{"title":"Genetic engineering Books","description":"","products":[{"product_id":"flowers-for-algernon-9781399607766","title":"Flowers For Algernon","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eCharlie Gordon, IQ 68, is a floor sweeper and the gentle butt of everyone''s jokes - until an experiment in the enhancement of human intelligence turns him into a genius.\u003cbr\u003e\u003cbr\u003e But then Algernon, the mouse whose triumphal experimental transformation preceded his, fades and dies, and Charlie has to face the possibility that his salvation was only temporary.\u003cbr\u003e\u003cbr\u003e\u003ci\u003eWinner of the 1960 Hugo Award for Best Short Story, and subsequently expanded into a Hugo-nominated novel, \u003c\/i\u003eFlowers for Algernon\u003ci\u003e earned Daniel Keyes the honour of SFWA Author Emeritus in 2000 for his contribution to Science Fiction and Fantasy.\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e''Heartbreaking and beautiful. Required reading, as far as I am concerned'' - Wil Wheaton\u003cbr\u003e''A masterpiece of poignant brilliance . . . heartbreaking, and utterly, completely brilliant'' - \u003ci\u003eThe Guardian\u003c\/i\u003e\u003cbr\u003e''Excellent . . . extremely moving'' - \u003ci\u003eThe Encyclopedia of Science Fiction\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eWelcome to The Best Of The Masterworks: a selection of\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis is one of the greats: a story and a central character that have stayed with me for thirty years, from the first moment I picked it up * Conn Iggulden *\u003cbr\u003eA masterpiece of poignant brilliance . . . heartbreaking, and utterly, completely brilliant * Guardian *\u003cbr\u003eA timeless tearjerker * Independent *\u003cbr\u003eExcellent . . . extremely moving * The Encyclopedia of Science Fiction *\u003cbr\u003eUnflinchingly honest . . . it will make you reflect on your own life . . . and completely and utterly break your heart * Guardian Online *\u003cbr\u003eA narrative \u003ci\u003etour de force\u003c\/i\u003e, very moving, beautiful and remorseless in its simple logic * Science Fiction, 100 Best Novels *\u003cbr\u003eStrikingly original * Publishers Weekly *\u003cbr\u003eA tale that is convincing, suspectful  and  touching * New York Times *\u003c\/b\u003e\u003c\/p\u003e","brand":"Orion Publishing Co","offers":[{"title":"Default Title","offer_id":47836752314711,"sku":"9781399607766","price":9.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781399607766.jpg?v=1710381988"},{"product_id":"dna-demystified-unravelling-the-double-helix-9780190092962","title":"DNA Demystified Unravelling the Double Helix","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDNA, once the exclusive domain of scientists in research labs, is now the darling of popular and social media. With personal genetic testing kits in homes and GMO foods in stores, DNA is an increasingly familiar term. Unfortunately, what people know, or think they know, about DNA and genetics is often confused or incorrect. Contrary to popular belief, for instance, genes don''t skip a generation and, no, human DNA is not different from DNA of other species. With popular misconceptions proliferating in the news and on the internet, how can anyone sort fact from fiction? DNA Demystified satisfies the public appetite for and curiosity about DNA and genetics. Alan McHughen, an accomplished academic and public science advocate, brings the reader up-to-speed on what we know, what we don''t, and where genetic technologies are taking us. The book begins with the basic groundwork and a brief history of DNA and genetics. Chapters then cover newsworthy topics, including DNA fingerprinting, using DNA in forensic analyses, and identifying cold-case criminals. For readers intrigued by the proliferation of at-home DNA tests, the text includes fascinating explorations of genetic genealogy and family tree construction-crucial for people seeking their biological ancestry. Other chapters describe genetic engineering in medicine and pharmaceuticals, and the use of those same technologies in creating the far more controversial GMOs in food and agriculture. Throughout, the book raises provocative ethical and privacy issues arising from DNA and genetic technologies.With the author''s comprehensive expertise, DNA Demystified offers an informal yet authoritative guide to the genetic marvel of DNA.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis will be a handy review for graduate students preparing for their qualifying oral exams and the author takes the time to understand the opposing views to DNA in agricultural, pharmaceutical, medical, or other applications of DNA in our lives. * Elof Axel Carlson, Biochemistry \u0026amp; Cell Biology, Stony Brook University, The Quarterly Review of Biology *\u003cbr\u003eDNA Demystified is perfect for the amateur science enthusiast who is fascinated by everything that touches on DNA, from forensics to genetic disease markers to family genealogy. Full of detail fascinating stories, this is ultimately an absorbing read. * Nina Fedoroff, Penn State University *\u003cbr\u003eAlan McHughen has superbly explained everything we know about DNA, the beautiful and ingenious coding device at the heart of life. This is a very useful book for all those who fear they cannot understand the science of DNA: they will soon find that they can and it's fascinating. * Matt Ridley, author of Genome: The Autobiography of a Species in 23 Chapters *\u003cbr\u003eA highly engaging book that explains the basic process of how genes work and the impact that current advances in DNA research has had on medicine, agriculture, and law, in simple and elegant terms. This wonderful book is designed for those who want to understand what DNA is and how it is changing our lives, with much promise and peril along the way. I found reading Alan McHughen's book a delightful and informative journey into the world of DNA. * Bob Goldberg, UCLA and Member of US National Academy of Sciences *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eDedication       Acknowledgements Preface Introduction         Chapter 1 Foundations      Chapter 2 DNA 101     Chapter 3 Human DNA     Chapter 4 Practical Applications    Chapter 5 Personal DNA and Genomics     Chapter 6 Medical and Health applications   Chapter 7 Genetic Genealogy     Chapter 8 DNA Tests for Genealogy  Chapter 9 Which company?     Chapter 10 Genetic Engineering and GMOs   Chapter 11 Ethical dilemmas     Chapter 12 Fighting Mother Nature?  Endnotes Glossary","brand":"Oxford University Press Inc","offers":[{"title":"Default Title","offer_id":48732533522775,"sku":"9780190092962","price":36.09,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780190092962.jpg?v=1719997310"},{"product_id":"genes-a-very-short-introduction-very-short-introductions-9780192856708","title":"Genes A Very Short Introduction Very Short","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eVery Short Introductions\u003cb\u003e: Brilliant, Sharp, Inspiring \u003c\/b\u003eIn this exploration of the concept of the gene, Jonathan Slack looks at the discovery, nature, and role of genes in both evolution and development. By explaining the nature of genetic variation in the human population, how hereditary factors were identified as molecules of DNA, and how certain specific mutations can lead to disease, Slack highlights how DNA variants are used to trace human ancestry and migration, and can also be used by forensic scientists to identify individuals in crime. He also explores issues such as the role of genetic heritability and IQ as well as the changes that occur in the genes of populations during evolution.An ideal guide for anyone curious about what genes are and how genetics can be put to use, this Very Short Introduction demonstrates the ways in which the gene concept has been understood and used by molecular biologists, population biologists, and social scientists around the world. This second edition has been fully updated and contains new sections on the CRISPR method for targeted genetic modification, on DNA profiling, and developments in our understanding of human ancestry using ancient DNA.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eThis is a concise and accurate account of genes and what they are in a readable and convenient format. * Sir Paul Nurse, Director, Francis Crick Institute *\u003cbr\u003eUnlike the genetic material itself, this book is short, sharp, and to the point. * Steve Jones, University College London *\u003cbr\u003eWe all need to know what genes are. Slack tells us with authority, clarity and grace. * Armand Leroi, Imperial College, London *\u003cbr\u003eThe essential guide for getting up to speed with the ever-changing and crazily complex science of genetics. * Adam Rutherford, University College London *\u003cbr\u003eWith more heat than light in many areas surrounding genetics, it is refreshing to have such a concise, precise and matter-of-fact introduction to the field. This is strongly recommended to anyone with even a passing interest in a field set to dominate our lives. * Laurence Hurst, Director of The Milner Centre for Evolution, University of Bath *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface List of illustrations 1: Genes before 1944 2: Genes as DNA 3: Mutations and gene variants 4: Genes as markers 5: Genes of small effect 6: Genes in evolution Conclusion: the varied concepts of the gene Further reading Glossary Index\u003c\/b\u003e","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732600172887,"sku":"9780192856708","price":9.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780192856708.jpg?v=1791378660"},{"product_id":"redesigning-life-9780198766834","title":"Redesigning Life","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eSince the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximise agricultural production and cater to our taste in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin''s theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering.In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. ''Mutation chain reaction'' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch.These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring  and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? In this extensively revised paperback edition, John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003ea thorough and comprehensive account of the methodologies for altering life that have been or are being developed, and the directions that they may take in future. * Nature *\u003cbr\u003epainstakingly researched...the examples themselves are clear, concise and often arresting . . . an engaging and comprehensive introduction * LSE Business Review *\u003cbr\u003ea comprehensive history of the research and discoveries underlying genome editing, as well as a broad coverage of research in the present day. * Bionews *\u003cbr\u003eThere is a revolution going on in the life sciences, one that has already transformed scientific discovery and will soon change medicine. It could even see us altering the ecosystem in a precise, targeted way. This revolution has a name--CRISPR--and the key part of John Parrington's Redesigning Life is a good summary of the gene-editing technique that lies behind the acronym. * New Scientist *\u003cbr\u003eJohn Parrington's engaging and thoughtful book explains the science behind recent rapid advances in genetic engineering that mean it is increasingly possible to enact precise changes at a molecular level . . . Parrington's clear descriptions and diagrams combined with interesting snippets from the narrative and biography of scientific discovery make the science behind these developments readily accessible. * Socialist Review *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eList of plates List of figures Introduction: The Gene Revolution 1: Natural Born Mutants 2: Supersize My Mouse 3: Light as a Life Tool 4: The Gene Scissors 5: Next Year's Models 6: The Molecular Farm 7: New Gene Therapy 8: Regenerating Life 9: Life as a Machine 10: A Redesigned Planet? Glossary Endnotes Index of names Index of subjects","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732779839831,"sku":"9780198766834","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198766834.jpg?v=1719998365"},{"product_id":"evolving-tomorrow-genetic-engineering-and-the-evolutionary-future-of-the-anthropocene-9780198874522","title":"Evolving Tomorrow Genetic Engineering and the","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe Anthropocene defines the here-and-now time period on Earth of indelible (and possibly irreversible) human disturbance to the natural world, from habitat destruction and mass extinction to global climate change. To ameliorate and repair the damage that threatens the world''s dwindling resources and our very existence, humanity is enacting massive interventions to fuse modern technologies with long established natural processes. Advances in genetic engineering have put us on the cusp of directly shaping the DNA of every living organism (including ourselves), as well as determining the evolution of completely novel species. The author invites the reader to explore how humans have manipulated the ancient forces of evolution and the future possibilities of genetic engineering for conservation and rewilding, de-extinction, and even the creation of viable populations of entirely new species. To entertain such possibilities of synthetic biology, he forces us to wrestle with the threats and ethical conundrums that surround the unintended consequences, as well as the values that humanity places on authenticity in nature. In so doing, this accessible and thought-provoking book explores the potential future of life on planet Earth.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eCutter presents us with a wonderfully stimulating book, elegantly weaving in personal narratives, natural history examples, and inspiring thought experiments. * Mohamed Noor, Professor of Biology and Interim Vice Provost for Academic Affairs, Duke University *\u003cbr\u003eThis book is a must-read for anyone curious about the potential of genetic technologies to control the very fate of nature, itself. And if you happen to be someone who wants to build a dragon from scratch, then it's a good book for you, too! * Daniel Riskin, Adjunct Professor, University of Toronto Mississauga, TV Host, and Producer *\u003cbr\u003eAn excellent primer for anyone hoping to understand how today's biotechnologies - and the way we choose to use them - have the power to change all of life on Earth. * Beth Shapiro, Professor, University of California, Santa Cruz. Author of How to Clone a Mammoth and Life As We Made It *\u003cbr\u003eA highly enjoyable and thought-provoking book about the ways in which timeless biological processes and ever more powerful human tinkering are, together, shaping the evolutionary future. * Rob Dunn, Professor, North Carolina State University *\u003cbr\u003eVery well written, this book contributes to the understanding of genetic editing and the significant changes that may result from it. Essential. All readership levels. * Choice *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface Part 1: The Hearts of Nature 1: Nature in the raw, and cooked 2: Selection, naturally and otherwise 3: Ancient forces 4: Evolution's racetracks 5: Evolutionary accelerants and speed bumps 6: Carjacking genetics 7: Genetic welding 8: On the origin of species 9: Do-it-yourself speciation 10: Ongoing evolutionary outcomes Part 2: Evolutionary Futures 11: How to evolve a dragon 12: Evolutionary engineering in the flesh 13: Nature, rewilded 14: When nature comes to call 15: Inspection by the department of health, safety, and ethics 16: When we become dragons 17: A midnight coterie of transcendent fauna","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732825813335,"sku":"9780198874522","price":34.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198874522.jpg?v=1719998566"},{"product_id":"an-introduction-to-statistical-genetic-data-analysis-the-mit-press-9780262538381","title":"An Introduction to Statistical Genetic Data","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eA comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics.\u003c\/b\u003e\u003cp\u003eHuman genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required.\u003c\/p\u003e\u003cp\u003eThe book first pro\u003c\/p\u003e","brand":"MIT Press","offers":[{"title":"Default Title","offer_id":48733469213015,"sku":"9780262538381","price":34.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780262538381.jpg?v=1720000193"},{"product_id":"decoding-the-world-9781472278630","title":"Decoding the World","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eA vision of the future where the latest Silicon Valley tech meets cutting-edge genetics.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003ci\u003eDecoding the World\u003c\/i\u003e is a buddy adventure about the quest to live meaningfully in a world with such uncertainty. It starts with Po Bronson coming to IndieBio.\u003cbr\u003e\u003cbr\u003eArvind Gupta created IndieBio as a laboratory for early biotech startups trying to solve major world problems. Glaciers melting. Dying bees. Infertility. Cancer. Ocean plastic. Pandemics.\u003cbr\u003e\u003cbr\u003eAs they travel around the world, finding scientists to join their cause, the authors bring their first-hand experience to the great mysteries that haunt our future. Natural resource depletion. Job-taking robots. China''s global influence.\u003cbr\u003e\u003cbr\u003e\u003ci\u003eDecoding the World \u003c\/i\u003eis the kind of book you get when you give two guys $40 million, a world full of messy big problems, a genetics laboratory to play in, and a set of Borges'' collected works\u003ci\u003e. \u003c\/i\u003eAfter looking through their lens, you''ll never see the world the same.\u003c\/p\u003e","brand":"Headline Publishing Group","offers":[{"title":"Default Title","offer_id":48739453010263,"sku":"9781472278630","price":10.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781472278630.jpg?v=1720052287"},{"product_id":"good-enough-to-eat-next-generation-gm-crops-9781788010856","title":"Good Enough to Eat?: Next Generation GM Crops","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eSo long as you have food in your mouth, you have solved all questions for the time being. So begins Good Enough to Eat?, which challenges Kafka’s culinary sentiments and proceeds to unravel our complex and deeply personal relationship with food.    Including interviews from both sides of the (farmyard) fence; from biologists to farmers and nutritionists to activists, Good Enough to Eat? charts the history of GM foods from the laboratory to the global dinner plate. Equally informative and entertaining, Godwin chronicles the social, political and philosophical arguments for and against GM crops, and the science and knowledge behind the battle for global food security and sustainability.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eIan Godwin has done that rare thing - written a book about science which is informal but informed, readable but authoritative, and sparkling with wit. I highly recommend it for anyone interested in the GM foods and crops issue. -- Mark Lynas, Journalist and author of Seeds of Science: Why We Got It So Wrong on GMOs\u003cbr\u003eGodwin’s book presents an authoritative account of the history of GM crops going back to their beginnings, including the science behind the technology and the first products that came to market. A wonderful story is woven of science, discovery and anecdote, with Australian directness and humour. Godwin explains and entertains. Information is drawn from many quarters from biologists, farmers, nutritionists and activists and from Godwin’s direct experiences over 30 years. . -- Dr Matthew Paul, Rothamsted Research UK * The Journal of the Institute of Food Science \u0026amp; Technology *\u003cbr\u003eThis book is easy reading and highly commendable, providing very useful information in a simple style; 'greenish' people should read it! -- Jose I. Cubero; The Journal of Agricultural Science\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eFood, Glorious Food; A Kind of Magic; Revolution; Chemical Heart; Wide Open Spaces; Bad Moon Rising; Paint It Black; Not Ready to Make Nice; O Fortuna!; New Kid in Town; For a Better Day","brand":"Royal Society of Chemistry","offers":[{"title":"Default Title","offer_id":48741568414039,"sku":"9781788010856","price":24.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781788010856.jpg?v=1791477498"},{"product_id":"animal-biotechnology-1-reproductive-biotechnologies-9783319923260","title":"Animal Biotechnology 1: Reproductive","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis two-volume textbook provides a comprehensive overview on the broad field of \u003ci\u003eAnimal Biotechnology\u003c\/i\u003e with a special focus on livestock reproduction and breeding. The reader will be introduced to a variety of state-of-the-art technologies and emerging genetic tools and their applications in animal production. Also, ethics and legal aspects of animal biotechnology will be discussed and new trends and developments in the field will be critically assessed. The two-volume work is a must-have for graduate students, advanced undergraduates and researchers in the field of veterinary medicine, genetics and  animal biotechnology.\u003cbr\u003eThis first volume mainly focuses on artificial insemination, embryo transfer technologies in diverse animal species and cryopreservation of oocytes and embryos. \u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e“This book is of interest to academicians and researchers in the various disciplines of life sciences, agricultural sciences, medicine, and biotechnology in universities, research institutions, and biotechnology industries. … the book achieves its goal of providing an overview of the new developments in assisted reproductive technologies.” (Juanmahel Davila, Doody's Book Reviews, July 05, 2019)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1.\tEvolution of animal breeding and animal biotechnology\tH. Niemann and R.F. Seamark\t\t\u003cbr\u003e2.\tFuture Agricultural Animals: The Need for Biotechnology\tG. Seidel \u003cbr\u003e3.\tArtificial insemination in domestic and wild animal species \tD. Waberski\t\u003cbr\u003e4.\tTechnique and Application of Sex Sorted Sperm in Domestic Farm Animals\tD. Rath and C. Maxwell \u003cbr\u003e5.\tET-technologies in domestic cattle \tG. Bo and R Mapletoft\u003cbr\u003e6.\tET-technology in small ruminants\tS. Ledda and A. Gonzalez-Bulnes\u003cbr\u003e7.\tET-technology in domestic pigs\tC. Youngs \u003cbr\u003e8.\tET-technologies in horses\tH. Sieme, J. Rau, D. Tiedemann, H. Oldenhof, L. Barros, R. Sanchez, M. Blanco, G.Martinsson, C. Herrera, D. Burger\u003cbr\u003e9.\tEndoscopy in Cattle Reproduction \tV. Havlicek, G. Brem, U. Besenfelder\u003cbr\u003e10.\tTransvaginal ultrasound-guided oocyte retrieval (OPU: Ovum Pick-Up) in cows and mares \tP. Bols and T. Stout\u003cbr\u003e11.\tPreservation of Gametes and Embryos\tA. Arav and J. Saragusty\u003cbr\u003e12.\tIn vitro production of farm animal embryos\t\tC. Wrenzycki","brand":"Springer International Publishing AG","offers":[{"title":"Default Title","offer_id":48743109919063,"sku":"9783319923260","price":98.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783319923260.jpg?v=1720064154"},{"product_id":"how-to-build-a-dragon-or-die-trying-a-satirical-look-at-cutting-edge-science-9789813275935","title":"How To Build A Dragon Or Die Trying: A Satirical","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e'This co-authored book explores how advances in cell biology, CRISPR gene editing and bioengineering might be used to make a live dragon. The result is a gloriously tongue-in-check scientific epic … How to Build a Dragon or Die Trying is deliberately flamboyant and outrageous. It’s also funny and smart. Far from a how-to guide for ne’er-do-wells to weaponize reptiles, it is designed to spark healthy curiosity in anyone who enjoys a ripping good science read.'NatureWhat if you could have your own real dragon? While that might seem like just a fantasy, today cutting-edge science has brought us to the point where it might really be possible. This book looks into the possibilities of making living, fire-breathing dragons. The world has been fascinated with dragons for thousands of years. Fictional dragons still have a firm place in pop culture, such as Smaug from The Hobbit as well as the dragons in Game of Thrones and in the How to Train Your Dragon movies. This new book discusses using powerful technologies such as CRISPR gene editing, stem cells, and bioengineering to make real dragons. It also goes through what useful information we can learn from animals such as Pteranodons and amazing present-day creatures in our quest to build actual dragons. The book goes on to discuss the possibility of building other mythical creatures such as unicorns and mermaids. Overall, How to Build A Dragon is also meant as a satirical look at cutting-edge science, and it pokes fun at science hype. Anyone who is interested in dragons or cutting-edge science will enjoy this book! It is written in a humorous, approachable way making science fun and easy to understand, including for young adults.The author is well-known scientist Paul Knoepfler who is familiar to the public for his science, his blog The Niche, and his frequent contributions to lay stories on new science concepts such as stem cells and CRISPR. He also is known for his TED talk on designer babies with more than 1.3 million views, and his two books — . The co-author, his daughter Julie Knoepfler, is a high school student interested in science and writing. She has her own blog on literary and film analysis, and enjoys taking a humorous look at culture through writing.","brand":"World Scientific Publishing Co Pte Ltd","offers":[{"title":"Default Title","offer_id":48743298007383,"sku":"9789813275935","price":23.75,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9789813275935.jpg?v=1720064980"},{"product_id":"gmo-sapiens-the-life-changing-science-of-designer-babies-9789814667005","title":"Gmo Sapiens: The Life-changing Science Of","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book won the INDIEFAB 2015 Bronze Award for Science (Adult nonfiction).Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.Should they do it? Could we become a healthier and 'better' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eIntroduction: GMO OMG; The History of GMOs; GMO People; The Possible Risks of GMO People; The Potential Benefits of Human Genetic Modification; The Cloning Connection; Stem Cells and GMOs; GMO Sapien Economics; Gene Therapy; GMO People in Pop Culture; GMO Myths; Big Green Men: Designer People and Eugenics; The Ethics of Human Genetic Modification;","brand":"World Scientific Publishing Co Pte Ltd","offers":[{"title":"Default Title","offer_id":48743300038999,"sku":"9789814667005","price":50.4,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9789814667005.jpg?v=1720064991"},{"product_id":"genomics-and-personalized-medicine-9780190234768","title":"Genomics and Personalized Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person''s health.  Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual''s genetic sequence -- their genome -- against known elements of Big Data, elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"Michael Snyder's Personalized Medicine: What Everyone Needs  to Know is a very readable introduction to current developments in science,  illustrated with multiple examples of individual cases.\" - European Journal of Health Law\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eAcknowledgements Introduction  1: Personalized Medicine What is personalized medicine? What personal factors impact your health?  2: Genome Fundamentals What is DNA? What is a genome? What does the genome do? How does one person's genome differ from another person's genome? How do genomes of men and women differ? How is the genome decoded?  3: An Introduction to Cancer Genetics What is cancer and how does it arise? How do the BRCA1 and BRCA2 genes cause cancer? What are examples of other genes implicated in cancer? How does genetic information help us treat cancer?  4: Genomics and Cancer Treatment What has been learned from genome sequencing of cancer? How can genome sequencing advance cancer treatment? If I have cancer should I get my tumor genome sequenced? Why do anticancer drugs fail and how might genomic approaches help address this issue? Can genetics and genomics help detect early cancer and monitor treatment effectiveness? A new approach: What is immunotherapy? How can genomics be used to harness the patient's own immune system to fight their cancer?  5: Solving Mystery Diseases What is a mystery genetic disease? How many Mendelian diseases are there? How are genes responsible for genetic disorders identified? How useful are genomic approaches to solving mystery genetic diseases? Why can't most Mendelian diseases be solved?   6: Complex genetic diseases What is a complex genetic disease? How do complex genetics affect neurological diseases? How does complex genetics affect metabolic diseases? Can some diseases be both monogenic and complex?  7: Pharmacogenomics How can your genome directly help guide drug treatments for treating disease?  What are other ways your DNA can guide drug treatments Are there sex differences in drug effects?  8: Genomics for the Healthy Person How can getting your genome sequence improve your health? Can genome sequencing affect the drugs someone take? Can genetic testing be used to predict sports performance and injuries? Will sequencing my genome affect my children and my relatives?  9: Prenatal Testing How are genome sequencing technologies changing prenatal testing? Can genome sequencing be used to identify other mutations, beyond chromosomal abnormalities, that might cause disease? Can genetic testing be useful for choosing healthier embryos and producing designer babies?  10: Effects of the environment on the genome and epigenetics How does the environment contribute to health? When did people first begin to study environmental effects? When do environmental effects begin? Can environmental factors directly impact the genome? What is epigenetics? What are some examples of environmental effects on physiology that are mediated through epigenetics? What is the role of epigenetics in disease?  How will increased understanding of epigenetics impact health care?  11: Other 'Omes What other 'omes are useful for medicine? How can the transcriptome and proteome be useful? How can the metabolome be useful? How deeply can a person be analyzed?  12:  The personal microbiome What is the microbiome? How is the microbiome studied? How does the microbiome affect health? How does diet affect the microbiome? Can the microbiome affect other aspects of our lives? Can the microbiome be altered to improve human health?  13: Your Immune System and Infectious Diseases  How does your immune system protect you? How does the immune system vary among people and affect our health? How can we analyze infectious diseases?  14: How does age affect your health?  Are there genetic factors underlying longevity? Are there environmental factors that affect aging and longevity? Does epigenetics control aging? Will we someday be able to control our aging?  15: Wearable Health Devices What other types of personal health information can be readily collected? How will this information be made available to, and used by, the individual?  16: Big Data and medicine How much data can be gathered about a single person? How much data can be gathered about a group of people? How can a large database assist in medical care? How can Big Data guide lifestyle decisions? What are the opportunities for industry in Big Data Medicine?  17: Delivery of genomic information Who controls your genomic and other health information? Who will deliver genomic information to you? What is the role of the physician? What are the implications of direct-to-consumer genomic testing?  18: Ethics Can your genetic information be used against you?  What are the concerns surrounding routine (or even mandated) genetic screening? What is a possible solution?  19: Education Can we educate people to understand genomic information? How do we educate physicians to understand genomic information Who else should we educate? What is the role of health care providers, insurers and policy makers?  20: Privacy: Identifying people from their sequences. Can people be identified solely from the genome sequence? Will getting my genome sequenced affect my family members?  21:  Paying for personalized medicine Who pays for genome sequencing in treating disease? Who pays for genome sequencing in preventive medicine? Will genome sequencing make health care cheaper? Will people act on genomic information?  22:  The future of personalized medicine What other technologies will be prevalent in the personalized medicine space? What will the future look like?  Index","brand":"Oxford University Press Inc","offers":[{"title":"Default Title","offer_id":48864199770455,"sku":"9780190234768","price":10.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780190234768.jpg?v=1722270864"},{"product_id":"cloning-gene-expression-and-protein-purification-9780195132946","title":"Cloning Gene Expression and Protein Purification","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe central purpose of this combination lecture\/laboratory manual is to present detailed protocols for the multi-step process involved in isolating a gene, cloning and characterizing it, expressing the encoded protein, purifying the protein, and characterizing rudimentary aspects of its basic physical properties. The manual includes 20 experiments designed to train students to prepare, manipulate, and analyse plasmids, to produce fusion proteins in bacteria, and to purify these proteins based on unique chemical properties or substrate affinities. Electrophoresis, Southern and Western blotting and cominatorial techniques are emphasized. Radioisotopes, fluorophores and solvent effects on protein structure are discussed. (No radioisotopes are required.)  The experiments included have been selected because of their high success rate and because they emphasize a project-oriented approach. Sufficient detail and background are provided such that the intended audience includes advanced undergr\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eINTRODUCTORY UNIT; PART I - NCULEIC ACIDS \u0026amp; CLONING; UNIT 1; UNIT 2; UNIT 3; UNIT 4; UNIT 5; UNIT 6; PART 2 - PROTEIN PURIFICATION; UNIT 7; UNIT 8; UNIT 9; UNIT 10; APPENDICES; INDEX","brand":"Oxford University Press Inc","offers":[{"title":"Default Title","offer_id":48864209961303,"sku":"9780195132946","price":70.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780195132946.jpg?v=1791454177"},{"product_id":"the-case-against-perfection-9780674036383","title":"The Case against Perfection","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eGenetic breakthroughs present us with a predicament: is it wrong to re-engineer our nature? Sandel explores the moral quandaries surrounding the quest to perfect ourselves and our children. He concludes that the pursuit of perfection is flawed for reasons beyond safety and fairness; it also suggests a failure to appreciate human achievements.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eThe Case against Perfection\u003c\/i\u003e by Michael Sandel is a brief, concise, and dazzling argument by one of America’s foremost moral and political thinkers that brings you up to speed on the core ethical issues informing current debates about genetic engineering and stem cell research. -- Gabriel Gbadamosi * BBC Radio *\u003cbr\u003eSandel’s arguments ultimately speak to our gut-level qualms about enhancement; and his aim in fact is to give these qualms a coherent moral basis… His book in the end is more a lyrical plea for reverence and humility than a lawyer’s watertight ‘case against.’… The ethicist Michael Sandel wants us at least to think about the line [between health and enhancement], however imaginary—and to think about where, in a hyper-competitive world, re-engineering our natures will ultimately lead. -- Michele Pridmore-Brown * Times Literary Supplement *\u003cbr\u003eMichael Sandel‘s dive into the sea of genetic engineering provides a great tasty gulp of contemporary ethical controversy. Quickly read, \u003ci\u003eThe Case against Perfection\u003c\/i\u003e is nonetheless dense with challenging quandaries, loaded with moral puzzles and filled with facts. An inveterate highlighter, I underlined half the book. -- John F. Kavanaugh * America *\u003cbr\u003eIn the future, genetic manipulation of embryos is expected to have the potential to go beyond the treatment of diseases to improvements: children who are taller, more athletic, and have higher IQs… In \u003ci\u003eThe Case against Perfection\u003c\/i\u003e, Michael Sandel argues that the unease many people feel about such manipulations have a basis in reason… This beautifully crafted little book…quickly and clearly lays out the key issues at stake. -- Gregory M. Lamb * Christian Science Monitor *\u003cbr\u003eGiven the vast gulf between progressive and conservative thinking, the time is ripe for a philosopher to take on the issues of biotechnology. And in \u003ci\u003eThe Case against Perfection\u003c\/i\u003e Harvard’s Michael Sandel does just that, attempting to develop a new position on biotechnology, one that, like Sandel himself, is not easily identified as either left or right. A former member of the President’s Council on Bioethics, Sandel is uniquely well suited for this task, and to challenge the left to get its bearings on the brave new biology… Sandel poses an important challenge to contemporary progressives who have failed to grasp the importance of the emerging biopolitics. -- Jonathan Moreno * Democracy *\u003cbr\u003eIn a highly readable, wise and little book titled \u003ci\u003eThe Case against Perfection: Ethics in the Age of Genetic Engineering\u003c\/i\u003e, Michael Sandel argues that parents’ quest to create the ideal child reflects a drive for mastery and domination over life. -- Douglas Todd * Vancouver Sun *\u003cbr\u003eAnyone who thinks our culture is too competitive and consumer-driven should find that Sandel’s diagnosis resonates. He provides not only a warning about the shape of the future, but equally an indictment of—or at least a call to examine—our individual moral lives and our contemporary social values. Those who support the practice of genetic enhancement argue that the technology is not substantially different from other forms of ‘enhancement’ we use to improve our lives and the lives of our children. Sandel agrees, but he does not base his argument on any particular distinction about the means of enhancement; rather he is deeply concerned about the underlying impetus of mastery and dominion. -- Debra Greenfield * Bioethics Forum *\u003cbr\u003eFor many years I have been ambivalent about reproductive innovations, from surrogate gestation to preimplantation screening for gender selection. After reading Sandel’s exceedingly elegant little book, \u003ci\u003eThe Case against Perfection: Ethics in the Age of Genetic Engineering\u003c\/i\u003e, I could finally put satisfactory names to core values implicit in my hesitation: acceptance and solidarity. I encountered Sandel’s book as a participant in the intellectual discourse about parenting. But the book’s greatest value to me was its validation of the commitments of solidarity expressed in my volunteer work on behalf of poor mothers and of acceptance implicit in my determination to mother a child with catastrophic mental illness. -- Anita L. Allen * Chronicle of Higher Education *\u003cbr\u003e[Sandel] makes the compelling case that gentic engineering to gain advantage for ourselves and our children is deeply disempowering, because it turns us away from the communal good, toward self-centered striving. -- Anne Harding * The Lancet *\u003cbr\u003e[A] graceful and intelligent new book. -- Carl Elliott * New England Journal of Medicine *\u003cbr\u003eNobody’s perfect, and Mr. Sandel’s book makes an instructive and engaging case that that nobody should be. -- Yuval Levin * New York Sun *\u003cbr\u003eIn this short and provocative treatise, Sandel, who is professor of government at Harvard and a member of the President’s Council on Bioethics, takes on the question of why certain kinds of newly available genetic technologies make us uneasy…[his] book reminds us that the proper starting point for bioethics is not, ‘what should we do?’ but rather, ‘what kind of society do we want?’ And ‘what kind of people are we?’ -- Faith McLellan * The Scientist *\u003cbr\u003eAn illuminating ethical analysis of stem-cell research concludes this stellar work of public philosophy. -- Ray Olson * Booklist *\u003cbr\u003eThis rather small book presents, in very succinct fashion, many of the arguments against proposals to bioengineer human life. Sandel…argues with care and clarity not only against the more extreme cases such as human cloning, but also against the more modest proposals of gene modification. As the title suggests, the arguments are almost exclusively negative, although Sandel’s most interesting and creative suggestion is the idea that such human bioengineering will cause human beings to lose the sense of life as a ‘gift,’ and that this will have a serious morally negative effect upon the entire social structure. -- P. A. Streveler * Choice *\u003cbr\u003eSandel explores a paramount question of our era: how to extend the power and promise of biomedical science to overcome debility without compromising our humanity. His arguments are acute and penetrating, melding sound logic with compassion. We emerge from this book feeling edified and inspired. -- Jerome Groopman, Harvard Medical School, author of \u003ci\u003eHow Doctors Think\u003c\/i\u003e\u003cbr\u003eWe live in a world, says Michael Sandel, where ‘science moves faster than moral understanding.’ But thanks to Sandel, moral understanding is catching up. Cloning, stem cell research, performance-enhancing drugs, pills that make you stronger or taller: if some scientific development bothers you, but you can’t explain why, Michael Sandel will help you to figure out why you’re troubled. And then he’ll tell you whether you should be. -- Michael Kinsley\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1. The Ethics of Enhancement   2. Bionic Athletes   3. Designer Children, Designing Parents   4. The Old Eugenics and the New   5. Mastery and Gift      Epilogue. Embryo Ethics: The Stem Cell Debate    Notes   Index","brand":"Harvard University Press","offers":[{"title":"Default Title","offer_id":48865477362007,"sku":"9780674036383","price":17.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780674036383.jpg?v=1722274156"},{"product_id":"gene-delivery-methods-and-applications-9781536162684","title":"Gene Delivery: Methods and Applications","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eGene Delivery: Methods and Applications provides a comprehensive overview on viral and non-viral methods used to genetically engineer human mesenchymal stromal cells. In addition, an update on ongoing and completed clinical studies with engineered mesenchymal stromal cells will be provided, as well as a snapshot of the advances and technical challenges yet to be addressed. Next, a variety of gene delivery systems including physical transfection techniques, virus-based delivery vectors, chemically engineered delivery systems and bio-inspired vehicles are reviewed and their strengths, shortcomings and biomedical applications are discussed. Selfish DNA called transposons capable of cutting out and pasting into the host genome are active throughout the phylogenetic kingdoms. Researchers have repurposed natural transposons for use in delivering a gene-of-interest, enabling for the study of a large and growing list of preclinical gene therapy applications. As such, the authors discuss the past achievements and future challenges of this early-stage technology. The closing chapter introduces cell-penetrating peptides as an efficient tool for DNA transfection. HR9, a designed cell-penetrating peptides, containing nona-arginine flanked by cysteine and penta-histidine displayed a high penetrating ability in mammalian cells.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886144205143,"sku":"9781536162684","price":67.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"cloning-chronology-abstracts-guide-to-books-9781590338797","title":"Cloning: Chronology, Abstracts \u0026 Guide to Books","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe terms ''recombinant DNA technology'', ''DNA cloning'', ''molecular cloning'' or ''gene cloning'' all refer to the same process: the transfer of a DNA fragment of interest from one organism to a self-replicating genetic element such as a bacterial plasmid. The DNA of interest can then be propagated in a foreign host cell. This technology has been around since the 1970s, and it has become a common practice in molecular biology labs today. Reproductive cloning is a technology used to generate an animal that has the same nuclear DNA as another currently or previously existing animal. Dolly was created by reproductive cloning technology. In a process called ''somatic cell nuclear transfer'' (SCNT), scientists transfer genetic material from the nucleus of a donor adult cell to an egg whose nucleus, and thus its genetic material, has been removed. The reconstructed egg containing the DNA from a donor cell must be treated with chemicals or electric current in order to stimulate cell division. Once the cloned embryo reaches a suitable stage, it is transferred to the uterus of a female host where it continues to develop until birth. Therapeutic cloning, also called \"embryo cloning,\" is the production of human embryos for use in research. The goal of this process is not to create cloned human beings, but rather to harvest stem cells that can be used to study human development and to treat disease. Stem cells are important to biomedical researchers because they can be used to generate virtually any type of specialised cell in the human body. This new book presents an up-to-date Chronology of Cloning along with current and selected abstracts dealing with cloning as well as a guide to books on the topic. Access to the abstract and books sections is provided by title, subject and author indexes.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886484435287,"sku":"9781590338797","price":76.49,"currency_code":"GBP","in_stock":false}]},{"product_id":"genetic-engineering-9781594547539","title":"Genetic Engineering","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book has a distinguishing feature of having condensed material with adequate information on genetic engineering especially of the microbes. The book covers almost all the topics of genetic engineering for the graduate, postgraduate students and young research scholars of biological sciences. The book is written as per syllabus of genetic engineering paper for Masters course in biotechnology, biochemistry, life sciences of most of the universities. The book is much useful for the students of Masters degree. Emphasis is given on the basic fundamentals. The book contains twelve chapters starting from '' Isolation, purification and estimation of nucleic acids'' as chapter 1. The chapter describes general techniques for the isolation and purification of DNA as well as RNA. It also describes methods for quantitative estimation of the nucleic acids. The second chapter describes general characteristics of the vectors used in genetic engineering and also the general account of commonly used individual vectors. The chapter also describes expression vectors. The third chapter describes various commonly used restriction endonucleases. The fourth chapter describes commonly used enzymes in genetic engineering viz. Reverse transcriptase, DNA polymerase I, polynucleotide kinase, teminal dcoxynucleotidyl transferase, alkaline phosphatase, SI nuclease, DNA ligase etc. The fifth chapter describes electrophoresis for the separation of nucleic acids fragments. The sixth chapter is of cloning strategies. It describes construction of genomic DNA library , chromosomal walking, cDNA library, cDNA cloning. The seventh chapter describes DNA sequencing techniques and includes chemical modification method of Maxam and Gilbert, dideoxy sequencing method of Sanger, modifications of chain terminator sequencing, analysis of the sequencing data. The eighth chapter includes various methods of site directed mutagenesis. The ninth chapter describes polymerase chain reaction (PCR). It also includes primer designing and various types of polymerase chain reactions viz. reverse transcriptase polymerase chain reaction (RT-PCR), nested PCR, multiplex PCR etc. Besides, there are chapters 10, 11 and 12 on gene therapy, human genome and proteomics. At the end, glossary has been put which explains main terms used in genetic engineering. One of the important factor introduced in the book is the chapter structure given in the beginning of each chapter that provides, at a glance, the contents of the whole chapter which offers a better learning mechanism. Each chapter is also presented with an introduction that covers the concept of the whole chapter in brief and offers clear understanding of the subject matter to the students. The author on the basis of his experience in teaching genetic engineering at the university level for more than a decade has offered the text in an easily understandable form to the postgraduate students. The book should be of invaluable help to the students, researchers and all those interested in understanding genetic engineering.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886529261911,"sku":"9781594547539","price":129.74,"currency_code":"GBP","in_stock":false}]},{"product_id":"dna-research-trends-9781600216466","title":"DNA Research Trends","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDeoxyribonucleic acid (DNA) is a chemical found primarily in the nucleus of cells. DNA is a long, spiralling molecule that orchestrates the cell''s daily operations and provides the genetic blueprint for the physical characteristics of all living organisms. It is the molecule that encodes genetic information in the nucleus of cells. It determines the structure, function and behaviour of the cell. DNA is made up of two complementary strands, the strands intertwine like a spiral staircase to form a structure called a double helix. Subunits, called bases, are the rungs of the staircase. The four nucleotides in DNA contain the bases: adenine (A), guanine (G), cytosine (C), and thymine (T). This volume presents the latest research from around the world.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886601974103,"sku":"9781600216466","price":187.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781600216466.jpg?v=1722540815"},{"product_id":"messenger-rna-research-perspectives-9781600218149","title":"Messenger RNA Research Perspectives","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003emRNA (messenger RNA) is the mediating template between DNA and proteins. The information from a particular gene is transferred from a strand of DNA by the construction of a complementary strand of RNA through a process known as transcription. Next three nucleotide segments of RNA, called tRNA (transfer RNA), which are attached to specific amino acids, match up with the template strand of mRNA to order the amino acids correctly. These amino acids are then bonded together to form a protein. This process called translation, occurs in the ribosome, which is composed of proteins and the third kind of RNA, rRNA (ribosomal RNA). This book presents new research in the field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886607544663,"sku":"9781600218149","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"genetic-discrimination-9781604563573","title":"Genetic Discrimination","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eGenetic information can be misused. It can be used to discriminate against people in health insurance and employment. People known to carry a gene that increases their likelihood of developing cancer, for example, may get turned down for health insurance. Without health insurance, it may be impossible for some people to get treatment for a disease that could be fatal. This may lead some people to decide against genetic testing for fear of what the results might show, and who might find out about them. It also could lead some people to decline participation in biomedical research such as studies of gene mutations associated with certain diseases that examine the history of families prone to those maladies. This book examines some of the hot areas of research in the field.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886635266391,"sku":"9781604563573","price":63.74,"currency_code":"GBP","in_stock":false}]},{"product_id":"rna-interference-research-progress-9781604564464","title":"RNA Interference Research Progress","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eRNA interference (RNAi) is a mechanism that inhibits gene expression by causing the degradation of specific RNA molecules or hindering the transcription of specific genes. RNAi targets include RNA from viruses and transposons (probably as a form of innate immune response), and also plays a role in regulating development and genome maintenance. Small interfering RNA strands (siRNA) are key to the RNAi process, and have complementary nucleotide sequences to the targeted RNA strand. Specific RNAi pathway proteins are guided by the siRNA to the targeted messenger RNA (mRNA), where they \"cleave\" the target, breaking it down into smaller portions that can no longer be translated into protein. A type of RNA transcribed from the genome itself, microRNA (miRNA), and works in the same way. This book presents the latest research in the field from around the globe.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886638772567,"sku":"9781604564464","price":149.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"genetic-recombination-research-progress-9781604564822","title":"Genetic Recombination Research Progress","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886640214359,"sku":"9781604564822","price":149.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"pluripotent-stem-cells-9781608767380","title":"Pluripotent Stem Cells","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003ePluripotent cells of the early embryo originate all types of somatic cells and germ cells of adult organism. Pluripotent stems cell lines were derived from mammalian embryos and adult tissues using different techniques and from different sources. Despite different origin, all pluripotent stem cell lines demonstrate considerable similarity of the major biological properties. This book examines the fundamental mechanisms which regulate normal development of pluripotent cells into different lineages and are disrupted in cancer initiating cells. Analysis gene expression profiles, differentiation potentials and cell cycle of normal and mutant pluripotent stem cells provide new data to search molecular targets to eliminate malignant cells in tumours. In this book, the authors also aim to present a global picture of how extracellular signals, intracellular signal transduction pathways and transcriptional networks co-operate together to determine the cell fate of pluripotent stem cells. Practical, ethical and legal considerations that must be addressed before induced pluripotent stem (iPS) cells can realise their potential in the treatment of degenerative disease is discussed as well. Recent advancements in the cancer stem cell hypothesis are also summarised and the challenges associated with targeting resistant cancers in the context of stem cell microenvironments are presented.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886768435543,"sku":"9781608767380","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"induced-stem-cells-9781613246139","title":"Induced Stem Cells","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eInduced pluripotent stem (iPS) cell technology has paved new ways for disease modelling and drug discovery. Disease modelling with the differentiated neuronal cells from patient-specific iPS cells partially recapitulated the phenotypes of spinal muscular atrophy, familial dysautonomia and Rett syndrome. In this book, the authors present current research in the study of induced stem cells, including the cryopreservation of pluipotent stem cells; tissue engineering approaches using bioactive ceramics towards bone regeneration; induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes; iPS technology for studying neurodegenerative diseases and iPS from cord blood cells.","brand":"Nova Science Publishers Inc","offers":[{"title":"Default Title","offer_id":48886841114967,"sku":"9781613246139","price":107.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781613246139.jpg?v=1722541825"},{"product_id":"genes-for-africa-9781919713571","title":"Genes for Africa","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn \u003cem\u003eGenes for Africa\u003c\/em\u003e, Jennifer Thomson separates fact from fiction and explains why and how GM crops can help us combat poverty, starvation and disease in the developing world, in a safe and responsible way. She explains the technology, addresses controversial issues such as food safety, patents, labelling, regulation and controls and ends with a focus on Africa and possible future developments in GM technology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"We have reassurances from those with a financial stake in GM technology that all is well and allegations from the anti-GM lobby that these organisms present a clear danger to the environment and human health. The truth, of course, is somewhere in between these two positions, and the public deserves a more factual and reliable source of information on this issue.\" Michael Shelby, National Institute of Environmental Health Sciences USA \"True environmentalism recognises the need for development, for growing food and making livelihoods available to the poor, and aims to minimise the risks and damage. You will find the real facts discussed here and placed before you in an enthusiastic but always scientifically controlled way.\" George Ellis, Department of Mathematics and Applied Mathematics, UCT\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePlant breeding \u0026amp; jumping genes; What is genetic modification of plants?; First generation GM crops; What's in it for the consumer?; Cost-benefit analysis - is it worth it?; GM crops \u0026amp; food safety; Patent or perish; The agriculture police; To label or not to label?; What's in it for Africa?; A look into the future; Index.","brand":"University of Cape Town Press","offers":[{"title":"Default Title","offer_id":48888673141079,"sku":"9781919713571","price":15.15,"currency_code":"GBP","in_stock":false}]},{"product_id":"plant-biotechnology-and-biodiversity-conservation-9788177540956","title":"Plant Biotechnology and Biodiversity Conservation","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Agro-Bios","offers":[{"title":"Default Title","offer_id":48889654346071,"sku":"9788177540956","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9788177540956.jpg?v=1722555316"},{"product_id":"charting-new-pathways-to-c4-rice-9789812709516","title":"Charting New Pathways To C4 Rice","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eFeeding Asia in the 21st century will require a second Green Revolution. However, unlike in the first generation, future yield increases will have to be grown using less water and nitrogen in a world of unfavorable climate change — this can only be done by increasing the efficiency of the photosynthetic system, i.e. developing a C4 rice plant. If and when achieved, it would be the first nonevolutionary example of reconstructing the primary metabolism of a plant. The impact of such a scientific achievement would be undeniable, but it requires either a superb feat of genetic engineering or forced evolution.This book describes the alternative ways of achieving C4 photosynthesis in rice. Featuring contributions from leading experts, case studies are used to present views on how C4 rice might be constructed and applied, along with the socioeconomic implications that it entails. Ultimately, readers will be better informed about this highly relevant and timely topic of improving rice yield in a global environment grappling with unpredictable climate change.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eWhy Build a New Rice Engine and Why Start Now? (J Sheehy); Hydrilla: Retrofitting a C3 Leaf with a C4 NADP-ME System (G Bowes); Balancing Light Capture with Distributed Metabolic Demand (J Evans); Redesigning C4 Rice from the Limiting C4 Photosynthesis (D-M Jiao); C4 Photosynthesis: Minor or Major Adjustments to a C3 Theme? (R Leegood); Catching Up with the Literature: What We Know Now and Didn't Then (P Mitchell); Learning from Nature to Develop Strategies for the Directed Evolution of C4 Rice (R Sage); C4 Photosynthesis and CO2 Diffusion (S von Caemmerer); and other papers.","brand":"World Scientific Publishing Co Pte Ltd","offers":[{"title":"Default Title","offer_id":48890210320727,"sku":"9789812709516","price":133.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9789812709516.jpg?v=1791484048"},{"product_id":"reference-shelf-gene-editing-genetic-engineering-9781637004982","title":"Reference Shelf: Gene Editing \u0026 Genetic","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe recent research into using the CRISPR gene-editing technology to change genetic coding in an organism’s DNA has generated tremendous public interest, but where is this technology going? In this issue of The Reference Shelf we look at gene editing and genetic engineering, drawing from periodicals, medical reports, and politics to see how this debate is progressing within popular culture. Issues investigated will include engineering new organisms, the potential for medical breakthroughs, the ethics of altering the human genome, and the campaign to bring back the dinosaurs.","brand":"H.W. Wilson Publishing Co.","offers":[{"title":"Default Title","offer_id":49084226666839,"sku":"9781637004982","price":67.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781637004982.jpg?v=1725551460"},{"product_id":"human-genetics-and-genomics-a-practical-guide-9783527337484","title":"Human Genetics and Genomics: A Practical Guide","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eFinally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. \u003cbr\u003e Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eAbout the Authors xi\u003c\/p\u003e \u003cp\u003eIntroduction xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Exploring Online Genetics Sources \u003c\/b\u003e\u003cb\u003e1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 1\u003c\/p\u003e \u003cp\u003eHuman Genome Project 2\u003c\/p\u003e \u003cp\u003eNational Center for Biotechnology Information (NCBI) 2\u003c\/p\u003e \u003cp\u003eUCSC Genome Browser 3\u003c\/p\u003e \u003cp\u003eThe Encyclopedia of DNA Elements (ENCODE) 3\u003c\/p\u003e \u003cp\u003eRoadmap Epigenomic Project 5\u003c\/p\u003e \u003cp\u003eReferences 5\u003c\/p\u003e \u003cp\u003eExercise Questions 6\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 11\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Observation of Human Inheritance \u003c\/b\u003e\u003cb\u003e13\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 13\u003c\/p\u003e \u003cp\u003eMendelian Genetics 13\u003c\/p\u003e \u003cp\u003eThe Transmission of Hereditary Characteristics 16\u003c\/p\u003e \u003cp\u003eMendelian Disorders 19\u003c\/p\u003e \u003cp\u003eReferences 20\u003c\/p\u003e \u003cp\u003eExercise Questions 21\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 22\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Reading, Understanding, and Constructing Human Pedigrees \u003c\/b\u003e\u003cb\u003e25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 25\u003c\/p\u003e \u003cp\u003eBasic Pedigree Nomenclature 26\u003c\/p\u003e \u003cp\u003eModes of Inheritance 26\u003c\/p\u003e \u003cp\u003eAutosomal Recessive Inheritance 28\u003c\/p\u003e \u003cp\u003ePedigrees Representing Autosomal Recessive Inheritance 28\u003c\/p\u003e \u003cp\u003eAutosomal Dominant Inheritance 29\u003c\/p\u003e \u003cp\u003ePedigrees Representing Autosomal Dominant Inheritance 30\u003c\/p\u003e \u003cp\u003eX-Linked Recessive Inheritance 30\u003c\/p\u003e \u003cp\u003ePedigrees Representing X-Linked Recessive Inheritance 31\u003c\/p\u003e \u003cp\u003eX-Linked Dominant Inheritance 32\u003c\/p\u003e \u003cp\u003ePedigrees Representing X-Linked Dominant Inheritance 32\u003c\/p\u003e \u003cp\u003eY-Linked Inheritance 34\u003c\/p\u003e \u003cp\u003ePedigrees Representing Y-Linked Inheritance 34\u003c\/p\u003e \u003cp\u003eNon-Mendelian Patterns of Inheritance 35\u003c\/p\u003e \u003cp\u003eConfounding Factors in Pedigree Generation and Interpretation 36\u003c\/p\u003e \u003cp\u003eReferences 36\u003c\/p\u003e \u003cp\u003eExercise Questions 38\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 39\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Cytogenetics \u003c\/b\u003e\u003cb\u003e43\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 43\u003c\/p\u003e \u003cp\u003eGeneration of Karyograms\/Chromosome Banding 45\u003c\/p\u003e \u003cp\u003eFISH, Fluorescent \u003ci\u003eIn Situ \u003c\/i\u003eHybridization 47\u003c\/p\u003e \u003cp\u003eComparative Genomic Hybridization (CGH) and Array-Based CGH Technology 48\u003c\/p\u003e \u003cp\u003eChromosomal Abnormalities 48\u003c\/p\u003e \u003cp\u003eNumerical Chromosomal Abnormalities 49\u003c\/p\u003e \u003cp\u003eStructural Chromosomal Abnormalities 50\u003c\/p\u003e \u003cp\u003eReferences 51\u003c\/p\u003e \u003cp\u003eExercise Questions 52\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 54\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Exploring DNA, RNA, and Protein Sequence Databases and Genome Browsers \u003c\/b\u003e\u003cb\u003e55\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 55\u003c\/p\u003e \u003cp\u003eGeneral Biological Databases 57\u003c\/p\u003e \u003cp\u003eRNA-Specific Databases 59\u003c\/p\u003e \u003cp\u003eProtein-Specific Databases 61\u003c\/p\u003e \u003cp\u003eRegulatory DNA Database 62\u003c\/p\u003e \u003cp\u003eGenome Browsers 65\u003c\/p\u003e \u003cp\u003eReferences 67\u003c\/p\u003e \u003cp\u003eExercise Questions 67\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 68\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Exploring Online Bioinformatics Tools \u003c\/b\u003e\u003cb\u003e71\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 71\u003c\/p\u003e \u003cp\u003eBLAST 71\u003c\/p\u003e \u003cp\u003eExPASy 72\u003c\/p\u003e \u003cp\u003eClustal Omega 74\u003c\/p\u003e \u003cp\u003eReactome 76\u003c\/p\u003e \u003cp\u003eReferences 77\u003c\/p\u003e \u003cp\u003eExercise Questions 77\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 79\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Multifactorial Inheritance and Common Complex Diseases \u003c\/b\u003e\u003cb\u003e81\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 81\u003c\/p\u003e \u003cp\u003ePolygenic Complex Diseases 82\u003c\/p\u003e \u003cp\u003eInvestigating Complex Traits 82\u003c\/p\u003e \u003cp\u003eObesity as a Complex Disease 83\u003c\/p\u003e \u003cp\u003eDiabetes Mellitus Type 2 as a Complex Disease 84\u003c\/p\u003e \u003cp\u003eCoronary Artery Diseases as Complex Diseases 85\u003c\/p\u003e \u003cp\u003eReferences 86\u003c\/p\u003e \u003cp\u003eExercise Questions 88\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 88\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Neurogenetics and Behavioral Genetics \u003c\/b\u003e\u003cb\u003e91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 91\u003c\/p\u003e \u003cp\u003eGenetic Regulation of Neural Development 91\u003c\/p\u003e \u003cp\u003eStructure and Function of the Nervous System 92\u003c\/p\u003e \u003cp\u003eUnderstanding the Genetics of Neurological Disease 94\u003c\/p\u003e \u003cp\u003eExamples of Neurogenetic Disorders 94\u003c\/p\u003e \u003cp\u003eHuntington’s Disease 94\u003c\/p\u003e \u003cp\u003eParkinson’s Disease 95\u003c\/p\u003e \u003cp\u003eRett Syndrome 95\u003c\/p\u003e \u003cp\u003eBehavioral Genetics 96\u003c\/p\u003e \u003cp\u003eGenetics of Depression 97\u003c\/p\u003e \u003cp\u003eGenetics of Drug Addiction 97\u003c\/p\u003e \u003cp\u003eGenetics of Schizophrenia 98\u003c\/p\u003e \u003cp\u003eReferences 99\u003c\/p\u003e \u003cp\u003eExercise Questions 100\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 101\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Cancer Genetics \u003c\/b\u003e\u003cb\u003e103\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 103\u003c\/p\u003e \u003cp\u003eCell Cycle and Its Regulation 104\u003c\/p\u003e \u003cp\u003eOncogenes and Tumor Suppressor Genes 105\u003c\/p\u003e \u003cp\u003eCarcinogens\/Environmental Factors in Cancer 107\u003c\/p\u003e \u003cp\u003eBreast Cancer 108\u003c\/p\u003e \u003cp\u003eRole of Molecular Medicine in Breast Cancer Treatment 110\u003c\/p\u003e \u003cp\u003eRecent Advances in Cancer Diagnosis and Treatment 111\u003c\/p\u003e \u003cp\u003eReferences 112\u003c\/p\u003e \u003cp\u003eExercise Questions 113\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 114\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Genetic Counseling \u003c\/b\u003e\u003cb\u003e115\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 115\u003c\/p\u003e \u003cp\u003eReferences 117\u003c\/p\u003e \u003cp\u003eExercise Questions 117\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Evolving Tools in Genome Editing: CRISPR-Cas \u003c\/b\u003e\u003cb\u003e121\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBackground 121\u003c\/p\u003e \u003cp\u003eMechanism of CRISPR-Cas9 System 123\u003c\/p\u003e \u003cp\u003eApplications of CRISPR-Cas9 System 123\u003c\/p\u003e \u003cp\u003eGeneration of Animal Models and Engineering Cells 123\u003c\/p\u003e \u003cp\u003eSomatic Genome Editing 124\u003c\/p\u003e \u003cp\u003eRepair of Genetic Disorders 124\u003c\/p\u003e \u003cp\u003eFunctional Genomic Screening 124\u003c\/p\u003e \u003cp\u003eTreatment of Infectious Diseases 125\u003c\/p\u003e \u003cp\u003eOther Applications of CRISPR-Cas9 System 125\u003c\/p\u003e \u003cp\u003eReferences 126\u003c\/p\u003e \u003cp\u003eAcknowledgment 127\u003c\/p\u003e \u003cp\u003eExercise Questions 127\u003c\/p\u003e \u003cp\u003eAdditional Exercise Questions 128\u003c\/p\u003e \u003cp\u003eGlossary 129\u003c\/p\u003e \u003cp\u003eIndex 139\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":49372701131095,"sku":"9783527337484","price":47.7,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527337484.jpg?v=1730163866"},{"product_id":"gmo-china-9780231171663","title":"GMO China","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eCong Cao presents a comprehensive and systematic analysis of how China’s policy toward research and commercialization of genetically modified crops has evolved that explains how China’s changing GMO stances reflect its shifting position on the world stage.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eCong Cao's is the first major study of China’s experience with the promotion of and the debate about genetically modified organisms. \u003ci\u003eGMO China\u003c\/i\u003e is a thoroughly researched and insightful work. -- Erik Baark, Hong Kong University of Science and Technology\u003cbr\u003eBased on a decade of fieldwork and interviews, Cong Cao's impressive research offers a fascinating window into the complexity of Chinese policy making on a highly contentious issue. Revealing the difficulty of formulating a consistent, sustainable policy that can reconcile the interests of the multiple actors and stakeholders, it will be of wide interest within Chinese and science and technology studies, as well as to those seeking business opportunities in agricultural biotechnology. -- Stanley Rosen, University of Southern California\u003cbr\u003eCong Cao’s book \u003ci\u003eGMO China\u003c\/i\u003e is refreshing and enlightening. * H-Asia *\u003cbr\u003eCao presents a comprehensive account of the policy maneuvering, narratives, actors's strategies, negotiations, and brokerage that shaped this new high-tech policy field. * China Journal *\u003cbr\u003eThe author offers gripping, vivid analyses not only of transgenic technology which continues to pose new ethical and policy challenges, but also of the unwieldy and tenuous trajectories that these create for all constituents both within and beyond China. * China Review International *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eAbbreviations\u003cbr\u003eAcknowledgments\u003cbr\u003eIntroduction\u003cbr\u003e1. Transgenic Technology and GMO Controversies\u003cbr\u003e2. Global GMO Policy\u003cbr\u003e3. Research and Commercialization of GM Crops in China\u003cbr\u003e4. Science, Biosafety, and Regulations\u003cbr\u003e5. Polarization and Politicization of Transgenic Technology\u003cbr\u003e6. The Chinese Media and Changing Policy\u003cbr\u003e7. Patents and China’s Bt Rice\u003cbr\u003e8. China as a GMO Nation\u003cbr\u003eNotes\u003cbr\u003eBibliography\u003cbr\u003eIndex","brand":"Columbia University Press","offers":[{"title":"Default Title","offer_id":49400292376919,"sku":"9780231171663","price":90.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780231171663.jpg?v=1730470303"},{"product_id":"genomics-in-drug-discovery-and-development-9780470096048","title":"Genomics in Drug Discovery and Development","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eEarly characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R\u0026amp;D and reduce drug candidate attrition and failure.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e?This book is highly recommended to active researchers in genomics and to the comparative and veterinary clinician or researchers looking for a focused review of the emerging discipline.? (\u003ci\u003eThe Veterinary Journal\u003c\/i\u003e , August 2009)  \u003cp\u003e?Overall, it provides excellent, up-to-date coverage of the application of genomics in drug development.? (\u003ci\u003eDoody's Reviews\u003c\/i\u003e, June 2009)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Introduction: Genomics and Personalized Medicine 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDimitri Semizarov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1. Fundamentals of Genomics 1\u003c\/p\u003e \u003cp\u003e1.2. The Concept of Personalized Medicine 5\u003c\/p\u003e \u003cp\u003e1.3. Genomics Technologies in Drug Discovery 8\u003c\/p\u003e \u003cp\u003e1.4. Scope of This Book 13\u003c\/p\u003e \u003cp\u003eReferences 20\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Genomics Technologies as Tools in Drug Discovery 25\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDimitri Semizarov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1. Introduction to Genomics Technologies 25\u003c\/p\u003e \u003cp\u003e2.2. Gene Expression Microarrays: Technology 27\u003c\/p\u003e \u003cp\u003e2.2.1. Standard Microarray Protocol 27\u003c\/p\u003e \u003cp\u003e2.2.2. Monitoring the Quality of Input RNA for Microarray Experiments 29\u003c\/p\u003e \u003cp\u003e2.2.3. Specialized Microarray Protocols for Archived and Small Samples 31\u003c\/p\u003e \u003cp\u003e2.2.4. Quality of Microarray Data and Technical Parameters of Microarrays 33\u003c\/p\u003e \u003cp\u003e2.2.5. Reproducibility of Expression Microarrays and Cross-Platform Comparisons 35\u003c\/p\u003e \u003cp\u003e2.2.6. Microarray Databases and Annotation of Microarray Data 38\u003c\/p\u003e \u003cp\u003e2.2.6.1. Target Identification 39\u003c\/p\u003e \u003cp\u003e2.2.6.2. Disease Classification 39\u003c\/p\u003e \u003cp\u003e2.2.6.3. Compound Assessment 40\u003c\/p\u003e \u003cp\u003e2.3. Gene Expression Microarrays: Data Analysis 47\u003c\/p\u003e \u003cp\u003e2.3.1. Identification of Significant Gene Expression Changes 47\u003c\/p\u003e \u003cp\u003e2.3.2. Sample Classification and Class Prediction with Expression Microarrays 48\u003c\/p\u003e \u003cp\u003e2.3.3. Pathway Analysis with Gene Expression Microarrays 49\u003c\/p\u003e \u003cp\u003e2.3.4. Common Problems Affecting the Validity of Microarray Studies 56\u003c\/p\u003e \u003cp\u003e2.4. Comparative Genomic Hybridization: Technology 57\u003c\/p\u003e \u003cp\u003e2.5. Comparative Genomic Hybridization: Data Analysis 69\u003c\/p\u003e \u003cp\u003e2.6. Microarray-Based DNA Methylation Profiling 76\u003c\/p\u003e \u003cp\u003e2.7. Microarray-Based MicroRNA Profiling 80\u003c\/p\u003e \u003cp\u003e2.8. Technical Issues in Genomics Experiments and Regulatory Submissions of Microarray Data 86\u003c\/p\u003e \u003cp\u003e2.8.1. Study of a Drug’s Mechanism of Action by Gene Expression Profiling 87\u003c\/p\u003e \u003cp\u003e2.8.2. Early Assessment of Drug Toxicity in Model Systems 88\u003c\/p\u003e \u003cp\u003e2.8.3. Biomarker Identification in Discovery and Early Development 89\u003c\/p\u003e \u003cp\u003e2.8.4. Patient Stratification in Clinical Trials with Gene Expression Signatures 90\u003c\/p\u003e \u003cp\u003e2.8.5. Genotyping of Patients in Clinical Studies to Predict Drug Response 91\u003c\/p\u003e \u003cp\u003e2.9. Conclusion 92\u003c\/p\u003e \u003cp\u003eReferences 93\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Genomic Biomarkers 105\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDimitri Semizarov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1. Introduction to Genomic Biomarkers 105\u003c\/p\u003e \u003cp\u003e3.2. DNA Biomarkers 109\u003c\/p\u003e \u003cp\u003e3.2.1. DNA Copy Number Alterations 110\u003c\/p\u003e \u003cp\u003e3.2.1.1. DNA Copy Number Alterations in Cancer 110\u003c\/p\u003e \u003cp\u003e3.2.1.2. DNA Copy Number Alterations in Other Diseases 118\u003c\/p\u003e \u003cp\u003e3.2.1.3. Identification of DNA Copy Number Biomarkers in Drug Discovery 119\u003c\/p\u003e \u003cp\u003e3.2.2. Mutations 123\u003c\/p\u003e \u003cp\u003e3.2.2.1. p53 Mutations 124\u003c\/p\u003e \u003cp\u003e3.2.2.2. K-ras Mutations 125\u003c\/p\u003e \u003cp\u003e3.2.2.3. EGFR Mutations 127\u003c\/p\u003e \u003cp\u003e3.2.2.4. Bcr-abl and KIT Mutations 129\u003c\/p\u003e \u003cp\u003e3.2.3. Epigenetic Markers 131\u003c\/p\u003e \u003cp\u003e3.3. RNA Biomarkers 137\u003c\/p\u003e \u003cp\u003e3.3.1. Gene Expression Biomarkers Validated as Diagnostic Tests 138\u003c\/p\u003e \u003cp\u003e3.3.2. Other Examples of Gene Expression Biomarkers 142\u003c\/p\u003e \u003cp\u003e3.4. Clinical Validation of Genomic Biomarkers 148\u003c\/p\u003e \u003cp\u003eReferences 156\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Fundamental Principles of Toxicogenomics 167\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEric Blomme\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1. Introduction 167\u003c\/p\u003e \u003cp\u003e4.2. Fundamentals of Toxicogenomics 168\u003c\/p\u003e \u003cp\u003e4.2.1. Principle of Toxicogenomics 169\u003c\/p\u003e \u003cp\u003e4.2.2. Technical Reproducibility 170\u003c\/p\u003e \u003cp\u003e4.2.3. Biological Reproducibility 174\u003c\/p\u003e \u003cp\u003e4.2.4. Species Extrapolation 175\u003c\/p\u003e \u003cp\u003e4.3. Analysis of Toxicogenomics Data 176\u003c\/p\u003e \u003cp\u003e4.3.1. Compound-Induced Gene Expression Changes 177\u003c\/p\u003e \u003cp\u003e4.3.2. Visualization Tools 181\u003c\/p\u003e \u003cp\u003e4.3.3. Class Prediction 184\u003c\/p\u003e \u003cp\u003e4.3.4. Network and Pathway Analysis 188\u003c\/p\u003e \u003cp\u003e4.4. Practical and Logistic Aspects of Toxicogenomics 191\u003c\/p\u003e \u003cp\u003e4.4.1. Species Considerations 191\u003c\/p\u003e \u003cp\u003e4.4.2. Toxicogenomics Studies 194\u003c\/p\u003e \u003cp\u003e4.4.2.1. Sample Considerations 194\u003c\/p\u003e \u003cp\u003e4.4.2.2. Experimental Design in Toxicogenomics Studies 196\u003c\/p\u003e \u003cp\u003e4.5. Toxicogenomics Reference Databases 199\u003c\/p\u003e \u003cp\u003e4.5.1. Utility of Reference Databases in Toxicogenomics 199\u003c\/p\u003e \u003cp\u003e4.5.2. Design and Development of Toxicogenomics Reference Databases 200\u003c\/p\u003e \u003cp\u003e4.5.3. Existing Toxicogenomics Databases 203\u003c\/p\u003e \u003cp\u003e4.5.3.1. Chemical Effects in Biological Systems (CEBS) 204\u003c\/p\u003e \u003cp\u003e4.5.3.2. ArrayTrack\u003csup\u003e®\u003c\/sup\u003e 206\u003c\/p\u003e \u003cp\u003e4.5.3.3. Gene Expression Omnibus 206\u003c\/p\u003e \u003cp\u003e4.5.3.4. ArrayExpress 207\u003c\/p\u003e \u003cp\u003e4.5.3.5. DbZach 207\u003c\/p\u003e \u003cp\u003e4.5.3.6. ToxExpress\u003csup\u003e®\u003c\/sup\u003e 208\u003c\/p\u003e \u003cp\u003e4.5.3.7. DrugMatrix\u003csup\u003e®\u003c\/sup\u003e 208\u003c\/p\u003e \u003cp\u003e4.6. Conclusion 208\u003c\/p\u003e \u003cp\u003eReferences 209\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Toxicogenomics: Applications to In Vivo Toxicology 219\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEric Blomme\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1. The Value of Toxicogenomics in Drug Discovery and Development 219\u003c\/p\u003e \u003cp\u003e5.2. Basic Principles of Toxicology in Drug Discovery and Development 221\u003c\/p\u003e \u003cp\u003e5.2.1. Preclinical Safety Assessment 221\u003c\/p\u003e \u003cp\u003e5.2.1.1. Genetic Toxicology 222\u003c\/p\u003e \u003cp\u003e5.2.1.2. Single-Dose Toxicity 223\u003c\/p\u003e \u003cp\u003e5.2.1.3. Repeat-Dose Toxicity 223\u003c\/p\u003e \u003cp\u003e5.2.1.4. Reproductive Toxicity 224\u003c\/p\u003e \u003cp\u003e5.2.1.5. Carcinogenicity 225\u003c\/p\u003e \u003cp\u003e5.2.2. Discovery Toxicology 226\u003c\/p\u003e \u003cp\u003e5.3. Toxicogenomics in Predictive Toxicology 227\u003c\/p\u003e \u003cp\u003e5.3.1. Prediction of Hepatotoxicity 229\u003c\/p\u003e \u003cp\u003e5.3.1.1. Hepatotoxicity: an Important Toxicology Problem in Drug Discovery and Development 229\u003c\/p\u003e \u003cp\u003e5.3.1.2. Predictive Genomic Models of Hepatotoxicity 230\u003c\/p\u003e \u003cp\u003e5.3.1.3. Additional Toxicogenomics Approaches to Predict Hepatotoxicity 233\u003c\/p\u003e \u003cp\u003e5.3.2. Prediction of Nephrotoxicity 235\u003c\/p\u003e \u003cp\u003e5.3.2.1. Kidney as a Target Organ of Toxicity 235\u003c\/p\u003e \u003cp\u003e5.3.2.2. Predictive Genomic Models of Nephrotoxicity 236\u003c\/p\u003e \u003cp\u003e5.3.3. Prediction of In Vivo Carcinogenicity 237\u003c\/p\u003e \u003cp\u003e5.3.3.1. Value Created by Toxicogenomics in the Assessment of Carcinogenicity 237\u003c\/p\u003e \u003cp\u003e5.3.3.2. Predictive Genomic Models of Carcinogenicity 238\u003c\/p\u003e \u003cp\u003e5.3.4. Gene Expression-Based Biomarkers in Other Tissues and the Promise of Hemogenomics 242\u003c\/p\u003e \u003cp\u003e5.3.5. Integration of Toxicogenomics in Discovery Toxicology 244\u003c\/p\u003e \u003cp\u003e5.4. Toxicogenomics in Mechanistic Toxicology 246\u003c\/p\u003e \u003cp\u003e5.4.1. Toxicogenomics to Investigate Mechanisms of Hepatoxicity 250\u003c\/p\u003e \u003cp\u003e5.4.2. Intestinal Toxicity and Notch Signaling 253\u003c\/p\u003e \u003cp\u003e5.4.3. Cardiac Toxicity 256\u003c\/p\u003e \u003cp\u003e5.4.4. Testicular Toxicity 260\u003c\/p\u003e \u003cp\u003e5.5. Toxicogenomics and Target-Related Toxicity 265\u003c\/p\u003e \u003cp\u003e5.5.1. Target Expression in Normal Tissues 266\u003c\/p\u003e \u003cp\u003e5.5.2. Target Modulation 267\u003c\/p\u003e \u003cp\u003e5.5.2.1. Genetically Modified Animals 268\u003c\/p\u003e \u003cp\u003e5.5.2.2. Tool Compounds 268\u003c\/p\u003e \u003cp\u003e5.5.2.3. Gene Silencing 269\u003c\/p\u003e \u003cp\u003e5.6. Predicting Species-Specific Toxicity 271\u003c\/p\u003e \u003cp\u003e5.7. Evaluation of Idiosyncratic Toxicity with Toxicogenomics 273\u003c\/p\u003e \u003cp\u003e5.8. Conclusion 277\u003c\/p\u003e \u003cp\u003eReferences 279\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Toxicogenomics: Applications in In Vitro Systems 293\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEric Blomme\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1. Introductory Remarks on In Vitro Toxicology 293\u003c\/p\u003e \u003cp\u003e6.2. Overview of Current Approaches to In Vitro Toxicology 294\u003c\/p\u003e \u003cp\u003e6.3. Toxicogenomics in In Vitro Systems: Technical Considerations 300\u003c\/p\u003e \u003cp\u003e6.3.1. Reproducibility 300\u003c\/p\u003e \u003cp\u003e6.3.2. Genomic Classifiers 300\u003c\/p\u003e \u003cp\u003e6.3.3. Testing Concentrations 301\u003c\/p\u003e \u003cp\u003e6.3.4. Throughput and Cost 302\u003c\/p\u003e \u003cp\u003e6.4. Proof-of-Concept Studies using Primary Rat Hepatocytes 303\u003c\/p\u003e \u003cp\u003e6.5. Use of Gene Expression Profiling to Assess Genotoxicity 306\u003c\/p\u003e \u003cp\u003e6.5.1. Toxicogenomics Can Differentiate Genotoxic Carcinogens from Nongenotoxic Carcinogens 307\u003c\/p\u003e \u003cp\u003e6.5.2. Toxicogenomics Can Differentiate DNA-Reactive from Non-DNA-Reactive Compounds Positive in In Vitro Mammalian Cell-Based Genotoxicity Assays 307\u003c\/p\u003e \u003cp\u003e6.5.3. Toxicogenomics Assays May Be Less Sensitive than the Standard Battery of In Vitro Genetic Toxicity Tests 308\u003c\/p\u003e \u003cp\u003e6.6. Application of Gene Expression Profiling for In Vitro Detection of Phospholipidosis 309\u003c\/p\u003e \u003cp\u003e6.7. Toxicogenomics in Assessment of Idiosyncratic Hepatotoxicity 312\u003c\/p\u003e \u003cp\u003e6.8. Do Peripheral Blood Mononuclear Cells Represent a Useful Alternative In Vitro Model? 314\u003c\/p\u003e \u003cp\u003e6.9. Current and Future Use of In Vitro Toxicogenomics 316\u003c\/p\u003e \u003cp\u003e6.9.1. Improved Gene Expression Platforms 316\u003c\/p\u003e \u003cp\u003e6.9.2. Standardization of Protocols and Experimental Approaches 316\u003c\/p\u003e \u003cp\u003e6.9.3. Performance Accuracy 317\u003c\/p\u003e \u003cp\u003e6.9.4. Battery of Gene Expression Signatures 317\u003c\/p\u003e \u003cp\u003e6.9.5. Clear, Actionable Data Points 318\u003c\/p\u003e \u003cp\u003e6.10. Conclusions 319\u003c\/p\u003e \u003cp\u003eReferences 321\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Germ Line Polymorphisms and Drug Response 329\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDimitri Semizarov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1. Introduction to Germ Line Polymorphisms 329\u003c\/p\u003e \u003cp\u003e7.2. Polymorphisms and Drug Response in Oncology 332\u003c\/p\u003e \u003cp\u003e7.2.1. UGT1A1 Polymorphism and Response to Irinotecan 333\u003c\/p\u003e \u003cp\u003e7.2.2. FGFR4 Polymorphism and Response to Chemotherapy 334\u003c\/p\u003e \u003cp\u003e7.2.3. Mdr-1 Polymorphism and Response to Paclitaxel 335\u003c\/p\u003e \u003cp\u003e7.2.4. DPD Polymorphisms and Response to 5-Fluorouracil 336\u003c\/p\u003e \u003cp\u003e7.2.5. TPMT Variants and Response to Thiopurines 337\u003c\/p\u003e \u003cp\u003e7.2.6. MTHFR Polymorphisms and Response to Chemotherapy 339\u003c\/p\u003e \u003cp\u003e7.2.7. Tandem Repeat Polymorphisms in the TS Gene and Response to Drugs Targeting Thymidylate Synthase 340\u003c\/p\u003e \u003cp\u003e7.2.8. Use of Cancer Cell Lines to Identify Predictive SNPs 342\u003c\/p\u003e \u003cp\u003e7.3. Polymorphisms and Response to Anticoagulants 343\u003c\/p\u003e \u003cp\u003e7.4. Polymorphisms in Neuroscience 345\u003c\/p\u003e \u003cp\u003e7.5. Polymorphisms and Drug Response in Immunology 347\u003c\/p\u003e \u003cp\u003e7.6. Polymorphisms and Response to Antiviral Agents 353\u003c\/p\u003e \u003cp\u003e7.6.1. Anti-HIV Drugs 353\u003c\/p\u003e \u003cp\u003e7.6.2. Interferon Therapy in Hepatitis B Treatment 356\u003c\/p\u003e \u003cp\u003e7.7. Gene Copy Number Polymorphisms 357\u003c\/p\u003e \u003cp\u003e7.8. Conclusion: Approaches to Identification of Polymorphisms as Predictors of Drug Response 360\u003c\/p\u003e \u003cp\u003e7.8.1. Candidate Gene Approach 360\u003c\/p\u003e \u003cp\u003e7.8.2. Genome-wide Approach 363\u003c\/p\u003e \u003cp\u003e7.8.3. Pathway Approach 366\u003c\/p\u003e \u003cp\u003e7.8.4. Use of Model Systems in Identification of Predictive Pharmacogenetic Markers 369\u003c\/p\u003e \u003cp\u003e7.8.5. Comparison of Methodologies in the Context of Drug Discovery 373\u003c\/p\u003e \u003cp\u003eReferences 375\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Pharmacogenetics of Drug Disposition 385\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnahita Bhathena\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1. Introduction 385\u003c\/p\u003e \u003cp\u003e8.2. Genes and Polymorphisms Affecting Drug Disposition 387\u003c\/p\u003e \u003cp\u003e8.2.1. Drug-Metabolizing Enzymes 391\u003c\/p\u003e \u003cp\u003e8.2.1.1. Cytochrome P450s 391\u003c\/p\u003e \u003cp\u003e8.2.1.2. Flavin-Containing Monooxygenases 396\u003c\/p\u003e \u003cp\u003e8.2.1.3. Arylamine N-Acetyltransferases 397\u003c\/p\u003e \u003cp\u003e8.2.1.4. UDP-Glucuronosyltransferases 397\u003c\/p\u003e \u003cp\u003e8.2.1.5. Sulfotransferases 399\u003c\/p\u003e \u003cp\u003e8.2.2. Drug Transport Proteins 400\u003c\/p\u003e \u003cp\u003e8.2.2.1. SLC Transporters 401\u003c\/p\u003e \u003cp\u003e8.2.2.2. ABC Transporters 402\u003c\/p\u003e \u003cp\u003e8.3. Genomic Biomarkers for PK Studies 403\u003c\/p\u003e \u003cp\u003e8.3.1. Warfarin, CYP2C9, and VKORC1 403\u003c\/p\u003e \u003cp\u003e8.3.2. Irinotecan and UGT1A1 404\u003c\/p\u003e \u003cp\u003e8.4. Utility of PG-PK Studies in Early Clinical Trials 405\u003c\/p\u003e \u003cp\u003e8.5. Limitations of PG-PK Studies 408\u003c\/p\u003e \u003cp\u003e8.6. Genotyping Technologies 408\u003c\/p\u003e \u003cp\u003e8.7. Conclusion 409\u003c\/p\u003e \u003cp\u003eReferences 411\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Overview of Regulatory Developments and Initiatives Related to the Use of Genomic Technologies in Drug Discovery and Development 423\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEric Blomme\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1. Introduction to Recent Regulatory Developments in the Genomic Area 423\u003c\/p\u003e \u003cp\u003e9.2. FDA Guidance on Pharmacogenomic Data Submission 428\u003c\/p\u003e \u003cp\u003e9.2.1. Voluntary Genomic Data Submission (VGDS) 428\u003c\/p\u003e \u003cp\u003e9.2.2. Pharmacogenomic Data Submission 431\u003c\/p\u003e \u003cp\u003e9.2.3. International Harmonization 432\u003c\/p\u003e \u003cp\u003e9.3. Pharmacogenomic Data Submissions: Draft Companion Guidance 434\u003c\/p\u003e \u003cp\u003e9.4. Drug-Diagnostic Co-development Concept Paper 436\u003c\/p\u003e \u003cp\u003e9.5. Regulations for In Vitro Diagnostic Assays 439\u003c\/p\u003e \u003cp\u003e9.5.1. General Overview of Regulatory Pathways for Devices in the U.S. 439\u003c\/p\u003e \u003cp\u003e9.5.2. Draft Guidance for Industry, Clinical Laboratories, and FDA Staff on In Vitro Diagnostic Multivariate Index Assays 440\u003c\/p\u003e \u003cp\u003e9.6. Biomarker Qualification 442\u003c\/p\u003e \u003cp\u003e9.7. Current Initiatives Relevant to Pharmacogenomics 443\u003c\/p\u003e \u003cp\u003e9.8. Future Impact of Genomic Data on Drug Development 444\u003c\/p\u003e \u003cp\u003eReferences 447\u003c\/p\u003e \u003cp\u003eIndex 449\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402285654359,"sku":"9780470096048","price":125.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470096048.jpg?v=1730479947"},{"product_id":"essentials-of-medical-genomics-9780470140192","title":"Essentials of Medical Genomics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cul\u003e \u003cli\u003eSix new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays\u003c\/li\u003e \u003cli\u003eNew edition responds to reviewers'' and users'' desire for greater coveragenow the most useful handbook on the market!\u003c\/li\u003e \u003cli\u003ePractical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know\u003c\/li\u003e \u003cli\u003eCovers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eNEW:\u003c\/b\u003e Includes chapter-end exercises, enhancing the utility of the new edition as a textbook\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eNEW:\u003c\/b\u003e PowerPoint slides of images available at instructor website\u003c\/li\u003e \u003c\/ul\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface.  \u003cp\u003e\u003cb\u003e1\u003c\/b\u003e \u003cb\u003eIntroduction to Molecular Genetics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe Principles of Inheritance.\u003c\/p\u003e \u003cp\u003eGenes Are Made of DNA.\u003c\/p\u003e \u003cp\u003eDNA Structure.\u003c\/p\u003e \u003cp\u003eThe Central Dogma.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2\u003c\/b\u003e \u003cb\u003eMolecular Biology Technology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCut, Copy, and Paste.\u003c\/p\u003e \u003cp\u003eRestriction Enzymes.\u003c\/p\u003e \u003cp\u003eDNA Cloning Is Copying.\u003c\/p\u003e \u003cp\u003ePCR Is Cloning without the Bacteria.\u003c\/p\u003e \u003cp\u003eDNA Sequencing.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3\u003c\/b\u003e \u003cb\u003eGenome Databases.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenome Sequencing.\u003c\/p\u003e \u003cp\u003eEntrez.\u003c\/p\u003e \u003cp\u003eBLAST.\u003c\/p\u003e \u003cp\u003eGenome Annotation.\u003c\/p\u003e \u003cp\u003eGenome Browser.\u003c\/p\u003e \u003cp\u003eHuman Genetic Diseases.\u003c\/p\u003e \u003cp\u003eA System for Naming Genes.\u003c\/p\u003e \u003cp\u003eModel Organisms (Comparative Genomics).\u003c\/p\u003e \u003cp\u003eSequencing Other Genomes.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4\u003c\/b\u003e \u003cb\u003eBioinformatics Tools.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePatterns and Tools.\u003c\/p\u003e \u003cp\u003eSequence Comparison.\u003c\/p\u003e \u003cp\u003eMultiple Alignment.\u003c\/p\u003e \u003cp\u003ePattern Finding.\u003c\/p\u003e \u003cp\u003ePhylogenetics.\u003c\/p\u003e \u003cp\u003eBiotechnology Exercise.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5\u003c\/b\u003e \u003cb\u003eHuman Genetic Variation.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMutation.\u003c\/p\u003e \u003cp\u003eSingle-Nucleotide Polymorphisms.\u003c\/p\u003e \u003cp\u003eLinkage.\u003c\/p\u003e \u003cp\u003eMultigene Diseases.\u003c\/p\u003e \u003cp\u003eGenetic Testing.\u003c\/p\u003e \u003cp\u003eSNP Chips.\u003c\/p\u003e \u003cp\u003eThe HapMap Project.\u003c\/p\u003e \u003cp\u003eResearch Uses of SNP Markers.\u003c\/p\u003e \u003cp\u003eEthnicity and Genome Diversity.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6\u003c\/b\u003e \u003cb\u003eGenetic Testing for the Practitioner\u003c\/b\u003e \u003ci\u003e(Harry Ostrer).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eClinical Applications of Genetic Testing.\u003c\/p\u003e \u003cp\u003eMethods of Genetic Testing.\u003c\/p\u003e \u003cp\u003eAdequacy of Genetic Testing.\u003c\/p\u003e \u003cp\u003eInformed Consent.\u003c\/p\u003e \u003cp\u003eGenetic Counseling.\u003c\/p\u003e \u003cp\u003eClinical Vignettes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7\u003c\/b\u003e \u003cb\u003eGene Therapy\u003c\/b\u003e \u003ci\u003e(John G. Hay).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHistorical Perspective.\u003c\/p\u003e \u003cp\u003eStrategies of Gene Therapy.\u003c\/p\u003e \u003cp\u003eDNA Elements for Gene Expression.\u003c\/p\u003e \u003cp\u003eGene Delivery Systems.\u003c\/p\u003e \u003cp\u003eTargeting Gene Delivery.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eFormative Years and Initial Clinical Approaches.\u003c\/p\u003e \u003cp\u003eThe Problems.\u003c\/p\u003e \u003cp\u003eThe Future.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8\u003c\/b\u003e \u003cb\u003eMicroarrays.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSpotting versus Synthesis on the Chip.\u003c\/p\u003e \u003cp\u003eOther Types of Arrays.\u003c\/p\u003e \u003cp\u003eDifferential Gene Expression.\u003c\/p\u003e \u003cp\u003eError and Reliability.\u003c\/p\u003e \u003cp\u003eEvolutionary Perspectives.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9\u003c\/b\u003e \u003cb\u003eAnalysis of Microarray Data.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eExperimental Design.\u003c\/p\u003e \u003cp\u003eData Analysis Workflow.\u003c\/p\u003e \u003cp\u003eFunctional Analysis.\u003c\/p\u003e \u003cp\u003eValidation.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10\u003c\/b\u003e \u003cb\u003ePharmacogenomics and Toxicogenomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePharmacogenomics.\u003c\/p\u003e \u003cp\u003eEnvironmental Chemicals.\u003c\/p\u003e \u003cp\u003eToxicogenomics for Drug Development.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11\u003c\/b\u003e \u003cb\u003eClinical Research Informatics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eClinical Databases.\u003c\/p\u003e \u003cp\u003eClinical Trials Management.\u003c\/p\u003e \u003cp\u003eData Standards and Ontologies.\u003c\/p\u003e \u003cp\u003eTissue Banks.\u003c\/p\u003e \u003cp\u003eApplication to Medical Practice.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12\u003c\/b\u003e \u003cb\u003eRNA Interference and MicroRNAs.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAntisense RNA.\u003c\/p\u003e \u003cp\u003eRNA Interference.\u003c\/p\u003e \u003cp\u003eRibozymes.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13\u003c\/b\u003e \u003cb\u003eAlternative Splicing.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eExon Arrays.\u003c\/p\u003e \u003cp\u003eMedical Applications of Alternative Splicing.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14\u003c\/b\u003e \u003cb\u003eGenome Tiling Chips.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenome Chips.\u003c\/p\u003e \u003cp\u003eResequencing Chips.\u003c\/p\u003e \u003cp\u003eWhole-Genome Transcription Profilig.\u003c\/p\u003e \u003cp\u003eChIP-chip.\u003c\/p\u003e \u003cp\u003eArrayCGH.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15\u003c\/b\u003e \u003cb\u003eCancer Genomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eUnderstanding Cancer Genomics.\u003c\/p\u003e \u003cp\u003eCopy Number Mutations.\u003c\/p\u003e \u003cp\u003eGene Expression Signatures.\u003c\/p\u003e \u003cp\u003eCancer Genome Atlas.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16\u003c\/b\u003e \u003cb\u003eProteomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProtein Modifications.\u003c\/p\u003e \u003cp\u003eQuantitative Approaches.\u003c\/p\u003e \u003cp\u003eBiomarkers.\u003c\/p\u003e \u003cp\u003eProtein Databases.\u003c\/p\u003e \u003cp\u003eProtein–Protein Interactions.\u003c\/p\u003e \u003cp\u003eDNA-Binding Proteins.\u003c\/p\u003e \u003cp\u003eStructural Proteomics.\u003c\/p\u003e \u003cp\u003eDrug Targets.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17\u003c\/b\u003e \u003cb\u003eConsumer Genomics and Genealogy.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenealogy.\u003c\/p\u003e \u003cp\u003eNutrigenomics.\u003c\/p\u003e \u003cp\u003ePrivacy Concerns.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18\u003c\/b\u003e \u003cb\u003eThe Ethics of Medical Genomics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEugenics.\u003c\/p\u003e \u003cp\u003eHuman Genome Diversity Project and Population Genetics.\u003c\/p\u003e \u003cp\u003eGenetic Discrimination.\u003c\/p\u003e \u003cp\u003eImpact on Physicians and Researchers.\u003c\/p\u003e \u003cp\u003eClinical Research.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eAppendix: Genetic Testing: Scientific Background for Policymakers (Amanda K. Sarata).\u003c\/p\u003e \u003cp\u003eGlossary.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49402295386455,"sku":"9780470140192","price":95.36,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470140192.jpg?v=1730479976"},{"product_id":"applications-of-toxicogenomics-in-safety-evaluation-and-risk-assessment-9780470449820","title":"Applications of Toxicogenomics in Safety","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. With the stress on practical risk assessment, the book sets a foundation for moving toxicogenomics from just a hot technology to an accepted approach.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePREFACE ix  \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003e1 TOXICOLOGY, \"OMICS\" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER 1\u003cbr\u003e \u003ci\u003eDarrell R. Boverhof and B. Bhaskar Gollapudi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13\u003cbr\u003e \u003ci\u003eIrene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD 41\u003cbr\u003e \u003ci\u003eDarrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA 65\u003cbr\u003e \u003ci\u003eZhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS 81\u003cbr\u003e \u003ci\u003eJiri Aubrecht and Ebru Caba\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99\u003cbr\u003e \u003ci\u003eMark R. Fielden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117\u003cbr\u003e \u003ci\u003eJorge M. Naciff and George P. Daston\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING 147\u003cbr\u003e \u003ci\u003eM. Ann Mongan and Hisham K. Hamadeh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177\u003cbr\u003e \u003ci\u003eCliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT 207\u003cbr\u003e \u003ci\u003eDaniel L. Villeneuve, Dalma Martinovi´c, and Gerald T. Ankley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 ANALYSIS OF TRANSCRIPTOMIC DOSE–RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT 237\u003cbr\u003e \u003ci\u003eRussell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES 251\u003cbr\u003e \u003ci\u003eAlan Dombkowski and J. Craig Rowlands\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267\u003cbr\u003e \u003ci\u003eAnne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293\u003cbr\u003e \u003ci\u003eKathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN 323\u003cbr\u003e \u003ci\u003eKen-ichi Aisaki and Jun Kanno\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION 331\u003cbr\u003e \u003ci\u003eLois D. Lehman-McKeeman and William R. Foster\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH 349\u003cbr\u003e \u003ci\u003eSarah N. Campion and Kim Boekelheide\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 357\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402335789399,"sku":"9780470449820","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470449820.jpg?v=1730480100"},{"product_id":"pharmacogenomics-of-human-drug-transporters-9780470927946","title":"Pharmacogenomics of Human Drug Transporters","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eSets the foundation for safer, more effective drug therapies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWith this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient''s genetics.\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePharmacogenomics of Human Drug Transporters\u003c\/i\u003e serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual''s genome affects those processes. The book''s eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the liter\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePREFACE vii\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS ix\u003c\/p\u003e \u003cp\u003eCHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS 1\u003cbr\u003e \u003ci\u003eMarianne K. DeGorter and Richard B. Kim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13\u003cbr\u003e \u003ci\u003eLiangfu Chen and Joseph W. Polli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39\u003cbr\u003e \u003ci\u003eLei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT 73\u003cbr\u003e \u003ci\u003eSook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109\u003cbr\u003e \u003ci\u003eToshihisa Ishikawa and Yoshihide Hayashizaki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 6 OATP1A2, OAT1, AND OAT3 125\u003cbr\u003e \u003ci\u003eRommel G. Tirona\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141\u003cbr\u003e \u003ci\u003eJ¨org K¨onig and Martin F. Fromm\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171\u003cbr\u003e \u003ci\u003eSophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. Giacomini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 9 MATE (SLC47) FAMILY 209\u003cbr\u003e \u003ci\u003eAtsushi Yonezawa and Ken-ichi Inui\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 10 PEPT (SLC15A) FAMILY 223\u003cbr\u003e \u003ci\u003eTomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY 243\u003cbr\u003e \u003ci\u003eM´ýriam Molina-Arcas and Marc¸al Pastor-Anglada\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 12 P-GLYCOPROTEIN (MDR1\/ABCB1) 271\u003cbr\u003e \u003ci\u003eIngolf Cascorbi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 13 BSEP (ABCB11) 295\u003cbr\u003e \u003ci\u003eBruno Stieger and Gerd A. Kullak-Ublick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 14 BCRP (ABCG2) 311\u003cbr\u003e \u003ci\u003eAgnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345\u003cbr\u003e \u003ci\u003eAnne T. Nies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 16 MRP4 (ABCC4) 365\u003cbr\u003e \u003ci\u003eSatish B. Cheepala, Mugdha Sukthankar and John D. Schuetz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 17 MRP8 (ABCC11) 387\u003cbr\u003e \u003ci\u003eYu Toyoda and Toshihisa Ishikawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 18 FUTURE PERSPECTIVES 401\u003cbr\u003e \u003ci\u003eToshihisa Ishikawa and Joseph Ware\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 417\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402460438871,"sku":"9780470927946","price":125.96,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470927946.jpg?v=1791462885"},{"product_id":"quality-assurance-for-biopharmaceuticals-9780471036562","title":"Quality Assurance for Biopharmaceuticals","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis volume provides basic guidelines concerning quality assurance and its responsibilities for biopharmaceuticals manufactured by either recombinant, monoclonal antibody or other biotechnological methodologies. Insight is given on the safety, purity and efficacy of the products produced.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eOrganization of Quality Assurance (J. Huxsoll).\u003cbr\u003e \u003cbr\u003e Coming into GMP Compliance (C. Orelli).\u003cbr\u003e \u003cbr\u003e Documentation Systems (C. Brochard).\u003cbr\u003e \u003cbr\u003e Validation (D. Colton).\u003cbr\u003e \u003cbr\u003e Quality Assurance (QA) of Production Materials for Biotechnology(D. Miller).\u003cbr\u003e \u003cbr\u003e Quality Assurance (QA) of Analytical Methods--Biochemical (F.Bogdansky).\u003cbr\u003e \u003cbr\u003e Applied Data Analysis, Sampling Methodologies, and StatisticalValidation Techniques (G. Swartz).\u003cbr\u003e \u003cbr\u003e Environmental and Safety Programs for Biotechnology (M.Sigourney).\u003cbr\u003e \u003cbr\u003e Regulatory Issues--United States (C. Spencer).\u003cbr\u003e \u003cbr\u003e Regulatory Issues--Europe (R. Wikberg-Leonardi \u0026amp; D.Mulder).\u003cbr\u003e \u003cbr\u003e Regulatory Issues--Japan (R. Rousell \u0026amp; E. Greene).\u003cbr\u003e \u003cbr\u003e Abbreviations.\u003cbr\u003e \u003cbr\u003e Appendices.\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402480099671,"sku":"9780471036562","price":155.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471036562.jpg?v=1730480536"},{"product_id":"applied-molecular-genetics-9780471156765","title":"Applied Molecular Genetics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn this state-of-the-art guide to applied molecular genetics, well-known teacher and author Roger L. Miesfeld presents a clear, no-nonsense approach to the principles underlying molecular genetics and its applications in biological and biomedical research.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"This book has a number of strengths, including the author's clear writing style and the large number of informative two-color line drawings which make the book easy to read.\" --Choice, 10\/99\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eLABORATORY TECHNIQUES.\u003cbr\u003e \u003cbr\u003e Biochemical Basis of Applied Molecular Genetics.\u003cbr\u003e \u003cbr\u003e Laboratory Tools for Molecular Genetic Applications.\u003cbr\u003e \u003cbr\u003e Overview of Gene Analysis Methods.\u003cbr\u003e \u003cbr\u003e CORE METHODS.\u003cbr\u003e \u003cbr\u003e Characterization of Genomic DNA.\u003cbr\u003e \u003cbr\u003e Isolation and Characterization of Gene Transcripts.\u003cbr\u003e \u003cbr\u003e The Polymerase Chain Reaction.\u003cbr\u003e \u003cbr\u003e SPECIALIZED APPLICATIONS.\u003cbr\u003e \u003cbr\u003e Expression of Cloned Genes in Cultured Cells.\u003cbr\u003e \u003cbr\u003e Construction of Transgenic Multicellular Organisms.\u003cbr\u003e \u003cbr\u003e Contemporary Applied Molecular Genetics.\u003cbr\u003e \u003cbr\u003e Appendices.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402502644055,"sku":"9780471156765","price":112.46,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471156765.jpg?v=1730480603"},{"product_id":"identification-and-expression-of-g-proteincoupled-receptors-9780471194934","title":"Identification and Expression of G ProteinCoupled","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe past decade has seen tremendous advances in the study of G protein-coupled receptors (GPCRs), including the molecular cloning and identification of more than 100 hundred GPCR genes. But while GPCRs serve as targets for more than 300 medicines in the modern pharmacopoeia, the shrinking pool of known ligands and the continuing discovery of orphan GPCR genes have underscored the need for new approaches to ligand identification.\u003cbr\u003e \u003cbr\u003e Identification and Expression of G Protein-Coupled Receptors addresses this new direction in GPCR biochemistry-offering a definitive laboratory bench manual that emphasizes expression over primary cloning strategies. In a series of expert contributions by well-known researchers, this book provides detailed protocols for various expression systems-from bacteria to mammalian cells-as well as straightforward opinions on the advantages and shortcomings of each approach. Topics covered include:\u003cbr\u003e * Homology screening and the polymerase chain reaction in t\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eCloning of G Protein-Coupled Receptor Genes: The Use of Homology Screening and the Polymerase Chain Reaction (A. Marchese, et al.).\u003cbr\u003e \u003cbr\u003e Practical Approaches for Cloning G Protein-Coupled Receptors Using Mammalian Cell Expression (T. Murphy).\u003cbr\u003e \u003cbr\u003e G Protein-Coupled Receptor Informatics and the Orphan Problem (K. Lynch).\u003cbr\u003e \u003cbr\u003e The Use of Xenopus laevis Oocytes for the Study of G Protein-Coupled Receptors (A. Lee \u0026amp; M. Durieux).\u003cbr\u003e \u003cbr\u003e Stable Expression of G Protein-Coupled Receptors in Mammalian Cells (K. Neve \u0026amp; R. Neve).\u003cbr\u003e \u003cbr\u003e Heterologous Expression in Primary Cell Cultures (R. Leonard).\u003cbr\u003e \u003cbr\u003e Expression of G Protein-Coupled Receptors in Escherichia coli (R. Grisshammer).\u003cbr\u003e \u003cbr\u003e Large-Scale Expression\/Purification of G Protein-Coupled Receptors Mammalian Cells (A. Robeva \u0026amp; J. Linden).\u003cbr\u003e \u003cbr\u003e High-Level Expression of G Protein-Coupled Receptors in the Baculovirus\/SF9 Cell Expression System (N. Rondeau, et al.).\u003cbr\u003e \u003cbr\u003e Expression of G Protein-Coupled Receptors in Drosophila Schneider 2 Cells (M. Graziano, et al.).\u003cbr\u003e \u003cbr\u003e Heterologous G Protein-Coupled Receptors Expressed in Saccharomyces cerevisiae: Methods for Genetic Analysis and Ligand Identification (M. Pausch, et al.).\u003cbr\u003e \u003cbr\u003e Index.","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402524008791,"sku":"9780471194934","price":161.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471194934.jpg?v=1730480660"},{"product_id":"plant-gene-containment-9780813803494","title":"Plant Gene Containment","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eWith the rise in cultivation of genetically modified organisms (GMOs), it is becoming increasingly important to find ways to prevent transgenes from escaping into related crops and plants in the wild.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors ix\u003c\/p\u003e \u003cp\u003eForeword xi\u003cbr\u003e \u003ci\u003eJ. Perry Gustafson and Peter H. Raven\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 1 Perspectives of Gene Flow 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1 Potential Environmental Impacts of Transgene Flow in Rice with a Particular View on Herbicide Resistance 3\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eBao-Rong Lu and Wei Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 3\u003c\/p\u003e \u003cp\u003eTransgene Escape and Its Potential Environmental Impacts 4\u003c\/p\u003e \u003cp\u003eHerbicide-Resistant Rice 8\u003c\/p\u003e \u003cp\u003eGene Flow from Herbicide-Resistant Rice and Its Potential Impacts 12\u003c\/p\u003e \u003cp\u003eManaging Potential Environmental Impacts from Transgene Flow 17\u003c\/p\u003e \u003cp\u003eConclusion 19\u003c\/p\u003e \u003cp\u003eAcknowledgments 20\u003c\/p\u003e \u003cp\u003eReferences 20\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 Assessment and Detection of Gene Flow 27\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eWei Wei, Charles Kwit, Reginald J. Millwood, Hong S. Moon, and C. Neal Stewart Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eImportance of Assessment and Detection of Gene Flow 27\u003c\/p\u003e \u003cp\u003eDetection Methodologies 29\u003c\/p\u003e \u003cp\u003eApplications in Assessment of Gene Flow 35\u003c\/p\u003e \u003cp\u003ePerspectives 36\u003c\/p\u003e \u003cp\u003eAcknowledgments 37\u003c\/p\u003e \u003cp\u003eReferences 37\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 Bt Resistance Monitoring in European Corn Borers and Western Corn Rootworms 43\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eBlair D. Siegfried and Terence Spencer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 43\u003c\/p\u003e \u003cp\u003eResistance Monitoring 44\u003c\/p\u003e \u003cp\u003eBioassay Methods and Baseline Susceptibility 47\u003c\/p\u003e \u003cp\u003eRecent Developments 49\u003c\/p\u003e \u003cp\u003eConclusions 51\u003c\/p\u003e \u003cp\u003eAcknowledgments 52\u003c\/p\u003e \u003cp\u003eReferences 52\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Commercialization of GMOs: the Company Perspective on Risks and Containment 57\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eKater Hake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCommercialization of Traits Derived from Plant Biotechnology (GMOs and Alien Chromosome Introgression) 57\u003c\/p\u003e \u003cp\u003eGene Containment During the Commercial Utilization of Crops Derived from Biotechnology 60\u003c\/p\u003e \u003cp\u003eGene Containment During Research, Development, and Seed Production 62\u003c\/p\u003e \u003cp\u003eStewardship and Gene Containment 63\u003c\/p\u003e \u003cp\u003eReferences 65\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 2 Strategies for Gene Containment 67\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Trait Control (Gene Switch Technology) 69\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eM. Isabel Ordiz, Jaemo Yang, and Roger N. Beachy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eComponents of Gene Switch Systems 69\u003c\/p\u003e \u003cp\u003eApplication of Gene Switch Technologies 75\u003c\/p\u003e \u003cp\u003eFuture Perspectives 79\u003c\/p\u003e \u003cp\u003eReferences 80\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 Male Sterility and Hybrid Plant Systems for Gene Confinement 85\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAlbert P. Kausch, Joel Hague, Adam Deresienski, Michael Tilelli, and Kimberly Nelson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 85\u003c\/p\u003e \u003cp\u003eCytoplasmic Male Sterility 86\u003c\/p\u003e \u003cp\u003eTransgenic Nuclear Male Sterility 87\u003c\/p\u003e \u003cp\u003eTransgenic Nuclear Male Sterility for Gene Confinement 89\u003c\/p\u003e \u003cp\u003eMale Sterility for Recovery of Wide Crosses with Gene Confinement 90\u003c\/p\u003e \u003cp\u003eHybrid Plant Systems 92\u003c\/p\u003e \u003cp\u003eSeed-Based Hybrid Plant Systems 92\u003c\/p\u003e \u003cp\u003eGene-Deletor System 92\u003c\/p\u003e \u003cp\u003eMale and Female Sterile Lines 94\u003c\/p\u003e \u003cp\u003eTotal Sterility 95\u003c\/p\u003e \u003cp\u003eStable Knockout Mutations 96\u003c\/p\u003e \u003cp\u003eReferences 96\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 Gene-Deletor Technology and Its Potential Applications in Addressing Gene Flow and Food Safety Concerns over Transgenic Plants 101\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYi Li, Hui Duan, Yongqin Chen, and Richard McAvoy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 101\u003c\/p\u003e \u003cp\u003eThe Principle of Gene-Deletor Technology and Supporting Experimental Data 102\u003c\/p\u003e \u003cp\u003eCharacteristics and Requirements of Gene-Deletor Technology 105\u003c\/p\u003e \u003cp\u003ePotential Applications of Gene-Deletor Technology 107\u003c\/p\u003e \u003cp\u003eConclusions and Perspectives 109\u003c\/p\u003e \u003cp\u003eAcknowledgments 110\u003c\/p\u003e \u003cp\u003eReferences 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 Seed-Based Gene Containment Strategies 113\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMelvin J. Oliver and Kater Hake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSeedless Crops 114\u003c\/p\u003e \u003cp\u003eSeed-Based Containment 115\u003c\/p\u003e \u003cp\u003eGeneSafe (Technology Protection System (TPS)) Technology 117\u003c\/p\u003e \u003cp\u003eExpression Cascades for Gene Containment 120\u003c\/p\u003e \u003cp\u003eReferences 123\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9 Transgenic Mitigation of Transgene Dispersal by Pollen and Seed 125\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJonathan Gressel and Hani Al-Ahmad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction—Containers Leak 125\u003c\/p\u003e \u003cp\u003eMitigation—The Concept of Conferring a Selective Disadvantage Outside of Cultivation 128\u003c\/p\u003e \u003cp\u003eEvidence That TM Mitigates Transgene Establishment 133\u003c\/p\u003e \u003cp\u003eTailoring Mitigator Genes to Crops and Cropping Situation 137\u003c\/p\u003e \u003cp\u003eConcluding Remarks 142\u003c\/p\u003e \u003cp\u003eReferences 142\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10 Tapping RNA Silencing for Transgene Containment through the Engineering of Sterility in Plants 147\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eZongrang Liu and Stacy D. Singer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 147\u003c\/p\u003e \u003cp\u003eReferences 166\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11 Control of Cleistogamy and Seed Dormancy for Biological Gene Containment in Oilseed Rape (Brassica napus L.) 175\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSabine Gruber and Alexandra H¨usken\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 175\u003c\/p\u003e \u003cp\u003ePathways of Gene Flow in Oilseed Rape 176\u003c\/p\u003e \u003cp\u003eManaging Gene Flow in Oilseed Rape 184\u003c\/p\u003e \u003cp\u003eCombining Biological Measures Package for Gene Containment 191\u003c\/p\u003e \u003cp\u003eConclusion 192\u003c\/p\u003e \u003cp\u003eAcknowledgments 192\u003c\/p\u003e \u003cp\u003eReferences 192\u003c\/p\u003e \u003cp\u003eIndex 199\u003c\/p\u003e \u003cp\u003eA color plate section appears between pages 114 and 115\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49405804806487,"sku":"9780813803494","price":128.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780813803494.jpg?v=1730493681"},{"product_id":"the-molecular-biology-and-biochemistry-of-fruit-ripening-9780813820392","title":"The Molecular Biology and Biochemistry of Fruit","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eA comprehensive and mechanistic perspective on fruit ripening, emphasizing commonalities and differences between fruit groups and ripening processes.      Fruits are an essential part of the human diet and contain important phytochemicals that provide protection against heart disease and cancers.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eContents\u003c\/p\u003e \u003cp\u003eList of Contributors ix\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1 Biochemistry of Fruit Ripening 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSonia Osorio and Alisdair R. Fernie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 1\u003c\/p\u003e \u003cp\u003eCentral Carbon Metabolism 4\u003c\/p\u003e \u003cp\u003eEthylene in Ripening 7\u003c\/p\u003e \u003cp\u003ePolyamines 9\u003c\/p\u003e \u003cp\u003eVolatiles 10\u003c\/p\u003e \u003cp\u003eCell Wall Metabolism 11\u003c\/p\u003e \u003cp\u003eConcluding Remarks 13\u003c\/p\u003e \u003cp\u003eReferences 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 Fruit—An Angiosperm Innovation 21\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSandra Knapp and Amy Litt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 21\u003c\/p\u003e \u003cp\u003eFruit in the Fossil Record 30\u003c\/p\u003e \u003cp\u003eFruit Variation and Angiosperm Phylogeny 32\u003c\/p\u003e \u003cp\u003eFruit Development 33\u003c\/p\u003e \u003cp\u003eFruit as a Driver of Angiosperm Diversity 36\u003c\/p\u003e \u003cp\u003eAcknowledgments 38\u003c\/p\u003e \u003cp\u003eReferences 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 Ethylene and the Control of Fruit Ripening 43\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDon Grierson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 43\u003c\/p\u003e \u003cp\u003eEthylene and Climacteric and Nonclimacteric Fruits 46\u003c\/p\u003e \u003cp\u003eA Molecular Explanation for System-1 and System-2 Ethylene 48\u003c\/p\u003e \u003cp\u003eEthylene and Ripening Gene Networks in Flower and Fruit Development 53\u003c\/p\u003e \u003cp\u003eEthylene Perception and Signaling 54\u003c\/p\u003e \u003cp\u003eEthylene Response Factors 60\u003c\/p\u003e \u003cp\u003eEthylene and Ripening Gene Expression 60\u003c\/p\u003e \u003cp\u003eConclusions 67\u003c\/p\u003e \u003cp\u003eAcknowledgments 68\u003c\/p\u003e \u003cp\u003eReferences 68\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Carotenoid Biosynthesis and Chlorophyll Degradation 75\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePeter M. Bramley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 75\u003c\/p\u003e \u003cp\u003eDistribution of Carotenoids and Chlorophylls in Fruit 75\u003c\/p\u003e \u003cp\u003eChlorophyll Degradation and Recycling 78\u003c\/p\u003e \u003cp\u003eCarotenoids and Carotenoid Metabolites 82\u003c\/p\u003e \u003cp\u003eFuture Perspectives 100\u003c\/p\u003e \u003cp\u003eAcknowledgments 102\u003c\/p\u003e \u003cp\u003eBibliography 102\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Phenylpropanoid Metabolism and Biosynthesis of Anthocyanins 117\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLaura Jaakola\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 117\u003c\/p\u003e \u003cp\u003eCinnamic Acids 119\u003c\/p\u003e \u003cp\u003eMonolignols, Lignans, and Lignin 120\u003c\/p\u003e \u003cp\u003eCoumarins 120\u003c\/p\u003e \u003cp\u003eStilbenoids 122\u003c\/p\u003e \u003cp\u003eFlavonoids 122\u003c\/p\u003e \u003cp\u003eEngineering Elevated Levels of Flavonoids and Other Phenylpropanoids 128\u003c\/p\u003e \u003cp\u003eConclusion 129\u003c\/p\u003e \u003cp\u003eReferences 129\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 Biosynthesis of Volatile Compounds 135\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAntonio Granell and Jose Luis Rambla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 135\u003c\/p\u003e \u003cp\u003eMetabolic Pathways 136\u003c\/p\u003e \u003cp\u003eIdentification of Quantitative Trait Loci for Volatiles 152\u003c\/p\u003e \u003cp\u003eMetabolic Engineering of the Fruit Volatile Pathways 153\u003c\/p\u003e \u003cp\u003eFuture Perspectives 154\u003c\/p\u003e \u003cp\u003eReferences 155\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 Cell Wall Architecture and Metabolism in Ripening Fruit and the Complex Relationship with Softening 163\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eEliel Ruiz-May and Jocelyn K.C. Rose\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 163\u003c\/p\u003e \u003cp\u003eBuilding Blocks of Fruit Cell Walls 164\u003c\/p\u003e \u003cp\u003eThe Architecture of Fruit Cell Walls 168\u003c\/p\u003e \u003cp\u003eCell Wall Dynamics in Ripening Fruit 171\u003c\/p\u003e \u003cp\u003eThe Cuticular Cell Wall and Fruit Softening 177\u003c\/p\u003e \u003cp\u003eSummary 179\u003c\/p\u003e \u003cp\u003eAcknowledgments 180\u003c\/p\u003e \u003cp\u003eReferences 180\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 Regulatory Networks Controlling Ripening 189\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eBetsy Ampopho, Natalie Chapman, Graham B. Seymour, and James J. Giovannoni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHormonal Control 189\u003c\/p\u003e \u003cp\u003eGenetic Networks 191\u003c\/p\u003e \u003cp\u003eEpigenetic Regulation 200\u003c\/p\u003e \u003cp\u003eReferences 201\u003c\/p\u003e \u003cp\u003eIndex 207\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49405821714775,"sku":"9780813820392","price":166.46,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780813820392.jpg?v=1730493701"},{"product_id":"transgenic-animals-in-agriculture-9780851992938","title":"Transgenic Animals in Agriculture","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIn the past decade, a number of advances have been made in genetic engineering as applied to farmed animals. This book has been developed from invited presentations at a conference held in California in August 1997 to address this issue. It is written by representatives from the leading laboratories involved in attempts to improve agriculturally important mammals, poultry and fish. Current knowledge, methodology, technical improvements and successes in the applications of transgenic technology to a range of animals which are important in agriculture are brought together for the first time under one cover. This book is essential reading for research workers in animal genetics, breeding and biotechnology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: Transgenic Farm Animals, C A Pinkert, University of Alabama at Birmingham, USA and J D Murray, University of California, USA 2: Development of Genetic Tools for Transgenic Animals, P B Hackett, University of Minnesota, USA 3: One Gene is Not Enough: Transgene Detection, Expression and Control, K D Wells and R J Wall, Agricultural Research Service, US Department of Agriculture, Beltsville, USA 4: Embryonic Stem Cells in Agricultural Species, G B Anderson, University of California, USA 5: Nuclear Transfer in the Production of Transgenic Farm Animals,I Wilmut, Roslin Institute, Roslin, UK et al. 6: Embryonic Stem Cell Chimaeras and Somatic Cell Nuclear Transplantation for Production of Transgenic Cattle, J M Robl, University of Massachusetts, USA et al. 7: Status of Sperm-mediated Delivery Methods for Gene Transfer, E J Squires, University of Guelph, Ontario, Canada 8: Understanding the Origin of Avian Primordial Germ Cells: Implications for Germ Cell Culture and Transgenesis in Poultry, J N Petitte, North Carolina State University, Davis, USA et al. 9: Generation of Transgenic Poultry by Transfection of Primordial Germ Cells, E A Wong, Virginia Polytechnic Institute and State University, Blacksburg, USA 10: Expression of Insulin-like Growth Factor-I in Skeletal Muscle of Transgenic Swine, V G Pursel, US Department of Agriculture, Beltsville, USA et al. 11: Production and Analysis of Transgenic Pigs Containing a Metallothionein Porcine Growth Hormone Gene Construct, M B Nottle, BresaGen Ltd., Adelaide, Australia 12: The Utilization of Bacterial Genes to Modify Domestic Animal Biochemistry, K A Ward CSIRO, NSW, Australia et al. 13: Production of Transgenic Cattle expressing a Recombinant Protein in Milk, W H Eyestone, PPL Therapeutics Inc., Blacksburg, USA 14: Changing the Composition and Properties of Milk, J D Murray et al 15: Comparison of Traditional Breeding and Transgenesis in Farmed Fish with Implications for Growth Enhancement and Fitness, R A Dunham, Auburn University, USA et al. 16: Direct and Correlated Responses to Short-term Selection of 8-week Body Weight in Lines of Transgenic (oMt1a-oGH) Mice, F Siewerdt, North Carolina State University, Raleigh, USA 17: Ethics, Animal Welfare and Transgenic Farm Animals, J A Mench, University of California, Davis, USA 18: The Future of Transgenic Farm Animals, G E Seidel Jr, Colorado State University, Fort Collins, Colorado, USA","brand":"CABI Publishing","offers":[{"title":"Default Title","offer_id":49406248911191,"sku":"9780851992938","price":101.25,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780851992938.jpg?v=1730495092"},{"product_id":"intellectual-property-rights-in-animal-breeding-and-genetics-9780851996417","title":"Intellectual Property Rights in Animal Breeding","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eIntellectual property (IP) and patents involving animals is an ever-changing field. The purpose of this book is to review the role that intellectual property plays in the development of modern animal breeding and genetics. It includes discussion of the history of animal patenting,common forms of intellectual property,economic issues related to patent protection and the funding of research, ethical issues, and the consequences of intellectual property in the modern animal genetics market place.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: Intellectual Property and Food Security – Policy Issues 2: Intellectual Property and Agriculture 3: International Intellectual Property Landscape 4: Plant Variety Protection and Food Security 5: Genetic Resources for Food and Agriculture 6: Traditional Agricultural Knowledge and Farmers Rights 7: Intellectual Property Aspects of GMOs and Food Security 8: Geographical Indications and Food Security 9: Competition Aspects 10: Intellectual Property and Agricultural Research 11: Recommendations","brand":"CABI Publishing","offers":[{"title":"Default Title","offer_id":49406253564247,"sku":"9780851996417","price":113.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780851996417.jpg?v=1730495113"},{"product_id":"poultry-genetics-breeding-and-biotechnology-9780851996608","title":"Poultry Genetics Breeding and Biotechnology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis comprehensive research book represents the first complete integration of current knowledge in this area. It addresses issues associated with poultry breeding particularly by examining quantitative and molecular genetics and the uses of transgenic technology. A special section covers the important area of disease resistance and transmission.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e1: Part I: Problems and Issues associated with Poultry Breeding 2: Industrial Perspective on Problems \u0026amp; Issues Associated with Poultry Breeding, J Arthur, Hy-Line International, Dallas Center, USA \u0026amp; G Albers, Nutreco Agriculture Research \u0026amp; Development, The Netherlands 3: Growth \u0026amp; Reproduction Problems Associated with Selection for Increased Broiler Meat Production, E Ducuypere, V Bruggeman, Catholic Uni Leuven, G Barbato, Pennsylvania Uni,\u0026amp; J Buyse, Catholic Uni Leuven, 4: Skeletal Problems Associated with Selection for Increased Production, C Whitehead, R Fleming, Bone Biology Group, Roslin Institute, R Julian, Ontario Veterinary College \u0026amp; P Sørensen, DIAS 5: Meat Quality Problems Associated with Selection for Increased Production, H Remignon, ENSAT, France and E Le Bihan-Duval, Station de Recherches Avicoles, INRA Centre de Tours, France 6: Behaviour Problems Associated with Selection for Increased Production, J B Kjaer, Danish Institute of Agricultural Sciences, Tjele, Denmark and J A Mench, University of California, USA 7: Problems with Genotype-Environment Interactions Associated with Selection for Increased Production, P K Mathur, Canadian Center for Swine Improvement Inc, Ottawa, Ontario, Canada 8: Part II: Breeding Strategies and Objectives 9: Breeding Objectives and Selection Strategies for Layer Production, A E Groen, Wageningen University, The Netherlands 10: Breeding Objectives and Selection Strategies for Broiler Production, D Emmerson, Aviagens, AL, USA 11: Use of Mixed Model Methodology in Breeding Strategies for Meat Type Birds, 12: B Besbes, Hubbard-ISA (Layer Division), Chateaubourg, France and V Ducrocq, Station de Genetique Quantitative et Appliquee, INRA, France 13: Application of Mixed Model Methodology in Breeding Strategies for Meat Type Birds, S Wezyk, Krowoderskich Zuchow, Poland and J Jankowski, University of Warmia and Mazury, Poland 14: Use of Mixed Model Methodology in Poultry Breeding: Estimation of Genetic Parameters, T Szwaczkowski, August Cieszkowski Agricultural University of Poznan, Poland 15: Use of Mixed Model Methodology in Poultry Breeding: Assumptions, limitations, and concerns of BLUP based selection programs, M Quinton, University of Guelph, Canada 16: Direct Selection for Improvement of Animal Well-Being, J Faure, Station de Recherches Avicoles, INRA Centre de Tours, France, W Bessei, Universitat Hohenheim, Germany \u0026amp; R Jones, Roslin Institute, Edinburgh 17: Indirect Selection for Improvement of Animal Well-Being, W M Muir 18: Genetic Diversity and Conservation of Poultry, M E Delany, University of California, USA 19: Part III: Disease Resistance and Transmission 20: Progress and Prospects in Resistance to Disease, U Kuhnlein, McGill University, Canada, S E Aggrey and A Zadworny, McGill University, Canada 21: Genetics of the Immune System, J Plachy, Academy of Sciences of the Czech Republic, P Kaiser, Institute of Animal Health, Compton Lab \u0026amp; K Hala, Institute of Pathophysiology, University of Innsbruck Medical School 22: Genetic Resistance and Transmission of Avian Bacteria and Viruses, N Bumstead, Institute of Animal Health, Compton Laboratory, Berkshire, UK 23: Genetic Resistance and Transmission of Avian Parasites, M-H Pinard van der Laan, Laboratoire de Genetique Factorille, INRA, France, H S Lillehoj and James J Zhu, USDA, Agricultural Research Service, USA 24: Selection for Disease Resistance: Conventional Breeding for Resistance to Bacteria and Viruses, C Beaumont, Station de Recherches Avicoles, G Dambrine, A Chausse, INRA \u0026amp; D Flock, Akazienweg, 25: Selection for Disease Resistance: Molecular Genetic Techniques, H H Cheng, USDA-ARS, Avian Diseases and Oncology Lab, MI, USA 26: Selection for Disease Resistance: Direct Selection on the Immune Response, S Lamont, Iowa Uni, M Pinard-van der Laan, A Cahaner, Hebrew Uni Jerusalem, J van der Poel \u0026amp; H Parmentier, Wageningen Uni 27: Part IV: The Use of Genomics and Bioinformatics in Poultry 28: Genetic Markers: Prospects and Applications in Genetic Analysis, S E Aggrey and R Okimoto, University of Arkansas, Fayetteville, USA 29: Designs and Methods to Detect QTL for Production Traits based on Mapped Genetic Markers, J A M Van Arendonk, and H Bovenhuis, Wageningen University, The Netherlands 30: Designs and Methods to Detect QTL for Production Traits based on Random Genetic Models, Yi Nengjun and S Xu, University of California, Riverside, USA 31: Structural Genomics: Integrating Linkage, Physical and Sequence Maps, M A M Groenen and R P M A Crooijmans, Wageningen University, The Netherlands 32: Incorporating Molecular Information in Breeding Programs: Methodology, R Fernando and L R Totir, Iowa State University, Ames, USA 33: Incorporating Molecular Information in Breeding Programs: Applications and Limitations, W M Muir 34: Comparative Genomics, D W Burt, Roslin Institute, Edinburgh, UK 35: Functional Genomics: Development and Gene Regulation, J Killefer, University of Illinois, Urbana, USA and H Kocamis, College of Agriculture, Morgantown, WV, USA 36: Expressed Sequence Tags, DNA Chip Technology and Gene Expression Profiling, L A Cogburn, R Morgan and J Burnside, University of Delaware, Newark, USA 37: DNA Polymorphisms in Functional Genes, U Kuhnlein, McGill University, Quebec, Canada, S E Aggrey, N Kansaku, Azabu University, Sagamihara, Japan and D Zadworny, McGill University, Quebec, Canada 38: Strategies for the Production of Transgenic Chickens, J N Petitte, North Carolina State University, Raleigh, USA 39: The Future of Molecular Genetics in Poultry Breeding, J Dodgson, Michigan State University, East Lansing, USA","brand":"CABI Publishing","offers":[{"title":"Default Title","offer_id":49406253990231,"sku":"9780851996608","price":217.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780851996608.jpg?v=1730495115"},{"product_id":"handbook-on-agriculture-biotechnology-and-development-elgar-original-reference-9780857938343","title":"Handbook on Agriculture Biotechnology and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book is a compendium of knowledge, experience and insight on agriculture, biotechnology and development. Beginning with an account of GM crop adoptions and attitudes towards them, the book assesses numerous crucial processes, concluding with detailed insights into GM products.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e'This is a timely assessment of the current and possible future status of GMOs, with useful observations on what has been learned along the way and how this knowledge might be applied. Well edited and produced.' -- L. C. Devis, Kansas State University, Choice\u003cbr\u003e‘This Handbook covers a contentious topic, so the approach of the editors is refreshing, especially their transparent introduction as to how they organized their work. A key theme is evidence. I have been involved in agro-biotechnology for 25 years, mainly at the international level; I know that evidence is what matters. This is a comprehensive coverage of many aspects of agro-biotechnology but it is easy to navigate through the chapters and follow any number of issues of interest.’ -- – Peter Kearns, OECD, Paris\u003cbr\u003e‘This Handbook is a tour de force, providing fascinating insights and nourishments for the mind that will shape views and visions. The rich interplay between science and society, between agriculture and development, comprehensively addressed in this Handbook is a must-read for anyone wishing to make a meaningful contribution to global development.’ -- Anatole Krattiger, Cornell University, US\u003cbr\u003e‘Over the last two decades one of the great global emerging technological trends has been the shift from chemistry to biology in agriculture. Bitterly contested and enduringly controversial, the shift to biotechnology has nevertheless led to greater sustainability and promises even greater gains in years to come. This Handbook is an invaluable compendium of detailed case study and insight.’\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eContents:   Editor’s Introduction: Conceptual Framing of the IAD framework and Methods, Models and Metrics   1. Introduction to Agriculture, Biotechnology and Development Stuart J. Smyth, Peter W.B. Phillips and David Castle  PART I: EXOGENOUS VARIABLES: THE ENVIRONMENT, ACTORS AND RULES 2. Global Adoption of GM Crops, 1995–2010 Graham Brookes  3. Structure of Public Research Richard Gray and Buwani Dayananda  4. The Private Sector: MNEs and SMEs Jill E. Hobbs  5. Biotechnology in North America: The United States, Canada and Mexico Julia Bognar and Grace Skogstad  6. South American Adopters: Argentina and Brazil Sybil D. Rhodes  7. Africa  Jennifer Thomson  8. China Valerie J. Karplus  9. Agricultural Biotechnology in India: Impacts and Controversies Matin Qaim  10. Oceania: Australia, New Zealand, Japan and The Philippines Karinne Ludlow and Jose Yorobe Jr.  11. European Union Policy Conflicts over Agbiotech: Ecological Modernisation Perspectives and Critiques Les Levidow  12. Africa Non-adopters Robert Paarlberg  13. Non-adopters of GM Crops in Latin American Jose Falck-Zepeda  14. The Cuban Context for Agriculture and Innovation Carlos G. Borroto  15. Risk Assessment Frameworks in the Multilateral Setting Lee Ann Jackson  16. The Trade System and Biotechnology William A. Kerr  17. Developing Countries and the Legal Institutions at the Intersection of Agbiotech and Development Chidi Oguamanam  18. Consumer Attitudes and Preferences for GM Products Stuart J. Smyth and David Castle  19. The Motivation and Impact of Organized Public Resistance Against Agricultural Biotechnology Philip Aerni  PART II: ACTION ARENAS 20. The Research Pipeline Peter W.B. Phillips  21. Clusters, Innovation Systems and Biotechnology in Developing Country Agriculture David J. Spielman, Douglas Zhihua Zeng and Xingliang Ma  22. Practice Driving Policy: Agbiotech Transfer as Capacity Building William O. Hennessey, Aarushi Gupta and Stanley P. Kowalski  23. The North American Crop Biotech Environment, Actors and Rules David Schimmelpfennig  24. Adoption Decisions Corinne Alexander  25. Co-existence Volker Beckmann, Claudio Soregaroli and Justus Wesseler  26. Biotechnology and the Inputs Industry Anwar Naseem and Latha Nagarajan  27. Market Power in the US Biotech Industry Alexandre Magnier, Nicholas Kalaitzandonakes and Douglas Miller  28. The Dynamic IP System in Crop Genetics and Biotechnology Derek Eaton and Greg Graff  29. Environment Effects LaReesa Wolfenbarger, Yves Carrière and Micheal Owen  30. Labelling of Genetically Modified Foods Wallace E. Huffman and Jill J. McCluskey  31. Biotechnology and Food Security Calestous Juma, Pedro Conceição and Sebastian Levine  32. International Regimes on Plant Intellectual Property Rights and Plant Genetic Resources: Implications for Stakeholders Deepthi Elizabeth Kolady  33. Engaging Publics on Agbiotech: A Retrospective Look Jennifer Medlock and Edna Einsiedel  34. Lessons from the California GM Labelling Proposition on the State of Crop Biotechnology David Zilberman, Scott Kaplan, Eunice Kim and Gina Waterfield  35. Biotechnology Communications, Mythmaking and the Media  Camille D. Ryan  PART III: OUTCOMES 36. Soybeans Jorge Fernandez-Cornejo and Seth Wechsler  37. Maize\/Corn Janet Carpenter, Marnus Gouse and Jose Yorobe Jr.  38. GM Cotton Jeffrey Vitale, Gaspard Vognan and Marc Ouattarra  39. Canola Derek Brewin and Stavroula Malla  40. The Hawaiian Papaya Story Carol V. Gonsalves and Dennis Gonsalves  41. Sugar Beet Koen Dillen and Matty Demont  42. Rice Matty Demont, Mao Chen, Gongyin Ye and Alexander J. Stein  43. Aggregate Effects: Adopters and Non-adopters, Investors and Consumers George B. Frisvold and Jeanne M. Reeves  44. Economic Success but Political Failure? The Paradox of GM Crops in Developing Countries Terri Raney, Ademola A. Adenle and Ira Matuschke  45. The Size and Distribution of the Benefits from the Adoption of Biotech Soybean Varieties Julian M. Alston, Nicholas Kalaitzandonakes and John Kruse  46. Wheat: Status, Outlook and Implications William W. Wilson  47. Small Grains: Barley, Oat and Rye Syed Masood H. Rizvi and Graham J. Scoles  48. Incremental Benefits of Genetically Modified Bananas in Uganda Enoch M. Kikulwe, Jose Falck-Zepeda and Justus Wesseler  49. Biofuels and GM Feedstocks Alphanso Williams and William A. Kerr  50. Non-food GM Crops: Phytoremediation, Industrial Products and Pharmaceuticals George G. Khachatourians  51. Tomatoes, Potatoes and Flax: Exploring the Cost of Lost Innovations Camille D. Ryan and Alan McHughen","brand":"Edward Elgar Publishing Ltd","offers":[{"title":"Default Title","offer_id":49406338629975,"sku":"9780857938343","price":251.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780857938343.jpg?v=1730495449"},{"product_id":"principles-of-gene-manipulation-and-genomics-9781405135443","title":"Principles of Gene Manipulation and Genomics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe increasing integration between gene manipulation and genomics is embraced in this new book, \u003ci\u003ePrinciples of Gene Manipulation and Genomics\u003c\/i\u003e, which brings together for the first time the subjects covered by the best-selling books \u003ci\u003ePrinciples of Gene Manipulation\u003c\/i\u003e and \u003ci\u003ePrinciples of Genome Analysis \u0026amp; Genomics\u003c\/i\u003e.  \u003cul\u003e \u003cli\u003eComprehensively revised, updated and rewritten to encompass within one volume, basic and advanced gene manipulation techniques, genome analysis, genomics, transcriptomics, proteomics and metabolomics\u003c\/li\u003e \u003cli\u003eIncludes two new chapters on the applications of genomics\u003c\/li\u003e \u003cli\u003eAn accompanying website - www.blackwellpublishing.com\/primrose - provides instructional materials for both student and lecturer use, including multiple choice questions, related websites, and all the artwork in a downloadable format.\u003c\/li\u003e \u003cli\u003eAn essential reference for upper level undergraduate and graduate students of genetics, genomics, molecular biology and recombinant DNA techno\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"\u003ci\u003ePrinciples of Gene Manipulation and Genomics\u003c\/i\u003e is well written and clearly illustrated throughout, as would be expected from these authors who have considerable experience in this subject.\"\u003cbr\u003e \u003ci\u003eGenetical Research\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface. \u003cp\u003e1. Gene Manipulation in the Post-Genomics Era.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I: Fundamental Techniques of Gene Manipulation:\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e2. Basic Techniques.\u003c\/p\u003e \u003cp\u003e3. Cutting and Joining DNA Molecules.\u003c\/p\u003e \u003cp\u003e4. Basic Biology of Plasmid and Phage Vectors.\u003c\/p\u003e \u003cp\u003e5. Cosmids, Phasmids and Other Advanced Vectors.\u003c\/p\u003e \u003cp\u003e6. Gene Cloning Strategies.\u003c\/p\u003e \u003cp\u003e7. Sequencing Genes and Short Stretches of DNA.\u003c\/p\u003e \u003cp\u003e8. Changing Genes: Site-directed Mutagenesis and Protein Engineering.\u003c\/p\u003e \u003cp\u003e9. Bioinformatics.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Manipulating DNA in Microbes, Plants and Animals:.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10. Cloning in Bacteria Other Than \u003ci\u003eEscherichia coli.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11. Cloning in \u003ci\u003eSaccharomyces cerevisiaea\u003c\/i\u003e and Other Fungi.\u003c\/p\u003e \u003cp\u003e12. Gene Transfer to Animal Cells.\u003c\/p\u003e \u003cp\u003e13. Genetic Manipulation of Animals.\u003c\/p\u003e \u003cp\u003e14. Gene Transfer to Plants.\u003c\/p\u003e \u003cp\u003e15. Advanced Transgenic Technology.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: Genome Analysis, Genomics and Beyond:.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16. The Organization and Structure of Genomes.\u003c\/p\u003e \u003cp\u003e17. Mapping and Sequencing Genomes.\u003c\/p\u003e \u003cp\u003e18. Comparative Genomics.\u003c\/p\u003e \u003cp\u003e19. Large-Scale Mutagenesis and Interference.\u003c\/p\u003e \u003cp\u003e20. Analysis of the Transcriptome.\u003c\/p\u003e \u003cp\u003e21. Proteomics I – Expression Analysis and Characterization of Proteins.\u003c\/p\u003e \u003cp\u003e22. Proteomics II – Analysis of Protein Structures.\u003c\/p\u003e \u003cp\u003e23. Proteomics III – Protein Interactions.\u003c\/p\u003e \u003cp\u003e24. Metabolomics and Global Biochemical Networks.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV: Applications of Gene Manipulation and Genomics:.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e25. Applications of Genomics: Understanding the Basis of Polygenic Disorders and Identifying Quantitative Trait Loci.\u003c\/p\u003e \u003cp\u003e26. Applications of Recombinant DNA Technology.\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49407873745239,"sku":"9781405135443","price":57.9,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781405135443.jpg?v=1730500813"},{"product_id":"bring-back-the-king-9781472912275","title":"Bring Back the King","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eIf you could bring back just one animal from the past, what would you choose?\u003c\/b\u003eIt can be anyone or anything from history, from the King of the Dinosaurs, T. rex, to the King of Rock n' Roll, Elvis Presley, and beyond. De-extinction  the ability to bring extinct species back to life  is fast becoming reality. Around the globe, scientists are trying to de-extinct all manner of animals, including the woolly mammoth, the passenger pigeon and a bizarre species of flatulent frog. But de-extinction is more than just bringing back the dead. It's a science that can be used to save species, shape evolution and sculpt the future of life on our planet.In \u003ci\u003eBring Back the King\u003c\/i\u003e, scientist and comedy writer Helen Pilcher goes on a quest to identify the perfect de-extinction candidate. Along the way, she asks if Elvis could be recreated from the DNA inside a pickled wart, investigates whether it's possible to raise a pet dodo, and considers the odds of a 21st century Neanderthal turning head\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003ePilcher's wit shines through ... You will be left with a newfound respect for conservationists' hands-on methods of preserving genetic material. * Sunday Times *\u003cbr\u003eA friendly tour of genetics and cloning, with a bit of history thrown in. * Wall Street Journal *\u003cbr\u003eScience at its funniest! -- Sara Pascoe, writer and comedian\u003cbr\u003eIs likely to make you think and chuckle in equal measure. * How it Works *\u003cbr\u003eA fluid and witty writer; up there with Bill Bryson. -- Dr Karl Kruszelnicki, science commentator, author and presenter\u003cbr\u003eBlending the very latest de-extinction technology with cloning, and hard-core popular science with levity, this charming book will generate a lot of thoughtful discussion and a chuckle or two. * Forbes.com *\u003cbr\u003eLeaping off the page are insights into many charismatic and neglected species, and the amazing humans who fight to preserve our future. This revolution will inspire our generation the way that voyages of the Beagle and Apollo have before it. -- George Church, Professor of Genetics at Harvard Medical School and Director of PersonalGenomes.org\u003cbr\u003ePilcher asks provocative questions about both the nature of science and what it means to be human. * Publisher's Weekly *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface Introduction: Bringin' It Back  1. King of the Dinosaurs 2. King of the Cavemen 3. King of the Ice Age 4. King of the Birds 5. King of Down Under 6. King of Rock 'n' Roll 7. Blue Christmas 8. I Just Can't Help Believing 9. Now You See It ...  Key References: A Little Less Conversation a Little More Reading Acknowledgements Index","brand":"Bloomsbury Publishing PLC","offers":[{"title":"Default Title","offer_id":49408774177111,"sku":"9781472912275","price":10.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781472912275.jpg?v=1730504158"},{"product_id":"applied-molecular-biotechnology-9781498714815","title":"Applied Molecular Biotechnology","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eApplied Molecular Biotechnology: The Next Generation of Genetic Engineering\u003c\/strong\u003e explains state-of-the-art advances in the rapidly developing area of molecular biotechnology, the technology of the new millennium. Comprised of chapters authored by leading experts in their respective fields, this authoritative reference text:\u003c\/p\u003e\u003cul\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eHighlights the latest omics-based tools and approaches used in modern biotechnology\u003c\/li\u003e\n\u003cli\u003eExplains how various molecular biology technologies can be used to develop transgenic plants and how those plants can meet growing food and plant-derived product demands\u003c\/li\u003e\n\u003cli\u003eDiscusses chloroplast gene expression systems, mitochondrial omics, plant functional genomics, and whole-genome resequencing for crop improvement\u003c\/li\u003e\n\u003cli\u003eExplores plantmicrobe and plantinsect interactions affecting plant protection and productivity\u003c\/li\u003e\n\u003cli\u003eCovers animal models, pharmacogenomics, human tissue banking, and the molecular diagnosis of diseases such as cervical\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\"... timely and very much needed. … a comprehensive … [book] covering all important aspects of the technology.\"\u003cbr\u003e—From the Foreword by Dr. Kauser Abdulla Malik, HI, SI, TI, Distinguished National Professor, Dean for Postgraduate Studies, Forman Christian College (A Chartered University), Lahore, Pakistan \u003c\/p\u003e\n\u003cp\u003e\"This book is certainly a very valuable guide for any safety manager intending to build and maintain an effective safety activity. The focus on human factors is on the most relevant aspects as much as the need to define the most valuable ways to perform a retrospective analysis of occurrences.\u003c\/p\u003e\n\u003cp\u003eThe implementation of a Safety Management System is the essential instrument on which safety processes and company operations are based. The correct approach to dealing with human factors and in particular to analyzing the contribution pf human errors to incident causation is a crucial pillar, but not the only one, on which the entire foundation of organizational safety is based. This book offers a valuable support in ensuring this is achieved.\" \u003cbr\u003e—\u003cem\u003eCogn Tech Work, 2016\u003c\/em\u003e\u003c\/p\u003e\n\u003cbr\u003e\u003cp\u003e\"... timely and very much needed. … a comprehensive … [book] covering all important aspects of the technology.\"\u003cbr\u003e—From the Foreword by Dr. Kauser Abdulla Malik, HI, SI, TI, Distinguished National Professor, Dean for Postgraduate Studies, Forman Christian College (A Chartered University), Lahore, Pakistan\u003c\/p\u003e\n\u003cp\u003e\"This book is certainly a very valuable guide for any safety manager intending to build and maintain an effective safety activity. The focus on human factors is on the most relevant aspects as much as the need to define the most valuable ways to perform a retrospective analysis of occurrences.\u003c\/p\u003e\n\u003cp\u003eThe implementation of a Safety Management System is the essential instrument on which safety processes and company operations are based. The correct approach to dealing with human factors and in particular to analyzing the contribution pf human errors to incident causation is a crucial pillar, but not the only one, on which the entire foundation of organizational safety is based. This book offers a valuable support in ensuring this is achieved.\" \u003cbr\u003e—\u003cem\u003eCogn Tech Work, 2016\u003c\/em\u003e\u003c\/p\u003e\n\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eEmerging Tools and Approaches to Biotechnology in the Omics Era. Plant Molecular Biology: Tools to Develop Transgenics. Plant Molecular Biotechnology: Applications of Transgenics. The Chloroplast Gene-Expression System. Molecular Biology of Mitochondria: Genome, Transcriptome, and Proteome. Plant Functional Genomics: Approaches and Applications. Whole-Genome Resequencing: Current Status and Future Prospects in Genomics-Assisted Crop Improvement. Molecular Biotechnology of Plant–Microbe–Insect Interactions. Biotechnology for Improved Crop Productivity and Quality. Overview of Methods to Unveil the Epigenetic Code. Animal Models and Biomedical Research. Variations in Our Genome: From Disease to Individualized Cure. Molecular Biotechnology for Diagnostics. Techniques for Cervical Cancer Screening and Diagnosis. Type 2 Diabetes Mellitus, Obesity, and Adipose Tissue Biology. Human Tissue Banking and Its Role in Biomedical Research. Microbial Biotechnology. Molecular Biology of Viruses: Disease Perspective. Viral Biotechnology: Production Perspective. Cell-Free Biosystems. Magnetic Nanoparticles with Multifunctional Water-Soluble Polymers for Bioapplications. Industrial Biotechnology: Its Applications in Food and Chemical Industries. Environmental Biotechnology: Approaches for Ecosystem Conservation. Marine Biotechnology: Focus on Anticancer Drugs. Engineering Genomes for Biofuels.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Taylor \u0026 Francis Inc","offers":[{"title":"Default Title","offer_id":49409280573783,"sku":"9781498714815","price":215.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781498714815.jpg?v=1730506268"},{"product_id":"zero-to-genetic-engineering-hero-2e-9781680457162","title":"Zero to Genetic Engineering Hero 2e","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eZero to Genetic Engineering Hero is made to provide you with a first glimpse of the inner-workings of a cell. It further focuses on skill-building for genetic engineering and the Biology-as-a-Technology mindset (BAAT).  This book is designed and written for hands-on learners who have little knowledge of biology or genetic engineering. This book focuses on the reader mastering the necessary skills of genetic engineering while learning about cells and how they function. The goal of this book is to take you from no prior biology and genetic engineering knowledge toward a basic understanding of how a cell functions, and how they are engineered, all while building the skills needed to do so.","brand":"O'Reilly Media","offers":[{"title":"Default Title","offer_id":49411289317719,"sku":"9781680457162","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781680457162.jpg?v=1730513089"},{"product_id":"protein-secretion-in-bacteria-9781683670278","title":"Protein Secretion in Bacteria","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"American Society for Microbiology","offers":[{"title":"Default Title","offer_id":49411348791639,"sku":"9781683670278","price":107.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781683670278.jpg?v=1730513295"},{"product_id":"crispr-biology-and-applications-9781683670377","title":"CRISPR: Biology and Applications","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"American Society for Microbiology","offers":[{"title":"Default Title","offer_id":49411348857175,"sku":"9781683670377","price":100.7,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781683670377.jpg?v=1730513296"},{"product_id":"biocatalysis-and-agricultural-biotechnology-fundamentals-advances-and-practices-for-a-greener-future-9781771886895","title":"Biocatalysis and Agricultural Biotechnology:","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThis new volume, \u003cem\u003eBiocatalysis and Agricultural Biotechnology: Fundamentals, Advances, and Practices for a Greener Future\u003c\/em\u003e, looks at the application of a variety of technologies, both fundamental and advanced, that are being used for crop improvement, metabolic engineering, and the development of transgenic plants. \u003c\/p\u003e\u003cp\u003eThe science of agriculture is among the oldest and most intensely studied by mankind. Human intervention has led to manipulation of plant gene structure for the use of plants for the production of bioenergy, food, textiles, among other industrial uses. A sound knowledge of enzymology as well as the various biosynthetic pathways is required to further utilize microbes as sources to provide the desired products for industrial utility. This volume provides an overview of all these aspects along with an updated review of the major plant biotechnology procedures and techniques, their impact on novel agricultural development, and crop plant improvement. Also discussed are the use of \"white biotechnology\" and \"metabolic engineering\" as prerequisites for a sustainable development. The importance of patenting of plant products, world food safety, and the role of several imminent organizations is also discussed. \u003c\/p\u003e\u003cp\u003eThe volume provides an holistic view that makes it a valuable source of information for researchers of agriculture and biotechnology as well as agricultural engineers, environmental biologists, environmental engineers, and environmentalists. Short exercises at the end of the chapters help to make the book suitable for course work in agriculture biotechnology, genetics, biology, biotechnology, and plant science.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eEnzymes. Immobilization Biocatalysis. Enzymes in Non-Conventional Media. Metabolic Engineering. Use of Enzymes in Industry. White Biotechnology. Agricultural Biotechnology. and History. Plant Breeding and Seed Technology. Plant Tissue Culture. Plant Nutrition and Phytohormones. Transgenic Plants. Global Food Safety.\u003c\/p\u003e","brand":"Apple Academic Press Inc.","offers":[{"title":"Default Title","offer_id":49411624272215,"sku":"9781771886895","price":117.8,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781771886895.jpg?v=1730514201"}],"url":"https:\/\/bookcurl.com\/collections\/genetic-engineering.oembed?page=3","provider":"Book Curl","version":"1.0","type":"link"}