\u003eGenetic diversity of modern humans 15\u003c\/p\u003e \u003cp\u003eThe genome and forensic genetics 16\u003c\/p\u003e \u003cp\u003eTandem repeats 16\u003c\/p\u003e \u003cp\u003eSingle nucleotide polymorphisms 18\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Biological material – collection, characterization and storage 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSources of biological evidence 21\u003c\/p\u003e \u003cp\u003eCollection and handling of material at the crime scene 23\u003c\/p\u003e \u003cp\u003eIdentification and characterization of biological evidence 23\u003c\/p\u003e \u003cp\u003eEvidence collection 29\u003c\/p\u003e \u003cp\u003eSexual and physical assault 31\u003c\/p\u003e \u003cp\u003eStorage of biological material 32\u003c\/p\u003e \u003cp\u003eReferences 32\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 DNA extraction and quantification 37\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDNA extraction 37\u003c\/p\u003e \u003cp\u003eGeneral principles of DNA extraction 37\u003c\/p\u003e \u003cp\u003eDNA extraction from challenging samples 41\u003c\/p\u003e \u003cp\u003eQuantification of DNA 45\u003c\/p\u003e \u003cp\u003eDNA IQ system 48\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Polymerase chain reaction 53\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe evolution of PCR-based profiling in forensic genetics 53\u003c\/p\u003e \u003cp\u003eDNA replication: the basis of the PCR 54\u003c\/p\u003e \u003cp\u003eThe components of PCR 54\u003c\/p\u003e \u003cp\u003eTaq DNA polymerase 54\u003c\/p\u003e \u003cp\u003eThe PCR process 56\u003c\/p\u003e \u003cp\u003ePCR inhibition 58\u003c\/p\u003e \u003cp\u003eSensitivity and contamination 60\u003c\/p\u003e \u003cp\u003eThe PCR laboratory 60\u003c\/p\u003e \u003cp\u003eFurther reading 62\u003c\/p\u003e \u003cp\u003eReferences 62\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 The analysis of short tandem repeats 67\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eStructure of STR loci 67\u003c\/p\u003e \u003cp\u003eThe development of STR multiplexes 67\u003c\/p\u003e \u003cp\u003eDetection of STR polymorphisms 70\u003c\/p\u003e \u003cp\u003eInterpretation of STR profiles 72\u003c\/p\u003e \u003cp\u003eFurther reading 77\u003c\/p\u003e \u003cp\u003eReferences 77\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Assessment of STR profiles 81\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eStutter peaks 81\u003c\/p\u003e \u003cp\u003eSplit peaks (±\u003ci\u003eN\u003c\/i\u003e) 81\u003c\/p\u003e \u003cp\u003ePull-up 83\u003c\/p\u003e \u003cp\u003eTemplate DNA 84\u003c\/p\u003e \u003cp\u003eOverloaded profiles 84\u003c\/p\u003e \u003cp\u003eLow template DNA typing 84\u003c\/p\u003e \u003cp\u003ePeak balance 86\u003c\/p\u003e \u003cp\u003eMixtures 86\u003c\/p\u003e \u003cp\u003eDegraded DNA 88\u003c\/p\u003e \u003cp\u003ePCR inhibition 90\u003c\/p\u003e \u003cp\u003eReferences 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Statistical interpretation of STR profiles 95\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePopulation genetics 95\u003c\/p\u003e \u003cp\u003eDeviation from the Hardy–Weinberg equilibrium 96\u003c\/p\u003e \u003cp\u003eStatistical tests to determine deviation from the Hardy–Weinberg equilibrium 97\u003c\/p\u003e \u003cp\u003eEstimating the frequencies of STR profiles 98\u003c\/p\u003e \u003cp\u003eCorrections to allele frequency databases 98\u003c\/p\u003e \u003cp\u003eWhich population frequency database should be used? 103\u003c\/p\u003e \u003cp\u003eConclusions 104\u003c\/p\u003e \u003cp\u003eFurther reading 104\u003c\/p\u003e \u003cp\u003eReferences 104\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Evaluation and presentation of DNA evidence 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHierarchies of propositions 107\u003c\/p\u003e \u003cp\u003eLikelihood ratios 109\u003c\/p\u003e \u003cp\u003eTwo fallacies 113\u003c\/p\u003e \u003cp\u003eComparison of three approaches 114\u003c\/p\u003e \u003cp\u003eFurther reading 115\u003c\/p\u003e \u003cp\u003eReferences 115\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Databases of DNA profiles 117\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe UK National DNA Database 117\u003c\/p\u003e \u003cp\u003eInternational situation 124\u003c\/p\u003e \u003cp\u003eFurther reading 128\u003c\/p\u003e \u003cp\u003eReferences 128\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Kinship testing 131\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eParentage testing 131\u003c\/p\u003e \u003cp\u003ePunnett square 132\u003c\/p\u003e \u003cp\u003eIdentification of human remains 139\u003c\/p\u003e \u003cp\u003eFurther reading 140\u003c\/p\u003e \u003cp\u003eReferences 140\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Single nucleotide polymorphisms 145\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSNPs – occurrence and structure 145\u003c\/p\u003e \u003cp\u003eDetection of SNPs 146\u003c\/p\u003e \u003cp\u003eSNP detection for forensic applications 148\u003c\/p\u003e \u003cp\u003eForensic applications of SNPs 149\u003c\/p\u003e \u003cp\u003eSNPs compared with STR loci 150\u003c\/p\u003e \u003cp\u003eReferences 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Lineage markers 155\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMitochondria 155\u003c\/p\u003e \u003cp\u003eApplications of mtDNA profiling 157\u003c\/p\u003e \u003cp\u003eHaplotypes and haplogroups 159\u003c\/p\u003e \u003cp\u003eThe Y chromosome 161\u003c\/p\u003e \u003cp\u003eForensic applications of Y chromosome polymorphisms 162\u003c\/p\u003e \u003cp\u003eFurther reading 165\u003c\/p\u003e \u003cp\u003eReferences 165\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Non-human DNA typing 171\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNon-human sample types 171\u003c\/p\u003e \u003cp\u003eSpecies identification 173\u003c\/p\u003e \u003cp\u003eLinkage to an individual using STR loci 174\u003c\/p\u003e \u003cp\u003eLinkage to an individual using mitochondrial loci 175\u003c\/p\u003e \u003cp\u003eMicrobial DNA testing 176\u003c\/p\u003e \u003cp\u003eConcluding comments 176\u003c\/p\u003e \u003cp\u003eFurther reading 176\u003c\/p\u003e \u003cp\u003eReferences 176\u003c\/p\u003e \u003cp\u003eAppendix A Forensic parameters 181\u003c\/p\u003e \u003cp\u003eAppendix B Useful web links 183\u003c\/p\u003e \u003cp\u003eGlossary 185\u003c\/p\u003e \u003cp\u003eAbbreviations 189\u003c\/p\u003e \u003cp\u003eIndex 193\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48864638173527,"sku":"9780470710197","price":37.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470710197.jpg?v=1722272841"},{"product_id":"how-we-age-9780691182636","title":"How We Age","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"Murphy has gathered a huge amount of research material on longevity, giving the book a tone of meticulous authority\" * Kirkus Reviews *\u003cbr\u003e\"[An] informative deep dive into the research behind living longer and the aging process.\"\u003cb\u003e---Tom Wilk, \u003ci\u003eNew Jersey Monthly\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e\"Meticulous. . . . [Murphy's] sweep is vast as she discourses on diet, exercise, insulin signaling and the genes that affect longevity. In her final, superb chapters, she takes on the associations between the human microbiome and cognitive deterioration, wrapping up with a look ahead to emerging drug therapies.\"\u003cb\u003e---Hamilton Cain, \u003ci\u003eWall Street Journal\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e\"In \u003ci\u003eHow We Age\u003c\/i\u003e, geneticist Coleen Murphy provides no silver bullets for remaining youthful. Rather, she offers a scholarly account of the state of ageing research that is both lively and personal. She also gives real insight into the ups and downs of leading a research laboratory. . . . \u003ci\u003eHow We Age\u003c\/i\u003e will be particularly useful to researchers, but it should also appeal to general readers who want to know what it took to arrive at the current understanding of ageing — and the prospects of undergoing it in better shape.\"\u003cb\u003e---Linda Partridge, \u003ci\u003eNature\u003c\/i\u003e\u003c\/b\u003e","brand":"Princeton University Press","offers":[{"title":"Default Title","offer_id":48865541226839,"sku":"9780691182636","price":27.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780691182636.jpg?v=1722274467"},{"product_id":"emerys-elements-of-medical-genetics-and-genomics-9780702079665","title":"Emerys Elements of Medical Genetics and Genomics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1 The History and Impact of Genetics in Medicine    Section A: The Scientific Basis of Human Genetics   2 The Cellular and Molecular Basis of Inheritance    3 Chromosomes and Cell Division    4 Finding the Cause of Monogenic Disorders by Identifying Disease Genes   5 Laboratory Techniques for Diagnosis of Monogenic Disorders   6 Patterns of Inheritance    7 Population and Mathematical Genetics   8 Risk Calculation   9 Developmental Genetics    Section B: Genetics in Medicine and Genomic Medicine   10 Common Disease, Polygenic and Multifactorial Genetics    11 Screening for Genetic Disease    12 Haemoglobin and the Haemoglobinopathies    13 Immunogenetics    14 The Genetics of Cancer. . .and Cancer Genetics    15 Pharmacogenomics, Precision Medicine and the Treatment of Genetic Disease    Section C: Clinical Genetics, Counselling and Ethics   16 Congenital Abnormalities, Dysmorphic Syndromes and Intellectual Disability    17 Chromosome Disorders    18 Inborn Errors of Metabolism    19 Mainstream Monogenic Disorders    20 Prenatal Testing and Reproductive Genetics    21 Genetic Counselling    22 Ethical and Legal Issues in Medical Genetics","brand":"Elsevier Health Sciences","offers":[{"title":"Default Title","offer_id":48865576616279,"sku":"9780702079665","price":40.84,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780702079665.jpg?v=1722274576"},{"product_id":"breathing-race-into-the-machine-9780816683598","title":"Breathing Race into the Machine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\"Breathing Race into the Machine brilliantly tracks the remarkable story—lasting to the present—of how ‘correcting for race’ in measures of lung capacity became unremarkable scientific practice. This eye-opening account demonstrates that precision technologies and statistical techniques that supposedly measure biological differences accurately can mask racial myths and wreak devastating consequences for black people’s health and legal rights. Essential reading for everyone concerned about the impact of race on science and technology.\"—Dorothy Roberts, University of Pennsylvania, author of \u003ci\u003eFatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"Lundy Braun illuminates how the development of a new machine to measure lung capacity could begin with a benign purpose to assess the impact of working conditions in the coal mines in the early 19th century, but would later ‘morph’ into a justification for the putative relationship between difference and hierarchy that has remained intact for nearly two centuries. Braun documents how the social, economic and political fabric of each period is interwoven into the science of measurement—a theme that deftly carries throughout the book, and will establish \u003ci\u003eBreathing Race into the Machine\u003c\/i\u003e as a landmark contribution to the social studies of science.\"—Troy Duster, author of \u003ci\u003eBackdoor to Eugenics\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"In \u003ci\u003eBreathing Race into the Machine\u003c\/i\u003e, Lundy Braun powerfully reinvigorates our understanding of how racial formation happens. An incisive, considered study of a seemingly conventional physiology instrument, this book reveals science as a foundational feature of the social construction of race. We create our own difference engines, but Braun’s astute book reminds us that we do not have to remain captive to them.\"—Alondra Nelson, author of \u003ci\u003eBody and Soul: The Black Panther Party and the Fight against Medical Discrimination\u003c\/i\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\"A fascinating read.\"—\u003ci\u003eChoice\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"Ultimately, \u003ci\u003eBreathing Race into the Machine\u003c\/i\u003e disrupts ideas about technology’s objectivity to show the pernicious persistence of racial bias.\"—\u003ci\u003eAfrican American Review\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"Great value to those with an interest in the history of science and technology, occupational health and disease, and the construction of whiteness and blackness.\"—\u003ci\u003eSocial History of Medicine\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"Intellectually provocative, original, and extensively researched.\"—\u003ci\u003eAmerican Historical Review\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"This book reminds us that tools have a history and that their history matters.\"—\u003ci\u003eJournal of American History\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"Lundy Braun provides her readers with the most meticulously detailed, and I should add sophisticated, historical analysis. . . her account of the career of the technical device of the spirometer offers surprising and valuable insights.\"—\u003ci\u003eScience as Culture\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\"\u003ci\u003eBreathing Race into the Machine \u003c\/i\u003eis theoretically informed, well researched, and well written. Its compelling account contributes to the scholarship of racialization in science and medicine.\"—\u003ci\u003eISIS\u003c\/i\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eContents\u003c\/p\u003e\u003cp\u003eAcknowledgments\u003c\/p\u003e\u003cp\u003eIntroduction: Measuring Vital Capacity\u003cb\u003e1. “Inventing” the Spirometer: Working-Class Bodies in Victorian England\u003cb\u003e2. Black Lungs and White Lungs: The Science of White Supremacy in the Nineteenth-Century United States\u003cb\u003e3. Filling the Lungs with Air: The Rise of Physical Culture in America\u003cb\u003e4. Progress and Race: Vitality in Turn-of-the-Century Britain\u003cb\u003e5. Globalizing Spirometry: The “Racial Factor” in Scientific Medicine\u003cb\u003e6. Adjudicating Disability in the Industrial Worker\u003cb\u003e7. Diagnosing Silicosis: Physiological Testing in South African Gold Mines\u003cb\u003eEpilogue: How Race Takes Root\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003eNotes\u003cb\u003eIndex\u003cb\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/b\u003e\u003c\/p\u003e","brand":"University of Minnesota Press","offers":[{"title":"Default Title","offer_id":48866006073687,"sku":"9780816683598","price":17.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780816683598.jpg?v=1722276586"},{"product_id":"basic-pharmacokinetics-and-pharmacodynamics-9781119143154","title":"Basic Pharmacokinetics and Pharmacodynamics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book provides a comprehensive foundation for the contemporary application of pharmacokinetics and pharmacodynamics. The second edition updates and strengthens existing chapters and adds new topics to address current needs     including physiologically based pharmacokinetic modeling, pharmacogenomics and predicting drug-drug interactions.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003eContributors xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction to Pharmacokinetics and Pharmacodynamics 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction: Drugs and Doses 2\u003c\/p\u003e \u003cp\u003e1.2 Introduction to Pharmacodynamics 3\u003c\/p\u003e \u003cp\u003e1.2.1 Drug Effects at the Site of Action 3\u003c\/p\u003e \u003cp\u003e1.2.2 Agonists, Antagonists, and Concentration–Response Relationships 6\u003c\/p\u003e \u003cp\u003e1.3 Introduction to Pharmacokinetics 9\u003c\/p\u003e \u003cp\u003e1.3.1 Plasma Concentration of Drugs 9\u003c\/p\u003e \u003cp\u003e1.3.2 Processes in Pharmacokinetics 11\u003c\/p\u003e \u003cp\u003e1.4 Dose–Response Relationships 12\u003c\/p\u003e \u003cp\u003e1.5 Therapeutic Range 14\u003c\/p\u003e \u003cp\u003e1.5.1 Determination of the Therapeutic Range 15\u003c\/p\u003e \u003cp\u003e1.6 Summary 18\u003c\/p\u003e \u003cp\u003eReference 18\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Passage of Drugs Through Membranes 19\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 20\u003c\/p\u003e \u003cp\u003e2.2 Structure and Properties of Membranes 20\u003c\/p\u003e \u003cp\u003e2.3 Passive Diffusion 21\u003c\/p\u003e \u003cp\u003e2.3.1 Transcellular Passive Diffusion 23\u003c\/p\u003e \u003cp\u003e2.3.2 Paracellular Passive Diffusion 25\u003c\/p\u003e \u003cp\u003e2.4 Carrier-Mediated Processes: Transport Proteins 26\u003c\/p\u003e \u003cp\u003e2.4.1 Uptake Transporters: SLC Superfamily 27\u003c\/p\u003e \u003cp\u003e2.4.2 Efflux Transporters: ABC Superfamily 29\u003c\/p\u003e \u003cp\u003e2.4.3 Characteristics of Transporter Systems 31\u003c\/p\u003e \u003cp\u003e2.4.4 Simulation Exercise 32\u003c\/p\u003e \u003cp\u003e2.4.5 Clinical Examples of Transporter Involvement in Drug Response 32\u003c\/p\u003e \u003cp\u003eReferences 33\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Drug Administration and Drug Absorption 35\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSteven C. Sutton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction: Local and Systemic Drug Administration 36\u003c\/p\u003e \u003cp\u003e3.2 Routes of Drug Administration 37\u003c\/p\u003e \u003cp\u003e3.2.1 Common Routes of Local Drug Administration 37\u003c\/p\u003e \u003cp\u003e3.2.2 Common Routes of Systemic Drug Administration 38\u003c\/p\u003e \u003cp\u003e3.3 Overview of Oral Absorption 41\u003c\/p\u003e \u003cp\u003e3.3.1 Anatomy and Physiology of the Oral-Gastric-Intestinal Tract and Transit Time 41\u003c\/p\u003e \u003cp\u003e3.4 Extent of Drug Absorption 44\u003c\/p\u003e \u003cp\u003e3.4.1 Bioavailability Factor 44\u003c\/p\u003e \u003cp\u003e3.4.2 Individual Bioavailability Factors 45\u003c\/p\u003e \u003cp\u003e3.5 Determinants of the Fraction of the Dose Absorbed (\u003ci\u003eF\u003c\/i\u003e) 46\u003c\/p\u003e \u003cp\u003e3.5.1 Disintegration 46\u003c\/p\u003e \u003cp\u003e3.5.2 Dissolution 46\u003c\/p\u003e \u003cp\u003e3.5.3 Formulation Excipients 50\u003c\/p\u003e \u003cp\u003e3.5.4 Adverse Events within the Gastrointestinal Lumen 50\u003c\/p\u003e \u003cp\u003e3.5.5 Transcellular Passive Diffusion 53\u003c\/p\u003e \u003cp\u003e3.5.6 Particulate Uptake 53\u003c\/p\u003e \u003cp\u003e3.5.7 Paracellular Passive Diffusion 53\u003c\/p\u003e \u003cp\u003e3.5.8 Uptake and Efflux Transporters 54\u003c\/p\u003e \u003cp\u003e3.5.9 Presystemic Intestinal Metabolism or Extraction 58\u003c\/p\u003e \u003cp\u003e3.5.10 Presystemic Hepatic Metabolism or Extraction 60\u003c\/p\u003e \u003cp\u003e3.6 Factors Controlling the Rate of Drug Absorption 61\u003c\/p\u003e \u003cp\u003e3.6.1 Dissolution-Controlled Absorption 63\u003c\/p\u003e \u003cp\u003e3.6.2 Membrane Penetration-Controlled Absorption 63\u003c\/p\u003e \u003cp\u003e3.6.3 Overall Rate of Drug Absorption 63\u003c\/p\u003e \u003cp\u003e3.7 Biopharmaceutics Classification System 64\u003c\/p\u003e \u003cp\u003e3.7.1 Intestinal Reserve Length 64\u003c\/p\u003e \u003cp\u003e3.7.2 Biopharmaceutics Classification System (BCS) 64\u003c\/p\u003e \u003cp\u003e3.7.3 Biopharmaceutics Drug Disposition Classification System (BDDCS) 65\u003c\/p\u003e \u003cp\u003e3.8 Food Effects 65\u003c\/p\u003e \u003cp\u003eProblems 66\u003c\/p\u003e \u003cp\u003eReferences 67\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Drug Distribution 71\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 72\u003c\/p\u003e \u003cp\u003e4.2 Extent of Drug Distribution 72\u003c\/p\u003e \u003cp\u003e4.2.1 Distribution Volumes 74\u003c\/p\u003e \u003cp\u003e4.2.2 Tissue Binding Plasma Protein Binding and Partitioning: Concentrating Effects 75\u003c\/p\u003e \u003cp\u003e4.2.3 Assessment of the Extent of Drug Distribution: Apparent Volume of Distribution 76\u003c\/p\u003e \u003cp\u003e4.2.4 Plasma Protein Binding 82\u003c\/p\u003e \u003cp\u003e4.3 Rate of Drug Distribution 89\u003c\/p\u003e \u003cp\u003e4.3.1 Perfusion-Controlled Drug Distribution 90\u003c\/p\u003e \u003cp\u003e4.3.2 Diffusion or Permeability-Controlled Drug Distribution 93\u003c\/p\u003e \u003cp\u003e4.4 Distribution of Drugs to the Central Nervous System 93\u003c\/p\u003e \u003cp\u003eProblems 96\u003c\/p\u003e \u003cp\u003eReferences 98\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Drug Elimination and Clearance 99\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 100\u003c\/p\u003e \u003cp\u003e5.1.1 First-Order Elimination 101\u003c\/p\u003e \u003cp\u003e5.1.2 Determinants of the Elimination Rate Constant and the Half-Life 102\u003c\/p\u003e \u003cp\u003e5.2 Clearance 102\u003c\/p\u003e \u003cp\u003e5.2.1 Definition and Determinants of Clearance 102\u003c\/p\u003e \u003cp\u003e5.2.2 Total Clearance, Renal Clearance, and Hepatic Clearance 104\u003c\/p\u003e \u003cp\u003e5.2.3 Relationships among Clearance, Volume of Distribution, Elimination Rate Constant, and Half-Life 105\u003c\/p\u003e \u003cp\u003e5.2.4 Primary and Secondary Parameters 106\u003c\/p\u003e \u003cp\u003e5.2.5 Measurement of Total Body Clearance 106\u003c\/p\u003e \u003cp\u003e5.3 Renal Clearance 108\u003c\/p\u003e \u003cp\u003e5.3.1 Glomerular Filtration 109\u003c\/p\u003e \u003cp\u003e5.3.2 Tubular Secretion 110\u003c\/p\u003e \u003cp\u003e5.3.3 Tubular Reabsorption 113\u003c\/p\u003e \u003cp\u003e5.3.4 Putting Meaning into the Value of Renal Clearance 114\u003c\/p\u003e \u003cp\u003e5.3.5 Measurement of Renal Clearance 115\u003c\/p\u003e \u003cp\u003e5.3.6 Fraction of the Dose Excreted Unchanged 118\u003c\/p\u003e \u003cp\u003e5.4 Hepatic Elimination and Clearance 119\u003c\/p\u003e \u003cp\u003e5.4.1 Phase I and Phase II Metabolism 120\u003c\/p\u003e \u003cp\u003e5.4.2 The Cytochrome P450 Enzyme System 121\u003c\/p\u003e \u003cp\u003e5.4.3 Glucuronidation 122\u003c\/p\u003e \u003cp\u003e5.4.4 Metabolism-Based Drug–Drug Interactions 122\u003c\/p\u003e \u003cp\u003e5.4.5 Hepatic Drug Transporters and Drug–Drug Interactions 125\u003c\/p\u003e \u003cp\u003e5.4.6 Kinetics of Drug Metabolism 127\u003c\/p\u003e \u003cp\u003e5.4.7 Hepatic Clearance and Related Parameters 128\u003c\/p\u003e \u003cp\u003eProblems 139\u003c\/p\u003e \u003cp\u003eReferences 142\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Compartmental Models in Pharmacokinetics 145\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 146\u003c\/p\u003e \u003cp\u003e6.2 Expressions for Component Parts of the Dose–Plasma Concentration Relationship 146\u003c\/p\u003e \u003cp\u003e6.2.1 Effective Dose 146\u003c\/p\u003e \u003cp\u003e6.2.2 Rate of Drug Absorption 147\u003c\/p\u003e \u003cp\u003e6.2.3 Rate of Drug Elimination 148\u003c\/p\u003e \u003cp\u003e6.2.4 Rate of Drug Distribution 148\u003c\/p\u003e \u003cp\u003e6.3 Putting Everything Together: Compartments and Models 149\u003c\/p\u003e \u003cp\u003e6.3.1 One-Compartment Model 149\u003c\/p\u003e \u003cp\u003e6.3.2 Two-Compartment Model 150\u003c\/p\u003e \u003cp\u003e6.3.3 Three-Compartment Model 150\u003c\/p\u003e \u003cp\u003e6.4 Examples of Complete Compartment Models 152\u003c\/p\u003e \u003cp\u003e6.4.1 Intravenous Bolus Injection in a One-Compartment Model with First-Order Elimination 152\u003c\/p\u003e \u003cp\u003e6.4.2 Intravenous Bolus Injection in a Two-Compartment Model with First-Order Elimination 153\u003c\/p\u003e \u003cp\u003e6.4.3 First-Order Absorption in a Two-Compartment Model with First-Order Elimination 154\u003c\/p\u003e \u003cp\u003e6.5 Use of Compartmental Models to Study Metabolite Pharmacokinetics 155\u003c\/p\u003e \u003cp\u003e6.6 Selecting and Applying Models 156\u003c\/p\u003e \u003cp\u003eProblems 157\u003c\/p\u003e \u003cp\u003eSuggested Readings 157\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Pharmacokinetics of an Intravenous Bolus Injection in a One-Compartment Model 159\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 160\u003c\/p\u003e \u003cp\u003e7.2 One-Compartment Model 160\u003c\/p\u003e \u003cp\u003e7.3 Pharmacokinetic Equations 162\u003c\/p\u003e \u003cp\u003e7.3.1 Basic Equation 162\u003c\/p\u003e \u003cp\u003e7.3.2 Half-Life 163\u003c\/p\u003e \u003cp\u003e7.3.3 Time to Eliminate a Dose 163\u003c\/p\u003e \u003cp\u003e7.4 Simulation Exercise 163\u003c\/p\u003e \u003cp\u003e7.5 Application of the Model 165\u003c\/p\u003e \u003cp\u003e7.5.1 Predicting Plasma Concentrations 165\u003c\/p\u003e \u003cp\u003e7.5.2 Duration of Action 166\u003c\/p\u003e \u003cp\u003e7.5.3 Value of a Dose to Give a Desired Initial Plasma Concentration 167\u003c\/p\u003e \u003cp\u003e7.5.4 Intravenous Loading Dose 167\u003c\/p\u003e \u003cp\u003e7.6 Determination of Pharmacokinetic Parameters Experimentally 168\u003c\/p\u003e \u003cp\u003e7.6.1 Study Design for the Determination of Parameters 168\u003c\/p\u003e \u003cp\u003e7.6.2 Pharmacokinetic Analysis 169\u003c\/p\u003e \u003cp\u003e7.7 Pharmacokinetic Analysis in Clinical Practice 173\u003c\/p\u003e \u003cp\u003eProblems 174\u003c\/p\u003e \u003cp\u003eSuggested Reading 176\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Pharmacokinetics of an Intravenous Bolus Injection in a Two-Compartment Model 177\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 178\u003c\/p\u003e \u003cp\u003e8.2 Tissue and Compartmental Distribution of a Drug 179\u003c\/p\u003e \u003cp\u003e8.2.1 Drug Distribution to the Tissues 179\u003c\/p\u003e \u003cp\u003e8.2.2 Compartmental Distribution of a Drug 180\u003c\/p\u003e \u003cp\u003e8.3 Basic Equation 181\u003c\/p\u003e \u003cp\u003e8.3.1 Distribution: \u003ci\u003eA,\u003c\/i\u003e α, and the Distribution \u003ci\u003et\u003c\/i\u003e\u003csub\u003e1\/2\u003c\/sub\u003e 182\u003c\/p\u003e \u003cp\u003e8.3.2 Elimination: \u003ci\u003eB,\u003c\/i\u003e β, and the β \u003ci\u003et\u003c\/i\u003e\u003csub\u003e1\/2\u003c\/sub\u003e 182\u003c\/p\u003e \u003cp\u003e8.4 Relationship Between Macro and Micro Rate Constants 183\u003c\/p\u003e \u003cp\u003e8.5 Primary Pharmacokinetic Parameters 183\u003c\/p\u003e \u003cp\u003e8.5.1 Clearance 184\u003c\/p\u003e \u003cp\u003e8.5.2 Distribution Clearance 184\u003c\/p\u003e \u003cp\u003e8.5.3 Volume of Distribution 186\u003c\/p\u003e \u003cp\u003e8.6 Simulation Exercise 188\u003c\/p\u003e \u003cp\u003e8.7 Determination of the Pharmacokinetic Parameters of the Two-Compartment Model 191\u003c\/p\u003e \u003cp\u003e8.7.1 Determination of Intercepts and Macro Rate Constants 191\u003c\/p\u003e \u003cp\u003e8.7.2 Determination of the Micro Rate Constants: \u003ci\u003ek\u003c\/i\u003e\u003csub\u003e12\u003c\/sub\u003e \u003ci\u003ek\u003c\/i\u003e\u003csub\u003e21\u003c\/sub\u003e and \u003ci\u003ek\u003c\/i\u003e\u003csub\u003e10\u003c\/sub\u003e 193\u003c\/p\u003e \u003cp\u003e8.7.3 Determination of the Primary Pharmacokinetic Parameters 193\u003c\/p\u003e \u003cp\u003e8.8 Clinical Application of the Two-Compartment Model 194\u003c\/p\u003e \u003cp\u003e8.8.1 Measurement of the Elimination Half-Life in the Postdistribution Phase 194\u003c\/p\u003e \u003cp\u003e8.8.2 Determination of the Loading Dose 195\u003c\/p\u003e \u003cp\u003e8.8.3 Evaluation of a Dose: Monitoring Plasma Concentrations and Patient Response 197\u003c\/p\u003e \u003cp\u003eProblems 197\u003c\/p\u003e \u003cp\u003eSuggested Readings 199\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Pharmacokinetics of Extravascular Drug Administration 201\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDr. Steven C. Sutton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 202\u003c\/p\u003e \u003cp\u003e9.2 First-Order Absorption in a One-Compartment Model 203\u003c\/p\u003e \u003cp\u003e9.2.1 Model and Equations 203\u003c\/p\u003e \u003cp\u003e9.2.2 Parameter Determination 205\u003c\/p\u003e \u003cp\u003e9.2.3 Absorption Lag Time 210\u003c\/p\u003e \u003cp\u003e9.2.4 Flip-Flop Model and Sustained-Release Preparations 212\u003c\/p\u003e \u003cp\u003e9.2.5 Determinants of \u003ci\u003eT\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e and \u003ci\u003eC\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e 212\u003c\/p\u003e \u003cp\u003e9.3 Modified Release and Gastric Retention Formulations 214\u003c\/p\u003e \u003cp\u003e9.3.1 Impact of the Stomach 214\u003c\/p\u003e \u003cp\u003e9.3.2 Moisture in the Gastrointestinal Tract 215\u003c\/p\u003e \u003cp\u003e9.4 Bioavailability 215\u003c\/p\u003e \u003cp\u003e9.4.1 Bioavailability Parameters 215\u003c\/p\u003e \u003cp\u003e9.4.2 Absolute Bioavailability 217\u003c\/p\u003e \u003cp\u003e9.4.3 Relative Bioavailability 217\u003c\/p\u003e \u003cp\u003e9.4.4 Bioequivalence 217\u003c\/p\u003e \u003cp\u003e9.4.5 Single-Dose Crossover Parallel and Steady-State Study Designs 219\u003c\/p\u003e \u003cp\u003e9.4.6 Example Bioavailability Analysis 219\u003c\/p\u003e \u003cp\u003e9.5 \u003ci\u003eIn Vitro-In Vivo \u003c\/i\u003eCorrelation 219\u003c\/p\u003e \u003cp\u003e9.5.1 Definitions 219\u003c\/p\u003e \u003cp\u003e9.5.2 Assumptions 220\u003c\/p\u003e \u003cp\u003e9.5.3 Utility 220\u003c\/p\u003e \u003cp\u003e9.5.4 Immediate Release IVIVC 220\u003c\/p\u003e \u003cp\u003e9.5.5 Modified Release IVIVC 221\u003c\/p\u003e \u003cp\u003e9.6 Simulation Exercise 222\u003c\/p\u003e \u003cp\u003eProblems 223\u003c\/p\u003e \u003cp\u003eReferences 224\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Introduction to Noncompartmental Analysis 225\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 225\u003c\/p\u003e \u003cp\u003e10.2 Mean Residence Time 226\u003c\/p\u003e \u003cp\u003e10.3 Determination of Other Important Pharmacokinetic Parameters 229\u003c\/p\u003e \u003cp\u003e10.4 Different Routes of Administration 231\u003c\/p\u003e \u003cp\u003e10.5 Application of Noncompartmental Analysis to Clinical Studies 232\u003c\/p\u003e \u003cp\u003eProblems 234\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Pharmacokinetics of Intravenous Infusion in a One-Compartment Model 237\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 238\u003c\/p\u003e \u003cp\u003e11.2 Model and Equations 239\u003c\/p\u003e \u003cp\u003e11.2.1 Basic Equation 239\u003c\/p\u003e \u003cp\u003e11.2.2 Application of the Basic Equation 241\u003c\/p\u003e \u003cp\u003e11.2.3 Simulation Exercise: Part 1 241\u003c\/p\u003e \u003cp\u003e11.3 Steady-State Plasma Concentration 242\u003c\/p\u003e \u003cp\u003e11.3.1 Equation for Steady-State Plasma Concentrations 242\u003c\/p\u003e \u003cp\u003e11.3.2 Application of the Equation 242\u003c\/p\u003e \u003cp\u003e11.3.3 Basic Formula Revisited 243\u003c\/p\u003e \u003cp\u003e11.3.4 Factors Controlling Steady-State Plasma Concentration 243\u003c\/p\u003e \u003cp\u003e11.3.5 Time to Steady State 244\u003c\/p\u003e \u003cp\u003e11.3.6 Simulation Exercise: Part 2 245\u003c\/p\u003e \u003cp\u003e11.4 Loading Dose 246\u003c\/p\u003e \u003cp\u003e11.4.1 Loading-Dose Equation 246\u003c\/p\u003e \u003cp\u003e11.4.2 Simulation Exercise: Part 3 248\u003c\/p\u003e \u003cp\u003e11.5 Termination of Infusion 248\u003c\/p\u003e \u003cp\u003e11.5.1 Equations for Termination Before and After Steady State 248\u003c\/p\u003e \u003cp\u003e11.5.2 Simulation Exercise: Part 4 249\u003c\/p\u003e \u003cp\u003e11.6 Individualization of Dosing Regimens 249\u003c\/p\u003e \u003cp\u003e11.6.1 Initial Doses 249\u003c\/p\u003e \u003cp\u003e11.6.2 Monitoring and Individualizing Therapy 250\u003c\/p\u003e \u003cp\u003eProblems 252\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Multiple Intravenous Bolus Injections in the One-Compartment Model 255\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 256\u003c\/p\u003e \u003cp\u003e12.2 Terms and Symbols Used in Multiple-Dosing Equations 257\u003c\/p\u003e \u003cp\u003e12.3 Monoexponential Decay During a Dosing Interval 259\u003c\/p\u003e \u003cp\u003e12.3.1 Calculation of Dosing Interval to Give Specific Steady-State Peaks and Troughs 260\u003c\/p\u003e \u003cp\u003e12.4 Basic Pharmacokinetic Equations for Multiple Doses 260\u003c\/p\u003e \u003cp\u003e12.4.1 Principle of Superposition 260\u003c\/p\u003e \u003cp\u003e12.4.2 Equations that Apply Before Steady State 261\u003c\/p\u003e \u003cp\u003e12.5 Steady State 262\u003c\/p\u003e \u003cp\u003e12.5.1 Steady-State Equations 263\u003c\/p\u003e \u003cp\u003e12.5.2 Average Plasma Concentration at Steady State 264\u003c\/p\u003e \u003cp\u003e12.5.3 Fluctuation 267\u003c\/p\u003e \u003cp\u003e12.5.4 Accumulation 267\u003c\/p\u003e \u003cp\u003e12.5.5 Time to Reach Steady State 269\u003c\/p\u003e \u003cp\u003e12.5.6 Loading Dose 270\u003c\/p\u003e \u003cp\u003e12.6 Basic Formula Revisited 270\u003c\/p\u003e \u003cp\u003e12.7 Pharmacokinetic-Guided Dosing Regimen Design 270\u003c\/p\u003e \u003cp\u003e12.7.1 General Considerations for Selection of the Dosing Interval 270\u003c\/p\u003e \u003cp\u003e12.7.2 Protocols for Pharmacokinetic-Guided Dosing Regimens 272\u003c\/p\u003e \u003cp\u003e12.8 Simulation Exercise 276\u003c\/p\u003e \u003cp\u003eProblems 277\u003c\/p\u003e \u003cp\u003eReference 278\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Multiple Intermittent Infusions 279\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 279\u003c\/p\u003e \u003cp\u003e13.2 Steady-State Equations for Multiple Intermittent Infusions 281\u003c\/p\u003e \u003cp\u003e13.3 Monoexponential Decay During a Dosing Interval: Determination of Peaks Troughs and Elimination Half-Life 284\u003c\/p\u003e \u003cp\u003e13.3.1 Determination of Half-Life 284\u003c\/p\u003e \u003cp\u003e13.3.2 Determination of Peaks and Troughs 286\u003c\/p\u003e \u003cp\u003e13.4 Determination of the Volume of Distribution 286\u003c\/p\u003e \u003cp\u003e13.5 Individualization of Dosing Regimens 289\u003c\/p\u003e \u003cp\u003e13.6 Simulation 289\u003c\/p\u003e \u003cp\u003eProblems 290\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Multiple Oral Doses 293\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 293\u003c\/p\u003e \u003cp\u003e14.2 Steady-State Equations 294\u003c\/p\u003e \u003cp\u003e14.2.1 Time to Peak Steady-State Plasma Concentration 295\u003c\/p\u003e \u003cp\u003e14.2.2 Maximum Steady-State Plasma Concentration 296\u003c\/p\u003e \u003cp\u003e14.2.3 Minimum Steady-State Plasma Concentration 296\u003c\/p\u003e \u003cp\u003e14.2.4 Average Steady-State Plasma Concentration 296\u003c\/p\u003e \u003cp\u003e14.2.5 Overall Effect of Absorption Parameters on a Steady-State Dosing Interval 297\u003c\/p\u003e \u003cp\u003e14.3 Equations Used Clinically to Individualize Oral Doses 298\u003c\/p\u003e \u003cp\u003e14.3.1 Protocol to Select an Appropriate Equation 298\u003c\/p\u003e \u003cp\u003e14.4 Simulation Exercise 300\u003c\/p\u003e \u003cp\u003eReferences 301\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Nonlinear Pharmacokinetics 303\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Linear Pharmacokinetics 304\u003c\/p\u003e \u003cp\u003e15.2 Nonlinear Processes in Absorption, Distribution, Metabolism, and Elimination 306\u003c\/p\u003e \u003cp\u003e15.3 Pharmacokinetics of Capacity-Limited Metabolism 307\u003c\/p\u003e \u003cp\u003e15.3.1 Kinetics of Enzymatic Processes 307\u003c\/p\u003e \u003cp\u003e15.3.2 Plasma Concentration–Time Profile 309\u003c\/p\u003e \u003cp\u003e15.4 Phenytoin 310\u003c\/p\u003e \u003cp\u003e15.4.1 Basic Equation for Steady State 311\u003c\/p\u003e \u003cp\u003e15.4.2 Estimation of Doses and Plasma Concentrations 313\u003c\/p\u003e \u003cp\u003e15.4.3 Influence of \u003ci\u003eK\u003csub\u003em\u003c\/sub\u003e \u003c\/i\u003eand \u003ci\u003eV\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e and Factors That Affect These Parameters 314\u003c\/p\u003e \u003cp\u003e15.4.4 Time to Eliminate the Drug 316\u003c\/p\u003e \u003cp\u003e15.4.5 Time to Reach Steady State 317\u003c\/p\u003e \u003cp\u003e15.4.6 Individualization of Doses of Phenytoin 318\u003c\/p\u003e \u003cp\u003eProblems 321\u003c\/p\u003e \u003cp\u003eReferences 322\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Introduction to Pharmacogenetics 323\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDr. Daniel Brazeau\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 324\u003c\/p\u003e \u003cp\u003e16.2 Genetics Primer 324\u003c\/p\u003e \u003cp\u003e16.2.1 Basic Terminology: Genes Alleles Loci and Polymorphism 324\u003c\/p\u003e \u003cp\u003e16.2.2 Population Genetics: Allele and Genotype Frequencies 326\u003c\/p\u003e \u003cp\u003e16.2.3 Quantitative Genetics and Complex Traits 327\u003c\/p\u003e \u003cp\u003e16.3 Pharmacogenetics 328\u003c\/p\u003e \u003cp\u003e16.3.1 Pharmacogenetics of Drug-Metabolizing Enzymes 330\u003c\/p\u003e \u003cp\u003e16.3.2 Pharmacogenetics of Drug Transporters 333\u003c\/p\u003e \u003cp\u003e16.4 Genetics and Pharmacodynamics 334\u003c\/p\u003e \u003cp\u003e16.4.1 Drug Target Pharmacogenetics 334\u003c\/p\u003e \u003cp\u003e16.5 Summary 335\u003c\/p\u003e \u003cp\u003eReference 335\u003c\/p\u003e \u003cp\u003eSuggested Readings 335\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Models Used to Predict Drug–Drug Interactions for Orally Administered Drugs 337\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 338\u003c\/p\u003e \u003cp\u003e17.2 Mathematical Models for Inhibitors and Inducers of Drug Metabolism Based on \u003ci\u003eIn Vitro \u003c\/i\u003eData 340\u003c\/p\u003e \u003cp\u003e17.2.1 Reversible Inhibition 340\u003c\/p\u003e \u003cp\u003e17.2.2 Time-Dependent Inhibition 341\u003c\/p\u003e \u003cp\u003e17.2.3 Induction 345\u003c\/p\u003e \u003cp\u003e17.3 Surrogate \u003ci\u003eIn Vivo \u003c\/i\u003eValues for the Unbound Concentration of the Perpetrator at the Site of Action 345\u003c\/p\u003e \u003cp\u003e17.3.1 Surrogate Measures of Hepatic Inhibitor and Inducer Concentrations 346\u003c\/p\u003e \u003cp\u003e17.3.2 Surrogate Measures of Intestinal Inhibitor and Inducer Concentrations 346\u003c\/p\u003e \u003cp\u003e17.4 Models Used to Predict DDIs \u003ci\u003eIn Vivo\u003c\/i\u003e 347\u003c\/p\u003e \u003cp\u003e17.4.1 Introduction 347\u003c\/p\u003e \u003cp\u003e17.4.2 Basic Predictive Models: \u003ci\u003eR \u003c\/i\u003eValues 348\u003c\/p\u003e \u003cp\u003e17.4.3 Predictive Models Incorporating Parallel Pathways of Elimination (\u003ci\u003efm\u003c\/i\u003e) 350\u003c\/p\u003e \u003cp\u003e17.4.4 Models Incorporating Intestinal Extraction 354\u003c\/p\u003e \u003cp\u003e17.4.5 Models Combining Multiple Actions of Perpetrators 358\u003c\/p\u003e \u003cp\u003e17.5 Predictive Models for Transporter-Based DDIs 359\u003c\/p\u003e \u003cp\u003e17.5.1 Kinetics of Drug Transporters 359\u003c\/p\u003e \u003cp\u003e17.6 Application of Physiologically Based Pharmacokinetic Models to DDI Prediction: The Dynamic Approach 362\u003c\/p\u003e \u003cp\u003e17.7 Conclusion 362\u003c\/p\u003e \u003cp\u003eProblems 363\u003c\/p\u003e \u003cp\u003eReferences 364\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Introduction to Physiologically Based Pharmacokinetic Modeling 367\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 368\u003c\/p\u003e \u003cp\u003e18.2 Components of PBPK Models 369\u003c\/p\u003e \u003cp\u003e18.3 Equations for PBPK Models 369\u003c\/p\u003e \u003cp\u003e18.4 Building a PBPK Model 373\u003c\/p\u003e \u003cp\u003e18.5 Simulations 377\u003c\/p\u003e \u003cp\u003e18.6 Estimation of Human Drug-Specific Parameters 378\u003c\/p\u003e \u003cp\u003e18.6.1 Tissue Plasma Partition Coefficient 379\u003c\/p\u003e \u003cp\u003e18.6.2 Volume of Distribution 379\u003c\/p\u003e \u003cp\u003e18.6.3 Clearance 380\u003c\/p\u003e \u003cp\u003e18.7 More Detailed PBPK Models 381\u003c\/p\u003e \u003cp\u003e18.7.1 Permeability-Limited Distribution 381\u003c\/p\u003e \u003cp\u003e18.7.2 Drug Transporters 383\u003c\/p\u003e \u003cp\u003e18.7.3 Models for Oral Absorption 386\u003c\/p\u003e \u003cp\u003e18.7.4 Reduced Models 387\u003c\/p\u003e \u003cp\u003e18.8 Application of PBPK Models 387\u003c\/p\u003e \u003cp\u003eReferences 388\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Introduction to Pharmacodynamic Models and Integrated Pharmacokinetic–Pharmacodynamic Models 391\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDrs. Diane Mould and Paul Hutson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 392\u003c\/p\u003e \u003cp\u003e19.2 Classic Pharmacodynamic Models Based on Receptor Theory 393\u003c\/p\u003e \u003cp\u003e19.2.1 Receptor Binding 394\u003c\/p\u003e \u003cp\u003e19.2.2 Concentration-Response Models 395\u003c\/p\u003e \u003cp\u003e19.3 Direct Effect Pharmacodynamic Models 402\u003c\/p\u003e \u003cp\u003e19.3.1 \u003ci\u003eE\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e and Sigmoidal \u003ci\u003eE\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e Models 402\u003c\/p\u003e \u003cp\u003e19.3.2 Inhibitory \u003ci\u003eI\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e and Sigmoidal \u003ci\u003eI\u003c\/i\u003emax Models 404\u003c\/p\u003e \u003cp\u003e19.3.3 Linear Adaptations of the \u003ci\u003eE\u003c\/i\u003emax and \u003ci\u003eI\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e Model 404\u003c\/p\u003e \u003cp\u003e19.4 Integrated PK–PD Models: Intravenous Bolus Injection in the One-Compartment Model and the Sigmoidal \u003ci\u003eE\u003c\/i\u003e\u003csub\u003emax\u003c\/sub\u003e Model 406\u003c\/p\u003e \u003cp\u003e19.4.1 Simulation Exercise 409\u003c\/p\u003e \u003cp\u003e19.5 Pharmacodynamic Drug–Drug Interactions 410\u003c\/p\u003e \u003cp\u003e19.5.1 Simulation Exercise 410\u003c\/p\u003e \u003cp\u003eProblems 411\u003c\/p\u003e \u003cp\u003eReferences 412\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Semimechanistic Pharmacokinetic–Pharmacodynamic Models 413\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDrs. Diane Mould and Paul Hutson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction 414\u003c\/p\u003e \u003cp\u003e20.2 Hysteresis and the Effect Compartment 416\u003c\/p\u003e \u003cp\u003e20.2.1 Simulation Exercise 419\u003c\/p\u003e \u003cp\u003e20.3 Physiological Turnover Models and Their Characteristics 419\u003c\/p\u003e \u003cp\u003e20.3.1 Points of Drug Action 421\u003c\/p\u003e \u003cp\u003e20.3.2 System Recovery After Change in Baseline Value 421\u003c\/p\u003e \u003cp\u003e20.4 Indirect Effect Models 422\u003c\/p\u003e \u003cp\u003e20.4.1 Introduction 422\u003c\/p\u003e \u003cp\u003e20.4.2 Characteristics of Indirect Effect Drug Responses 424\u003c\/p\u003e \u003cp\u003e20.4.3 Characteristics of Indirect Effect Models Illustrated Using Model I 426\u003c\/p\u003e \u003cp\u003e20.5 Other Indirect Effect Models 432\u003c\/p\u003e \u003cp\u003e20.5.1 Transit Compartment Models 435\u003c\/p\u003e \u003cp\u003e20.5.2 Model for Hematological Toxicity of Anticancer Drugs 439\u003c\/p\u003e \u003cp\u003e20.5.3 Alternate Parameterizations of Transit Models 442\u003c\/p\u003e \u003cp\u003e20.6 Models of Tolerance 442\u003c\/p\u003e \u003cp\u003e20.6.1 Introduction to Pharmacologic Tolerance 442\u003c\/p\u003e \u003cp\u003e20.6.2 Counter-Regulatory Force Tolerance Model 444\u003c\/p\u003e \u003cp\u003e20.6.3 Precursor Pool Model of Tolerance 447\u003c\/p\u003e \u003cp\u003e20.7 Irreversible Drug Effects 450\u003c\/p\u003e \u003cp\u003e20.7.1 Application of the Turnover Model to Irreversible Drug Action 450\u003c\/p\u003e \u003cp\u003e20.8 Disease Progression Models 452\u003c\/p\u003e \u003cp\u003e20.8.1 Drug Pharmacokinetics 452\u003c\/p\u003e \u003cp\u003e20.8.2 Pharmacodynamics 452\u003c\/p\u003e \u003cp\u003e20.8.3 Disease Activity Models 453\u003c\/p\u003e \u003cp\u003e20.8.4 Disease Progression Models 453\u003c\/p\u003e \u003cp\u003eProblems 459\u003c\/p\u003e \u003cp\u003eReferences 465\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix A Review of Exponents and Logarithms 469\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eA.1 Exponents 469\u003c\/p\u003e \u003cp\u003eA.2 Logarithms: Log and Ln 470\u003c\/p\u003e \u003cp\u003eA.3 Performing Calculations in the Logarithmic Domain 471\u003c\/p\u003e \u003cp\u003eA.3.1 Multiplication 471\u003c\/p\u003e \u003cp\u003eA.3.2 Division 472\u003c\/p\u003e \u003cp\u003eA.3.3 Reciprocals 472\u003c\/p\u003e \u003cp\u003eA.3.4 Exponents 472\u003c\/p\u003e \u003cp\u003eA.4 Calculations Using Exponential Expressions and Logarithms 472\u003c\/p\u003e \u003cp\u003eA.5 Decay Function: \u003ci\u003ee\u003c\/i\u003e\u003csup\u003e−\u003ci\u003ekt\u003c\/i\u003e\u003c\/sup\u003e 474\u003c\/p\u003e \u003cp\u003eA.6 Growth Function: 1 − \u003ci\u003ee\u003c\/i\u003e\u003csup\u003e−\u003ci\u003ekt\u003c\/i\u003e\u003c\/sup\u003e 475\u003c\/p\u003e \u003cp\u003eA.7 Decay Function in Pharmacokinetics 475\u003c\/p\u003e \u003cp\u003eProblems 476\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix B Rates of Processes 479\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eB.1 Introduction 479\u003c\/p\u003e \u003cp\u003eB.2 Order of a Rate Process 480\u003c\/p\u003e \u003cp\u003eB.3 Zero-Order Processes 480\u003c\/p\u003e \u003cp\u003eB.3.1 Equation for Zero-Order Filling 480\u003c\/p\u003e \u003cp\u003eB.3.2 Equation for Zero-Order Emptying 481\u003c\/p\u003e \u003cp\u003eB.3.3 Time for Zero-Order Emptying to Go to 50% Completion 481\u003c\/p\u003e \u003cp\u003eB.4 First-Order Processes 482\u003c\/p\u003e \u003cp\u003eB.4.1 Equation for a First-Order Process 482\u003c\/p\u003e \u003cp\u003eB.4.2 Time for 50% Completion: the Half-Life 483\u003c\/p\u003e \u003cp\u003eB.5 Comparison of Zero- and First-Order Processes 484\u003c\/p\u003e \u003cp\u003eB.6 Detailed Example of First-Order Decay in Pharmacokinetics 484\u003c\/p\u003e \u003cp\u003eB.6.1 Equations and Semilogarithmic Plots 484\u003c\/p\u003e \u003cp\u003eB.6.2 Half-Life 485\u003c\/p\u003e \u003cp\u003eB.6.3 Fraction or Percent Completion of a First-Order Process Using First-Order Elimination as an Example 485\u003c\/p\u003e \u003cp\u003eB.7 Examples of the Application of First-Order Kinetics to Pharmacokinetics 487\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix C Creation of Excel Worksheets for Pharmacokinetic Analysis 489\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eC.1 Measurement of AUC and Clearance 489\u003c\/p\u003e \u003cp\u003eC.1.1 Trapezoidal Rule 490\u003c\/p\u003e \u003cp\u003eC.1.2 Excel Spreadsheet to Determine AUC\u003csub\u003e0→∞\u003c\/sub\u003e and Clearance 491\u003c\/p\u003e \u003cp\u003eC.2 Analysis of Data from an Intravenous Bolus Injection in a One-Compartment Model 494\u003c\/p\u003e \u003cp\u003eC.3 Analysis of Data from an Intravenous Bolus Injection in a Two-Compartment Model 496\u003c\/p\u003e \u003cp\u003eC.4 Analysis of Oral Data in a One-Compartment Model 498\u003c\/p\u003e \u003cp\u003eC.5 Noncompartmental Analysis of Oral Data 501\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix D Derivation of Equations for Multiple Intravenous Bolus Injections 505\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eD.1 Assumptions 505\u003c\/p\u003e \u003cp\u003eD.2 Basic Equation for Plasma Concentration After Multiple Intravenous Bolus Injections 505\u003c\/p\u003e \u003cp\u003eD.3 Steady-State Equations 508\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix E Enzyme Kinetics: Michaelis–Menten Equation and Models for Inhibitors and Inducers of Drug Metabolism 509\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum and Roberta S. King\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eE.1 Kinetics of Drug Metabolism: The Michaelis–Menten Model 510\u003c\/p\u003e \u003cp\u003eE.1.1 Overview 510\u003c\/p\u003e \u003cp\u003eE.1.2 Assumptions for Validity of Michaelis–Menten Model 510\u003c\/p\u003e \u003cp\u003eE.1.3 \u003ci\u003eKm \u003c\/i\u003eand \u003ci\u003eV\u003c\/i\u003emax 511\u003c\/p\u003e \u003cp\u003eE.1.4 Derivation of the Michaelis–Menten Equation 511\u003c\/p\u003e \u003cp\u003eE.1.5 Summary, Practical Considerations, and Interpretations 513\u003c\/p\u003e \u003cp\u003eE.1.6 Relationship Between Intrinsic Clearance and the Michaelis–Menten Parameters 514\u003c\/p\u003e \u003cp\u003eE.2 Effect of Perpetrators of DDI on Enzyme Kinetics and Intrinsic Clearance 515\u003c\/p\u003e \u003cp\u003eE.2.1 Reversible Inhibition 515\u003c\/p\u003e \u003cp\u003eE.2.2 Time-Dependent Inhibition 518\u003c\/p\u003e \u003cp\u003eE.2.3 Enzyme Induction 524\u003c\/p\u003e \u003cp\u003eReferences 526\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix F Summary of the Properties of the Fictitious Drugs Used in the Text 527\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix G Computer Simulation Models 529\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSara E. Rosenbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eGlossary of Terms 531\u003c\/p\u003e \u003cp\u003eIndex 537\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48866387591511,"sku":"9781119143154","price":62.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119143154.jpg?v=1722278408"},{"product_id":"the-code-breaker-9781398518605","title":"The Code Breaker","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eThe best-selling author of \u003ci\u003eLeonardo da Vinci\u003c\/i\u003e and \u003ci\u003eSteve Jobs\u003c\/i\u003e returns.\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e In 2012, Nobel Prize winning scientist Jennifer Doudna hit upon an invention that will transform the future of the human race: an easy-to-use tool that can edit DNA. \u003c\/p\u003e\u003cp\u003e Known as CRISPR, it opened a brave new world of medical miracles and moral questions. It has already been deployed to cure deadly diseases, fight the coronavirus pandemic of 2020, and make inheritable changes in the genes of babies.  \u003c\/p\u003e\u003cp\u003e But what does that mean for humanity? Should we be hacking our own DNA to make us less susceptible to disease? Should we democratise the technology that would allow parents to enhance their kids? \u003c\/p\u003e\u003cp\u003e After discovering this CRISPR, Doudna is now wrestling these even bigger issues. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eTHE CODE BREAKERS\u003c\/i\u003e is an examination of how life as we know it is about to change – and a brilliant portrayal of the woman leading the way. \u003c\/p\u003e","brand":"Simon \u0026 Schuster Ltd","offers":[{"title":"Default Title","offer_id":48866633417047,"sku":"9781398518605","price":11.69,"currency_code":"GBP","in_stock":true}]},{"product_id":"our-transgenic-future-9781479814411","title":"Our Transgenic Future","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHow scientific advances in genetic modification will fundamentally change the natural worldThe process of manipulating the genetic material of one animal to include the DNA of another creates a new transgenic organism. Several animals, notably goats, mice, sheep, and cattle are now genetically modified in this way. In Our Transgenic Future, Lisa Jean Moore wonders what such scientific advances portend. Will the natural world become so modified that it ceases to exist? After turning species into hybrids, can we ever get back to the original, or are they forever lost? Does genetic manipulation make better lives possible, and if so, for whom?Moore centers the story on goats that have been engineered by the US military and civilian scientists using the DNA of spiders. The goat's milk contains a spider-silk protein fiber; it can be spun into ultra-strong fabric that can be used to manufacture lightweight military body armor. Researchers also hope the transgenically produced spider silk will\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"Lisa Jean Moore contributes a very needed conversation regarding the ways technology is built, maintained, and destroyed, and the tensions that evolve in its creation between funding entities, scientific knowledge production, and the general public. Moore walks a narrow line between a fear of dystopian consequences and a realization of the sheer possibilities associated with their human-driven existence. Her voice is nicely interwoven with interspecies relationships, the commodification of nonhuman-nonanimal animals (at least in the natural sense), scientific facts, economic drivers, and the oft-unrealized presence of transgenic technologies in our daily lives.\" * Andrea Laurent-Simpson, author of \u003ci\u003eJust Like Family: How Companion Animals Joined the Household\u003c\/i\u003e *\u003cbr\u003e\"A fascinating and fun read. Lisa Jean Moore deftly analyzes a biologically and ethically complex topic, using reflexive analyses to guide the reader along, and contributing to emergent knowledge about genetically modified animals. Moore’s reflexivity invites the reader to witness her thinking about difficult issues, and thus the book also provides a path for us as readers to think alongside her. She doesn’t tell readers what to think on the topic, or even how to think about it, but by modeling her thinking through the topic, we are able to fully grasp the issue at hand and come to our own (messy) conclusions.\" * Elizabeth Cherry, author of \u003ci\u003eFor the Birds: Protecting Wildlife through the Naturalist Gaze\u003c\/i\u003e *\u003cbr\u003e\"For a reader interested in the details and daily routine of this kind of scientific interaction with large animals, there is much in this book to enjoy. One may also learn something about spiders, which are undoubtedly fascinating creatures.\" -- John Dupré * Los Angeles Review of Books *\u003cbr\u003e\"Moore's narration is delicate, respectful, and wonder-filled... genuinely fun and eminently accessible. Lisa Jean Moore’s Our Transgenic Future is an entertaining, thoughtful inquiry into genetic engineering in general and all of the many ethical questions that it raises.\" -- Rebecca Coffey * Forbes *","brand":"New York University Press","offers":[{"title":"Default Title","offer_id":48867291300183,"sku":"9781479814411","price":23.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781479814411.jpg?v=1722282626"},{"product_id":"new-clinical-genetics-fourth-edition-a-guide-to-genomic-medicine-9781911510703","title":"New Clinical Genetics, fourth edition: A guide to","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e\u003ci\u003eNew Clinical Genetics \u003c\/i\u003econtinues to offer the most innovative case-based approach to investigation, diagnosis, and management in genomic medicine.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e \u003ci\u003eNew Clinical Genetics\u003c\/i\u003e is used worldwide as a textbook for medical students, but also as an essential guide to the field for genetic counselors, physician assistants, clinical and nurse geneticists, and students studying healthcare courses allied to medicine. Readers love the \u003cb\u003eintegrated case-based approach\u003c\/b\u003e which ties the science to real-life clinical scenarios to really aid understanding.\u003cbr\u003e\u003cbr\u003e Clinical genetics is a fast-moving field and there have been many advances in the few years since the previous edition was published. This 4th edition has been completely updated and revised to reflect new science, new techniques and new ways of thinking.\u003cbr\u003e\u003cbr\u003e Nowhere is this more clear than in the chapter discussing genetics services which is now significantly expanded to reflect the increasing role of genomic medicine and the use of multidisciplinary teams in the management of patients with genetic disorders.\u003cbr\u003e\u003cbr\u003e The unique case-based structure and format remains the same, but substantial new material has been added to cover: \u003cul\u003e\n\u003cli\u003epolygenic risk scores – now starting to become useful clinical service tools\u003c\/li\u003e\n\u003cli\u003epreimplantation diagnosis\u003c\/li\u003e\n\u003cli\u003enoninvasive prenatal diagnosis\u003c\/li\u003e\n\u003cli\u003ecompanion diagnostics for prescribed drugs\u003c\/li\u003e\n\u003cli\u003eliquid biopsies in cancer\u003c\/li\u003e\n\u003cli\u003eepigenetics and gene regulation\u003c\/li\u003e\n\u003cli\u003ethe widespread use of next-generation sequencing as a routine diagnostic tool\u003c\/li\u003e\n\u003cli\u003ethe checking of a patient’s whole exome for the cause of their problem\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eIncredible Book with Great Teaching Capability\u003c\/strong\u003e\u003cbr\u003e ‘This book is incredibly well put together. The author gives both a typical textbook description of material, as well as a case-study based presentation. There are questions at the end of each chapter to help check your understanding. The only thing I don’t like is that there are no provided answers to these questions, only basic hints. However, I recognize why the author did this as it provides a better academic challenge to the reader.\u003cbr\u003e  I didn’t even buy this for a class. I bought this to read for personal enjoyment and have not been disappointed! Especially for how cheap this is (for a textbook) this is a steal!' \u003cem\u003e Amazon reviewer\u003c\/em\u003e \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1 What can we learn from a family history?\u003cbr\u003e 2 How can a patient's chromosomes be studied?\u003cbr\u003e 3 How do genes work?\u003cbr\u003e 4 How can a patient's DNA be studied?\u003cbr\u003e 5 How can we check a patient's DNA for gene mutations?\u003cbr\u003e 6 What do mutations do?\u003cbr\u003e 7 Is cancer genetic?\u003cbr\u003e 8 How do researchers identify genes for mendelian diseases?\u003cbr\u003e 9 Why are some conditions common and others rare?\u003cbr\u003e 10 How do our genes affect our metabolism, drug responses and immune system?\u003cbr\u003e 11 How are genes regulated?\u003cbr\u003e 12 When is screening useful?\u003cbr\u003e 13 Should we be testing for genetic susceptibility to common diseases?\u003cbr\u003e 14 What clinical services are available for families with genetic disorders?\u003cbr\u003e 15 How to use linkage to map a disease gene\u003cbr\u003e Glossary\u003cbr\u003e Index\u003cbr\u003e Disease index","brand":"Scion Publishing Ltd","offers":[{"title":"Default Title","offer_id":48868981014871,"sku":"9781911510703","price":42.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781911510703.jpg?v=1722290666"},{"product_id":"inborn-metabolic-diseases-diagnosis-and-treatment-9783662631225","title":"Inborn Metabolic Diseases: Diagnosis and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThis 7th edition is a milestone in the series of Inborn Metabolic Diseases (IMD), recognised as the standard textbook for professionals involved in the diagnosis and management of IMD.\u003c\/p\u003e\u003cp\u003eWithin the last 5 years a Copernican revolution in our understanding of IMD has changed the definition, concepts, paradigms, and classification. This new edition now extends the concept of IMD to include those disturbances in molecular machinery diagnosed by molecular techniques but currently without measurable metabolic markers.\u003c\/p\u003e\u003cp\u003eThe book presents a clinical and biochemical approach to the diagnosis and management of IEM with many diagnostic algorithms for patients of all ages and with a particular focus on neurological presentations. It includes separate, comprehensive sections on IEM classified in 3 major pathophysiological categories: disorders of energy metabolism, both mitochondrial and non-mitochondrial; small molecule disorders, mostly diagnosed with metabolic markers; and complex molecules disorders, mostly diagnosed with molecular techniques.\u003c\/p\u003e\u003cp\u003eTwo new chapters were added, describing around 600 disorders of nucleic acid metabolism, tRNA metabolism, ribosomal biogenesis, and cellular trafficking.\u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eI Diagnosis and treatment: General principles:  \u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e1 Clinical Approach to Inborn Errors of Metabolism in Paediatrics.- 2 Inborn Errors of Metabolism in Adults: A Diagnostic Approach to Neurological and Psychiatric Presentations.- \u003c\/p\u003e  \u003cp\u003e3 Diagnostic Procedures.- 4 Emergency Treatments \u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eII Disorders of Energy Metabolism\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e5 The Glycogen Storage Diseases and Related Disorders.- 6 Congenital Hyperinsulinism and Genetic Disorders of Insulin Resistance and Signalling.- 7 Disorders of Glycolysis and the Pentose Phosphate Pathway.- 8 Disorders of Glucose and Monocarboylic Acid Monocarboxylate Transporters.- 9 \u003c\/p\u003e  \u003cp\u003eDisorders of Creatine Metabolism.- 10 Disorders of the Oxidative Phosphorylation .- 11 \u003c\/p\u003e  \u003cp\u003eDisorders of Pyruvate Metabolism and the Tricarboxylic Acid Cycle.- 12 Disorders of Mitochondrial Fatty Acid Oxidation and Riboflavin Metabolism.- 13 Disorders of Ketogenesis and Ketolysis \u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eIII Small Molecule Disorders \u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e14 Disorders of Galactose Metabolism.- 15  Disorders of Fructose Metabolism.- 16 \u003c\/p\u003e  \u003cp\u003e Hyperphenylalaninaemia.- 17 Disorders of Tyrosine Metabolism.- 18 Branched-chain Organic Acidurias\/Acidaemias.- 19  Disorders of the Urea Cycle and Related Enzymes.- 20 Disorders of Sulfur Amino Acid Metabolism.- 21  Disorders of Ornithine and Proline Metabolism.- 22 Cerebral Organic Acid Disorders and Other Disorders of Lysine Catabolism.- 23 Nonketotic Hyperglycinaemia and Lipoate Deficiency Disorders.- 24  Disorders of Glutamine, Serine and Asparagine Metabolism.- 25 \u003c\/p\u003e  \u003cp\u003e Disorders of Amino Acid Transport at the Cell Membrane.- 26  Cystinosis.- 27 Biotin-Responsive Disorders.- 28 Disorders of Cobalamin and Folate Transport and Metabolism.- 29  Disorders of Thiamine and Pyridoxine Metabolism.- 30 Disorders of Neurotransmission.- 31 Disorders of Peptide and Amine Metabolism.- 32 Disorders of Purine and Pyrimidine Metabolism.- 33  Disorders of Haem Biosynthesis.- 34 Disorders in the Transport of Copper, Iron, Magnesium, Manganese, Selenium and Zinc  \u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eIV Complex Molecule Disorders and Cellular Trafficking Disorders\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e35 Disorders of intracellular triglycerides and phospholipid metabolism.- 36 Inborn Errors of Lipoprotein Metabolism Presenting in Childhood.- 37 Disorders of Isoprenoid\/Cholesterol Synthesis.- \u003c\/p\u003e  \u003cp\u003e38 Disorders of Bile Acid Synthesis.- 39 Disorders of Nucleic Acid Metabolism, tRNA Metabolism and Ribosomal Biogenesis.- 40 Disorders of Sphingolipid Synthesis, Sphingolipidoses, Niemann-Pick Disease Type C and Neuronal Ceroid- Lipofuscinoses.- 41 Glycosaminoglycans and Oligosaccharides Disorders: Glycosaminoglycans Synthesis Defects, Mucopolysaccharidoses, Oligosaccharidoses and Sialic Acid Disorders.- 42 Inborn Errors of Non-Mitochondrial Fatty Acid Metabolism Including Peroxisomal Disorders.- 43 Congenital Disorders of Glycosylation, Dolichol and Glycosylphosphatidylinositol Metabolism.- 44 Disorders of Cellular Trafficking \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eV Appendices\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e45 Medications Used in the Treatment of Inborn Errors  \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003c\/p\u003e","brand":"Springer-Verlag Berlin and Heidelberg GmbH \u0026 Co. KG","offers":[{"title":"Default Title","offer_id":48869392515415,"sku":"9783662631225","price":208.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783662631225.jpg?v=1722292530"},{"product_id":"human-gene-transfer-9780861963010","title":"Human Gene Transfer","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"John Libbey \u0026 Co","offers":[{"title":"Default Title","offer_id":48884819788119,"sku":"9780861963010","price":45.04,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780861963010.jpg?v=1722533604"},{"product_id":"how-to-build-a-better-human-9781442217638","title":"How to Build a Better Human","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eMedicine has recently discovered spectacular tools for human enhancement. Yet to date, it has failed to use them well, in part because of ethical objections. Meanwhile, covert attempts flourish to enhance with steroids, mind-enhancing drugs, and cosmetic surgeryall largely unstudied scientifically. The little success to date has been sporadic and financed privately. In How to Build a Better Human, prominent bioethicist Gregory E. Pence argues that people, if we are careful and ethical, can use genetics, biotechnology, and medicine to improve ourselves, and that we should publicly study what people are doing covertly. Pence believes that we need to transcend the two common frame stories of bioethics: bioconservative alarmism and uncritical enthusiasm, and that bioethics should become part of the solutionnot the problemin making better humans.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eHuman enhancement is an important topic. However, too many authors dwell on improbable scenarios, such as genetic engineering of super-babies. By contrast, this book tackles the real ethical dilemmas that our society faces today. Is it wrong for healthy college students to boost academic performance with Ritalin and similar drugs? Is increased longevity a bane or a boon? How can simple interventions like good nutrition and vaccinations produce children who are not only healthier but smarter? Professor Gregory Pence uses science, logic, and ethics to analyze these and many other topics. Along the way, he explains why we need not fear designer babies and other Brave New World scenarios. Legislators and other policymakers should read this timely and fascinating book so that they will know what to regulate—and what to leave alone -- Kerry Lynn Macintosh, Santa Clara University\u003cbr\u003eFrom Frankenstein to GATTACA innovative biomedical technologies have been portrayed as bogeymen and dystopias. Bringing commonsense to bear on subjects often misrepresented by enthusiasts and alarmists, bioethics professor Gregory Pence, author of Whose Afraid of Human Cloning, clarifies the science and dispels the hype and paranoia surrounding the bioethics of everyday life. He offered reasonable answers to such questions as: Should I use life extending medical or mind enhancing drugs? Is there anything wrong with extending peoples' lives? Should I vaccinate my children? Is it OK to take anti-depressants? Is there something to fear from the new genetics or from stem cell research? How to Build a Better Human provides astute and invaluable advice on these issues and is without a doubt the best \"How To\" book ever published in bioethics. -- Robert Baker, Union Graduate College, FiT Publishing\u003cbr\u003eGregory E. Pence has managed to wed nuance, rigor and wit in the service of one of the thorniest issues in bioethics. The debate over human enhancement is too often shaped by ideologues and zealots – and too infrequently informed by the kind of thoughtful and enjoyable analysis found in How to Build a Better Human. -- Kenneth W. Goodman, University of Miami\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface Part I—Competent Adults Chapter 1: What if Your Virtual Life Surpasses Your Real Life? Chapter 2: Lessons from Bioethics’ History Chapter 3: Expanding the Mind with Drugs Chapter 4: Building Better Female Bodies Chapter 5: Building Better Male Bodies Chapter 6: Is it Moral to Feel Better than Well? Chapter 7: Practical Ways to Build a Longer Life Chapter 8: Is It Wrong to Live to a Hundred? Chapter 9: Personalized Genomics: Caveat Emptor! Part II—Choosing Better, Future Children Chapter 10: Choosing a Better Embryo Chapter 11: Eugenic Abortions? Chapter 12: Building Better Fetuses in Utero Chapter 13: Building Better Kids at Birth: Vaccinations Chapter 14: Building Better Minds of Children: Ritalin and Adderal Part III—Changing Human Nature? Chapter 15: How Not to think about Genetic Enhancement Chapter 16: Human Enhancement; Six Psychosocial Objections Chapter 17: Overview: Cloning, Primordial Cells \u0026amp; Enhancement Chapter 18: Conclusions and Six Practical Proposals Acknowledgments","brand":"Rowman \u0026 Littlefield","offers":[{"title":"Default Title","offer_id":48885636464983,"sku":"9781442217638","price":30.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781442217638.jpg?v=1722537175"},{"product_id":"advances-in-genetics-research-volume-18-9781536132649","title":"Advances in Genetics Research: Volume 18","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn this collection, the authors present research supporting the claim that the study of autochthonous microbial communities is of crucial importance for understanding the genetic and biotechnological potential of bioremediation in environments close to the areas of extraction and susceptible to contamination. They discuss the main characteristics of petroleum, including its exploitation aspects, the process of geological formation, and environmental impacts. Following this, this book suggests that in case of accidental defects occurring in any part of the system, a coordinated counteraction of numerous mediators may successfully help in the restoration of physiologic processes by means of either overexpression or hyperactivity. Even serious defects of genome stabilizer mechanisms may be kept in balance for a long duration, showing the clinical signs of good health. The authors go on to discuss Rett Syndrome, a rare, neurodevelopmental genetic disorder that develops in early childhood and influences many functions within neurobehavioural domains. The core of phenotype symptoms includes severe linguistic and motor impairments. The correlations between genotype and motor abilities in subjects with Rett Syndrome are discussed. Next, this book examines Cornelia de Lange syndrome (CdLS) (also known as Bushy syndrome, Amsterdam dwarfism and Brachmann- de Lange syndrome) a genetic multi system disorder, usually caused by spontaneous mutation. The estimated occurence is about 1:10,000-30,000 births. A separate paper is presented illustrating the clinical variability of cognitive-behavioral phenotype in the different SCAs, determining that a precise identification of the cognitive and behavioral phenotype in different SCAs may enhance the clinical treatment, anticipatory guidance, and care throughout the lifespan. Transcranial direct current stimulation (tDCS), a non-invasive, painless brain stimulation treatment, is examined. tDCS uses direct electrical currents of low intensity to stimulate specific parts of the brain.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886082830679,"sku":"9781536132649","price":205.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536132649.jpg?v=1722538757"},{"product_id":"an-essential-guide-to-cytogenetics-9781536133707","title":"An Essential Guide to Cytogenetics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAn Essential Guide to Cytogenetics explores the use of cytogenetic data for studies of frogs as well as the insights that hypotheses of phylogenetic relationships have added to this issue. The authors provide an overview of PcP190 satellite DNA, sex chromosome systems and B chromosomes found in Anura. This book also aim to establish the health effects of various activities and exposures by examining the levels of exposure and the biological effects resulting from the interaction between the organism and the chemical agent. Following this, a chapter is included which focuses on on the complex karyotype issues in myelodysplastic diseases, leukemias, lymphomas and multiple myelomas as the authors see them in daily practice in their center. The authors investigate hybridization, suggesting that the viability of a hybrid between species with a chromosomal discrepancy may offer important hypotheses to explain the morphological, molecular, and cytogenetic diversity of the genus. Trichorhinophalangeal syndrome is analyzed, suggesting that in cases of cytogenetically-invisible alterations, parental FISH analysis as well as aCGH should be considered as part of the clinical baseline testing.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886084469079,"sku":"9781536133707","price":92.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536133707.jpg?v=1722538763"},{"product_id":"acetylcholine-receptors-in-health-and-disease-9781536154474","title":"Acetylcholine Receptors in Health and Disease","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAcetylcholine Receptors in Health and Disease opens with a review of the results of an investigation on the cholinergic modulation of excitatory synaptic transmission in the frog tectum carried out in the laboratory of neurophysiology at the Lithuanian University of Health Sciences. Experiments were done in vivo on the common grass frog Rana temporaria. Next, the authors review the function of M4 MR and discuss possible detection methods. M4 MR regulated locomotion is studied in conjunction with recent data on consequences to biorhythms. In the closing chapter, the authors review the environmental enrichment paradigm in rodents, as well as their effects on neurobiological, physiological and behavioral variables in preclinical studies.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eFor more information, please visit our website at:https:\/\/novapublishers.com\/shop\/acetylcholine-receptors-in-health-and-disease\/","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886125691223,"sku":"9781536154474","price":62.04,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536154474.jpg?v=1722538909"},{"product_id":"dna-background-laws-and-backlog-of-evidence-9781536161175","title":"DNA: Background, Laws and Backlog of Evidence","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDeoxyribonucleic acid, or DNA, is the fundamental building block for an individual''s entire genetic makeup. DNA is a powerful tool for law enforcement investigations because each person''s DNA is different from that of every other individual (except for identical twins). As early as the 1980s, states began enacting laws that required the collection of DNA samples from offenders convicted of certain sexual and other violent crimes. Chapter 1 provides an overview of how DNA is used to investigate crimes and help protect the innocent. Chapters 2 and 3 report on the establishment of a system for integration of Rapid DNA instruments for use by law enforcement to reduce violent crime and reduce the current DNA analysis backlog. Chapter 4 examines what is known about the amount of backlogged DNA evidence at state and local government labs; the extent to which OJP measures CEBR grant performance; and the extent to which OJP has designed controls to identify conflicts of interest related to CEBR grants. Chapter 5 reviews the level of crime scene DNA evidence backlogs among CEBR grantees and the factors that contribute to such backlogs; the extent to which DOJ has clearly defined goals for CEBR; and the extent to which OJP has controls for CEBR related to federal conflicts of interest and lobbying requirements. In 2016, about 323,000 individuals age 12 or older were reported victims of sexual assault, according to the Bureau of Justice Statistics. Studies have shown that exams performed by sexual assault forensic examiners -- medical providers trained in collecting and preserving forensic evidence -- may result in better physical and mental health care for victims, better evidence collection, and higher prosecution rates. Chapter 6 describes what was known in 2016 about the availability of sexual assault forensic examiners nationally and in selected states and the challenges selected states faced in maintaining a supply of sexual assault forensic examiners.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886141026647,"sku":"9781536161175","price":113.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536161175.jpg?v=1722538961"},{"product_id":"gene-mutations-causes-and-effects-9781536169843","title":"Gene Mutations: Causes and Effects","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886157574487,"sku":"9781536169843","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536169843.jpg?v=1722539025"},{"product_id":"advances-in-genetics-research-volume-20-9781536181548","title":"Advances in Genetics Research: Volume 20","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eGenetic disorders constitute an important portion of childhood mortality, stillbirths, and ongoing disability. Single gene disorders arising from gene mutations, affecting any aspect of function or structure of the gene, are extraordinarily diverse. Most of these gene disorders are usually rare, but collectively they constitute an important public health burden. As such, the authors address the requirement for essential genetic and management services. Age-related macular degeneration is discussed, with risk factors including age, gender, ethnicity, smoking, body weight, hypertension and diet. Confluence of genetic and environmental risk factors lends credence to a complex, multifactorial etiologic model of development of age-related macular degeneration. Continuing, this compilation explores the molecular mechanisms of telomere attachment, specifically during the interphase. Their study is important not only for general telomere biology, but also for the understanding of cell aging and etiology of telomere-associated aging diseases. The important transcriptomic analyses performed in Streptomyces are discussed, particularly addressing how they contribute to uncovering the biochemical mechanisms that regulate morphology and secondary metabolism activation. A focus on bovine mastitis is provided, the most economically devastating disease affecting the dairy industry. Resistance to mastitis is a complex function involving various biological pathways, molecules and cells. Genetic factors are one of several factors affecting the occurrence of mastitis. The closing study centers on the way in which extracellular DNA is enriched with pericentromeric tandem repeats, the most variable portion of the genome up to species specificity.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface; The Burden of Genetic Disorders and Role of Advanced Diagnostic, Therapeutic, Screening, and Counseling Approaches in Reducing it; Genetics of Age-Related Macular Degeneration: An Overview; Molecular Links between Telomeres and the Nuclear Envelope; Transcriptomics in Streptomyces; Polymorphism in CD14 Gene and Its Association with Mastitis in Dairy Animals; Repetitive Sequences in the Extracellular DNA for the Evolutionary Theory Unsolved Problems; Index.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886177104215,"sku":"9781536181548","price":177.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536181548.jpg?v=1722539098"},{"product_id":"p53-structure-functions-and-role-in-disease-9781536187717","title":"p53: Structure, Functions and Role in Disease","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003ep53: Structure, Functions and Role in Disease discusses the role of p53 dysregulation in different hematologic neoplasms defined by the current WHO classification. The prevalence of p53 aberration, mechanisms of p53 inactivation, regulation of p53 signaling pathway, and prognostic implications of p53 dysfunction in different hematologic malignancies are reviewed. The authors also discuss the prevalence of p53 mutations in cancers and important mechanisms underlying the impact of p53 mutations such as loss of function, dominant negative effect and gain of function. Recent findings related to the p53-mediated neuroprotective effects of natural compounds at the cellular, molecular, and behavioral level in various in vitro and in vivo models of neurodegenerative diseases are described, with a focus on Alzheimer''s disease.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886187786583,"sku":"9781536187717","price":72.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536187717.jpg?v=1722539136"},{"product_id":"stem-cells-in-disease-pathogenesis-9781536196306","title":"Stem Cells in Disease Pathogenesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe normal functioning of the human female reproductive system is sacrosanct, as it allows for the essential nurturing of offspring. Conditions such as endometriosis and fibroid formation can have devastating consequences to the progeny, as well as the parents, both physically and mentally. This book has several chapters that deal with the role of stem cells in the safer outcome of pregnancies. Mesenchymal stem cells continue to make waves as various researchers dwell on their low immunogenicity to prevent graft rejection when used for therapeutic strategies. Dental pulp-derived stem cells are being sought after to address many therapies. However, researchers must exercise ethical caution to avoid resorting to pulling out the teeth of live, healthy animals, including those qualified for pets. The efficacy of cancer treatments with naturally occurring plant-derived substances and the characterization of cancer stem cells and lesions continue to engage researchers of this ever-perennial disease and its potentially lethal pathology. Stem cells to replenish the pancreatic islet cells from induced pluripotent stem cells are an actively pursued subject in regenerative medicine for diabetes patients. Stem cells in immune responses are also attracting researchers to investigate immune tolerance and autoimmunity.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface; Stem Cells of Female Reproductive System: Endometrium vs Fallopian Tube; Anti-angiogenic Potential of Itraconazole and Its Reversal by Endometrial Stem Cells Using Chick Embryo Model; Intrauterine Infusion of Human Autologous Peripheral Blood Mononuclear Cells Improves In Vitro Fertilization Success in Infertile Women; Development and Characterization of Hematopoietic Stem Cells from Human Embryonic Stem Cells; Mutation Analysis of MTHFR Gene in Indian Women with Unexplained Recurrent Miscarriages; Folic Acid Supplementation Improves Pregnancy Outcomes; Comparison of the Proliferation Potential of Bone Marrow and Adipose- Derived Mesenchymal Stem Cells Cultivating on Human Amniotic Membrane; Efficacy of the Mesenchymal Stem Cells Therapy Combined with Core Decompression in Avascular Necrosis of the Femoral Head: A Systematic Review and Meta-analysis of Clinical Trials; Proliferation Capacity and Osteogenic Potential of Human Gingival Stem Cells versus Human Dental Pulp Stem Cells; Comparison between the Effect of MTA and Biodentine on Proliferation and Odontogenic Differentiation of Dental Pulp Stem Cells (In Vitro Study); The Monomeric Resins TEGDMA and HEMA Regulate the Transcriptional Control of Matrix Metalloproteinases MMP-2 and MMP-9, in Human Pulp Fibroblasts and Mesenchymal Stem Cells; Effect of Dental Stem Cells on T Cell Proliferation; Amount of Bone Morphogenetic Protein-2, Epidermal Growth Factor, and Vascular Endothelial Growth Factor in Adipose Tissue, Umbilical Cord, and Bone Marrow Mesenchymal Stem Cell Derived Secretome: An In-Vitro Study; Identified Cancer Stem Cells (CSCs) in Ex- Vivo Cultured Acute Lymphoid Leukemia (B-ALL) Cells; Role of Simarouba glauca DC Plant in Cancer: A Short Review; Study of Histomorphological Spectrum of Thyroid Lesions in Thyroidectomy Specimens, Along with Cytological Correlation: Cross Sectional Study from 2015 to 2018; Generation of Pancreatic β Cells from Peripheral Blood Mononucleocytes Derived Induced Pluripotent Stem Cells; Stem Cells: An Exciting Avenue for Diabetes Mellitus; Regenerations Role in the Development of Desensitization and Immunological Tolerance; Features of the Immune Response to Ones Own Antigens and Foreign Antigens; Regenerative Approach to the Treatment of COVID-19 Patients; Medical Applications of Infrared Thermography: A Narrative Review; Index.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886204760407,"sku":"9781536196306","price":163.19,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536196306.jpg?v=1722539200"},{"product_id":"on-the-way-to-individuality-current-methodological-issues-in-behavioral-genetics-9781560724278","title":"On the Way to Individuality: Current","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book is intended to provide a bridge between behavioural genetics, psychiatric genetics, developmental psychopathology and developmental psychology.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886322528599,"sku":"9781560724278","price":85.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781560724278.jpg?v=1722539616"},{"product_id":"focus-on-stem-cell-research-9781594540431","title":"Focus on Stem Cell Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAmong the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson''s disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson''s disease, and Alzheimer''s disease. Stem cells are self-renewing, unspecialized cells that can give rise to multiple types all of specialized cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, fetal tissue and embryonic sources. This new book brings together leading research from throughout the world in this frontier field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886508257623,"sku":"9781594540431","price":129.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594540431.jpg?v=1722540376"},{"product_id":"trends-in-gene-therapy-research-9781594543067","title":"Trends in Gene Therapy Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886516908375,"sku":"9781594543067","price":129.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594543067.jpg?v=1722540414"},{"product_id":"progress-in-medical-genetics-9781594544897","title":"Progress in Medical Genetics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eOver the past decade, medical genetics has emerged as an important and powerful medical speciality with increasing appreciation of its role and function among the medical specialities. This emergence is related to a great extent to the progress in the Human Genome Project which promises wide ranging applications in the diagnosis, treatment and prevention of human diseases Nevertheless, discussions about the role of genetics in preventive medicine and public health rightfully lead to ethical, legal and social concerns about general applicability of genetic testing in the population. The interpretation of the word prevention in the context of genetic diseases leads to the unavoidable discussions of genetic engineering, prenatal diagnosis and selective termination, as well as broader concerns about discrimination in health care coverage, employment and in society.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886521987415,"sku":"9781594544897","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594544897.jpg?v=1722540437"},{"product_id":"trends-in-dna-research-9781594546358","title":"Trends in DNA Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDeoxyribonucleic acid (DNA) is a chemical found primarily in the nucleus of cells. DNA is a long, spiralling molecule that orchestrates the cell''s daily operations and provides the genetic blueprint for the physical characteristics of all living organisms. It is the molecule that encodes genetic information in the nucleus of cells. It determines the structure, function and behaviour of the cell. DNA is made up of two complementary strands, the strands intertwine like a spiral staircase to form a structure called a double helix. Subunits, called bases, are the rungs of the staircase. The four nucleotides in DNA contain the bases: adenine (A), guanine (G), cytosine (C), and thymine (T). This new book presents leading-edge research in this dynamic field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886525886807,"sku":"9781594546358","price":173.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594546358.jpg?v=1722540456"},{"product_id":"new-developments-in-mutation-research-9781594546648","title":"New Developments in Mutation Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eMutation refers to any change in the DNA of a cell. Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment. Mutations can be harmful, beneficial, or have no effect. If they occur in cells that make eggs or sperm, they can be inherited; if mutations occur in other types of cells, they are not inherited. Certain mutations may lead to cancer or other diseases. This book gathers together and presents the latest research in this field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886526837079,"sku":"9781594546648","price":176.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594546648.jpg?v=1722540462"},{"product_id":"genetic-testing-scientific-background-nondiscrimination-legislation-9781594547836","title":"Genetic Testing: Scientific Background \u0026","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eCollectively, genetic diseases and common diseases with a genetic component pose a significant public health burden. With completion of the human genome sequence, scientists will now focus on understanding the clinical implications of the sequence information. Clinical genetic tests are becoming available at a rapid rate. Testing is regulated by the federal government and tests are beginning to be included in health insurance benefits packages. Issues surrounding genetic testing and non-discrimination addressed in this book include: What is health information and how is it currently used by health insurers and employers?; What is genetic information?; Is genetic information different from other health information?; What are the implications of having genetic information: for the individual undergoing testing? for his\/her family? for society?; What evidence exists to suggest that discrimination is a problem?; Will the proposed legislation have been sufficient to protect \"genetic information\" and \"genetic tests\" that are of concern?; How does the proposed legislation compare with existing laws and regulations governing discrimination?","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886530441559,"sku":"9781594547836","price":46.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594547836.jpg?v=1722540478"},{"product_id":"gene-silencing-new-research-9781594548321","title":"Gene Silencing: New Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eGene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the ''switching off'' of a gene by a mechanism other than genetic mutation. That is, a gene which would be expressed (turned on) under normal circumstances, is switched off by machinery in the cell. Genes are regulated at either the transcriptional or post-transcriptional level. Transcriptional gene silencing is the result of histone modifications, creating an environment of heterochromatin around a gene that makes it inaccessible to transcriptional machinery (RNA polymerase, transcription factors, etc.). Post-transcriptional gene silencing is the result of mRNA of a particular gene being destroyed. The destruction of the mRNA prevents translation to form an active gene product (in most cases, a protein). A common mechanism of post-transcriptional gene silencing is RNAi. Both transcriptional and post-transcriptional gene silencing are used to regulate endogenous genes. This book presents the latest research in this important field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886531555671,"sku":"9781594548321","price":173.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594548321.jpg?v=1722540484"},{"product_id":"stem-cell-therapy-9781594548482","title":"Stem Cell Therapy","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAmong the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson''s disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson''s disease, and Alzheimer''s disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. 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Interwoven advances in genetics, comparative genomics, high throughput biochemistry and bioinformatics are combining to attack basic understanding of human life and disease and to develop strategies to combat disease. Genomic Research began with The Human Genome Project (HGP), the international research effort that determined the DNA sequence of the entire human genome, completed in April 2003. The HGP also included efforts to characterise and sequence the entire genomes of several other organisms, many of which are used extensively in biological research. Identification of the sequence or function of genes in a model organism is an important approach to finding and elucidating the function of human genes. Integral to the HGP are similar efforts to understand the genomes of various organisms commonly used in biomedical research, such as mice, fruit flies and roundworms. 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Genetic tests are used for several reasons, including: Carrier screening, which involves identifying unaffected individuals who carry one copy of a gene for a disease that requires two copies for the disease to be expressed; Preimplantation genetic diagnosis prenatal diagnostic testing new-born screening; Presymptomatic testing for predicting adult-onset disorders such as Huntington''s disease; Presymptomatic testing for estimating the risk of developing adult-onset cancers and Alzheimer''s disease; Confirmational diagnosis of a symptomatic individual forensic\/identity testing. In gene tests, scientists scan a patient''s DNA sample for mutated sequences. A DNA sample can be obtained from any tissue, including blood. For some types of gene tests, researchers design short pieces of DNA called probes, whose sequences are complementary to the mutated sequences. These probes will seek their complement among the three billion base pairs of an individual''s genome. 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