{"title":"Haematology Books","description":"","products":[{"product_id":"transfusion-and-transplantation-science-9780198735731","title":"Transfusion and Transplantation Science","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eBiomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible.The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposedfrom microbiology to cytopathology to transfusion science.The science of transfusion and transplantation demands a multifaceted understanding of immunology, haematology, and\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eReview from previous edition Excellent teaching material for those studying Biomedical Science. * Dr Stephen F. Hughes, University of Chester *\u003cbr\u003eThere is a clear focus on practical application of the theory in the transfusion lab. * Dr Christine Shirras, Lancaster University *\u003cbr\u003eThe main strength is the Biomedical Science perspective. The emphasis is on transfusion practice within the laboratory: the biochemistry backs up the practical applications, not the other way round as biochemistry texts often do. * Trish Procter, Keele University *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: Neil D. Avent: Introduction to Basic Immunology and Techniques 2: Neil D. Avent: Human Blood Group Antigens 3: Neil D. Avent: Haemolytic Disease of the Fetus and Newborn 4: Lionel Mohabir: Clinical Use of Blood Components 5: Catherine Hyland, John Barbara, and Lionel Mohabir: Microbiological Testing of Blood Donations 6: Geoff Lucas: Human Platelet Antigens (HPA) and Human Neutrophil Antigens (HNA) and their Clinical Significance 7: Malcolm Needs: Compatibility Testing and Adverse Effects 8: Malcolm Needs: Immune Mediated Red Cell Destruction 9: Neil D. Avent: Human Leucocyte Antigens (HLA) and their Clinical Significance 10: Ruth Morse and Saeed Kabrah: Haematopoietic Stem Cell Transplantation and Stem Cell Plasticity 11: Richard Lomas, Neil D. Avent, and Vehid Salih: Tissue Banking 12: Joan Jones: Quality Issues","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732773515607,"sku":"9780198735731","price":38.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198735731.jpg?v=1719998336"},{"product_id":"blood-9780199581450","title":"Blood","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eBlood is vital to most animals. In mammals it transports oxygen and food, carries away waste, and contains the white cells that attack invading microbes. Playing a central role in life, it has had profound cultural and historical significance and plays an important role in religious ritual. Blood was one of the four humours in early Western medicine and is still probably the major diagnostic tool in the doctor''s armoury. In this Very Short Introduction, Chris Cooper analyses the components of blood, explains blood groups, and looks at transfusions, blood tests, and blood-borne diseases. He considers what the future may hold, including the possibility of making artificial blood, and producing blood from stem cells in the laboratory.ABOUT THE SERIES: The  Very Short Introductions  series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eBlood is over-flowing with such fascinating historical observations, as well as with an equally generous amount of practical information that everyone possessing blood should know. * The Well-Read Naturalist *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1:  A history of blood 2: What is blood? 3: Fighting Disease 4: Haemoglobin 5: Blood pressure and blood flow 6: Blood transfusion 7: Epilogue: the future of blood Further Reading Index","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732869067095,"sku":"9780199581450","price":9.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780199581450.jpg?v=1719998742"},{"product_id":"oxford-handbook-of-clinical-haematology-9780199683307","title":"Oxford Handbook of Clinical Haematology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals.The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e.g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis new edition follows the tradition of the highly respected Oxford medical handbook series which is a compact, well produced book brimming with knowledge that will help the clinician in a large number of situations. *  Dr Harry Brown, glycosmedia.com  *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Clinical approach ; 2. Red cell disorders ; 3. White blood cell abnormalities ; 4. Leukaemia ; 5. Lymphoma ; 6. Myelodysplasia ; 7. Myeloproliferative neoplasms (MPNs) ; 8. Paraproteinaemias ; 9. Haematopoietic stem cell transplantation (SCT) ; 10. Haemostasis and thrombosis ; 11. Immunodeficiency ; 12. Paediatric haematology ; 13. Haematological emergencies ; 14. Supportive care ; 15. Protocols and procedures ; 16. Haematological investigations ; 17. Blood transfusion ; 18. Rare diseases ; A1 Haematology online ; A2 Charts and nomograms ; A3 Normal ranges","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732883059031,"sku":"9780199683307","price":36.09,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780199683307.jpg?v=1719998805"},{"product_id":"haematology-a-core-curriculum-9781786348869","title":"Haematology: A Core Curriculum","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e'The test cases are particularly variable, including pertinent management tips in the answers. The book also contains a set of useful self-assessment questions. Being pedantic, this could now benefit from an increase in the proportion of 'Single Best Answer Questions', now ubiquitous in undergraduate assessment. This will continue to be on my local recommended reading list, particularly for those students wanting a thorough understanding of Haematology, from the laboratory through to basic management. It would also be a good text for those starting a career in Haematology, such as Physician Associates and doctors early in their training.'British Journal of HaematologyThis second edition of Haematology: A Core Curriculum is written by a haematologist with more than forty-five years of experience in teaching haematology to medical students and whose pedagogical and writing skills are widely admired within the field.The textbook takes a useful, practical approach, incorporating self-evaluation questions and learning objectives that give students the information needed to understand the topic and clear indications of the core knowledge required to progress within the field of haematology. Themes covered include clinical haematology and the scientific basis of the discipline and the causes and pathogenesis of haematological disorders as well as how conditions are diagnosed and treated.Haematology closely follows the Imperial College London curriculum but medical students, trainee nurses and biomedical science students from other institutions will find the textbook equally suitable, since it includes the core student haematology curriculum as recommended by the Royal College of Pathologists.Related Link(s)","brand":"World Scientific Europe Ltd","offers":[{"title":"Default Title","offer_id":48741447991639,"sku":"9781786348869","price":58.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781786348869.jpg?v=1720057612"},{"product_id":"blood-results-in-clinical-practice-a-practical-guide-to-interpreting-blood-test-results-9781910451168","title":"Blood Results in Clinical Practice: A practical","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"M\u0026K Update Ltd","offers":[{"title":"Default Title","offer_id":48742561775959,"sku":"9781910451168","price":25.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781910451168.jpg?v=1720061913"},{"product_id":"chronic-lymphocytic-leukemia-9783030113919","title":"Chronic Lymphocytic Leukemia","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThis book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePathophysiolgoy.- Diagnostics.- Clinical Presentation.- Prognostic Markers.- Treatment.- Follow-up and Complications.- Related Entities.","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743023935831,"sku":"9783030113919","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"essential-current-concepts-in-stem-cell-biology-9783030339227","title":"Essential Current Concepts in Stem Cell Biology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThis textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material.\u003c\/p\u003e\u003cp\u003eBased on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge.\u003c\/p\u003e\u003cp\u003eThis textbook is a valuable complement to \u003ci\u003eConcepts and Applications of Stem Cell Biology, \u003c\/i\u003ealso published in the Learning Materials in Biosciences textbook series.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e“The books ... ‘compactly and concisely discuss a specific bio-topic based on lectures for upper-level undergraduates, master’s and graduate students’: this means that both beginners and well-trained students can benefit from reading this and other books in the same collection. ... All chapters are decorated by clear and well-designed color illustrations. I am pretty sure the book will meet the reader’s expectations.” (Manuela Monti, European Journal of Histochemistry, Vol. 64, 2020)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. Hematopoietic stem cells\u003cp\u003e2. Mesenchymal stem cells \u003c\/p\u003e  \u003cp\u003e3. Cord blood stem cells  \u003c\/p\u003e  \u003cp\u003e4. Induced pluripotent stem cells \u003c\/p\u003e  \u003cp\u003e5. Epigenetic regulation in somatic cell reprogramming \u003c\/p\u003e  \u003cp\u003e6. MET in reprogramming \u003c\/p\u003e  \u003cp\u003e7. Extracellular vesicles      \u003c\/p\u003e  \u003cp\u003e8. Neural stem cells   \u003c\/p\u003e  \u003cp\u003e9. Neural stem cell niche\u003c\/p\u003e  \u003cp\u003e10. Human pluripotent stem cells and neural regeneration                                                                 \u003c\/p\u003e  \u003cp\u003e11. Organoids \u003c\/p\u003e  \u003cp\u003e12. Ethical aspects of human stem cell research                       \u003c\/p\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743033504087,"sku":"9783030339227","price":59.99,"currency_code":"GBP","in_stock":true}]},{"product_id":"patients-lived-experiences-during-the-transplant-and-cellular-therapy-journey-harvest-and-hope-9783031256011","title":"Patients’ Lived Experiences During the Transplant","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe book was envisioned by bedside nurses caring for transplant and cellular therapy patients as a way to teach novice nurses and health care colleagues about the care required for this complex patient population. The nurse authors recruited an oncology nurse practitioner, transplant physician, nurse scientist and expert in medical humanities and health studies to join the project team. The dedication of the team and the willingness of the patients to contribute to the project, has led to a unique case study approach focused on the lived experience of patients and care partner(s) during the transplant\/cellular therapy journey. The case studies are unique in that they encompass a qualitative narrative developed using Interpretive Phenomenological Analysis (IPA) and the inclusion of the individual's actual medical and nursing care from their health record. At every step along the trajectory of the illness, the medications and care received are described, interspersed with the voice of the patient and care partner(s) sharing their experiences. The chapters follow the individual patients and their care partner(s) through all phases of their illness. The interviews were conducted, and case studies written by the bedside clinical nurses. Visual art and prose created by patients and care partner(s)s are included in the chapters. The book also includes an introduction written by the nurse authors, a methods chapter on the inclusion of IPA in a case study, and poignant epilogue. The premise of nursing support for survivorship is woven throughout the book, highlighting how giving back aids in recovery identity.\u003cbr\u003e\u003cbr\u003eThis book, full of beautiful artworks and poems, is the work of clinical nurses devoted to improving care for their patients by sharing the patient stories with others. It introduces a unique approach to the case study which could be replicated and applied to any diagnosis.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eForeword by Susan K. Stewart, Executive Director of Blood and Marrow Transplant Information Network\u003cbr\u003eIntroduction Lisa Wesinger, RN, BSN,  OCN, Judi Gentes, RN, ADN, Carissa Morton, RN, BSN,(5 pages)\u003cbr\u003eCreating a Patient-Centered Case Study, Jennifer Holl, DNP,RN,  Jean Coffey PhD, APRN, FAAN (15 pages)\u003cbr\u003e\u003cb\u003ePart A. The Autologous Stem Cell Transplant Journey\u003c\/b\u003eChapter 1. Hope and Determination by Lisa Wesinger, Judi Gentes, Carissa Morton and Jennifer Holl (18 pages)Chapter 2. The Hugger by Lisa Wesinger (13 pages)Chapter 3. Spaces in Between by Judi Gentes (8 pages) \u003cb\u003ePart B. The Allogeneic Stem Cell Transplant Journey\u003c\/b\u003eChapter 4. Saving Superman by Sara Cooke (9 pages)Chapter 5. Brothers in Arms by Lisa Wesinger (10 pages)Chapter 6. Letting Go by Carissa Morton (7 pages)Chapter 7. Another Ode to August by Lisa Wesinger (10 pages)Chapter 8. Dr’s Orders by Ashley Prokopik (TBD)Chapter 9. Am I Dreaming by Judi Gentes (9 pages)Chapter 10. With Every Sunrise I’ll Do Better by Sara Cooke (7 pages) \u003cb\u003ePart C. The CAR T-Cell Journey\u003c\/b\u003eChapter 11. Second Chances by Kate Caldon (TBD) Epilogue: Saying Goodbye, Lasting Reflections and New Horizons by John Hill (TBD)\u003cbr\u003e","brand":"Springer International Publishing AG","offers":[{"title":"Default Title","offer_id":48743077151063,"sku":"9783031256011","price":58.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783031256011.jpg?v=1720064009"},{"product_id":"diagnostic-bone-marrow-haematopathology-book-with-online-content-9781107040137","title":"Diagnostic Bone Marrow Haematopathology Book with","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eWritten by global experts, this indispensable guide includes over 200 illustrations and essential information in clear tabular formatting, giving hematopathologists rapid access to diagnostic criteria at the microscope. General principles of bone marrow biopsy and aspirate processing are covered, together with the normal and reactive bone marrow, infective, infiltrative and neoplastic diseases. Chapters also guide readers through the use of immunohistochemistry, flow cytometry and molecular diagnosis, whilst extensive referencing provides further reading in specialist and rare topics. Whether working as a generalist, specialist, trainee or resident, this in an essential bench guide for hematopathologists at all levels of experience. The print book comes with access to the text and expandable figures online at Cambridge Core, which can be accessed via the code printed on the inside of the cover.","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":48866338636119,"sku":"9781107040137","price":105.45,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781107040137.jpg?v=1722278202"},{"product_id":"hematologies-9781501761683","title":"Hematologies","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eIn this ground-breaking account of the political economy and cultural meaning of blood in contemporary India, Jacob Copeman and Dwaipayan Banerjee examine how the giving and receiving of blood has shaped social and political life. \u003ci\u003eHematologies\u003c\/i\u003e traces how the substance congeals political ideologies, biomedical rationalities, and activist practices.\u003c\/p\u003e\u003cp\u003eUsing examples from anti-colonial appeals to blood sacrifice as a political philosophy to contemporary portraits of political leaders drawn with blood, from the use of the substance by Bhopali children as a material of activism to biomedical anxieties and aporias about the excess and lack of donation, \u003ci\u003eHematologies\u003c\/i\u003e broaches how political life in India has been shaped through the use of blood and through contestations about blood. As such, the authors offer new entryways into thinking about politics and economy through a bloodscape of difference: different sovereignties; different proportionalities; and different temporal\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eAcknowledgments\u003cbr\u003e 1. Bloodscape of Difference\u003cbr\u003e 2. Sovereignty and Blood\u003cbr\u003e 3. Substantial Activisms\u003cbr\u003e 4. Hemo Economicus: From Blood Sacrifice to Blood Science?\u003cbr\u003e 5. The Broken World of Transfusion\u003cbr\u003e 6. Blood in the Time of the Civic\u003cbr\u003e 7. Hematic Futures\u003cbr\u003e Notes\u003cbr\u003e References\u003cbr\u003e Index\u003c\/p\u003e","brand":"Cornell University Press","offers":[{"title":"Default Title","offer_id":48867346579799,"sku":"9781501761683","price":20.89,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781501761683.jpg?v=1722282905"},{"product_id":"plasmapheresis-intravenous-immunoglobin-clinical-uses-potential-complications-long-term-health-effects-9781631179167","title":"Plasmapheresis \u0026 Intravenous Immunoglobin:","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003ePlasmapheresis is a therapeutic tool used to treat a wide range of disease processes, and in which the priority aim is to ensure sufficient plasma exchange to reduce or eliminate symptoms resulting from the action of pathogenic elements vehiculised in the plasma. Scientific selective apheresis with principles of evidence-based medicine involves the application of one of the oldest therapeutic modalities (bleeding), widely used between the fourth century B.C. and the second industrial revolution. This book provides information on the use of plasmapheresis during pregnancy; therapeutic use of autologous plasma for the treatment of dry eye disease; and therapeutic plasma exchange in the neurological setting. It also discusses intravenous immunoglobulins. During the past decades intravenous immunoglobulins (IVIG) have gained more and more popularity for the treatment of a wide range of diseases and conditions. This treatment is extensively used in immune deficits, autoimmune thrombocytopenia, Kawasaki''s disease, for the prevention of infectious complications due to hypogammaglobulinaemia secondary to myeloma, chronic lymphatic leukaemia and post-bone marrow and stem cell transplantation, in Guillain-Barre syndrome, etc. IV-Ig is obtained from the plasma of healthy blood donors and contains normal, polyclonal, polyspecific immunoglobins (Ig), mostly consisting of intact IgG. These antibodies are directed against non-self-antigens, self-antigens (natural autoantibodies), and other antibodies (idiotypic antibodies). The administration of intravenous immunoglobulin (IVIG) is generally safe and well tolerated. However, the treatment of autoimmune disorders usually requires high dose therapy (1-2 g\/kg) that may result in a greater frequency of side effects and adverse events. This book discusses several topics including the clinical application of intravenous immunoglobulins in autoimmune mediated ocular inflammatory diseases; complications of intravenous immunoglobulin therapy; clinical uses; and side effects.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48867843703127,"sku":"9781631179167","price":152.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781631179167.jpg?v=1722285233"},{"product_id":"wintrobes-clinical-hematology-9781975184698","title":"Wintrobe's Clinical Hematology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eSelected as a Doody’s Core Title for 2023!\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e Comprehensive in scope and thoroughly up to date, \u003cb\u003e\u003ci\u003eWintrobe’s Clinical Hematology,\u003c\/i\u003e 15th Edition,\u003c\/b\u003e combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.  \u003cul\u003e\n\u003cli\u003e\u003cp\u003e Provides expert coverage of new topics, including COVID-19, palliative care and survivorship, transitioning from pediatric to adult care, and ethical issues in hematology such as management of individuals with religious\/cultural objections to transfusion  \u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e Integrates WHO classifications of hematologic neoplasms and the latest knowledge in genetics and genomics, and includes focused chapters on hematopoietic cell transplantation, gene therapy, and immunotherapy  \u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e Emphasizes four components of diagnosis: the morphology of the peripheral smear, bone marrow, lymph nodes, and other tissues; flow cytometry; cytogenetics; and molecular markers and mutations  \u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e Offers fresh perspectives from new section editors Drs. John Leonard (Lymphoma) and Laura Michaelis (Leukemia\/MPN), as well as numerous new contributing authors, many of whom provide international viewpoints on hematology \u003cbr\u003e   \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eEnrich Your eBook Reading Experience \u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e Read directly on your preferred device(s), such as computer, tablet, or smartphone.  \u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e Easily convert to audiobook, powering your content with natural language text-to-speech.  \u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wolters Kluwer Health","offers":[{"title":"Default Title","offer_id":48869287526743,"sku":"9781975184698","price":288.9,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781975184698.jpg?v=1722291996"},{"product_id":"the-bethesda-handbook-of-clinical-hematology-9781975211837","title":"The Bethesda Handbook of Clinical Hematology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eWritten by national recognized experts and senior fellows at leading research institutions, including the National Institutes of Health, and edited by Drs. Griffin P. Rodgers and Neal S. Young, \u003cb\u003eThe Bethesda Handbook of Clinical Hematology, 5th Edition\u003c\/b\u003e, is a concise, comprehensive handbook designed for everyday clinical use. Organized in a quick-reference, portable format, it covers the clinical information you need to know for the diagnosis and treatment all of blood and bone marrow disorders. Readable and practical, the Bethesda Handbook features numerous tables, algorithms, illustrations, and bulleted lists throughout to help bridge the gap between cutting-edge science and everyday clinical practice. \u003cul\u003e\n\u003cli\u003e Provides \u003cb\u003eclinically focused, authoritative, and current guidance\u003c\/b\u003e in this complex area, logically organized by disease category \u003c\/li\u003e\n\u003cli\u003e Discusses the \u003cb\u003epathophysiology, natural history, risk factors, diagnosis, management, and follow-up\u003c\/b\u003e of common hematological diseases \u003c\/li\u003e\n\u003cli\u003e Features \u003cb\u003enew diagnostic and treatment strategies\u003c\/b\u003e, updated references, and revised information throughout \u003c\/li\u003e\n\u003cli\u003e An \u003cb\u003eideal resource for practitioners at every level of training\u003c\/b\u003e: students, residents, and fellows on a hematology or oncology service, as well as internists, hospitalists, family practitioners, pediatricians, and nurse practitioners whose practice includes patients with blood diseases \u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wolters Kluwer Health","offers":[{"title":"Default Title","offer_id":48869288804695,"sku":"9781975211837","price":60.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781975211837.jpg?v=1722292001"},{"product_id":"management-of-hematologic-malignancies-9780521896405","title":"Management of Hematologic Malignancies","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field o\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface; 1. Molecular pathology of leukemia Maher Albitar and Amber Donahue; 2. Management of acute myeloid leukemia Alan K. Burnett; 3. Treatment of acute lymphoblastic leukemia (ALL) in adults Ryan Mattison, Sarah Larson and Wendy Stock; 4. Chronic myeloid leukemia Elias Jabour, Hagop M. Kantarjian and Jorge Cortes; 5. Chronic lymphosytic leukemia\/small lymphocytic lymphoma Karen W. L. Yee and Susan O'Brien; 6. Myelodysplastic syndromes (MDS) Stefan H. Faderl, Guillermo Garcia-Manerio and Hagop M. Kantarjian; 7. Hairy cell leukemia Darren S. Sigal and Alan Saven; 8. Acute promyelocytic leukemia: pathophysiology and clinical results update Francesco Lo Coco; 9. Myeloproliferative neoplasms Ayalew Tefferi; 10. Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and multiple myeloma S. Vincent Rajkumar and Suzanne R. Hayman; 11. Amyloidosis and other rare plasma cell dyscrasias Angela Dispenzieri and Suzanne R. Hayman; 12. Waldenstrom's macrogloblinemia\/lymphoplasmacytic lymphoma Steven P. Treon and Giampaolo Merlini; 13. WHO classification of lymphomas William W. L. Choi and Wing C. Chan; 14. Molecular pathology of lymphoma David J. Good and Randy D. Gascoyne; 15. International staging and response criteria for lymphomas Bruce D. Cheson; 16. Treatment approach to diffuse large B-cell lymphomas Sonali M. Smith and Julie M. Vose; 17. Mantle cell lymphoma Andre Goy; 18. Follicular lymphomas Francisco J. Hernandez-Ilizaturri and Myron Czuczman; 19. Hodgkin lymphoma: epidemiology, diagnosis, and treatment Andrew M. Evens and Sandra J. Horning; 20. Treatment approaches to MALT\/marginal zone lymphoma Stephanie A. Gregory and Parameswaran Venugopal; 21. Peripheral T-cell lymphomas Matthew J. Matasar and Steven Horwitz; 22. Mycosis fungoides and Sezary syndrome Christine Querfeld and Steven T. Rosen; 23. Central nervous system lymphoma Elizabeth R. Gerstner and Tracy T. Batchelor; 24. HIV-related lymphomas Caroline M. Behler and Lawrence D. Kaplan; 25. Lymphoblastic lymphoma Anuj Mahindra and John W. Sweetenham; 26. Burkitt lymphoma Julie M. Vose; Index.","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":48884168196439,"sku":"9780521896405","price":136.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780521896405.jpg?v=1722530749"},{"product_id":"inhibitors-of-hematopoiesis-9780861961252","title":"Inhibitors of Hematopoiesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eProceedings of the First International Symposium on Inhibitory Factors in the Regulation of Hematopoiesis, Paris (France), 26-28 April 1987.","brand":"John Libbey \u0026 Co","offers":[{"title":"Default Title","offer_id":48884818674007,"sku":"9780861961252","price":45.04,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780861961252.jpg?v=1722533600"},{"product_id":"williams-hematology-hemostasis-and-thrombosis-9781260117080","title":"Williams Hematology Hemostasis and Thrombosis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003ePublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, \u003cspan\u003e\u003c\/span\u003eauthenticity, or access to any online entitlements included with the product.\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eHemostasis and Thrombosis as only \u003ci\u003eWilliams\u003c\/i\u003e can cover it\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eIN FULL COLOR!\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eA Doodyâs Core Title for 2019! \u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cbr\u003eFeaturing twenty-five clinically relevant chapters originally appearing in \u003ci\u003eWilliams Hematology, Ninth Edition \u003c\/i\u003eâ many carefully updated by the original authors to reflect the latest developments -- this concise, full-color resource delivers comprehensive and up-to-date coverage of hemostasis and thrombosis. \u003cbr\u003e\u003cbr\u003e\u003cbr\u003eThe result of this unique compilation is a focused, timely resource that will be of particular value to advanced medical students who seeks a more detailed review of hematology than generally presented in second year medical school, medicine and pediatric reside\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eTable of Contents\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eChapter 1. Megakaryopoiesis and Thrombosis\u003c\/p\u003e\u003cp\u003eChapter 2. Platelet Morphology, Biochemistry, and Function\u003c\/p\u003e\u003cp\u003eChapter 3. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis\u003c\/p\u003e\u003cp\u003eChapter 4. Control of Coagulation Reactions\u003c\/p\u003e\u003cp\u003eChapter 5. Vascular Function in Hemostasis\u003c\/p\u003e\u003cp\u003eChapter 6. Classification, Clinical Manifestations and Evaluation of Disorders of Hemostasis \u003c\/p\u003e\u003cp\u003eChapter 7. Thrombocytopenia\u003c\/p\u003e\u003cp\u003eChapter 8. Heparin-Induced Thrombocytopenia\u003c\/p\u003e\u003cp\u003eChapter 9. Reactive Thrombocytosis\u003c\/p\u003e\u003cp\u003eChapter 10. Hereditary Qualitative Platelet Disorders\u003c\/p\u003e\u003cp\u003eChapter 11. Acquired Qualitative Platelet Disorders\u003c\/p\u003e\u003cp\u003eChapter 12. The Vascular Purpuras\u003c\/p\u003e\u003cp\u003eChapter 13. Hemophilia A and Hemophilia B\u003c\/p\u003e\u003cp\u003eChapter 14. Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII\u003c\/p\u003e\u003cp\u003eChapter 15. Hereditary Fibrinogen Abnormalities\u003c\/p\u003e\u003cp\u003eChapter 16. von Willebrand Disease\u003c\/p\u003e\u003cp\u003eChapter 17. Antibody-Mediated Coagulation Factor Deficiencies\u003c\/p\u003e\u003cp\u003eChapter 18. Hemostatic Alterations in Liver Disease and Liver Transplantation\u003c\/p\u003e\u003cp\u003eChapter 19. Disseminated Intravascular Coagulation\u003c\/p\u003e\u003cp\u003eChapter 20. Hereditary Thrombophilia\u003c\/p\u003e\u003cp\u003eChapter 21. The Antiphospholipid Syndrome\u003c\/p\u003e\u003cp\u003eChapter 22. Thrombotic Microangiopathies\u003c\/p\u003e\u003cp\u003eChapter 23. Venous Thrombosis\u003c\/p\u003e\u003cp\u003eChapter 24. Atherothrombosis: Disease Initiation, Progression, and Treatment\u003c\/p\u003e\u003cp\u003eChapter 25. Fibrinolysis and Thrombolysis\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e","brand":"McGraw-Hill Education","offers":[{"title":"Default Title","offer_id":48885304852823,"sku":"9781260117080","price":70.19,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781260117080.jpg?v=1722535820"},{"product_id":"hoffbrands-essential-haematology-9781394168156","title":"Hoffbrands Essential Haematology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48885458829655,"sku":"9781394168156","price":50.3,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781394168156.jpg?v=1722536484"},{"product_id":"benign-and-malignant-disorders-of-large-granular-lymphocytes-diagnostic-and-therapeutic-pearls-9781536129991","title":"Benign and Malignant Disorders of Large Granular","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eNatural killer (NK) cells are important effector cells of innate immune system implicated in many physiological processes including elimination of cancer cells and virus infected cells. NK cells comprise a majority of large granular lymphocytes circulating in peripheral blood with a minority derived from T cell lineage. Even though NK cells were first described more than 40 years ago, it was not until the 1980s and 1990s when immunophenotyping was incorporated into clinical diagnostic methods and resulted in discovery of distinct disorders of large granular lymphocytes and NK cells. Since then, significant progress was made in our better understanding of immunophenotypic and genotypic characteristics, biology, functions as well as disorders of these cells. Most recently, clinical studies using NK-cell based immunotherapy have shown promising results in treatment of some of malignant diseases. Disorders of large granular lymphocytes and NK cells are rare comprising only about 1% of all lymphoid malignancies in western countries. The rarity of these conditions was a main reason that the progress in our understanding of pathogenesis and development of novel therapeutic approaches has been delayed compared to development in more common B cell lymphoid malignancies. The low incidence of these diseases and scarcity of prospective clinical trials also limit the availability of evidence based research literature as well as comprehensive reviews about NK cell disorders. Thus, the editors decided to take on the challenging task and summarize our current knowledge about malignant and benign diseases of large granular lymphocytes in this book based on the best available evidence. The editors selected topics most relevant to clinical practice in order to provide a useful guide for practicing physicians. Chapters describing four disorders (T-cell large granular lymphocytic leukemia, chronic lymphoproliferative disorder of NK cells, extranodal NK cell lymphoma and aggressive NK cell leukemia) incorporated into most recent 2016 revision of classification of lymphoid malignancies are separated into experimental, diagnositc and clinical parts for easier understanding and reading. We are aware of challenges and inherited limitations of any larger project like this one due to a rapid progress especially in the field of genomics, which may not be incorporated in this book before it is published. The editors and contributing authors would like to thank the publisher NOVA for their support.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886078570839,"sku":"9781536129991","price":195.19,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536129991.jpg?v=1722538741"},{"product_id":"a-closer-look-at-blood-serum-9781536155570","title":"A Closer Look at Blood Serum","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe opening chapter of this compilation is dedicated to the quantification of selenium and platinum in blood serum by electrothermal atomic absorption spectrometry. While selenium is an essential trace element in many selenoproteins, platinum is found in the human body as a consequence of chemotherapy treatment after the administration of Pt-based drugs. For these reasons, their reliable quantification is extremely important. The authors go on to discuss how the early diagnosis of neurodegenerative diseases is important for more efficient treatment and prophylaxis. Currently, the dominant hypothesis of the pathogenesis of Alzheimer's disease is amyloid cascade resulting in accumulation of amyloid-Î² in brain structures. In conclusion, the authors discuss the major barrier to a widespread use of blood serum eye drops represented by the lack of standardized processes for the preparation, conservation, and dispensation of the products. Future perspectives of homologous serum eye drops include the introduction of tailored eye drops screened for the desired content of growth factors for each patient and ocular surface disease.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eFor more information, please visit our website at:https:\/\/novapublishers.com\/shop\/a-closer-look-at-blood-serum\/","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886127395159,"sku":"9781536155570","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"erythrocytes-structure-functions-and-clinical-aspects-9781536159141","title":"Erythrocytes: Structure, Functions and Clinical","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe authors summarise advances in human pluripotent stem cells-derived erythroid development and molecular regulatory mechanisms. This research may provide a new perspective on human embryo erythropoiesis and a possible treatment for some hematological diseases. Erythrocytes are well equipped to carry out their functions due to a dynamic cell membrane, their inherent shape and lack of organelles and cytoplasmic viscosity. As such, the following section focusses on the causes of these modifications and their clinical implications. As an example of complexity in research towards the development of erythrocyte membrane-based drug delivery systems starting from animal erythrocyte, morphological, biochemical and drug release profiles will be reviewed in the penultimate chapter. The final chapter investigates the electrochemical behavior of erythrocytes at platinum, carbonaceous, and optically transparent electrodes via polarization and coulometric measurements. The order of magnitude of the quantity of electrons transferred between erythrocytes and electrodes was determined, and potential ranges showing indifference of the electrode toward red blood cells were identified.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886135882071,"sku":"9781536159141","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"platelets-overview-function-and-disorders-9781536165920","title":"Platelets: Overview, Function and Disorders","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHemostasis involves a set of strictly regulated processes that maintain blood in its fluid state within the vascular bed and, in case of vessel injury, promote the formation of platelet plugs and fibrin clots to prevent blood extravasation. As such, Platelets: Overview, Function and Disorders explores how platelets play an important role in the blood coagulation process, and how platelet deficiencies or functional defects may be the cause of some bleeding disorders. The worldwide incidence of cutaneous melanoma has been increasing annually at a more rapid rate in comparison to any other type of cancer affecting predominantly young and middle-aged individuals. It is known that when melanoma cells leave the primary tumor and enter the blood stream, they activate surrounding platelets via some molecules, inducing microthrombus formation. The authors discuss how platelets contribute to inflammation, cancer invasion, and metastasis. Additionally, the role of platelet-rich-plasma in stimulating the healing process in difficult-to-heal ulcers has been investigated over the past 25 years. It is suggested that platelet-rich-plasma is capable of transforming the difficult-to-heal skin ulcer with low metabolic activity into a healing ulcer with increased capacity for tissue regeneration. This closing study focuses on the causes, diagnosis, and prognosis of various types of thrombocytopenia, providing an outline on the future prospects of using antioxidants for the treatment of a few thrombocytopenic conditions.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886150725975,"sku":"9781536165920","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"fetal-hemoglobin-the-panacea-for-major-b-hemoglobinopathies-9781536179552","title":"Fetal Hemoglobin: The Panacea for Major","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIntricate processes involved in perpetuating the multitude of physiological phenomena in the human body often encounter aberrations and omissions in the genetic code of life. While such errors often lead to lethal diseases, at other times they provide distinctive survival advantages and thus unscramble cues to unconventional therapeutic strategies for life-threatening conditions. Hereditary Persistence of Fetal Hemoglobin (HPFH) is one such condition wherein the typically inactivated fetal form of hemoglobin (HbF) remains overexpressed even in adult stages of the bearer's life. Strikingly, this condition is known to ameliorate pathological manifestations in patients with aberrant adult hemoglobin synthesis (e.g. Î²-hemoglobinopathies like Î²-thalassemia, sickle cell disease etc.). Early researchers in the field expected such patients to suffer from clinical challenges owing to HbF's high affinity to oxygen and consequent difficulty in its release to cells and tissues. Surprisingly, these patients are known to lead a physiologically normal life. Modern-day hematologists and clinical researchers have looked-up to the concept of \"HbF reactivation\" as a potential curative strategy for patients suffering from Î²-hemoglobinopathies like Î²-thalassemia and sickle cell disease. As a result, several drugs like hydroxyurea, 5-azacytidine, cytosine arabinoside, natural products etc. have been tried in clinics to elevate HbF levels in such patients with limited success and poor understanding on the mechanisms of their action. Associated side-effects and complications of using cytotoxic agents like these restrict their use in most instances. Fortunately, with the advent of newer molecular tools and techniques, researchers are focusing their attention to reengineer the molecular machinery and thus reactivate the gamma-globin gene. This book brings together a selection of chapters dedicated to fetal hemoglobin -- its physiological role, regulation, methodologies to manipulate and future strategies. Researchers and scientists interested in the topic will have a comprehensive understanding of the current concepts on fetal hemoglobin modulation and therefore will serve as a launching pad for their research ideas.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eDedication; Preface; Acknowledgements; Hemoglobin: A Biochemical and Molecular Overview; Prenatal and Postnatal Hemoglobins: Formation and Gaseous Exchange; An Introduction to Fetal Hemoglobin and Its Characteristics; Regulation of the Gamma Globin Gene: Current Concepts and Perspectives; Role of Cell Signaling Pathways in Fetal Hemoglobin Regulation in Beta-Hemoglobinopathies; Molecular Tools for Editing Globin Genes; Genetic Modifiers of Fetal Hemoglobin and Their Role in Alleviating the Clinical Severity of Hemoglobinopathies; Therapeutic Induction of Fetal Hemoglobin Expression: Methods in Practice and Newer Modalities; Genetic Modifiers of β-Thalassemia and Their Therapeutic Implications; Clinical Management of β-thalassemia; Current Practices in the Management of Beta-Hemoglobinopathies; About the Editor; Index.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886172942679,"sku":"9781536179552","price":163.19,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536179552.jpg?v=1722539080"},{"product_id":"a-guide-to-paediatric-red-blood-cell-disorder-9781536186956","title":"A Guide to Paediatric Red Blood Cell Disorder","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eA Guide to Paediatric Red Blood Cell Disorders is a comprehensive text on common red blood cell disorders encountered in children. It is a useful guide to postgraduate doctors training in paediatrics and haematology, medical undergraduates, primary care physicians and practising clinicians. The book is divided into five sections. The first section provides a detailed understanding of the basic concepts and approach to red blood cell disorders in children. This section includes information on the structure and function of red blood cells and haemoglobin, epidemiology and aetiology of anaemia and clinical and laboratory evaluation of childhood anaemia. The next three sections will provide information on paediatric conditions that result in microcytic, normocytic and macrocytic anaemia, respectively. The final section will be on conditions leading to polycythaemia in neonates and children. Throughout the book, the emphasis is given to common conditions that are frequently encountered in clinical practice. However, rare but clinically important conditions have also been included. Each chapter is divided into subheadings to describe the epidemiology, aetiology, genetic basis, molecular pathology, pathophysiology, classification, clinical features, investigations, diagnosis, treatment, follow-up and prognosis of each disorder. At the end of each chapter, a section on recent advances provides information on promising novel developments and experimental approaches for treating these diseases. This book will help medical undergraduates to grasp concepts and understand the entire spectrum of red blood cell disorders in children. For practising clinicians, this will be a useful guide on how to approach a child with anaemia, which is one of the most common presentations to general practice, field clinics and hospitals. For postgraduate doctors training in paediatrics and haematology, the book will provide comprehensive information on how to manage common as well as complex red blood cell disorders in children. This book is concise, reader-friendly and written in simple English, which can be understood by non-native speakers. It will aid readers across the globe to grasp the concepts of paediatric red blood cell disorders easily and be knowledgeable and up to date in managing these patients.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface; Part 1: Basic Concepts and an Approach to Red Blood Cell Disorders; Red Blood Cells and Haemoglobin; Evaluation of Childhood Anaemia. Part 2: Microcytic Anaemias -- Iron Deficiency Anaemia; Thalassaemia; Sickle Cell Disease; Other Microcytic Anaemias. Part 3: Normocytic Anaemias -- Hereditary Spherocytosis and Other Membranopathies; Glucose 6-Phosphate Dehydrogenase Deficiency and Other Enzymopathies; Autoimmune Haemolytic Anaemias; Microangiopathic Haemolytic Anaemias; Neonatal Anaemias; Other Normocytic Anaemias. Part 4: Macrocytic Anaemias -- Megaloblastic Anaemia; Red Blood Cell Aplasia; Other Macrocytic Anaemias. Part 5: Polycythaemia -- Neonatal Polycythaemia; Childhood Polycythaemia; Index.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886186541399,"sku":"9781536186956","price":113.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536186956.jpg?v=1722539132"},{"product_id":"new-research-on-hematological-malignancies-9781536199550","title":"New Research on Hematological Malignancies","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHaematological malignancies, defined as cancers that affect the blood, bone marrow, and lymph nodes, represent a serious health care challenge for oncologists. Chapter One focuses on cytogenetic and molecular markers and summarizes their importance in identification, treatment and prognosis in patients with myeloproliferative neoplasms. Chapter Two details the efficacy of treatment of myeloid hematologic malignancies with isocitrate dehydrogenase mutations by inhibitors of this enzyme. Chapter Three describes the use of Selinexor and other drugs for the treatment of hematologic malignancies. Chapter Four explains the utility of poly(ADP-ribose) polymerase inhibitors in the treatment of myelodysplastic syndrome and acute myeloid leukaemia.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface; Molecular and Cytogenetic Markers and Their Clinical Implications in Myeloproliferative Neoplasms; Treatment of Myeloid Hematologic Malignancies with Isocitrate Dehydrogenase Mutations by Inhibitors of This Enzyme; Inhibition of Nuclear Export as a New Therapy in Hematologic Malignancies; Poly(adp-Ribose) Polymerase Inhibitors in the Treatment of Myelodysplastic Syndrome and Acute Myeloid Leukemia; Index.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886210822487,"sku":"9781536199550","price":62.04,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781536199550.jpg?v=1722539222"},{"product_id":"focus-on-sickle-cell-research-9781590339206","title":"Focus on Sickle Cell Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eSickle cell anaemia is an inherited blood disorder, characterised primarily by chronic anaemia and periodic episodes of pain and occurring in approximately 1 in every 400 African-American infants born in the United States each year. Individuals of Mediterranean, Arabian, Caribbean, South and Central American, and East Indian ancestry can also be affected. The underlying problem involves haemoglobin, a component of the red cells in the blood. The haemoglobin molecules in each red blood cell carry oxygen from the lungs to the body organs and tissues and bring back carbon dioxide to the lungs. In sickle cell anaemia, the haemoglobin is defective. After the haemoglobin molecules give up their oxygen, some of them may cluster together and form long, rod-like structures. These structures cause the red blood cells to become stiff and to assume a sickle shape. Unlike normal red cells, which are usually smooth and donut-shaped, the sickled red cells cannot squeeze through small blood vessels. Instead, they stack up and cause blockages that deprive the organs and tissue of oxygen-carrying blood. This process produces the periodic episodes of pain and ultimately can damage the tissues and vital organs and lead to other serious medical problems. Unlike normal red blood cells, which last about 120 days in the bloodstream, sickled red cells die after only about 10 to 20 days. Because they cannot be replaced fast enough, the blood is chronically short of red blood cells, a condition called anaemia. Sickle cell anaemia is caused by an error in the gene that tells the body how to make haemoglobin. The defective gene tells the body to make the abnormal haemoglobin that results in deformed red blood cells. This book gathers the latest research in this important field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886485582167,"sku":"9781590339206","price":92.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781590339206.jpg?v=1722540280"},{"product_id":"new-angiogenesis-research-9781594542398","title":"New Angiogenesis Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAngiogenesis -- the growth of new blood vessels -- is an important natural process occurring in the body, both for health and as related to disease. Angiogenesis occurs in the healthy body to help heal wounds and to help restore blood flow to tissues after injury or insult. In females, Angiogenesis also occurs during the monthly reproductive cycle (to rebuild the uterus lining, to mature the egg during ovulation) and during pregnancy (to build the placenta, the circulation between mother and foetus). The healthy body controls Angiogenesis through a series of ''on'' and ''off'' switches. The main ''on'' switches are known as Angiogenesis-stimulating growth factors. The main ''off'' switches are known as Angiogenesis inhibitors. When angiogenic growth factors are produced in excess of angiogenesis inhibitors the balance is tipped in favour of blood vessel growth. When inhibitors are present in excess of stimulators, angiogenesis is stopped. The normal, healthy body maintains a perfect balance of angiogenesis modulators. In general, angiogenesis is ''turned off'' by the production of more inhibitors than stimulators. Tumour angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Tumour angiogenesis actually starts with cancerous tumour cells releasing molecules that send signals to surrounding normal host tissue. This signalling activates certain genes in the host tissue that, in turn, cause proteins to encourage growth of new blood vessels. This new book examines its angiogenesis within the context of theory and its applications to cancer treatment.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886514975063,"sku":"9781594542398","price":113.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594542398.jpg?v=1722540401"},{"product_id":"new-developments-in-sickle-cell-disease-research-9781594547928","title":"New Developments in Sickle Cell Disease Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eSickle cell anaemia is an inherited blood disorder, characterised primarily by chronic anaemia and periodic episodes of pain and occurring in approximately 1 in every 400 African-American infants born in the United States each year. Individuals of Mediterranean, Arabian, Caribbean, South and Central American, and East Indian ancestry can also be affected. The underlying problem involves haemoglobin, a component of the red cells in the blood. The haemoglobin molecules in each red blood cell carry oxygen from the lungs to the body organs and tissues and bring back carbon dioxide to the lungs. In sickle cell anaemia, the haemoglobin is defective. After the haemoglobin molecules give up their oxygen, some of them may cluster together and form long, rod-like structures. These structures cause the red blood cells to become stiff and to assume a sickle shape. Unlike normal red cells, which are usually smooth and donut-shaped, the sickled red cells cannot squeeze through small blood vessels. Instead, they stack up and cause blockages that deprive the organs and tissue of oxygen-carrying blood. This process produces the periodic episodes of pain and ultimately can damage the tissues and vital organs and lead to other serious medical problems. Unlike normal red blood cells, which last about 120 days in the bloodstream, sickled red cells die after only about 10 to 20 days. Because they cannot be replaced fast enough, the blood is chronically short of red blood cells, a condition called anaemia. Sickle cell anaemia is caused by an error in the gene that tells the body how to make haemoglobin. The defective gene tells the body to make the abnormal haemoglobin that results in deformed red blood cells. This book gathers the latest research in this important field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886530670935,"sku":"9781594547928","price":173.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781594547928.jpg?v=1722540478"},{"product_id":"thrombohemostatic-disease-research-9781600213236","title":"Thrombohemostatic Disease Research","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThrombohemostatic disorder is a common haematological problem. This book focuses on the \"thrombohemostatic disorder\" in several aspects including summative data from the molecular to the population scales, as well as additional metanalysis for important topics.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886592176471,"sku":"9781600213236","price":176.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781600213236.jpg?v=1722540770"},{"product_id":"blood-infections-scientific-clinical-public-health-aspects-9781600216855","title":"Blood Infections: Scientific, Clinical \u0026 Public","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe proposed book focuses on ''blood infections'', a common group of haematology and infectious disorders in aspects relating to the tropical medicine. The book covers specifically the clinical aspects, scientific laboratory aspects, public health aspects, as well as the social sciences relating to these important diseases. The common blood infections, including other disorders, which relate to blood disorders are summarised, presented, and discussed. The book presents summative data from the molecular to the population scales, as well as additional metanalysis for important topics.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886603514199,"sku":"9781600216855","price":129.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781600216855.jpg?v=1722540821"},{"product_id":"coumarin-anticoagulant-research-progress-9781600219900","title":"Coumarin Anticoagulant Research Progress","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eWarfarin (also known under the brand names of Coumadin, Jantoven, Marevan, and Waran) is an anticoagulant medication that is administered orally or, very rarely, by injection. It is used for the prophylaxis of thrombosis and embolism in many disorders. Its activity has to be monitored by frequent blood testing for the international normalised ratio (INR). It is named for the Wisconsin Alumni Research Foundation. Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in liquorice, lavender and various other species. Warfarin was originally developed as a rat poison; however, more modern poisons are much more potent and toxic (e.g., brodifacoum). Warfarin and contemporary rodenticides belong to the same class of drugs (coumarins) and both decrease blood coagulation by interfering with vitamin K metabolism. For this reason, drugs in this class are also referred to as vitamin K antagonists.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886612918615,"sku":"9781600219900","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"hemostasis-laboratory-yearbook-volume-1-9781607410898","title":"Hemostasis Laboratory Yearbook: Volume 1","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This yearbook gathers important contributions in this field and presents them in a coherent and logical format.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886717546839,"sku":"9781607410898","price":155.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781607410898.jpg?v=1722541290"},{"product_id":"handbook-of-hematology-research-hemorheology-hemophilia-blood-coagulation-9781607416197","title":"Handbook of Hematology Research: Hemorheology,","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eHaematology is the branch of medicine that deals with diseases of the blood and blood-forming organs. Haemophilia is one of the most important diseases of haematology research. Medically, the classical treatment of haemophilia is transfusion therapy, which has been widely used for years. However, the transfusion can bring several complications for haemophilic patients, such as the onset of blood borne infectious diseases. This book discusses such diseases, as well as the new trend in blood product safety management. Until present, the new modality of gene therapy is the hope for successfully treating haemophilia. The authors of this book briefly review and discuss this new haemophilia treatment. In addition to examining the aetiology, pathogenesis and treatment of haemophilia, the factors involved in the activation of blood coagulation are examined as well. Other chapters in this book explore the immune responses and induction of immune tolerance to FVIII\/FIX in haemophilia gene transfer, the haemostatic changes in complicated pregnancy states like preeclampsia and pregnancy-induced hypertension, a review of the new routine parameters for diagnosis of the early phases of pathologic disseminated intravascular coagulation (PDIC), and the quantitative and qualitative congenital plasminogen defects of the fibrinolytic system.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886740025687,"sku":"9781607416197","price":232.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781607416197.jpg?v=1722541353"},{"product_id":"cell-determination-during-hematopoiesis-9781607417330","title":"Cell Determination During Hematopoiesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eFor many years the mammalian blood cell system has provided cell biologists and haematologists with one of the best experimental models in which to unravel how one stem cell -- the hematopoietic stem cell -- gives rise to many different types of progeny. Numerous models of lineage relationships have emerged, but the most influential of these, in which differentiating cells undergo a series of binary choices, has been increasingly challenged in recent years -- to the extent that the accumulation of new findings recently culminated in a Nature commentary suggesting that \"the latest research will necessitate revision of textbook accounts\". This book brings together contributions from many leading experts in the field of blood cell development who each discuss both the overall process of hematopoiesis and the origins and development of each of the cells of the blood and immune systems. It describes how new molecular, cellular and -- particularly -- transgenic tools are helping us understand the processes that control the lineage fates of hematopoietic stem and progenitor cells and how lineage-committed progeny develop along particular maturation pathways.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886743105879,"sku":"9781607417330","price":86.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781607417330.jpg?v=1722541361"},{"product_id":"hemostasis-laboratory-yearbook-volume-2-9781613241509","title":"Hemostasis Laboratory Yearbook: Volume 2","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886833480023,"sku":"9781613241509","price":146.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781613241509.jpg?v=1722541785"},{"product_id":"hemostasis-laboratory-yearbook-volume-3-9781613245606","title":"Hemostasis Laboratory Yearbook: Volume 3","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886840197463,"sku":"9781613245606","price":146.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781613245606.jpg?v=1722541820"},{"product_id":"hemostasis-laboratory-yearbook-volume-4-9781613246412","title":"Hemostasis Laboratory Yearbook: Volume 4","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886841704791,"sku":"9781613246412","price":146.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781613246412.jpg?v=1722541825"},{"product_id":"hemostasis-laboratory-yearbook-volume-5-9781613246429","title":"Hemostasis Laboratory Yearbook: Volume 5","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886841803095,"sku":"9781613246429","price":146.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781613246429.jpg?v=1722541826"},{"product_id":"von-willebrand-disease-diagnosis-management-9781619423688","title":"von Willebrand Disease: Diagnosis \u0026 Management","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003evon Willebrand disease (VWD) is an inherited bleeding disorder that is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and also binds and stabilizes blood clotting factor VIII (FVIII) in the circulation. This book examines the need for more information on VWD prevalence and the relationship between low VWF levels of bleeding symptoms or risk and improving clinical and laboratory diagnostic tools.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886931063127,"sku":"9781619423688","price":106.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781619423688.jpg?v=1722542221"},{"product_id":"trends-in-national-blood-collection-cord-blood-banking-9781619423695","title":"Trends in National Blood Collection \u0026 Cord Blood","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book examines the 2009 National Blood Collection and Utilization Survey Report which provides data for national bio-vigilance safety monitoring; and monitors business practices in the blood collection, transfusion medicine, and cellular therapy communities. Also discussed are important trends in U.S. blood supply collection; blood transfusion practices and National Cord Blood Inventory practices for increasing availability for transplants and related challenges.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886931194199,"sku":"9781619423695","price":106.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781619423695.jpg?v=1722542221"},{"product_id":"hematomas-types-treatments-health-risks-9781619423855","title":"Hematomas: Types, Treatments \u0026 Health Risks","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book presents topical research in the study of the types, treatments and health risks associated with hematomas. Topics discussed include the physiotherapeutic treatments of hematomas; cerebrospinal hematoma; infected hematomas; the etiology of pelvic hematomas; intracranial hematomas in pediatric patients; massive retroperitoneal hematoma following vaginal correction of vault prolapse and retropharyngeal hematomas.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886931259735,"sku":"9781619423855","price":106.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781619423855.jpg?v=1722542221"},{"product_id":"sickle-cell-disease-a-new-vision-for-an-old-problem-9781622574698","title":"Sickle Cell Disease: A New Vision for an Old","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eSickle cell hemoglobin (HbS) is the result of a single nucleotide change (GAG → GTG) in the β-globin gene, where valine replaces glutamic acid at the sixth amino acid position in the β-globin chain. Sickle cell disease is a growing global health problem. The World Health Organization has estimated that 7% of the world population has the mutation and 300,000400,000 affected children are born every year. The disease progresses towards a severe chronic hemolytic anemia, and it shows a heterogeneous clinical course, related with different genetic factors. Despite the fact that all subjects with sickle cell disease (SCD) have the same single base pair mutation in the DNA, we further confirmed here that the severity of the clinical and hematological manifestations is extremely variable. Increasing evidence has indicated a role of oxidative stress in the vascular pathophysiology of SCD. The vascular endothelium is central to disease pathogenesis because it displays adhesion molecules for blood cells, balances procoagulant and anticoagulant properties of the vessel wall and regulates vascular homeostasis by synthesizing vasoconstricting and vasodilating substances. In addition, recent studies support the existence of a hyperoxidative status in SCD patients that may account, at least in part, for the clinical manifestations of these patients. Moreover, SCD patients with mild clinical outcomes were associated with low oxidative status, whereas high oxidative stress was related to severe phenotypes. Thus, the use of oxidative stress biomarkers may be important in the evaluation of the clinical condition of SCD patients, whereas the use of therapies to improve their redox status and increase NO bioavailability would be beneficial to reduce the severity of sickle disease. The global burden of SCD is now significantly increased and, thus, it is currently a public health problem around the world. This disease has passed from being a problem of the developing countries to affect many people in developed countries. This book summarizes the current epidemiology status and the latest discoveries in the pathophysiology of SCD, and the potential therapies that may improve the clinical course of this disease.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886990963031,"sku":"9781622574698","price":146.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781622574698.jpg?v=1722542506"},{"product_id":"deep-vein-thrombosis-symptoms-diagnosis-treatments-9781622575190","title":"Deep Vein Thrombosis: Symptoms, Diagnosis \u0026","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDeep venous thrombosis (DVT) is the third most common cardiovascular disease. Two-thirds of patients with DVT are first episodes, and the remainders are recurrences. Pulmonary embolism is the most common complication of DVT. And now, DVT and pulmonary are considered two spectra of the same disease, namely venous thromboembolism (VTE). This book provides a comprehensive review of current diagnosis and treatment of DVT. This book includes chapters on clinical approaches in DVT, VTE and cancer, prevention of DVT in neurological surgery, combination of pretest clinical probability score and different D-dimer cut-off value for exclusion of VTE, ambulatory therapy for DVT, management of DVT with oral anticoagulant, surgical intervention for acute DVT, and recent multi-centre survey of DVT from Japan. In this book, the mechanisms of VTE, diagnostic strategy of DVT, various treatment options for DVT, and prevention of VTE are discussed.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886991782231,"sku":"9781622575190","price":86.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781622575190.jpg?v=1722542511"},{"product_id":"myelodysplastic-syndromes-from-pathogenesis-to-diagnosis-therapy-9781624175749","title":"Myelodysplastic Syndromes: From Pathogenesis to","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn spite of tremendous advances in the field, the current understanding of pathogenesis of myelodysplastic syndromes (MDS) remains limited. Furthermore, the correct diagnosis and effective therapy of this heterogeneous group of clonal haematological disorders represent a common challenge in daily practice of haematology. This book provides a thorough, up-to-date, and comprehensive review of different aspects of MDS. Chapters are written by selected investigators and clinicians with specific expertise and track record of research in the field. Of particular interest, the clinical chapters provide a practical approach to the treatment of patients with different manifestations of the disease. This book would be a useful asset to researchers in the field as well as haematologists in practice. Other health care members such as haematology fellows in training, residents, medical students and nurses will also find this book helpful for better understanding of the disease and clinical management of patients with MDS.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887008919895,"sku":"9781624175749","price":206.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781624175749.jpg?v=1722542602"},{"product_id":"cord-blood-banks-banking-ethical-issues-risks-benefits-9781626180727","title":"Cord Blood: Banks \u0026 Banking, Ethical Issues \u0026","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn this book, the authors discuss cord blood banks and banking, the ethical issues involved and the risks and benefits. Topics include the virological risks and benefits of cord blood banking; mesenchymal stem cells and their role in regenerative medicine applications; osteogenic potential of human umbilical cord-derived mesenchymal stromal cells; public versus private cord blood banking; CCR5 deficient cord blood as a means of treatment for HIV-1 infection; and the therapeutic use of umbilical cord blood.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887036182871,"sku":"9781626180727","price":119.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781626180727.jpg?v=1722542701"},{"product_id":"quality-management-in-transfusion-medicine-9781626186651","title":"Quality Management in Transfusion Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eTransfusion Medicine is a key part of modern health care. It bridges the healthy community with the bedside in hospitals. It is the responsibility of the national blood program to provide an adequate supply of blood for all patients requiring transfusion, and to ensure the quality of blood and blood products for clinical use and the in-hospital transfusion chain. All products must be safe, clinically effective and of appropriate, and consistent quality. Every blood transfusion service, whether serving in a resource restricted environment or in an advanced ambience, should develop an effective quality (QS) and quality management system (QMS) to ensure the implementation of these strategies from vein to vein. The quality system and its management should cover all aspects of its activities and ensure full traceability (hemovigilance), from the motivation, mobilisation and selection of blood donors to the transfusion of blood and blood products to patients. It should also reflect the structure, needs and capabilities of the procurement establishments, as well as the needs of the hospitals and patients that it serves. Management commitment and support are essential for the development, implementation and monitoring of a national quality system and quality management system in order to ensure change management and continuous quality improvement. All staff should understand the importance of quality and the consequences of failure in the quality system (error management and cost effectiveness).","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887045718359,"sku":"9781626186651","price":245.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781626186651.jpg?v=1722542745"},{"product_id":"disseminated-intravascular-coagulation-dic-clinical-manifestations-diagnosis-treatment-options-9781629483238","title":"Disseminated Intravascular Coagulation (DIC):","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDisseminated Intravascular Coagulation is a devastating syndrome characterised by the systemic activation of widespread activation of the coagulation cascade and thrombosis, which may result in severe bleeding and may lead to organ failure. Recent studies have shown that the incidence of DIC is decreasing, especially in men. Despite the improvements in health care delivery, the morbidity and mortality due to DIC remains very high. Early diagnosis and accurate prognosis are important in improving the outcomes of patients with DIC. However, there is a lack of a gold standard diagnostic test to diagnose DIC and there is a scarcity of treatment or management strategies. Therefore, an understanding of the pathophysiology, ability to diagnose the DIC syndrome and treat it early, is the key. This book provides an important timely update on the clinical manifestations, important risk factors, and treatment strategies for DIC, and provides in-depth information on pathophysiological aspects and various diagnostic scores used to diagnose DIC. Furthermore, we focused on certain important factors related to DIC such as sepsis, chronic DIC in cancer patients, coagulopathy of liver disorders vs. DIC, and DIC in urological malignancies. In addition, this book provides evidence from an important study determining the predictors influencing the hospital mortality rates of critically ill patients with DIC. This book offers a wide scope of information for physicians in all fields, whether they are intensivists, primary care physicians or oncologists, this will be an important source for identifying the DIC syndrome early, and the appropriate steps to improve patient outcomes will be taken sooner.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887082713431,"sku":"9781629483238","price":92.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781629483238.jpg?v=1722542918"},{"product_id":"venous-thrombosis-risk-factors-management-complications-9781631172939","title":"Venous Thrombosis: Risk Factors, Management \u0026","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThrombophilias can be defined as a group of inherited or acquired disorders that increase the risk of developing thrombosis. Venous thromboembolism (VT) is considered a multifactorial disease produced by a sum of risk factors that predispose to the thrombotic event. This predisposition includes genetic and acquired defects. Thrombosis can occur in any section of the venous system, but commonly manifests as deep vein thrombosis of the leg and pulmonary embolism. Major complications of venous thrombosis are a disabling post-thrombotic syndrome, pulmonary hypertension, and sudden death duo to a pulmonary embolism and therefore, it poses a burden on health economy. Venous thrombosis is a common clinical challenge for doctors of all disciplines, as it is a complex multicausal disease. This books discusses in further detail the many complications and risk factors caused by venous thrombosis.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887103717719,"sku":"9781631172939","price":122.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781631172939.jpg?v=1722543016"},{"product_id":"deep-vein-thrombosis-risk-factors-treatment-clinical-outcomes-9781631174698","title":"Deep-Vein Thrombosis: Risk Factors, Treatment \u0026","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eInferior Vena Cava (IVC) filters have become an important part of deep venous thrombosis and pulmonary embolism treatment and prevention. With the advent of retrievable filters a new era of IVC instrumentation has been initiated. This book will begin to review the history of IVC filtration, indications for permanent and temporary filter use and filter use in special populations such as the pregnant patient or those with upper extremity venous thrombosis. The authors also review the technical aspects of filter placement and retrieval and discuss immediate and long-term complications from IVC filters. The book will also continue to discuss how acute spinal cord injury provides risks for developing deep vein thrombosis; and discuss the efficacy and safety of novel oral anticoagulants for venous thromboembolisms.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887106601303,"sku":"9781631174698","price":73.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781631174698.jpg?v=1722543032"},{"product_id":"thalassemia-causes-treatment-options-long-term-health-outcomes-9781631179549","title":"Thalassemia: Causes, Treatment Options \u0026","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThalassemia is one of the most common genetic disorders worldwide and presents major public health and social challenges in areas of high incidence. The frequency of this disorder varies considerably with geographic locations and racial groups. Thalassemia refers to a group of inherited hemolytic anemia disorders that involve defects in the synthesis of hemoglobin α- or β-polypeptide chains. It leads to decreased hemoglobin production and hypochromic microcytic anemia associated with erythrocyte dysplasia and destruction. Homozygous β-thalassemia (also known as thalassemia major, Cooley''s anemia, or Mediterranean anemia) is associated with the most severe signs and symptoms. Thalassemia major (TM) is a life-threatening condition that commonly manifests during early infancy, after which progressive pallor, severe anemia, and failure to thrive are common. Children with TM often develop feeding problems, recurrent fever, bleeding tendencies (especially epistaxis), susceptibility to infection, pathologic fractures of long bones and vertebrae, endocrine abnormalities, splenomegaly, lack of sexual maturation, and growth retardation. This book discusses cures and treatments available for thalassemia, as well as the causes and the type of long-term health outcomes it may cause.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887115284823,"sku":"9781631179549","price":182.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781631179549.jpg?v=1722543074"},{"product_id":"myeloproliferative-disorders-symptoms-risk-factors-and-treatment-options-9781633212015","title":"Myeloproliferative Disorders: Symptoms, Risk","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eMyeloproliferative disorders are a group of clonal haematological neoplasms characterised by proliferation of one or more cells of myeloid lineage. They are the result of acquired mutations in the progenitor cell leading to hyper proliferation or neoplastic expansion of more mature forms of myeloid cells. Cells retain their functional ability with some degree of defects and also lead to suppression of normal stem cells. The most common type of Myeloproliferative Neoplasms (MPN) can broadly be classified into BCR ABL positive (Chronic Myelogenous Leukemia) and BCR ABL negative Disorders (Polycythemia Vera PV, Essential Thrombocytosis ET and Primary Myelofibrosis PMF). There are other rare types which have relatively low incidence like chronic neutrophilic leukemia, chronic eosinophilic leukemia, systemic mastocytosis and myeloproliferative neoplasms unclassifiable. These are the indolent type of haematological malignancies associated with marrow hypercellularity and organomegaly, with gradual progression to myelofibrosis or transformation to acute leukemias. During the dormant course of the BCR ABL negative MPN, they are more prone to thrombo-hemorrhagic complications and the treatment strategy is directed mostly to prevent complications. The past decade; therapies for BCR ABL positive disease (CML) have been a milestone achievement in keeping the disease in remission for many years, preventing major complications and halting the progression of the disease. This book discusses the classification, diagnosis and treatment of myeloproliferative diseases and provides insight on the symptoms and risk factors involved in the diseases.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48887135830359,"sku":"9781633212015","price":86.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781633212015.jpg?v=1722543172"}],"url":"https:\/\/bookcurl.com\/collections\/haematology.oembed?page=3","provider":"Book Curl","version":"1.0","type":"link"}