{"title":"Medical diagnosis Books","description":"","products":[{"product_id":"oxford-handbook-of-clinical-and-laboratory-investigation-9780198766537","title":"Oxford Handbook of Clinical and Laboratory","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eProvides an authoritative guide to investigation and diagnosis. Describes key symptoms and signs, alongisde appropriate tests, and highlights pitfalls in interpreting results. Describes a clear, rational method of investigation in order to aid quick and efficient diagnosis, and prevent over-investigation of patients.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eBeing a member of the superb Oxford Handbook series, I automatically assume this book will be very good and put very simply, it is very good and certainly lives up to its heritage. Dont be put off by the title handbook; this is a chunky but portable book that is full of useful information about the numerous tests we order on a daily as well as infrequent basis. The net result is a book that many of us would want to own and a book in the right hands is likely to be used often. * Dr Harry Brown, Glycosmedia *\u003cbr\u003eFrom the Foreword:  \"Its size, scope and relevance mean that it is likely to be used daily as a quick reference and aide-memoire...No medical student or junior doctor should be without this book (it's ideal for revision), in fact any doctor at any stage of their career will find it useful.\" * Suzy Lishman, President of The Royal College of Pathologists, 2018 *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: The Patient 1: Drew Provan: Symptoms \u0026amp; signs 2: Investigations 2: Colin Dayan: Endocrinology \u0026amp; metabolism 3: Vanessa Fogo and Drew Provan: Haematology 4: Gavin Spickett: Immunology \u0026amp; allergy 5: Prof Brian Angus: Infectious \u0026amp; tropical diseases 6: Andrew R. Houghton: Cardiology 7: Emma Greig: Gastroenterology 8: Joanna Brown: Respiratory medicine 9: Martyn Bracewell: Neurology 10: Charlie Tomson and Sarah McLoskey: Renal medicine 11: Alison Jones: Poisoning \u0026amp; overdose 12: Suzanne Lane: Rheumatology 13: Tanya Chawla: Radiology 14: Jim Ballinger and Gopinath Gnanasegaran: Nuclear medicine","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732779774295,"sku":"9780198766537","price":34.19,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198766537.jpg?v=1719998366"},{"product_id":"emergencies-in-clinical-medicine-9780198779117","title":"Emergencies in Clinical Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAcutely unwell patients can deteriorate dangerously without timely recognition and intervention. Emergencies in Clinical Medicine provides an easy-to-use guide to the prompt management of common medical emergencies. Designed for rapid use, it explains how to arrive at a differential diagnosis and how to prevent, manage, or treat an emergency. The second edition has been fully updated to reflect current clinical guidelines and includes several new topics, from pulmonary oedemas to the overdose patient. Revised to cover the curricula for core medical training (CMT) and acute care common stem (ACS), this text addresses exactly what the trainee doctor needs to know. The text covers emergencies from both a problem-based and disease-based approach. Cross-referencing between these two sections enables quick reference under pressure, with clear, step-by-step instructions and advice on when and who to call for help.With key algorithms for quick reference and easy to follow symbols indicating cl\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: Ben Skinner, John Page, Alan Weir, Piers Page: The basics 2: Upsana Tayal,  Simon Patel , Geri Keane, Adam Stannard, Mark Garside, Will Sedley, Ben Skinner, Jim Shawcross,  Alan Weir, Erin Hurst, Jenny Koo Ng, Anna Gruener, Caroline Page, Asif Shah, Natasha Eagles, Bojidar Goranov, Piers Page, Rachel Pearson, Chris Crome: Presentations 3: Upsana Tayal: Cardiology 4: Rebecca Taylor: Respiratory 5: Jonathan Schofield:: Endocrine 6: Geri Keane: Gastoenterology 7: Jenny Koo and Jim Shawcross: Renal and urology 8: Erin Hurst, Bojidar Goranov, and Will Sedley: Haematology and Oncology 9: Will Sedley: Neurology and neurosurgery 10: Piers Page, Chris Crome, Rachel Pearson, Seth Makin: Musculoskeletal medicine and dermatology 11: Matt Thomas, Elizabeth Ward: Surgery 12: Will Coles: Clinical biochemistry \/ drug toxicity","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732781609303,"sku":"9780198779117","price":31.34,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198779117.jpg?v=1719998375"},{"product_id":"oxford-clinical-guidelines-newly-qualified-doctor-9780198834502","title":"Oxford Clinical Guidelines Newly Qualified Doctor","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eMedical practice in the modern age requires familiarity with clinical guidelines and standards, which are often published separately in long and discursive documents. This new addition to the Oxford Medical Publications summarises the key clinical practice guidelines which all final year medical students and Foundation Year 1 and 2 doctors should know when managing common conditions. Logically organised by medical specialty, the reader can quickly familiarise themselves with the key principles of diagnosis and management at the appropriate level for beginning a new rotation on the wards. Each guideline summary is tailored to the education level expected of doctors in their first two years of training, with clear instructions for when a more senior colleague should be called upon to help. Written by a team of junior doctors under the supervision of senior clinicians, this is the first resource to distil a range of guidelines from different locations (such as NICE, SIGN, and more) into a\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eIncredibly thorough and really well thought out. This [book] would be incredibly helpful both in clinical practice day to day and as a tool to prepare for exams * Foundation Year 1 doctor (newly qualified doctor), Croydon University Hospital, UK *\u003cbr\u003ePerfectly pitched to its target audience. I wish I had this book when I started as a medical trainee * ST1 Radiology Trainee, University Hospital Southampton, UK *\u003cbr\u003eClear, informative, and full of detail * Internal medical trainee stage 2 (qualified doctor for 4 years), County Durham and Darlington Foundation Trust, UK *\u003cbr\u003eThe book will be a valuable resource for students and trainees seeing patients in the clinic or hospital. It will also be beneficial for more experienced general practice doctors, as a refresher for infrequently seen conditions. The book can serve as a reference text in a medical school library, as it provides an overview of topics likely to be on in-training tests. I recommend this book to physicians-in-training in the U.K., especially trainees in medical school and general practice. * Jack Harrigan, MD Candidate (University of Kansas School of Medicine - Wichita) *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePart 1 Cardiology:Benjamin Bussman, Liora Wittner, Emily Yeung, Rebecca Webb-Mitchell:  1: Acute coronary syndromes 2: Acute heart failure 3: Aortic stenosis and mitral regurgitation 4: Atrial fibrillation 5: Chronic heart failure 6: Hypertension 7: Pericardial diseases 8: Stable angina 9: Transient loss of consciousness Part 2 Care of the elderly:Elizabeth Tan, Stephanie Choo:  10: Delirium 11: Dementia 12: Falls 13: Hip fractures Part 3 Endocrinology:David Fisher, Sabrina Ahmed, Tom Owens, Nicola West, Laura Brodie, James Andren, Alison Hare, Ben Coombs, Vanessa Jessop, Adam Maxwell:  14: Adrenal insufficiency 15: Diabetic ketoacidosis 16: Hypercalcaemia 17: Hyperglycaemia 18: Hyperglycaemic hyperosmolar syndrome 19: Hyperthyroidism 20: Hypocalcaemia 21: Hypoglycaemia 22: Hyponatraemia 23: Hypothyroidism 24: Osteoporosis 25: Type 1 diabetes 26: Type 2 diabetes and diabetic foot problems Part 4 Gastrointestinal:John Creamer, David Fisher, Prabhsimran Singh:  27: Acute upper gastrointestinal bleeding and variceal bleeding 28: Coeliac disease 29: Crohn s disease 30: Gastro-oesophageal reflux disease and dyspepsia 31: Irritable bowel syndrome 32: Ulcerative colitis Part 5 Hepatobiliary:Tom Owens, Catharine Pearce, Vanessa Jessop, John Creamer:  33: Acute liver failure 34: Alcohol-related liver disease 35: Alcohol use disorders 36: Liver cirrhosis Part 6 Mental health:Sarah Orr, George Blanchard, Thomas McCabe:  37: Bipolar disorder 38: Depression 39: Eating disorders 40: Generalized anxiety disorder 41: Panic disorder 42: Post-traumatic stress disorder 43: Psychosis and schizophrenia 44: Self-harm 45: Violence and aggression Part 7 Nephrology:Mohammed Al-Talib, Catharine Pearce, Nicola West:  46: Acute kidney injury 47: Chronic kidney disease 48: Hyperkalaemia Part 8 Neurology:Angharad Everden, Bina Patel, Catharine Pearce, Ann Maria Albert, Nicola West, Stephanie Choo:  49: Acute encephalitis 50: Epilepsy 51: Headache 52: Meningitis 53: Metastatic spinal cord compression 54: Neuropathic pain 55: Parkinson s disease 56: Stroke and transient ischaemic attack Part 9 Obstetrics and gynaecology:Emma Shephard, Georgina Clark, Yasmin Smith, Harriet Gardner:  57: Antenatal care 58: Antepartum haemorrhage 59: Diabetes in pregnancy 60: Ectopic pregnancy and miscarriage 61: Hypertension in pregnancy 62: Intrapartum care 63: Nausea and vomiting in pregnancy 64: Pelvic organ prolapse in women 65: Postpartum haemorrhage 66: Sepsis in and following pregnancy 67: Thrombosis and embolism during pregnancy and the postnatal period 68: Urinary incontinence in women Part 10 Paediatrics:Clemency Nye, Liora Wittner, Samantha Williamson, Shervin Poladi, Ann Maria Albert:  69: Child maltreatment 70: Fever in under 5s 71: Neonatal infections 72: Paediatric asthma 73: Paediatric bacterial meningitis and meningococcal septicaemia 74: Paediatric bronchiolitis 75 : Paediatric diabetic ketoacidosis 76: Paediatric gastroenteritis 77: Paediatric type 1 diabetes 78: Paediatric urinary tract infections Part 11 Respiratory:Angharad Everden, Matthew Sutton:  79: Acute oxygen therapy 80: Asthma 81: Chronic obstructive pulmonary disease 82: Pleural effusion 83: Pneumonia Part 12 Rheumatology and musculoskeletal:Liora Wittner, Laura Brodie, Adam Maxwell, Clemency Nye, Harriet Blundell, Alison Hare:  84: Giant cell arteritis 85: Gout 86: Hot swollen joint 87: Low back pain and sciatica 88: Osteoarthritis 89: Polymyalgia rheumatica 90: Rheumatoid arthritis 91: Spondyloarthritis Part 13 Surgery:Darryl Bernstein:  92: Preoperative care 93: Postoperative care Part 14 Miscellaneous:Mohammed Al-Talib, Liora Wittner, James Andren, Gabriella Bathgate, Harriet Blundell:  94: Blood transfusion 95: Care of dying patients in the last days of life 96: Intravenous fluid therapy 97: Lower urinary tract symptoms in men 98: Venous thromboembolic diseases 99: Malaria Part 15 Cancer guidelines:Dinta Thakkar, Yasmin Smith, Mohammed Al-Talib, Clemency Nye, Elizabeth Tan, Ben Coombs, Ashwini Virgincar, Adam Maxwell, Gabriella Bathgate:  100: Brain and central nervous system cancers 101: Breast cancer 102: Childhood cancers 103: Gynaecological cancers 104: Haematological cancers 105: Head and neck cancers 106: Lower gastrointestinal cancers 107: Lung cancer 108: Sarcomas 109: Skin cancers 110: Upper gastrointestinal cancers 111: Urological cancers Part 16 Professional guidelines:Thomas McCabe, Vanessa Jessop, Gabriella Bathgate, Harriet Blundell:  112: Capacity and consent 113 Confidentiality:  114: DNACPR 115: Fitness to drive Part 17 Resuscitation:Tom Owens, Laura Brodie, Ashwini Virgincar, James Andren, Alison Hare, Sabrina Ahmed, Ben Coombs, Benjamin Bussman:  116: Advanced life support 117: Anaphylaxis and drug allergy 118: Bradycardia 119: Choking 120: Major trauma 121: Neutropenic sepsis 122: Sepsis 123: Tachycardia","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732803858775,"sku":"9780198834502","price":31.34,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198834502.jpg?v=1719998469"},{"product_id":"the-pocketbook-for-paces-9780199574186","title":"The Pocketbook for PACES","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book provides an easily portable yet comprehensive guide to the PACES examination. It includes all of the most relevant clinical information for the PACES exam supplemented by tips supplied by the highly experienced chapter authors. The main aim of the book is to consolidate candidates'' theoretical knowledge and help them apply it to the clinical examination scenario. In addition the book forms an excellent pocket reference for trainees in acute medicine, accident and emergency medicine, anaesthetics and critical care and general practice.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Introduction ; 2. Respiratory ; 3. Abdomen ; 4. History taking ; 5. Cardiology ; 6. Neurology ; 7. Communication skills ; 8. Brief clinical consultation ; 9. MRCPI","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732867363159,"sku":"9780199574186","price":63.65,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780199574186.jpg?v=1719998735"},{"product_id":"clinical-skills-9780199574926","title":"Clinical Skills","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eClinical Skills, Second Edition is a comprehensive, practical guide to the art of history taking and examination. Heavily illustrated and packed with sage advice, this textbook is essential reading for medical students preparing for OSCEs and beyond.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eReview from previous edition This book tells you what is important and what one should most concentrate on... precisely the sort of guidance every clinical student looks for... I greatly liked what I saw and read. * Mark O'Shea, Medical Student, Nottingham *\u003cbr\u003eExcellent. A clearly written book that provides exactly what is needed on the wards as a clinical student....Loved the style of writing... it is a winner. * Richard Duggan, Medical Student, Newcastle *\u003cbr\u003eStudent-friendly language avoiding jargon, and with a practical approach with good emphasis on presentation and exam technique. * Alan Cheung, Medical Student, University College London *\u003cbr\u003eIt looks excellent and is very readable... Phonetic spellings are an excellent touch and I cannot believe every book does not include them. Every student lives in fear of mispronouncing a word... the case histories are well constructed... these would give me more confidence in diagnosing signs and symptoms. * Nicholas Hoque, Medical Student, Imperial College *\u003cbr\u003eThe book explains everything with simplicity and even the Jugular Venous Pressure appears doable after a read of the chapter on the cardiovascular system. I especially liked the explanation of all the abbreviations used in medical notes. Practical information like this separates the book from others and after having read numerous clinical skills books during Phase 1, this is by far my favourite. ... this book is the best of its kind available. * Louise Murphy,(phase 3) Cambridge Medical Journal   *\u003cbr\u003eThe book feels as though you are at the bedside being taught by a doctor. * Nicole Ward, Medical Student, Manchester *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Introduction ; 2. Clinical settings ; 3. Core aspects of history taking ; 4. Cardiovascular system ; 5. Respiratory system ; 6. Neurological examination ; 7. Abdominal examination ; 8. Rectal examination ; 9. Genitourinary system ; 10. Breast examination ; 11. Neck examination ; 12. Joints ; 13. Spot diagnosis ; 14. Examination of the child ; 15. Chest x-ray ; 16. Finals","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732867526999,"sku":"9780199574926","price":54.15,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780199574926.jpg?v=1719998737"},{"product_id":"oxford-handbook-of-clinical-diagnosis-9780199679867","title":"Oxford Handbook of Clinical Diagnosis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis handbook describes the diagnostic process clearly and logically, aiding medical students and others who wish to improve their diagnostic performance and to learn more about the diagnostic process.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis is a nice memory aid for new clinicians as well as a refresher for clinicians who have been in the practice of medicine for a long time. * Doody's Notes *\u003cbr\u003eThis book is useful for medical students of all years... and is perfect for ILAs, finals revision and wards round. As with all Oxford Handbooks, its handy size makes it very placement friendly. * North Wing *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. The diagnostic process ; 2. Interpreting the history and examination ; 3. General and endocrine symptoms and physical signs ; 4. Skin symptoms and physical signs ; 5. Cardiovascular symptoms and physical signs ; 6. Respiratory symptoms and physical signs ; 7. Gastrointestinal symptoms and physical signs ; 8. Urological and gynaecological symptoms and physical signs ; 9. Joint, limb, and back symptoms and physical signs ; 10. Psychiatric and neurological symptoms and physical signs ; 11. Laboratory tests ; 12. Chest x-rays ; 13. Making the diagnostic process evidence-based","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732882043223,"sku":"9780199679867","price":32.29,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780199679867.jpg?v=1719998800"},{"product_id":"chinese-medicine-9780712602815","title":"Chinese Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eIn the ancient tradition of Chinese medicine, illness is a disharmony of the whole body.  The aim is to restore harmony through herbal medicine, acupuncture, moxibustion and the diagnostic skills of the physician.  The governing principle is to balance Yin and Yang and to restore the interconnections between all aspects of the organism.             This remarkable book explains the theory and practice of Chinese medicine.  More than that, it mixes the most up-to-date knowledge of the oriental approach to healing with cutting-edge scientific research. \u003cbr\u003e\u003cbr\u003e''While the book''s rich detail makes it of great use to practising healers, it is in its entirety very simply written, enjoyable reading for the layman... An instructive, profound and important work.''  Professor Martin Schwartz, University of California, Berkeley\u003c\/p\u003e","brand":"Ebury Publishing","offers":[{"title":"Default Title","offer_id":48736027246935,"sku":"9780712602815","price":21.25,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780712602815.jpg?v=1723810463"},{"product_id":"overdiagnosed-making-people-sick-in-the-pursuit-of-health-9780807021996","title":"Overdiagnosed Making People Sick in the Pursuit","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Beacon Press","offers":[{"title":"Default Title","offer_id":48737411596631,"sku":"9780807021996","price":15.29,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780807021996.jpg?v=1723811173"},{"product_id":"fetal-medicine-9781009015943","title":"Fetal Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis comprehensive approach to the diagnosis, investigation, counselling and management of fetal abnormalities and disorders offers practical clinical guidance to decision making. Highly illustrated throughout in an easy-to-read, algorithm format this book is for all maternal-fetal care specialists and allied healthcare professionals in fetal care.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Fetal anatomy: first trimester assessment; 2. Screening for common chromosomal abnormalities and other genetic conditions; 3. Fetal Anatomy: second and third trimester assessment; 3.1 Head and neck; 3.2 Fetal heart and common antenatally diagnosed cardiac anomalies; 3.3 Thoracic and pulmonary abnormalities; 3.4 Spine; 3.5 Abdomen; 3.6 Genito-urinary tract; 3.7 Skeletal Anomalies; 4. Small for gestational age and fetal growth restriction; 5. Large for gestation age fetus; 6. Rhesus disease; 7. Fetal alloimune Thrombocytopenia; 8. Hydrops in second and third trimester; 9. Abnormal placenta; 10. Umbilical cord abnormalities; 11. Amniotic fluid abnormalities; 12. Multiple pregnancy; 13. Short cervix in asymptomatic women; 14. Fetal infections; 15. Drugs in pregnancy and teratogenesis; 16. Ultrasound guided invasive diagnostic and therapeutic procedures; 17. Fetoscopy and ultrasound guided thermal therapeutic prodecures; 18. Fetal surgery for spina bifida; 19. Genetic syndromes; 20. Termination of pregnancy for fetal abnormality.","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":48738004107607,"sku":"9781009015943","price":66.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781009015943.jpg?v=1723811675"},{"product_id":"handbook-of-nursing-diagnosis-9781284197976","title":"Handbook of Nursing Diagnosis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Jones and Bartlett Publishers, Inc","offers":[{"title":"Default Title","offer_id":48738515714391,"sku":"9781284197976","price":43.7,"currency_code":"GBP","in_stock":true}]},{"product_id":"unnatural-causes-9781405923538","title":"Unnatural Causes","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eTHE TRUE CRIME BOOK OF THE YEAR AND \u003ci\u003eSUNDAY TIMES \u003c\/i\u003eTOP 10 BESTSELLER\u003c\/b\u003e\u003cbr\u003e \u003cb\u003e\u003cbr\u003e ''One of the most fascinating books I have read in a long time. Engrossing, a haunting page-turner. A book I could not put down'' \u003c\/b\u003e\u003ci\u003eThe Times, BOOKS OF THE YEAR\u003c\/i\u003e\u003cbr\u003e __________\u003cbr\u003e\u003cbr\u003e \u003cb\u003eMeet the forensic pathologist, Dr Richard Shepherd.\u003c\/b\u003e\u003cbr\u003e \u003cb\u003e\u003cbr\u003e He solves the mysteries of unexplained or sudden death.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e He has performed over 23,000 autopsies, including some of the most high-profile cases of recent times; the Hungerford Massacre, the Princess Diana inquiry, and 9\/11. \u003cbr\u003e\u003cbr\u003e He has faced serial killers, natural disaster, ''perfect murders'' and freak accidents.\u003cbr\u003e\u003cbr\u003e His evidence has put killers behind bars, freed the innocent, and turned open-and-shut cases on their heads. \u003cbr\u003e\u003cbr\u003e Yet all this has come at a huge personal cost. \u003cbr\u003e\u003cbr\u003e \u003ci\u003eUnnatural Causes \u003c\/i\u003etells the story of not only the cases and bodies that have haunted him the most, but also how to live a\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eUnnatural Causes\u003c\/i\u003e gives a sense of the toll that dealing with so many dead bodies takes. It's a very human book that looks at the cases he has been involved with, from the Hungerford massacre to the murder of Stephen Lawrence * The Times (Books of the Year, 2018) *\u003cbr\u003eAn unputdownable record of an extraordinary life * 100 sizzling summer books, Daily Mail *\u003cbr\u003eOne of the most fascinating books I have read in a long time. Engrossing, a haunting page-turner. A book I could not put down * The Times *\u003cbr\u003e\u003cb\u003eFabulous\u003c\/b\u003e . . . The UK's top pathologist investigating high-profile deaths such as that of Diana, Princess of Wales * The Sunday Post *\u003cbr\u003ePuts the reader at his elbow as he wields the scalpel * Guardian *\u003cbr\u003eInsightful, candid and compassionate * Observer *\u003cbr\u003eFascinating, gruesome yet engrossing * Richard and Judy, Daily Express *\u003cbr\u003eHeart-wrenchingly honest * Professor Sue Black, author of All That Remains *\u003cbr\u003eDarkly fascinating * Daily Mirror *\u003cbr\u003eA deeply mesmerising memoir of forensic pathology.  Human and fascinating * Nigella Lawson *\u003cbr\u003ePartly an autobiography, but also a love letter to pathology. It's dignified and graceful and painfully honest about the human and emotional cost of so much time with the dead. Insightful, moving and mesmerising * Marylebone Journal *\u003cbr\u003eThis book holds within its pages the story of a life told with honesty, and this is partly why it is such a pleasure to read. A fascinating autobiography. Unputdownable. * Live Ribble Valley *\u003cbr\u003eA unique insight into a remarkable profession * The Times *\u003cbr\u003eHis experiences, from morgue to court, are sometimes gruesome, always gripping * Sunday Mirror *\u003cbr\u003eThe true crime book of the year; a thoughtful, revealing, chilling and bizarre record of an extraordinary life and profession * Visit Norwich *\u003cbr\u003eHe recounts experiences in a gripping memoir that melds the personal and professional * The People *\u003cbr\u003eMust Read * Daily Mail *\u003cbr\u003eA brilliantly written and compelling account of a medical detective who has worked on many appalling crimes and human tragedies * Woman's Weekly *\u003cbr\u003eMust read * Daily Mail *\u003cbr\u003eMedical science books are rarely as gripping as \u003ci\u003eUnnatural Causes\u003c\/i\u003e. It's grimly fascinating, and I suspect I'll read it at least twice. * Evening Standard *\u003c\/p\u003e","brand":"Penguin Books Ltd","offers":[{"title":"Default Title","offer_id":48738967191895,"sku":"9781405923538","price":10.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781405923538.jpg?v=1720050730"},{"product_id":"the-seven-ages-of-death-9781405947107","title":"The Seven Ages of Death","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eThe heart-wrenchingly honest new book about life and death from forensic pathologist and bestselling author of \u003ci\u003eUNNATURAL CAUSES\u003c\/i\u003e, Dr Richard Shepherd\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eA TIMES AND SUNDAY TIMES BOOK OF THE YEAR\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003e''Deeply insightful. Unflinching'' \u003c\/b\u003e\u003ci\u003eTHE TIMES\u003c\/i\u003e\u003cbr\u003e\u003cb\u003e''A finely-crafted detective story''\u003c\/b\u003e\u003ci\u003e DAILY TELEGRAPH\u003c\/i\u003e\u003cbr\u003e\u003cb\u003e''Enlightening, strangely uplifting'' \u003c\/b\u003e\u003ci\u003eDAILY MAIL\u003c\/i\u003e\u003cbr\u003e\u003cb\u003e''Fascinating'' \u003c\/b\u003e\u003ci\u003eDAILY EXPRESS\u003c\/i\u003e\u003cbr\u003e_________\u003cbr\u003e\u003cbr\u003eDr Richard Shepherd, a medical detective and Britain''s top forensic pathologist, shares twenty-four of his most intriguing, enlightening and never-before-told cases.\u003cbr\u003e\u003cbr\u003eThese autopsies, spanning the seven ages of human existence, uncover the secrets not only of how a person died, but also of how they lived.\u003cbr\u003e\u003cbr\u003eFrom old to young, murder to misadventure, and illness to accidental death, each body has something to reveal - about its owner''s life story, how we age, justice, society, the certainty o\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eThis sequel is more ruminative, more meditative . . . 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Shepherd is unflinching in his self-dissection\u003c\/b\u003e * The Times *\u003cbr\u003e\u003cb\u003eFascinating\u003c\/b\u003e * Daily Express *\u003cbr\u003e\u003cb\u003eFascinating. He has the ability to examine himself and other people with the same forensic eye that he applies to corpses - one of the reasons why his books feel so life-enhancing\u003c\/b\u003e * Daily Telegraph *\u003cbr\u003e\u003cb\u003eGrippingly elegiac yet wonderfully life-affirming, full of pithy observations about the inexorability of death and the marvels of existence\u003c\/b\u003e -- Felicia Yap, author of Future Perfect * Daily Express *\u003cbr\u003e\u003cb\u003ePraise for Dr Richard Shepherd\u003c\/b\u003e * - *\u003cbr\u003e\u003cb\u003eOne of the most fascinating books I have read in a long time. Engrossing, a haunting page-turner. A book I could not put down\u003c\/b\u003e * The Times *\u003cbr\u003e\u003cb\u003eHeart-wrenchingly honest\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eGripping, grimly fascinating, and I suspect I'll read it at least twice\u003c\/b\u003e * Evening Standard *\u003cbr\u003e\u003cb\u003eA deeply mesmerising memoir of forensic pathology. Human and fascinating\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eAn absolutely brilliant book. 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It teaches students to recognize when clinical reasoning is needed, and what reasoning is involved, and to avoid reasoning errors. This is important for nurses, since good quality of their clinical reasoning leads to a good quality of their decisions. Thus, it is directly connected to better nursing care.   \u003cbr\u003e\u003cbr\u003eThis volume is based on current knowledge about learning complex cognitive skills. From this knowledge, four sets of standard questions have been formulated that allow students to develop cognitive scripts for reasoning about diagnosis, etiology, prognosis, and interventions. Special attention is payed to diversity-sensitive reasoning in this English edition. From the 4C\/ID model, a scientific educational whole task model for learning and developing and complex cognitive skills, complexity levels, learning tasks and subtask exercises are included. Learning clinical reasoning is supported with case videos and flash lectures, among other things. It consists of three parts: the first part, on clinical reasoning, is written for first- and second-year bachelor students in nursing. Part two, on evidence-based practice (EBP), is also suitable for later years. It teaches students to read and critically appraise scientific articles, and to assess whether they can be used in their own practice. Part three contains more in-depth information, extra explanations, examples, and material that teachers can use in a flexible way. This book is illustrated with videos.\u003cbr\u003eThe translation from Dutch to English was done with the help of artificial intelligence (machine translation by the service DeepL.com). 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E.g. clinical examples and elaborations.13. 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It provides good explanations of treatment without scaring readers off with too much technical detail. Unique features that contribute to the value of the book include the case studies..., the specific criteria for when a patient should be referred to a practitioner, and the emergency care information where appropriate.\" Anastasia Shields, BS, PharmD, Doody's Notes, May 2013. -- Anastasia Shields * Doody's Notes *\u003cbr\u003e\"It is a comprehensive textbook. Helpful to students to remember the concept in-relation to common clinical disease state conditions with well prepared short case studies followed by a few MCQs.\" Dr Praveen Bhugra, University of Sunderland, June 2013. -- Dr Praveen Bhugra\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e1. Introduction \u003cbr\u003e2. Cardiovascular and cerebrovascular conditions \u003cbr\u003e3. Motion sickness \u003cbr\u003e4. Pain \u003cbr\u003e5. Ear problems \u003cbr\u003e6. Eye conditions \u003cbr\u003e7. Athlete’s foot \u003cbr\u003e8. Foot (podiatric) problems \u003cbr\u003e9. Fungal nail infection (onychomycosis) \u003cbr\u003e10. Verrucas (plantar warts) and warts (common warts) \u003cbr\u003e11. Constipation \u003cbr\u003e12. Diarrhoea \u003cbr\u003e13. Haemorrhoids (piles) \u003cbr\u003e14. Irritable bowel syndrome \u003cbr\u003e15. Indigestion \u003cbr\u003e16. Mouth ulcers (minor aphthous ulcers) \u003cbr\u003e17. Head lice \u003cbr\u003e18. Scabies \u003cbr\u003e19. Threadworm \u003cbr\u003e20. Benign prostatic hyperplasia \u003cbr\u003e21. Erectile dysfunction \u003cbr\u003e22. Musculoskeletal conditions \u003cbr\u003e23. Common cold and influenza \u003cbr\u003e24. Cough \u003cbr\u003e25. Hay fever \u003cbr\u003e26. Nicotine replacement therapy \u003cbr\u003e27. Acne \u003cbr\u003e28. Cold sores (oral herpes simplex) \u003cbr\u003e29. Eczema\/dermatitis \u003cbr\u003e30. Fungal skin infections \u003cbr\u003e31. Scalp conditions \u003cbr\u003e32. Cystitis \u003cbr\u003e33. Menstrual disorders – dysmenorrhoea and menorrhagia \u003cbr\u003e34. Emergency hormonal contraception \u003cbr\u003e35. Premenstrual syndrome \u003cbr\u003e36. Vaginal thrush\u003c\/p\u003e","brand":"Pharmaceutical Press","offers":[{"title":"Default Title","offer_id":48866068791639,"sku":"9780857113887","price":26.6,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780857113887.jpg?v=1722276888"},{"product_id":"immunohistochemistry-and-immunocytochemistry-9781118717776","title":"Immunohistochemistry and Immunocytochemistry","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eImmunohistochemistry and immunocytochemistry are invaluable tools for the visualization of tissue and cellular antigens in diagnostic and biological research environments. The need to obtain accurate, reliable and reproducible results is paramount.\u003cbr\u003e\u003cbr\u003eIt is with this fundamental aim in mind that we have compiled Immunohistochemistry: Essential Methods. We have achieved this by examining each aspect of immunochemistry in turn, with each chapter including detailed information regarding the subject matter in question. Each chapter is written by an expert in their field and includes protocols that are typically used in their own research. Subjects covered are, amongst others, antibodies and their production; selection of reporter labels; immunochemical staining methods and experimental design (both using single and multiple reporter labels); quality assurance; automated immunochemistry; confocal microscopy and electron microscopy. In addition, benefits and limitations of each appro\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eList of Contributors vii \u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eAcknowledgements xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1: Antibodies for Immunochemistry 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMark Cooper and Sheriden Lummas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 1\u003c\/p\u003e \u003cp\u003eImmunogens for Antibody Production 5\u003c\/p\u003e \u003cp\u003eAntibody Production 12\u003c\/p\u003e \u003cp\u003eAntibody Purification 16\u003c\/p\u003e \u003cp\u003eFragment Antibody Preparations 20\u003c\/p\u003e \u003cp\u003eAntibody Labelling 21\u003c\/p\u003e \u003cp\u003eAntibody Stability and Storage 23\u003c\/p\u003e \u003cp\u003eReferences 24\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2: The Selection of Reporter Labels 25\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJudith Langenick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 25\u003c\/p\u003e \u003cp\u003eEnzymatic Labels 26\u003c\/p\u003e \u003cp\u003eFluorescence Detection 29\u003c\/p\u003e \u003cp\u003eReferences 32\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3: Immunohistochemistry and Immunocytochemistry 35\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSimon Renshaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSpecimen Formats for Immunochemistry 36\u003c\/p\u003e \u003cp\u003eFixation 37\u003c\/p\u003e \u003cp\u003eProcessing Tissue Blocks to Paraffin Wax 46\u003c\/p\u003e \u003cp\u003eMicrotomy 47\u003c\/p\u003e \u003cp\u003eTissue Microarrays 47\u003c\/p\u003e \u003cp\u003eSpecimen Storage 48\u003c\/p\u003e \u003cp\u003eDecalcification 49\u003c\/p\u003e \u003cp\u003eAntigen Retrieval 50\u003c\/p\u003e \u003cp\u003eControls 56\u003c\/p\u003e \u003cp\u003eImmunochemical Staining Techniques (Optimizing a New Antibody) 57\u003c\/p\u003e \u003cp\u003eCounterstains 71\u003c\/p\u003e \u003cp\u003eMounting 74\u003c\/p\u003e \u003cp\u003eTroubleshooting 76\u003c\/p\u003e \u003cp\u003eExamples of Immunostaining Photomicrographs 76\u003c\/p\u003e \u003cp\u003eAcknowledgements 101\u003c\/p\u003e \u003cp\u003eReferences 101\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4: Multiple Immunochemical Staining Techniques 103\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSofia Koch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 103\u003c\/p\u003e \u003cp\u003eMethods and Approaches 115\u003c\/p\u003e \u003cp\u003eReferences 122\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5: Quality Assurance in Immunochemistry 123\u003c\/b\u003e\u003cbr\u003e\u003ci\u003ePeter Jackson and Michael Gandy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 123\u003c\/p\u003e \u003cp\u003eMethods and Approaches 125\u003c\/p\u003e \u003cp\u003eAutomated Immunochemical Staining 147\u003c\/p\u003e \u003cp\u003eTroubleshooting 149\u003c\/p\u003e \u003cp\u003eReferences 154\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6: Automated Immunochemistry 157\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eEmanuel Schenck and Simon Renshaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 157\u003c\/p\u003e \u003cp\u003eMethods and Approaches 160\u003c\/p\u003e \u003cp\u003eOther Forms of Automation 164\u003c\/p\u003e \u003cp\u003eReferences 168\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7: Confocal Microscopy 169\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnn Wheeler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 169\u003c\/p\u003e \u003cp\u003eWhen Should Confocal be Used? 173\u003c\/p\u003e \u003cp\u003eApplications: For Example Co-localization, Quantification, 3D Visualization and Kinetics 173\u003c\/p\u003e \u003cp\u003eHow To Set Up a Confocal Experiment? 174\u003c\/p\u003e \u003cp\u003eReferences 198\u003c\/p\u003e \u003cp\u003eFurther Readings 198\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8: Ultrastructural Immunochemistry 199\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJeremy Skepper and Janet Powell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 199\u003c\/p\u003e \u003cp\u003eMethods and Approaches 207\u003c\/p\u003e \u003cp\u003eReferences 222\u003c\/p\u003e \u003cp\u003eIndex 227\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":48866376188247,"sku":"9781118717776","price":47.45,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118717776.jpg?v=1722278359"},{"product_id":"immunophenotyping-for-haematologists-9781119606116","title":"Immunophenotyping for Haematologists","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eOffers clear and concise instruction on running, reporting and interpreting immunophenotyping studies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWritten by two well-known haematology educators and experts on the topic, \u003ci\u003eImmunophenotyping for Haematologists\u003c\/i\u003e contains an introduction to running, reporting and interpreting immunophenotyping studies. The book offers a unique approach to the topic by putting the focus on clinical and laboratory haematologists who are not routinely involved in running and reporting on immunophenotyping studies.\u003c\/p\u003e \u003cp\u003eImmunophenotyping using flow cytometry has become the method of choice in identifying and sorting cells within complex populations, for example, the analysis of immune or neoplastic cells in a blood sample. The text reviews the purpose and principles of immunophenotyping and includes an introduction and explanation of the principles and the role of immunophenotyping. The authors examine immunophenotypic characteristics of the disease groups commonly encountered and\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePreface and Acknowledgement vii\u003c\/p\u003e \u003cp\u003eAbbreviations Used in the Book ix\u003c\/p\u003e \u003cp\u003ePart 1 Purpose and Principles of Immunophenotyping 1\u003c\/p\u003e \u003cp\u003ePart 2 Immunophenotyping for Haematologists 11\u003c\/p\u003e \u003cp\u003ePart 3 Immunophenotyping in the Diagnosis and Monitoring of Haematological Neoplasms and Related Conditions with Tables and Figures for Quick Reference 47\u003c\/p\u003e \u003cp\u003ePart 4 Test Yourself 89\u003c\/p\u003e \u003cp\u003eIndex 127\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":48866405318999,"sku":"9781119606116","price":88.16,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119606116.jpg?v=1722278489"},{"product_id":"diagnostic-electron-microscopy-9781119973997","title":"Diagnostic Electron Microscopy","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIntegrating detailed methodology with basic interpretation of the commonly encountered diagnostic problems in electron microscopy,   Diagnostic Electron Microscopy provides a basic stand-alone diagnostic 'how to' book.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e“Thus, this book is a “must-have” for all pathology departments, even if they are not equipped with an EM facility, and it is also a solid proof of the current role of electron microscopy in health care.”  (\u003ci\u003eMicroscopy \u0026amp; Microanalysis\u003c\/i\u003e, 1 August 2013)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors xvii\u003c\/p\u003e \u003cp\u003ePreface – Introduction xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Renal Disease 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJohn W. Stirling and Alan Curry\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 The Role of Transmission Electron Microscopy (TEM) in Renal Diagnostics 1\u003c\/p\u003e \u003cp\u003e1.2 Ultrastructural Evaluation and Interpretation 2\u003c\/p\u003e \u003cp\u003e1.3 The Normal Glomerulus 3\u003c\/p\u003e \u003cp\u003e1.3.1 The Glomerular Basement Membrane 4\u003c\/p\u003e \u003cp\u003e1.4 Ultrastructural Diagnostic Features 5\u003c\/p\u003e \u003cp\u003e1.4.1 Deposits: General Features 5\u003c\/p\u003e \u003cp\u003e1.4.2 Granular and Amorphous Deposits 6\u003c\/p\u003e \u003cp\u003e1.4.3 Organised Deposits: Fibrils and Tubules 7\u003c\/p\u003e \u003cp\u003e1.4.4 Nonspecific Fibrils 11\u003c\/p\u003e \u003cp\u003e1.4.5 General and Nonspecific Inclusions and Deposits 11\u003c\/p\u003e \u003cp\u003e1.4.6 Fibrin 12\u003c\/p\u003e \u003cp\u003e1.4.7 Tubuloreticular Bodies (Tubuloreticular Inclusions) 12\u003c\/p\u003e \u003cp\u003e1.4.8 The Glomerular Basement Membrane 13\u003c\/p\u003e \u003cp\u003e1.4.9 The Mesangial Matrix 14\u003c\/p\u003e \u003cp\u003e1.4.10 Cellular Components of the Glomerulus 14\u003c\/p\u003e \u003cp\u003e1.4.11 Parietal Epithelium 16\u003c\/p\u003e \u003cp\u003e1.5 The Ultrastructural Pathology of the Major Glomerular Diseases 16\u003c\/p\u003e \u003cp\u003e1.5.1 Diseases without, or with Only Minor, Structural GBM Changes 16\u003c\/p\u003e \u003cp\u003e1.5.2 Diseases with Structural GBM Changes 19\u003c\/p\u003e \u003cp\u003e1.5.3 Diseases with Granular Deposits 25\u003c\/p\u003e \u003cp\u003e1.5.4 Diseases with Organised Deposits 40\u003c\/p\u003e \u003cp\u003e1.5.5 Hereditary Metabolic Storage Disorders 46\u003c\/p\u003e \u003cp\u003eReferences 47\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Transplant Renal Biopsies 55\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJohn Brealey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 55\u003c\/p\u003e \u003cp\u003e2.2 The Transplant Renal Biopsy 55\u003c\/p\u003e \u003cp\u003e2.3 Indications for Electron Microscopy of Transplant Kidney 56\u003c\/p\u003e \u003cp\u003e2.3.1 Transplant Glomerulopathy 56\u003c\/p\u003e \u003cp\u003e2.3.2 Recurrent Primary Disease 64\u003c\/p\u003e \u003cp\u003e2.3.3 De Novo Glomerular Disease 72\u003c\/p\u003e \u003cp\u003e2.3.4 Donor-Related Disease 74\u003c\/p\u003e \u003cp\u003e2.3.5 Infection 74\u003c\/p\u003e \u003cp\u003e2.3.6 Inconclusive Diagnosis by LM and\/or IM 79\u003c\/p\u003e \u003cp\u003e2.3.7 Miscellaneous Topics 81\u003c\/p\u003e \u003cp\u003eReferences 84\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Electron Microscopy in Skeletal Muscle Pathology 89\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eElizabeth Curtis and Caroline Sewry\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 89\u003c\/p\u003e \u003cp\u003e3.1.1 The Biopsy Procedure 90\u003c\/p\u003e \u003cp\u003e3.1.2 Sampling 90\u003c\/p\u003e \u003cp\u003e3.1.3 Tissue Processing 90\u003c\/p\u003e \u003cp\u003e3.1.4 Artefacts 91\u003c\/p\u003e \u003cp\u003e3.2 Normal Muscle 91\u003c\/p\u003e \u003cp\u003e3.3 Pathological Changes 96\u003c\/p\u003e \u003cp\u003e3.3.1 Sarcolemma 96\u003c\/p\u003e \u003cp\u003e3.3.2 Myofibrils 99\u003c\/p\u003e \u003cp\u003e3.3.3 Glycogen 102\u003c\/p\u003e \u003cp\u003e3.3.4 Cores 104\u003c\/p\u003e \u003cp\u003e3.3.5 Target Fibres 105\u003c\/p\u003e \u003cp\u003e3.3.6 Myonuclei 105\u003c\/p\u003e \u003cp\u003e3.3.7 Mitochondria 106\u003c\/p\u003e \u003cp\u003e3.3.8 Reticular System 108\u003c\/p\u003e \u003cp\u003e3.3.9 Vacuoles 109\u003c\/p\u003e \u003cp\u003e3.3.10 Capillaries 110\u003c\/p\u003e \u003cp\u003e3.3.11 Other Structural Defects 111\u003c\/p\u003e \u003cp\u003eReferences 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Diagnostic Electron Microscopy of Nerve 117\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eRosalind King\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 117\u003c\/p\u003e \u003cp\u003e4.2 Tissue Processing 118\u003c\/p\u003e \u003cp\u003e4.2.1 Preparation of Nerve Biopsy Specimens 118\u003c\/p\u003e \u003cp\u003e4.3 Normal Nerve Ultrastructure 120\u003c\/p\u003e \u003cp\u003e4.3.1 Axons 120\u003c\/p\u003e \u003cp\u003e4.3.2 Schwann Cells 120\u003c\/p\u003e \u003cp\u003e4.3.3 The Myelin Sheath 120\u003c\/p\u003e \u003cp\u003e4.3.4 Node of Ranvier 122\u003c\/p\u003e \u003cp\u003e4.3.5 Paranode 123\u003c\/p\u003e \u003cp\u003e4.3.6 Juxtaparanode 123\u003c\/p\u003e \u003cp\u003e4.3.7 Internode 123\u003c\/p\u003e \u003cp\u003e4.3.8 Schmidt–Lanterman Incisures 124\u003c\/p\u003e \u003cp\u003e4.3.9 Remak Fibres 124\u003c\/p\u003e \u003cp\u003e4.3.10 Fibroblasts 124\u003c\/p\u003e \u003cp\u003e4.3.11 Renaut Bodies 125\u003c\/p\u003e \u003cp\u003e4.4 Pathological Ultrastructural Features 125\u003c\/p\u003e \u003cp\u003e4.4.1 Axonal Degeneration 125\u003c\/p\u003e \u003cp\u003e4.4.2 Axonal Regeneration 126\u003c\/p\u003e \u003cp\u003e4.4.3 Remak Fibre Abnormalities 128\u003c\/p\u003e \u003cp\u003e4.4.4 Polyglucosan Bodies 128\u003c\/p\u003e \u003cp\u003e4.4.5 Nonspecific Axonal Inclusions 128\u003c\/p\u003e \u003cp\u003e4.4.6 Demyelination and Remyelination 130\u003c\/p\u003e \u003cp\u003e4.4.7 Specific Schwann Cell Inclusions 135\u003c\/p\u003e \u003cp\u003e4.4.8 Nonspecific Schwann Cell Inclusions 136\u003c\/p\u003e \u003cp\u003e4.4.9 Fibroblasts 142\u003c\/p\u003e \u003cp\u003e4.4.10 Perineurial Abnormalities 142\u003c\/p\u003e \u003cp\u003e4.4.11 Cellular Infiltration 143\u003c\/p\u003e \u003cp\u003e4.4.12 Endoneurial Oedema 143\u003c\/p\u003e \u003cp\u003e4.4.13 Connective Tissue Abnormalities 143\u003c\/p\u003e \u003cp\u003e4.4.14 Endoneurial Blood Vessels 145\u003c\/p\u003e \u003cp\u003e4.4.15 Mast Cells 145\u003c\/p\u003e \u003cp\u003e4.5 Artefact 145\u003c\/p\u003e \u003cp\u003e4.6 Conclusions 147\u003c\/p\u003e \u003cp\u003eReferences 148\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Diagnostic Electron Microscopy of Tumours 153\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eBrian Eyden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 153\u003c\/p\u003e \u003cp\u003e5.2 Principles and Procedures for Diagnosing Tumours by Electron Microscopy 154\u003c\/p\u003e \u003cp\u003e5.2.1 The Objective of Tumour Diagnosis 154\u003c\/p\u003e \u003cp\u003e5.2.2 The Intellectual Requirements for Tumour Diagnosis by Electron Microscopy 155\u003c\/p\u003e \u003cp\u003e5.2.3 Technical Considerations 156\u003c\/p\u003e \u003cp\u003e5.2.4 Identifying Good Preservation 158\u003c\/p\u003e \u003cp\u003e5.2.5 Distinguishing Reactive from Neoplastic Cells 162\u003c\/p\u003e \u003cp\u003e5.3 Organelles and Groups of Cell Structures Defining Cellular Differentiation 162\u003c\/p\u003e \u003cp\u003e5.3.1 Rough Endoplasmic Reticulum 162\u003c\/p\u003e \u003cp\u003e5.3.2 Melanosomes 165\u003c\/p\u003e \u003cp\u003e5.3.3 Desmosomes 167\u003c\/p\u003e \u003cp\u003e5.3.4 Tonofibrils 167\u003c\/p\u003e \u003cp\u003e5.3.5 Basal Lamina 169\u003c\/p\u003e \u003cp\u003e5.3.6 Glandular Epithelial Differentiation and Cell Processes 171\u003c\/p\u003e \u003cp\u003e5.3.7 Neuroendocrine Granules 171\u003c\/p\u003e \u003cp\u003e5.3.8 Smooth-Muscle Myofilaments 173\u003c\/p\u003e \u003cp\u003e5.3.9 Sarcomeric Myofilaments (Thick-and-Thin Filaments with Z-Disks) 176\u003c\/p\u003e \u003cp\u003eReferences 178\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Microbial Ultrastructure 181\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAlan Curry\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 181\u003c\/p\u003e \u003cp\u003e6.2 Practical Guidance 182\u003c\/p\u003e \u003cp\u003e6.3 Viruses 183\u003c\/p\u003e \u003cp\u003e6.4 Current Use of EM in Virology 185\u003c\/p\u003e \u003cp\u003e6.5 Viruses in Thin Sections of Cells or Tissues 186\u003c\/p\u003e \u003cp\u003e6.6 Bacteria 191\u003c\/p\u003e \u003cp\u003e6.7 Fungal Organisms 194\u003c\/p\u003e \u003cp\u003e6.8 Microsporidia 196\u003c\/p\u003e \u003cp\u003e6.9 Parasitic Protozoa 206\u003c\/p\u003e \u003cp\u003e6.9.1 Cryptosporidium 207\u003c\/p\u003e \u003cp\u003e6.9.2 Isospora belli 211\u003c\/p\u003e \u003cp\u003e6.10 Examples of Non-enteric Protozoa 212\u003c\/p\u003e \u003cp\u003e6.11 Parasitic Amoebae 213\u003c\/p\u003e \u003cp\u003e6.12 Conclusions 214\u003c\/p\u003e \u003cp\u003eAcknowledgements 214\u003c\/p\u003e \u003cp\u003eReferences and Additional Reading 214\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 The Contemporary Use of Electron Microscopy in the Diagnosis of Ciliary Disorders and Sperm Centriolar Abnormalities 221\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eP. Yiallouros, M. Nearchou, A. Hadjisavvas and K. Kyriacou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 221\u003c\/p\u003e \u003cp\u003e7.2 Ultrastructure of Motile Cilia 224\u003c\/p\u003e \u003cp\u003e7.3 Genetics of PCD 226\u003c\/p\u003e \u003cp\u003e7.4 Current Diagnostic Modalities 228\u003c\/p\u003e \u003cp\u003e7.5 Clinical Features 229\u003c\/p\u003e \u003cp\u003e7.6 Procurement and Assessment of Ciliated Specimens 230\u003c\/p\u003e \u003cp\u003e7.7 Centriolar Sperm Abnormalities 231\u003c\/p\u003e \u003cp\u003e7.8 Discussion 232\u003c\/p\u003e \u003cp\u003eAcknowledgements 234\u003c\/p\u003e \u003cp\u003eReferences 234\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Electron Microscopy as a Useful Tool in the Diagnosis of Lysosomal Storage Diseases 237\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJoseph Alroy, Rolf Pfannl and Angelo A. Ucci\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 237\u003c\/p\u003e \u003cp\u003e8.2 Morphological Findings 247\u003c\/p\u003e \u003cp\u003e8.3 Conclusion 261\u003c\/p\u003e \u003cp\u003eReferences 262\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) 269\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJohn W. Stirling\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 269\u003c\/p\u003e \u003cp\u003e9.2 Diagnostic Strategies – Comparative Specificity and Sensitivity 271\u003c\/p\u003e \u003cp\u003e9.3 Diagnosis by TEM 271\u003c\/p\u003e \u003cp\u003eReferences 274\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Diagnosis of Platelet Disorders by Electron Microscopy 277\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHilary Christensen and Walter H.A. Kahr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 277\u003c\/p\u003e \u003cp\u003e10.2 TEM Preparation of Platelets 278\u003c\/p\u003e \u003cp\u003e10.3 Whole-Mount EM Preparation of Platelets 280\u003c\/p\u003e \u003cp\u003e10.4 EM Preparation of Bone Marrow 281\u003c\/p\u003e \u003cp\u003e10.5 Pre-embed Immunogold Labelling of Von Willibrand Factor in Platelets 282\u003c\/p\u003e \u003cp\u003e10.6 Ultrastructural Features of Platelets 282\u003c\/p\u003e \u003cp\u003e10.7 Normal Platelets 283\u003c\/p\u003e \u003cp\u003e10.8 Grey Platelet Syndrome 285\u003c\/p\u003e \u003cp\u003e10.9 Arthrogryposis, Renal Dysfunction and Cholestasis Syndrome 285\u003c\/p\u003e \u003cp\u003e10.10 Jacobsen Syndrome 285\u003c\/p\u003e \u003cp\u003e10.11 Hermansky–Pudlak Syndrome, Chediak–Higashi Syndrome and Other Dense-Granule Deficiencies 287\u003c\/p\u003e \u003cp\u003e10.12 Type 2B von Willebrand Disease and Platelet-Type von Willebrand Disease 288\u003c\/p\u003e \u003cp\u003eReferences 290\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Diagnosis of Congenital Dyserythropoietic Anaemia Types I and II by Transmission Electron Microscopy 293\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYong-xin Ru\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 293\u003c\/p\u003e \u003cp\u003e11.2 Preparation of Bone Marrow and General Observation Protocol 294\u003c\/p\u003e \u003cp\u003e11.3 CDA Type I 294\u003c\/p\u003e \u003cp\u003e11.3.1 Proerythroblasts and Basophilic Erythroblasts 294\u003c\/p\u003e \u003cp\u003e11.3.2 Polychromatic and Orthochromatic Erythroblasts 295\u003c\/p\u003e \u003cp\u003e11.3.3 Reticulocytes and Erythrocytes 299\u003c\/p\u003e \u003cp\u003e11.4 CDA Type II 299\u003c\/p\u003e \u003cp\u003e11.4.1 Erythroblasts 301\u003c\/p\u003e \u003cp\u003e11.4.2 Erythrocytes 306\u003c\/p\u003e \u003cp\u003e11.5 Summary 306\u003c\/p\u003e \u003cp\u003eAcknowledgements 307\u003c\/p\u003e \u003cp\u003eReferences 307\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Ehlers–Danlos Syndrome 309\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eTrinh Hermanns-L\u003c\/i\u003e\u003ci\u003eê, Marie-Annick Reginster, Claudine Pi\u003c\/i\u003e\u003ci\u003eérard-Franchimont and G\u003ci\u003eé\u003c\/i\u003erald E. Pi\u003c\/i\u003e\u003ci\u003eérard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 309\u003c\/p\u003e \u003cp\u003e12.2 Collagen Fibrils 310\u003c\/p\u003e \u003cp\u003e12.3 Elastic Fibers 310\u003c\/p\u003e \u003cp\u003e12.4 Nonfibrous Stroma and Granulo-Filamentous Deposits 311\u003c\/p\u003e \u003cp\u003e12.5 Connective Tissue Disorders 311\u003c\/p\u003e \u003cp\u003e12.5.1 Ehlers–Danlos Syndrome 311\u003c\/p\u003e \u003cp\u003e12.5.2 Spontaneous Cervical Artery Dissection 317\u003c\/p\u003e \u003cp\u003e12.5.3 Recurrent Preterm Premature Rupture of Fetal Membrane Syndrome 319\u003c\/p\u003e \u003cp\u003eReferences 319\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Electron Microscopy in Occupational and Environmental Lung Disease 323\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eVictor L. Roggli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 323\u003c\/p\u003e \u003cp\u003e13.2 Asbestos 324\u003c\/p\u003e \u003cp\u003e13.2.1 Preparatory Techniques 324\u003c\/p\u003e \u003cp\u003e13.2.2 Analytical Methodology 326\u003c\/p\u003e \u003cp\u003e13.2.3 Asbestos-Related Diseases 326\u003c\/p\u003e \u003cp\u003e13.2.4 Exposure Categories 330\u003c\/p\u003e \u003cp\u003e13.3 Hypersensitivity Pneumonitis and Sarcoidosis 330\u003c\/p\u003e \u003cp\u003e13.3.1 Preparatory Techniques and Analytical Methodology 331\u003c\/p\u003e \u003cp\u003e13.4 Silicosis 331\u003c\/p\u003e \u003cp\u003e13.4.1 Preparatory Techniques and Analytical Methodology 333\u003c\/p\u003e \u003cp\u003e13.5 Silicate Pneumoconiosis 333\u003c\/p\u003e \u003cp\u003e13.5.1 Talc Pneumoconiosis 333\u003c\/p\u003e \u003cp\u003e13.5.2 Kaolin Worker’s Pneumoconiosis 334\u003c\/p\u003e \u003cp\u003e13.5.3 Mica and Feldspar Pneumoconiosis 334\u003c\/p\u003e \u003cp\u003e13.5.4 Mixed Dust Pneumoconiosis 335\u003c\/p\u003e \u003cp\u003e13.5.5 Preparatory Techniques and Analytical Methodology 335\u003c\/p\u003e \u003cp\u003e13.6 Metal-Induced Diseases 335\u003c\/p\u003e \u003cp\u003e13.6.1 Siderosis 336\u003c\/p\u003e \u003cp\u003e13.6.2 Aluminosis 336\u003c\/p\u003e \u003cp\u003e13.6.3 Hard Metal Lung Disease 336\u003c\/p\u003e \u003cp\u003e13.6.4 Berylliosis 337\u003c\/p\u003e \u003cp\u003e13.6.5 Preparatory Techniques and Analytical Methodology 337\u003c\/p\u003e \u003cp\u003e13.7 Rare-Earth Pneumoconiosis 338\u003c\/p\u003e \u003cp\u003e13.8 Miscellaneous Disorders 338\u003c\/p\u003e \u003cp\u003eReferences 339\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 General Tissue Preparation Methods 341\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJohn W. Stirling\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 341\u003c\/p\u003e \u003cp\u003e14.1.1 Specimens Suitable for Diagnostic TEM 341\u003c\/p\u003e \u003cp\u003e14.2 Tissue Collection and Dissection 342\u003c\/p\u003e \u003cp\u003e14.2.1 Tissue Cut-Up 343\u003c\/p\u003e \u003cp\u003e14.3 Tissue Processing 345\u003c\/p\u003e \u003cp\u003e14.3.1 Fixatives and Fixation 345\u003c\/p\u003e \u003cp\u003e14.3.2 Primary Fixation: Glutaraldehyde 347\u003c\/p\u003e \u003cp\u003e14.3.3 Secondary Fixation (Post-fixation): Osmium Tetroxide 347\u003c\/p\u003e \u003cp\u003e14.3.4 Fixative Vehicles and Wash Buffers 347\u003c\/p\u003e \u003cp\u003e14.3.5 En Bloc Staining with Uranyl Acetate 348\u003c\/p\u003e \u003cp\u003e14.3.6 Dehydrant and Transition Fluids 348\u003c\/p\u003e \u003cp\u003e14.3.7 Resin Infiltration and Embedding Media 349\u003c\/p\u003e \u003cp\u003e14.3.8 Tissue Embedding 352\u003c\/p\u003e \u003cp\u003e14.4 Tissue Sectioning 352\u003c\/p\u003e \u003cp\u003e14.4.1 Ultramicrotomy 352\u003c\/p\u003e \u003cp\u003e14.4.2 Sectioning Technique and Ultramicrotome Setup 355\u003c\/p\u003e \u003cp\u003e14.4.3 Common Sectioning Problems and Artefacts 356\u003c\/p\u003e \u003cp\u003e14.4.4 Section Staining 362\u003c\/p\u003e \u003cp\u003e14.4.5 Section Contamination and Staining Artefacts 363\u003c\/p\u003e \u003cp\u003eProtocol 364\u003c\/p\u003e \u003cp\u003eProcessing Schedules 364\u003c\/p\u003e \u003cp\u003eReferences 379\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Ultrastructural Pathology Today – Paradigm Change and the Impact of Microwave Technology and Telemicroscopy 383\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJosef A. Schroeder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Diagnostic Electron Microscopy and Paradigm Shift in Pathology 383\u003c\/p\u003e \u003cp\u003e15.2 Standardised and Automated Conventional Tissue Processing 385\u003c\/p\u003e \u003cp\u003e15.3 Microwave-Assisted Sample Preparation 390\u003c\/p\u003e \u003cp\u003e15.4 Cyberspace for Telepathology via the Internet 397\u003c\/p\u003e \u003cp\u003e15.5 Conclusions and Future Prospects 400\u003c\/p\u003e \u003cp\u003eAcknowledgements 404\u003c\/p\u003e \u003cp\u003eReferences 404\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Electron Microscopy Methods in Virology 409\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAlan Curry\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Biological Safety Precautions 409\u003c\/p\u003e \u003cp\u003e16.2 Collection of Specimens 410\u003c\/p\u003e \u003cp\u003e16.3 Preparation of Faeces, Vomitus or Urine Samples 410\u003c\/p\u003e \u003cp\u003e16.4 Viruses in Skin Lesions 410\u003c\/p\u003e \u003cp\u003e16.5 Reagents and Methods 411\u003c\/p\u003e \u003cp\u003e16.5.1 Negative Stains 411\u003c\/p\u003e \u003cp\u003e16.6 Coated Grids 412\u003c\/p\u003e \u003cp\u003e16.7 Important Elements in the Negative Staining Procedure 412 \u003c\/p\u003e \u003cp\u003e16.8 TEM Examination 413\u003c\/p\u003e \u003cp\u003e16.9 Immunoelectron Microscopy 413\u003c\/p\u003e \u003cp\u003e16.9.1 Immune Clumping 413\u003c\/p\u003e \u003cp\u003e16.9.2 Solid-Phase Immunoelectron Microscopy 413\u003c\/p\u003e \u003cp\u003e16.9.3 Immunogold Labelling 414\u003c\/p\u003e \u003cp\u003e16.9.4 Particle Measurement 414\u003c\/p\u003e \u003cp\u003e16.10 Thin Sectioning of Virus-Infected Cells or Tissues 414\u003c\/p\u003e \u003cp\u003e16.11 Virology Quality Assurance (QA) Procedures 415\u003c\/p\u003e \u003cp\u003e16.11.1 External QA 415\u003c\/p\u003e \u003cp\u003e16.11.2 Internal QA 415\u003c\/p\u003e \u003cp\u003eAcknowledgements 415\u003c\/p\u003e \u003cp\u003eReferences 416\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Digital Imaging for Diagnostic Transmission Electron Microscopy 419\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGary Paul Edwards\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 419\u003c\/p\u003e \u003cp\u003e17.2 Camera History 419\u003c\/p\u003e \u003cp\u003e17.3 The Pixel Dilemma 420\u003c\/p\u003e \u003cp\u003e17.4 Camera Positioning 421\u003c\/p\u003e \u003cp\u003e17.5 Resolution 422\u003c\/p\u003e \u003cp\u003e17.6 Fibre Coupled or Lens Coupled? 423\u003c\/p\u003e \u003cp\u003e17.7 Sensitivity, Noise and Dynamic Range 424\u003c\/p\u003e \u003cp\u003e17.8 CCD Chip Type (Full Frame or Interline) 426\u003c\/p\u003e \u003cp\u003e17.9 Binning and Frame Rate 426\u003c\/p\u003e \u003cp\u003e17.10 Software 427\u003c\/p\u003e \u003cp\u003e17.11 Choosing the Right Camera 428\u003c\/p\u003e \u003cp\u003eReferences 429\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Uncertainty of Measurement 431\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePierre Filion\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 431\u003c\/p\u003e \u003cp\u003e18.2 Purpose 432\u003c\/p\u003e \u003cp\u003e18.2.1 Diagnostic Value 432\u003c\/p\u003e \u003cp\u003e18.2.2 Internal Quality Control 432\u003c\/p\u003e \u003cp\u003e18.2.3 External Quality Control and Accreditation 432\u003c\/p\u003e \u003cp\u003e18.3 Factors That Influence Quantitative Measurements 433\u003c\/p\u003e \u003cp\u003e18.3.1 Sources of Variation 433\u003c\/p\u003e \u003cp\u003e18.3.2 Alteration of the Intrinsic Dimension of the Structure 434\u003c\/p\u003e \u003cp\u003e18.3.3 Variation Due to the Analytical Equipment and Method 436\u003c\/p\u003e \u003cp\u003e18.3.4 Variation Due to Selection Bias 438\u003c\/p\u003e \u003cp\u003e18.3.5 Measurement Using a Digital Camera 439\u003c\/p\u003e \u003cp\u003e18.4 How to Calculate the UM 440\u003c\/p\u003e \u003cp\u003e18.4.1 Steps Required to Analyse and Calculate the UM 440\u003c\/p\u003e \u003cp\u003e18.4.2 Type of Error and Distribution of Measurements 440\u003c\/p\u003e \u003cp\u003e18.4.3 Calculating the UM 442\u003c\/p\u003e \u003cp\u003e18.4.4 Precision of Measurement and Biological Significance 443\u003c\/p\u003e \u003cp\u003e18.4.5 The Electronic Spread Sheet as an Aid to Calculating UM 443\u003c\/p\u003e \u003cp\u003e18.4.6 Reporting the UM 444\u003c\/p\u003e \u003cp\u003e18.5 Worked Examples 444\u003c\/p\u003e \u003cp\u003e18.5.1 Diameter of Fibrils in a Glomerular Deposit 444\u003c\/p\u003e \u003cp\u003e18.5.2 Thickness of the Glomerular Basement Membrane 445\u003c\/p\u003e \u003cp\u003e18.6 Conclusion 446\u003c\/p\u003e \u003cp\u003eReferences 447\u003c\/p\u003e \u003cp\u003eIndex 449\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48866426782039,"sku":"9781119973997","price":77.36,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119973997.jpg?v=1722278592"},{"product_id":"first-aid-clinical-algorithms-for-the-usmle-step-2-ck-9781264270132","title":"First Aid Clinical Algorithms for the USMLE Step","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eFirst Aidâ remains the most trusted name in USMLE  reviewâjust ask any medical student!\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003ci\u003eFirst Aid Clinical Algorithms for the USMLE Step 2 CK \u003c\/i\u003ewas designed to help you develop and refine your clinical thinking skillsâpreparing you for success in your clerkship and on the Step 2 CK exam. This new addition to the First Aidâ series uses an algorithmic approach that allows you to methodically walk through the diagnostic decision making process.\u003c\/p\u003e\u003cp\u003eThe content is organized by symptom to reflect how information will be presented in an actual clinical setting. Clinical vignettes focusing on specific illnesses are followed by step-by-step flowcharts outlining the diagnosis and treatment of the illness and its relevant differential diagnoses.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eUnique algorithmic approach\u003c\/li\u003e\n\u003cli\u003eClinical vignettes accompany decision-making algorithms\u003c\/li\u003e\n\u003cli\u003e Flowcharts outline the diagnosis and treatment process\u003cp\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"McGraw-Hill Education","offers":[{"title":"Default Title","offer_id":48866498576727,"sku":"9781264270132","price":40.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781264270132.jpg?v=1722278946"},{"product_id":"lab-literacy-for-doctors-a-guide-to-ordering-the-right-tests-for-better-patient-care-9781550595765","title":"Lab Literacy for Doctors: A Guide to Ordering the","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eFinally, a highly readable, practical guide for physicians that focuses on the ordering of laboratory tests based on the underlying clinical context. A valuable resource that promises to advance health care quality through promoting patient-centred, appropriate care.--Richard G. Hegele, MD, FRCPC, PhD -- Professor \u0026amp; Chair, Dept. of Laboratory Medicine \u0026amp; Pathobiology, University of Toronto; Chief, Dept. of Paediatric Laboratory Medicine, The Hospital for Sick Children Appropriate utilization of clinical laboratory tests is an important part of practicing medicine in the 21st century. Dr. Naugler has done an excellent job by providing the most up-to-date information in a relatively complicated subject in an easy-to-follow format.--Hossein Sadrzadeh, PhD, DABCC, FACB -- Chief, Clinical Biochemistry Section, Calgary Laboratory Services; Clinical Professor, Pathology and Laboratory Medicine, University of Calgary \"This is a great book to have handy when questioned about the most appropriate laboratory testing strategy for diagnosis or management. Your reputation as an expert consultant will dramatically increase. Get it!\" -- Valerie Ng, PhD, MD (Alameda County Medical Center\/Highland Hospital) Doody Review: 94\/100 \"This is a great book to have handy when questioned about the most appropriate laboratory testing strategy for diagnosis or management. Your reputation as an expert consultant will dramatically increase. Get it!\" - Valerie Ng, PhD, MD (Alameda County Medical Center\/Highland Hospital) Doody Review: 94\/100 Doody Review: 94\/100 This is a great book to have handy when questioned about the most appropriate laboratory testing strategy for diagnosis or management. Your reputation as an expert consultant will dramatically increase. Get it! Valerie Ng, PhD, MD (Alameda County Medical Center\/Highland Hospital)\" Doody Review: 4 Stars, 94\/100 ?This is a great book to have handy when questioned about the most appropriate laboratory testing strategy for diagnosis or management. Your reputation as an expert consultant will dramatically increase. Get it! - Valerie Ng, PhD, MD, Alameda County Medical Center\/Highland Hospital Doody Review: 4 Stars, 94\/100  This is a great book to have handy when questioned about the most appropriate laboratory testing strategy for diagnosis or management. Your reputation as an expert consultant will dramatically increase. Get it! - Valerie Ng, PhD, MD, Alameda County Medical Center\/Highland Hospital Doody Review: 4 Stars, 94\/100 ?This is a great book to have handy when questioned about the most appropriate laboratory testing strategy for diagnosis or management. Your reputation as an expert consultant will dramatically increase. Get it! - Valerie Ng, PhD, MD, Alameda County Medical Center\/Highland Hospital","brand":"Brush Education Inc","offers":[{"title":"Default Title","offer_id":48867558392151,"sku":"9781550595765","price":28.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781550595765.jpg?v=1722283865"},{"product_id":"ecg-facts-made-incredibly-quick-9781605474762","title":"ECG Facts Made Incredibly Quick!","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eUpdated with new treatments and algorithms, \u003cb\u003eECG Facts Made Incredibly Quick! Second Edition\u003c\/b\u003e provides instant access to information that every nurse needs for safe patient care. The book fits comfortably into a pocket, and the wipeable page surface allows nurses to write notes and remove them easily. Coverage includes basic electrocardiography including cardiac conduction, lead placement, and heart rate calculation; rhythm strip interpretation; causes, signs and symptoms, interventions, and treatment for arrhythmias; 12-lead and 15-lead ECG interpretation; ECG changes with angina, MI, pericarditis, and bundle branch block; and antiarrhythmic drugs, pacemakers, and ICDs. Scores of ECG waveforms, treatment algorithms, and charts are included. 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I have traveled the world to observe and study with many practitioners—from standard-of-care, state-of-the-art hospitals to shamans in remote villages—and I always learn something new! No one person has all the answers. Just as there are unique fingerprints, there are unique perspectives and approaches to tend to the terrain of the individual. Having had the honor of visiting Dr. Saupe’s beautiful clinic, spending time with his patients, and presenting together at some international conferences, it is clear we resonate deeply in how we think about and care for the patient. 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It's great for learning, for revision and general quick referencing. It enables you to ask the appropriate, vital questions in treating the patient, not simply the condition, taking you logically through the thought processes, based on essential guided history taking.' \u003cem\u003eAmazon reviewer\u003c\/em\u003e   \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eExcellent resource for ACPs \u003c\/strong\u003e\u003cbr\u003e 'As a trainee ACP this is my new best friend. The only way I will put it down is if i am surgically removed from it.' \u003cem\u003eAmazon reviewer\u003c\/em\u003e  \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eA new bible for the modern healthcare professional!! \u003c\/strong\u003e\u003cbr\u003e 'So, I got the Eureka: Clinical Skills, Diagnostics and Reasoning book today in the post. Some classic clinical pearls and very much evidenced based medicine. This book not only gives you the knowledge, but it seems to have a different approach than other books I have read. Reasoning and formulating treatment plans in healthcare is definitely not missing in this book. Excellent work, highly recommended.' \u003cem\u003eAmazon reviewer\u003c\/em\u003e  \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eDoes exactly what it says on the tin\u003c\/strong\u003e\u003cbr\u003e 'Great book for learning how to take patient's history, perform clinical examinations and make reasoned judgements. It explains why to do them, and what differential diagnosis we should consider. Overall, a really good book, highly recommended.' \u003cem\u003eAmazon reviewer\u003c\/em\u003e  \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eMust have book\u003c\/strong\u003e\u003cbr\u003e 'This has quickly become my new bible. As an aspiring ANP\/ENP this book is invaluable. Filled with practical, helpful tips. Clear layout and excellent pictures for visual learning. Breaks down each body system brilliantly without any excessive or unnecessary text. Transition into advanced practice will undoubtably be made a little easier with books like this one. Highly recommended.'  \u003cem\u003eAmazon reviewer\u003c\/em\u003e  \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eA modern and realistic approach to medicine\u003c\/strong\u003e\u003cbr\u003e 'This book is a great tool for anybody in the field of patient assessment who wishes to make effective diagnoses and develop their logical clinical reasoning. As a paramedic, I have found the book to be a great resource in my pre-hospital assessment as it incorporates realistic clinical cases, something a lot of other medical textbooks lack.' \u003cem\u003eAmazon reviewer\u003c\/em\u003e   \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePerfect Compendium\u003c\/strong\u003e\u003cbr\u003e 'Put together not just by experts in their field, but by incredible educators, and it shows. 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This book is also useful for those working in emergency medicine, internal medicine, surgery, and pre-hospital medicine. With POCUS likely to become a core competency in intensive care medicine over the coming years, this book is the perfect handbook for trainees.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\"With POCUS likely to become a core competency in ICM in the coming years, choosing a practical and easily accessible text is important. \u003cbr\u003e This book is comprehensive but accessible, and it is clear the authors have tried hard to make it un-intimidating. I think they have succeeded! There are a great many of us who are unsure where to start with POCUS – FUSIC is a well-known, beautifully packaged programme for most. This book is small enough to put in your bag and will undoubtedly help you improve your practice, even if a mentor is not around.\u003cbr\u003e The author list is a veritable rogues gallery of ultrascoundrels. Names such as Marcus Peck and Ashley Miller (co-chairs of the FUSIC committee) and Manni Waraich (neuro POCUS guru) reassure the reader that this is an absolute treasure trove of expert knowledge (in fact, many of the FUSIC committee are included in the list). There are over 40 contributors listed, each one bringing a career’s worth of expertise.\u003cbr\u003e A highly useful book which has something for everyone, from beginner to advanced. One of the most comprehensive guides to all elements of critical care POCUS.... Even though there is a wealth of online material covering POCUS, sometimes there’s nothing like a book to refer to. I expect this will be a regular in my work bag.\"\u003cbr\u003e \u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cstrong\u003e\u003cem\u003eCriticalCareNorthampton.com\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cem\u003e'Point-of-Care Ultrasound in Critical Care\u003c\/em\u003e is a delightful review of the constantly evolving realm of point-of-care ultrasound, or POCUS, as it has been colloquially referred.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eWith over 41 contributors, 28 chapters, and 350 pages, the book covers a variety of important point-of-care topics, with early chapters dedicated to the familiar examinations, including echocardiography and lung, abdominal, and vascular ultrasound. These topics are broken into multiple chapters, with early chapters dedicated to view acquisition and later chapters dedicated to assessment and clinical judgement of normal physiology and pathology.\u003c\/p\u003e \u003cp\u003eAs one of the first attempts to encompass a young and everexpanding field, \u003cem\u003ePoint-of-Care Ultrasound in Critical Care\u003c\/em\u003e is an excellent guide to the discipline. For readers across all specialties and experiences, this book will provide a thorough but unintimidating approach to a skillset that will continue to guide the practice of medicine in years to come.'\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003e\u003cem\u003eBritish Journal of Anaesthesia 17\/1\/2023\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eA must buy for ICU POCUS enthusiasts\u003c\/strong\u003e \u003cbr\u003e 'An excellent book with chapters from some of the best sonographers around. Something for beginners and experts and a great collection of images and video clips. Would highly recommend!'  \u003cem\u003eAmazon review\u003c\/em\u003e  \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e'Such a great book. Can’t wait to try out my new POCUS knowledge on the ward! An essential for all medical libraries.' \u003cem\u003eAmazon review\u003c\/em\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eState of the Art\u003c\/strong\u003e\u003cbr\u003e 'The most current literature in this field. I recommend it to everyone working in this field. Even an experienced sonographer will get some pearls for clinical practice.' \u003cem\u003eAmazon review\u003c\/em\u003e \u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eUseful for my ITU rotation\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e ‘Very useful for applying USS skills in Critical Care.' \u003cem\u003e Amazon reviewer\u003c\/em\u003e \u003c\/p\u003e\u003cbr\u003eIf, like me, you are yet to fully master your ultrasound skills, then ‘Point of Care Ultrasound in Critical Care’ edited by Flower and Madhivathan is worth your precious time and cash. Kudos to these editors, and to each of contributing ultrasound gurus: they have ably summarized what ‘luddites’, like me, need….\u003cbr\u003e If your ultrasound skills can be described with the same words that a Francophone colleague used to summarize my French language skills – namely ‘enthusiastic but modest’ – then you are, like me, this book’s target audience. I can happily report that I am now, if not ultrasound fluent, then at least more able to get around…\u003cbr\u003e The authors and publishers deserve further kudos because this 28-chapter book is Goldilocks-long (340 pages), and affordably priced... -- Peter Brindley * Journal of Intensive Care Society *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eAn introduction to ultrasound\u003c\/b\u003e\u003cbr\u003e 1. The evolution of critical care ultrasound – \u003ci\u003eLuke Flower \u0026amp; Pradeep Madhivathanan\u003c\/i\u003e\u003cbr\u003e 2. Basic ultrasound physics – \u003ci\u003eAbhishek Jha \u0026amp; Pablo Rojas Zamora\u003c\/i\u003e\u003cbr\u003e 3. Image optimization and artefacts – \u003ci\u003eElliot Smith\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eEchocardiography\u003c\/b\u003e\u003cbr\u003e 4. Focused versus advanced echocardiography – \u003ci\u003eAngus McKnight \u0026amp; Stuart Gillon\u003c\/i\u003e\u003cbr\u003e 5. Fundamentals of transthoracic echocardiography – \u003ci\u003eRichard Fisher\u003c\/i\u003e\u003cbr\u003e 6. Fundamentals of transoesophageal echocardiography – \u003ci\u003eDan Aston\u003c\/i\u003e\u003cbr\u003e 7. Assessment of the left heart – \u003ci\u003eFilippo Sanfilippo, Luigi La Via \u0026amp; Gianluca Paternoster\u003c\/i\u003e\u003cbr\u003e 8. Assessment of the right heart – \u003ci\u003eSam Clark\u003c\/i\u003e\u003cbr\u003e 9. Focused valvular assessment – \u003ci\u003eTim Keady \u0026amp; Sam Clark\u003c\/i\u003e\u003cbr\u003e 10. Assessment of the pericardium and pericardiocentesis – \u003ci\u003eAlejandra Ceballos, Julian Rios Rios \u0026amp; Pradeep Madhivathanan\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eLung ultrasound\u003c\/b\u003e\u003cbr\u003e 11. Fundamentals of point-of-care lung ultrasound – \u003ci\u003eHatem Soliman-Aboumarie \u0026amp; Luna Gargani\u003c\/i\u003e\u003cbr\u003e 12. Lung and pleural pathology – \u003ci\u003eAshley Miller, Marcus Peck \u0026amp; Jonny Wilkinson\u003c\/i\u003e\u003cbr\u003e 13. Ultrasound-guided thoracentesis – \u003ci\u003eChuen Khaw, Luke Flower \u0026amp; Jim Buckley\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eAbdominal ultrasound\u003c\/b\u003e\u003cbr\u003e 14. Basic hepatic and biliary ultrasound – \u003ci\u003eJonny Wilkinson, Marcus Peck \u0026amp; Ashley Miller\u003c\/i\u003e\u003cbr\u003e 15. Ultrasound assessment of the renal tract and bladder – \u003ci\u003eMaryam Khosravi\u003c\/i\u003e\u003cbr\u003e 16. Ultrasound-guided abdominal paracentesis – \u003ci\u003eCharlotte Hateley \u0026amp; Arun Sivananthan\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eVascular ultrasound\u003c\/b\u003e\u003cbr\u003e 17. Basic aortic ultrasound – \u003ci\u003eJonny Wilkinson, Marcus Peck \u0026amp; Ashley Miller\u003c\/i\u003e\u003cbr\u003e 18. Deep vein thrombosis scanning in critical care – \u003ci\u003eRosie Baruah, David Hall \u0026amp; Colum O’Hare\u003c\/i\u003e\u003cbr\u003e 19. Ultrasound-guided venous access – \u003ci\u003eZdenek Bares\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eNeurological ultrasound\u003c\/b\u003e\u003cbr\u003e 20. Transcranial Doppler and optic nerve sheath diameter – \u003ci\u003eManni Waraich\u003c\/i\u003e\u003cbr\u003e 21. Ultrasound-guided spinal procedures – \u003ci\u003eJohn Dick \u0026amp; Kay Mak\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eAirway ultrasound\u003c\/b\u003e\u003cbr\u003e 22. Ultrasound to confirm airway placement and guide percutaneous dilatational tracheostomy – \u003ci\u003eAdrian Wong\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eSituational ultrasound\u003c\/b\u003e\u003cbr\u003e 23. 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Ultrasound education in critical care – \u003ci\u003eJonathan Aron \u0026amp; Sarah Morton\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e Index","brand":"Scion Publishing Ltd","offers":[{"title":"Default Title","offer_id":48868981178711,"sku":"9781911510994","price":42.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781911510994.jpg?v=1722290667"},{"product_id":"humanizing-brain-tumors-strategies-for-you-and-your-physician-9781947603608","title":"Humanizing Brain Tumors – Strategies for You and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eThree practicing doctors present the stories of nine individuals diagnosed with brain tumors.\u003c\/b\u003e\u003cbr\u003e  \u003cbr\u003e\u003ci\u003eHumanizing Brain Tumors\u003c\/i\u003e details the lived experiences of patients and their loved ones, from the presentation of symptoms to diagnosis and treatment. 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