{"title":"Biotechnology Books","description":"","products":[{"product_id":"microbial-biotechnology-9780198822813","title":"Microbial Biotechnology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eWritten primarily for students embarking on an undergraduate bioscience degree, this primer will introduce students to topics at the forefront of the subject that are being applied to probe biological problems, or to address the most pressing issues facing society. These topics will include those that form the cornerstone of contemporary research, helping students to make the transition to active researcher.Students will acquire a solid understanding of the essentials of microbial biotechnology, its applications in agriculture, diagnostics and urban and artistic conservation, as well as the potential threats genetic modification may pose to public health, the environment and intellectual property.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e1: The basic principles of a biotechnology process 2: Microbial growth 3: Microbial bio-production 4: Biotechnology and food and drink production 5: Environmental biotechnology 6: Application of synthetic biology to biotechnology 7: Diagnostics 8: Microbial biotechnology and agriculture 9: Using extremophiles in biotechnology 10: Microbial biotechnology in the art and built environment 11: Ethical considerations","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":48732797337943,"sku":"9780198822813","price":23.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780198822813.jpg?v=1719998440"},{"product_id":"recreating-nature-science-technology-and-human-values-in-the-twentyfirst-century-9780817320294","title":"ReCreating Nature Science Technology and Human","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eAddresses emerging biotechnologies with prodigious potential to benefit humankind but that are also fraught with ethical consequences. James Bradley guides discussions of the thorny issues resulting from the development of new biotechnologies. He also highlights the responsibilities of scientists to conduct research in an ethical manner.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTrade Review\u003c\/h2\u003e“Building further on his remarkable scholarly work, James Bradley once again observes and dissects modern science and modern life in ways that challenge any kind of reader: student, scholar, research scientist, and most especially political decision makers. His interdisciplinary approach to studying the implications of biotechnology is the most accessible and useful, yet profound, of any academic work in this vast field. With characteristic good humor and patience, he confronts the fundamental issues within not only life sciences but moral and political philosophy as well. This is a necessary, although uncomfortable, wake-up call for humankind generally.\" - Timothy P. Terrel, Emory University School of Law and author of \u003ci\u003eThe Dimensions of Legal Reasoning: Developing Analytical Acuity from Law School to Law Practice\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eAbbreviations and Acronyms\u003c\/li\u003e\n\u003cli\u003ePreface\u003c\/li\u003e\n\u003cli\u003eAcknowledgments\u003c\/li\u003e\n\u003cli\u003eChapter 1:   Cells, Molecules, Genes, and Nature\u003c\/li\u003e\n\u003cli\u003eChapter 2:   Embryos, Stem Cells, Genetic Enhancement, Genomics, and Synthetic Biology\u003c\/li\u003e\n\u003cli\u003eChapter 3:   Genetically Engineered Organisms\u003c\/li\u003e\n\u003cli\u003eChapter 4:   CRISPR and Life's Future\u003c\/li\u003e\n\u003cli\u003eChapter 5:   Nanotechnology, Life, and Nanoethics\u003c\/li\u003e\n\u003cli\u003eChapter 6:   Brains, Minds, and Neuroethics\u003c\/li\u003e\n\u003cli\u003eChapter 7:   Robots and Roboethics\u003c\/li\u003e\n\u003cli\u003eChapter 8:   Responsibilities and Living Well with Modern Biotechnologies\u003c\/li\u003e\n\u003cli\u003eChapter 9:   The Urgency of Now\u003c\/li\u003e\n\u003cli\u003eAppendix 1: The Central Dogma of Biology, CRISPR, and Gene Drive\u003c\/li\u003e\n\u003cli\u003eAppendix 2: Tools for Neuroscience and Clinical Neurology\u003c\/li\u003e\n\u003cli\u003eAppendix 3: Sources of Scientific Information for Non-Scientists\u003c\/li\u003e\n\u003cli\u003eReferences\u003c\/li\u003e\n\u003cli\u003eIndex\u003c\/li\u003e\n\u003cli\u003e\u003cul\u003e\u003c\/ul\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"The University of Alabama Press","offers":[{"title":"Default Title","offer_id":48737459011927,"sku":"9780817320294","price":30.56,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780817320294.jpg?v=1723811219"},{"product_id":"career-opportunities-in-biotechnology-and-drug-development-9780879698805","title":"Career Opportunities in Biotechnology and Drug","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Cold Spring Harbor Laboratory Press,U.S.","offers":[{"title":"Default Title","offer_id":48737797538135,"sku":"9780879698805","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780879698805.jpg?v=1723811471"},{"product_id":"practical-techniques-in-molecular-biotechnology-9781108486408","title":"Practical Techniques in Molecular Biotechnology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003ePractical Techniques in Molecular Biotechnology intends to familiarise students with the basics of the well-known experiments of molecular biotechnology and related courses like chemical biotechnology and cell biology. The content of the book will be useful in strengthening the basic skills and help students to apply the concepts to real-world problems. This book emphasises important concepts like bioanalytical techniques, biochemical analysis of proteins, recombinant DNA, and protein technology etc. The text will help students to understand the theoretical aspects of the techniques and provide experience with hands-on techniques to demonstrate practical troubleshooting and data analysis.  The text is supported with diagrams, data, summaries for the quick recap and appendices with useful protocols and calculation methods.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003ePreface; Acknowledgements; 1. Introduction; 2. Molecular Biology; 3. Recombinant DNA and Protein Technology; 4. Biochemical Analysis of Proteins; 5. Bioanalytical Techniques; 6. Cell Culture and Tissue Engineering; 7. Antibody Technology; Appendix A. Useful Protocols; Appendix B. Practical Applications; Appendix C. Significant Figures and Scientific Notations; Appendix D. Statistical Parameters Used in the Biochemical Measurements.","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":48738309734743,"sku":"9781108486408","price":52.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781108486408.jpg?v=1723811913"},{"product_id":"bioceramics-and-biocomposites-9781119049340","title":"Bioceramics and Biocomposites","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003e\u003cb\u003eProvides comprehensive coverage of the research into and clinical uses of bioceramics and biocomposites\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDevelopments related to bioceramics and biocomposites appear to be one the most dynamic areas in the field of biomaterials, with multiple applications in tissue engineering and medical devices. This book covers the basic science and engineering of bioceramics and biocomposites for applications in dentistry and orthopedics, as well as the state-of-the-art aspects of biofabrication techniques, tissue engineering, remodeling, and regeneration of bone tissue. It also provides insight into the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures.\u003c\/p\u003e \u003cp\u003eFeaturing contributions from leading experts in the field, \u003ci\u003eBioceramics and Biocomposites: From Research to Use in Clinical Practice\u003c\/i\u003e offers complete coverage of everything from extending the concept of hemopoietic and stromal niches, to the evolution of biocera\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003eChapter 1. Multi-functionalized ferri-liposomes for hyperthermia induced glioma targeting and brain drug delivery\u003cbr\u003e\u003ci\u003eDi Shi, Gujie Mi, and Thomas J Webste\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 2. Biofabrication techniques for ceramics and composite bone scaffolds\u003cbr\u003e\u003ci\u003eFengyuan Liu, Boyang Huang, Sri Hinduja, Paulo Jorge da Silva Bartolo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 3. Developments in hydrogel-based scaffolds and bioceramics for bone regeneration\u003cbr\u003e\u003ci\u003eIzabela-Cristina Stancu, Daniel Chappard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 4. Zirconia-based composites for biomedical applications\u003cbr\u003e\u003ci\u003ePaula Palmero\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 5. Bioceramics derived from marble and sea shells as potential bone substitution materials\u003cbr\u003e\u003ci\u003eMiculescu Florin, Mocanu Aura Cătălina, Stan GE, Maidaniuc Andreea, Miculescu Marian, Voicu Stefan Ioan, Antoniac Iulian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 6. Bioglasses and glass-ceramics in the Na2O-CaO-MgO-SiO2-P2O5-CaF2 system\u003cbr\u003e\u003ci\u003eS. Agathopoulos and D.U. Tulyaganov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 7. Electrical functionalization and fabrication of nanostructured hydroxyapatite coatings\u003cbr\u003e\u003ci\u003eVladimir Bystrov, Anna Bystrova, Yuri Dekhtyar, Igor Khlusov, Vladimir Pichugin, Konstantin Prosolov, Yurii Sharkeev\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 8. Bioactive microarc calcium phosphate coatings on nanostructured and ultrafine-grained bioinert metals and alloys\u003cbr\u003e\u003ci\u003eYurii Sharkeev, Ekaterina Komarova, Maria Sedelnikova, Igor Khlusov, Anna Eroshenko, Larisa Litvinova, Valeria Shupletsova\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 9. Engineering of bioceramics- based scaffold and its clinical applications in dentistry\u003cbr\u003e\u003ci\u003eIka Dewi Ana\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 10. Bioceramics in endodontics\u003cbr\u003e\u003ci\u003eAlexandru Andrei Iliescu, Paula Perlea, Gabriel Tulus, Mihaela Georgiana Iliescu, Irina Maria Gheorghiu, Horia Octavian Manolea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 11. Extending the concept of hemopoietic and stromal niches as an approach to regenerative medicine\u003cbr\u003e\u003ci\u003eIgor A. Khlusov and Marina Yu. Khlusova\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 12. Experimental and pilot clinical study of different tissue-engineered bone grafts based on calcium phosphate, mesenchymal stem cells and adipose-derived stromal vascular fraction\u003cbr\u003e\u003ci\u003eI.Y. Bozo, G.A. Volozhin, V.L. Zorin, R.V. Deev, S.I. Rozhkov, P.S. Eremin, E.N. Toropov, A.A. Pulin, B.I. Grachev, I.I. Eremin, V.S. Komlev\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 13. Bone substitutes in orthopedic and trauma surgery\u003cbr\u003e\u003ci\u003eLupescu Olivera, Antoniac Iulian\u003c\/i\u003e\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48738355937623,"sku":"9781119049340","price":143.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119049340.jpg?v=1723811968"},{"product_id":"engineering-and-technology-for-healthcare-9781119644248","title":"Engineering and Technology for Healthcare","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eInnovation in healthcare is currently a hot topic. Innovation allows us to think differently, to take risks and to develop ideas that are far better than existing solutions. Currently, there is no single book that covers all topics related to microelectronics, sensors, data, system integration and healthcare technology assessment in one reference. This book aims to critically evaluate current state-of-the-art technologies and provide readers with insights into developing new solutions. With contributions from a fully international team of experts across electrical engineering and biomedical fields, the book discusses how advances in sensing technology, computer science, communications systems and proteomics\/genomics are influencing healthcare technology today.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003eIntroduction xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Maximizing the Value of Engineering and Technology Research in Healthcare: Development-Focused Health Technology Assessment \u003c\/b\u003e\u003cb\u003e1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJanet Boutell Hawkins and Eleanor Grieve\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 What Is HTA? 3\u003c\/p\u003e \u003cp\u003e1.3 What Is Development-Focused HTA? 4\u003c\/p\u003e \u003cp\u003e1.4 Illustration of Features of Development-Focused HTA 5\u003c\/p\u003e \u003cp\u003e1.4.1 Use-Focused HTA 6\u003c\/p\u003e \u003cp\u003e1.4.2 Development-Focused HTA 6\u003c\/p\u003e \u003cp\u003e1.5 Activities of Development-Focused HTA 7\u003c\/p\u003e \u003cp\u003e1.6 Analytical Methods of Development-Focused HTA 9\u003c\/p\u003e \u003cp\u003e1.6.1 Clinical Value Assessment 11\u003c\/p\u003e \u003cp\u003e1.6.2 Economic Value Assessment 11\u003c\/p\u003e \u003cp\u003e1.6.3 Evidence Generation 14\u003c\/p\u003e \u003cp\u003e1.7 What Are the Challenges in the Development and Assessment of Medical Devices? 15\u003c\/p\u003e \u003cp\u003e1.7.1 What Are Medical Devices? 15\u003c\/p\u003e \u003cp\u003e1.7.2 Challenges Common to All medical Devices 16\u003c\/p\u003e \u003cp\u003e1.7.2.1 Licensing and Regulation 16\u003c\/p\u003e \u003cp\u003e1.7.2.2 Adoption 17\u003c\/p\u003e \u003cp\u003e1.7.2.3 Evidence 18\u003c\/p\u003e \u003cp\u003e1.7.3 Challenges Specific to Some Categories of Device 19\u003c\/p\u003e \u003cp\u003e1.7.3.1 Learning Curve 19\u003c\/p\u003e \u003cp\u003e1.7.3.2 Short Lifespan and Incremental Improvement 19\u003c\/p\u003e \u003cp\u003e1.7.3.3 Workflow 19\u003c\/p\u003e \u003cp\u003e1.7.3.4 Indirect Health Benefit 19\u003c\/p\u003e \u003cp\u003e1.7.3.5 Behavioral and Other Contextual Factors 20\u003c\/p\u003e \u003cp\u003e1.7.3.6 Budgetary Challenges 20\u003c\/p\u003e \u003cp\u003e1.8 The Contribution of DF-HTA in the Development and Translation of Medical Devices 20\u003c\/p\u003e \u003cp\u003e1.8.1 Case Study 1 - Identifying and Confirming Needs 21\u003c\/p\u003e \u003cp\u003e1.8.2 Case Study 2 - What Difference Could This Device Make? 21\u003c\/p\u003e \u003cp\u003e1.8.3 Case Study 3 - Which Research Project Has the Most Potential? 21\u003c\/p\u003e \u003cp\u003e1.8.4 Case Study 4 - What Is the Required Performance to Deliver Clinical Utility? 21\u003c\/p\u003e \u003cp\u003e1.8.5 Case Study 5 - What Are the Key Parameters for Evidence Generation? 22\u003c\/p\u003e \u003cp\u003e1.9 Conclusion 22\u003c\/p\u003e \u003cp\u003eReferences 23\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Contactless Radar Sensing for Health Monitoring \u003c\/b\u003e\u003cb\u003e29\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eFrancesco Fioranelli and Julien Le Kernec\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction: Healthcare Provision and Radar Technology 29\u003c\/p\u003e \u003cp\u003e2.2 Radar and Radar Data Fundamentals 32\u003c\/p\u003e \u003cp\u003e2.2.1 Principles of Radar Systems 32\u003c\/p\u003e \u003cp\u003e2.2.2 Principles of Radar Signal Processing for Health Applications 35\u003c\/p\u003e \u003cp\u003e2.2.3 Principles of Machine Learning Applied to Radar Data 38\u003c\/p\u003e \u003cp\u003e2.2.4 Complementary Approaches: Passive Radar and Channel State Information Sensing 41\u003c\/p\u003e \u003cp\u003e2.3 Radar Technology in Use for Health Care 42\u003c\/p\u003e \u003cp\u003e2.3.1 Activities Recognition and Fall Detection 42\u003c\/p\u003e \u003cp\u003e2.3.2 Gait Monitoring 46\u003c\/p\u003e \u003cp\u003e2.3.3 Vital Signs and Sleep Monitoring 48\u003c\/p\u003e \u003cp\u003e2.4 Conclusion and Outstanding Challenges 50\u003c\/p\u003e \u003cp\u003e2.5 Future Trends 52\u003c\/p\u003e \u003cp\u003e2.5.1 Paradigm Change in Radar Sensing 52\u003c\/p\u003e \u003cp\u003e2.5.2 Multimodal Sensing 55\u003c\/p\u003e \u003cp\u003eReferences 55\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Pervasive Sensing: Macro to Nanoscale \u003c\/b\u003e\u003cb\u003e61\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eQammer H. Abbasi, Hasan T. Abbas, Muhammad Ali Imran and Akram Alomainy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 61\u003c\/p\u003e \u003cp\u003e3.2 The Anatomy of a Human Skin 64\u003c\/p\u003e \u003cp\u003e3.3 Characterization of Human Tissue 65\u003c\/p\u003e \u003cp\u003e3.4 Tissue Sample Preparation 70\u003c\/p\u003e \u003cp\u003e3.5 Measurement Apparatus 70\u003c\/p\u003e \u003cp\u003e3.6 Simulating the Human Skin 72\u003c\/p\u003e \u003cp\u003e3.6.1 Human Body Channel Modelling 73\u003c\/p\u003e \u003cp\u003e3.7 Networking and Communication Mechanisms for Body-Centric Wireless Nano-Networks 76\u003c\/p\u003e \u003cp\u003e3.8 Concluding Remarks 78\u003c\/p\u003e \u003cp\u003eReferences 78\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Biointegrated Implantable Brain Devices \u003c\/b\u003e\u003cb\u003e81\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRupam Das and Hadi Heidari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Background 81\u003c\/p\u003e \u003cp\u003e4.2 Neural Device Interfaces 83\u003c\/p\u003e \u003cp\u003e4.3 Implant Tissue Biointegration 84\u003c\/p\u003e \u003cp\u003e4.4 MRI Compatibility of the Neural Devices 87\u003c\/p\u003e \u003cp\u003e4.5 Conclusion 90\u003c\/p\u003e \u003cp\u003eReferences 90\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Machine Learning for Decision Making in Healthcare \u003c\/b\u003e\u003cb\u003e95\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAli Rizwan, Metin Ozturk, Najah Abu Ali, Ahmed Zoha, Qammer H. Abbasi and M. Ali Imran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 95\u003c\/p\u003e \u003cp\u003e5.2 Data Description 98\u003c\/p\u003e \u003cp\u003e5.3 Proposed Methodology 99\u003c\/p\u003e \u003cp\u003e5.3.1 Collection of the Data 99\u003c\/p\u003e \u003cp\u003e5.3.2 Selection of the Window Size 100\u003c\/p\u003e \u003cp\u003e5.3.3 Extraction of the Features 101\u003c\/p\u003e \u003cp\u003e5.3.4 Selection of the Features 101\u003c\/p\u003e \u003cp\u003e5.3.5 Deployment of the Machine Learning Models 102\u003c\/p\u003e \u003cp\u003e5.3.6 Quantitative Assessment of the Models 103\u003c\/p\u003e \u003cp\u003e5.3.7 Parallel Processing 104\u003c\/p\u003e \u003cp\u003e5.4 Results 105\u003c\/p\u003e \u003cp\u003e5.5 Analysis and Discussion 108\u003c\/p\u003e \u003cp\u003e5.5.1 Postures 108\u003c\/p\u003e \u003cp\u003e5.5.2 Window Sizes 109\u003c\/p\u003e \u003cp\u003e5.5.3 Feature Combinations 109\u003c\/p\u003e \u003cp\u003e5.5.4 Machine Learning Algorithms 111\u003c\/p\u003e \u003cp\u003e5.6 Conclusions 113\u003c\/p\u003e \u003cp\u003eReferences 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Information Retrieval from Electronic Health Records \u003c\/b\u003e\u003cb\u003e117\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMeshal Al-Qahtani, Stamos Katsigiannis and Naeem Ramzan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 117\u003c\/p\u003e \u003cp\u003e6.2 Methodology 118\u003c\/p\u003e \u003cp\u003e6.2.1 Parallel LSI (PLSI) 119\u003c\/p\u003e \u003cp\u003e6.2.2 Distributed LSI (DLSI) 121\u003c\/p\u003e \u003cp\u003e6.3 Results and Analysis 122\u003c\/p\u003e \u003cp\u003e6.4 Conclusion 126\u003c\/p\u003e \u003cp\u003eReferences 126\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Energy Harvesting for Wearable and Portable Devices \u003c\/b\u003e\u003cb\u003e129\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRami Ghannam, You Hao, Yuchi Liu and Yidi Xiao\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 129\u003c\/p\u003e \u003cp\u003e7.2 Energy Harvesting Techniques 130\u003c\/p\u003e \u003cp\u003e7.2.1 Photovoltaics 130\u003c\/p\u003e \u003cp\u003e7.2.2 Piezoelectric Energy Harvesting 134\u003c\/p\u003e \u003cp\u003e7.2.3 Thermal Energy Harvesting 137\u003c\/p\u003e \u003cp\u003e7.2.3.1 Latest Trends 139\u003c\/p\u003e \u003cp\u003e7.2.4 RF Energy Harvesting 141\u003c\/p\u003e \u003cp\u003e7.3 Conclusions 145\u003c\/p\u003e \u003cp\u003eReferences 146\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Wireless Control for Life-Critical Actions \u003c\/b\u003e\u003cb\u003e153\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBurak Kizilkaya, Bo Chang, Guodong Zhao and Muhammad Ali Imran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 153\u003c\/p\u003e \u003cp\u003e8.2 Wireless Control for Healthcare 155\u003c\/p\u003e \u003cp\u003e8.3 Technical Requirements 156\u003c\/p\u003e \u003cp\u003e8.3.1 Ultra-Reliability 156\u003c\/p\u003e \u003cp\u003e8.3.2 Low Latency 156\u003c\/p\u003e \u003cp\u003e8.3.3 Security and Privacy 157\u003c\/p\u003e \u003cp\u003e8.3.4 Edge Artificial Intelligence 157\u003c\/p\u003e \u003cp\u003e8.4 Design Aspects 157\u003c\/p\u003e \u003cp\u003e8.4.1 Independent Design 158\u003c\/p\u003e \u003cp\u003e8.4.2 Co-Design 159\u003c\/p\u003e \u003cp\u003e8.5 Co-Design System Model 159\u003c\/p\u003e \u003cp\u003e8.5.1 Control Function 159\u003c\/p\u003e \u003cp\u003e8.5.2 Performance Evaluation Criterion 161\u003c\/p\u003e \u003cp\u003e8.5.2.1 Control Performance 161\u003c\/p\u003e \u003cp\u003e8.5.2.2 Communication Performance 161\u003c\/p\u003e \u003cp\u003e8.5.3 Effects of Different QoS 162\u003c\/p\u003e \u003cp\u003e8.5.4 Numerical Results 163\u003c\/p\u003e \u003cp\u003e8.6 Conclusions 165\u003c\/p\u003e \u003cp\u003eReferences 165\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Role of D2D Communications in Mobile Health Applications: Security Threats and Requirements \u003c\/b\u003e\u003cb\u003e169\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMuhammad Usman, Marwa Qaraqe, Muhammad Rizwan Asghar and Imran Shafique Ansari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 169\u003c\/p\u003e \u003cp\u003e9.2 D2D Scenarios for Mobile Health Applications 170\u003c\/p\u003e \u003cp\u003e9.3 D2D Security Requirements and Standardization 171\u003c\/p\u003e \u003cp\u003e9.3.1 Security Issues on Configuration 171\u003c\/p\u003e \u003cp\u003e9.3.1.1 Configuration of the ProSe Enabled UE 171\u003c\/p\u003e \u003cp\u003e9.3.2 Security Issues on Device Discovery 172\u003c\/p\u003e \u003cp\u003e9.3.2.1 Direct Request and Response Discovery 172\u003c\/p\u003e \u003cp\u003e9.3.2.2 Open Direct Discovery 173\u003c\/p\u003e \u003cp\u003e9.3.2.3 Restricted Direct Discovery 173\u003c\/p\u003e \u003cp\u003e9.3.2.4 Registration in Network-Based ProSe Discovery 173\u003c\/p\u003e \u003cp\u003e9.3.3 Security Issues on One-to-Many Communications 174\u003c\/p\u003e \u003cp\u003e9.3.3.1 One-to-many communications between UEs 174\u003c\/p\u003e \u003cp\u003e9.3.3.2 Key Distribution for Group Communications 174\u003c\/p\u003e \u003cp\u003e9.3.4 Security Issues on One-to-One Communication 175\u003c\/p\u003e \u003cp\u003e9.3.4.1 One-to-One ProSe Direct Communication 175\u003c\/p\u003e \u003cp\u003e9.3.4.2 One-to-One ProSe Direct Communication 175\u003c\/p\u003e \u003cp\u003e9.3.5 Security Issues on ProSe Relays 175\u003c\/p\u003e \u003cp\u003e9.3.5.1 Maintaining 3GPP Communication Security through Relay 175\u003c\/p\u003e \u003cp\u003e9.3.5.2 UE-Network Relay 176\u003c\/p\u003e \u003cp\u003e9.3.5.3 UE-to-UE Relay 176\u003c\/p\u003e \u003cp\u003e9.4 Existing Solutions 176\u003c\/p\u003e \u003cp\u003e9.4.1 Key Management 176\u003c\/p\u003e \u003cp\u003e9.4.2 Routing 178\u003c\/p\u003e \u003cp\u003e9.4.3 Social Trust and Social Ties 178\u003c\/p\u003e \u003cp\u003e9.4.4 Access Control 180\u003c\/p\u003e \u003cp\u003e9.4.5 Physical Layer Security 180\u003c\/p\u003e \u003cp\u003e9.4.6 Network Coding 183\u003c\/p\u003e \u003cp\u003e9.5 Conclusion 183\u003c\/p\u003e \u003cp\u003eReferences 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Automated Diagnosis of Skin Cancer for Healthcare: Highlights and Procedures \u003c\/b\u003e\u003cb\u003e187\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMaram A. Wahba and Amira S. Ashour\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 187\u003c\/p\u003e \u003cp\u003e10.2 Framework of Computer-Aided Skin Cancer Classification Systems 188\u003c\/p\u003e \u003cp\u003e10.2.1 Image Acquisition 188\u003c\/p\u003e \u003cp\u003e10.2.2 Image Pre-Processing 189\u003c\/p\u003e \u003cp\u003e10.2.2.1 Color Contrast Enhancement 189\u003c\/p\u003e \u003cp\u003e10.2.2.2 Artifact Removal 190\u003c\/p\u003e \u003cp\u003e10.2.3 Image Segmentation 191\u003c\/p\u003e \u003cp\u003e10.2.3.1 Thresholding-Based Segmentation 192\u003c\/p\u003e \u003cp\u003e10.2.3.2 Edge-Based Segmentation 192\u003c\/p\u003e \u003cp\u003e10.2.3.3 Region-Based Segmentation 193\u003c\/p\u003e \u003cp\u003e10.2.3.4 Active Contours-Based Segmentation 193\u003c\/p\u003e \u003cp\u003e10.2.3.5 Artificial Intelligence-Based Segmentation 194\u003c\/p\u003e \u003cp\u003e10.2.4 Feature Extraction 195\u003c\/p\u003e \u003cp\u003e10.2.4.1 Color-based Features 196\u003c\/p\u003e \u003cp\u003e10.2.4.2 Dimensional Features 196\u003c\/p\u003e \u003cp\u003e10.2.4.3 Texture-Based Features 196\u003c\/p\u003e \u003cp\u003e10.2.4.4 Dermoscopic Rules and Methods 197\u003c\/p\u003e \u003cp\u003e10.2.5 Feature Selection 200\u003c\/p\u003e \u003cp\u003e10.2.6 Classification 201\u003c\/p\u003e \u003cp\u003e10.2.7 Classification Performance Evaluation 202\u003c\/p\u003e \u003cp\u003e10.2.8 Computer-Aided Diagnosis Systems in Dermoscopic Images 203\u003c\/p\u003e \u003cp\u003e10.3 Conclusion 205\u003c\/p\u003e \u003cp\u003eAcknowledgment 205\u003c\/p\u003e \u003cp\u003eReferences 205\u003c\/p\u003e \u003cp\u003eConclusions 213\u003c\/p\u003e \u003cp\u003eIndex 215\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48738363310423,"sku":"9781119644248","price":89.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119644248.jpg?v=1723811976"},{"product_id":"pharmaceutical-biotechnology-9781461464853","title":"Pharmaceutical Biotechnology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eThis introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate\/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003e1: Molecular Biotechnology: From DNA Sequence to Therapeutic Protein.- 2: Biophysical and Biochemical Analysis of Recombinant Proteins.- 3: Production and Purification of Recombinant Proteins.- 4: Formulation of Biotech Products, Including Biopharmaceutical Considerations.- 5: Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics.- 6: Immunogenicity of Therapeutic Proteins.- 7: Monoclonal Antibodies: From Structure to Therapeutic Application.- 8: Genomics, Other “Omic” Technologies, Personalized Medicine, and Additional Biotechnology-Related Techniques.- 9: Dispensing Biotechnology Products: Handling, Professional Education, and Product Information.- 10: Economic Considerations in Medical Biotechnology.- 11: Regulatory Framework for Biosimilars.- 12: Insulin.- 13: Follicle-Stimulating Hormone.- 14: Human Growth Hormone.- 15: Recombinant Coagulation Factors and Thrombolytic Agents.- 16: Recombinant Human Deoxyribonuclease I.- 17: Monoclonal Antibodies in Cancer.- 18: Hematopoietic Growth Factors: Focus on Erythropoiesis-Stimulating Agents.- 19: Monoclonal Antibodies in Solid Organ Transplantation.- 20: Monoclonal Antibodies and Antibody-Based Biotherapeutics in Inflammatory Diseases.- 21: Interferons and Interleukins.- 22: Vaccines.-  23: Oligonucleotides.- 24: Gene Therapy.- 25: Stem Cell Technology\u003c\/p\u003e\u003cp\u003e\u003ci\u003e\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003ci\u003e\u003c\/i\u003e","brand":"Springer-Verlag New York Inc.","offers":[{"title":"Default Title","offer_id":48739349430615,"sku":"9781461464853","price":82.49,"currency_code":"GBP","in_stock":false}]},{"product_id":"inside-the-orphan-drug-revolution-the-promise-of-patient-centered-biotechnology-9781621824688","title":"Inside the Orphan Drug Revolution: The Promise of","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Cold Spring Harbor Laboratory Press,U.S.","offers":[{"title":"Default Title","offer_id":48740661789015,"sku":"9781621824688","price":20.9,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781621824688.jpg?v=1723812316"},{"product_id":"biotechnology-science-for-the-new-millennium-9781639890811","title":"Biotechnology: Science for the New Millennium","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"States Academic Press","offers":[{"title":"Default Title","offer_id":48740760813911,"sku":"9781639890811","price":100.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781639890811.jpg?v=1720055553"},{"product_id":"biocatalysis-in-organic-synthesis-the-retrosynthesis-approach-9781782625308","title":"Biocatalysis in Organic Synthesis: The","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eThe application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years.  This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. 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Thus, unlike traditional inkjet printing, the printed film chemistry differs to that of the initial ink droplets. The appeal of reactive inkjet printing as a chemical synthesis tool is linked to its ability to produce droplets whose size is both controllable and predictable, which means that the individual droplets can be thought of as building blocks where droplets can be added to the substrate in a high precision format to give good control and predictability over the chemical reaction.   The book starts by introducing the concept of using reactive inkjet printing as a building block for making materials. Aspects such as the behaviour of printed droplets on substrate and their mixing is discussed in the first chapters. The following chapters then discuss different applications of the technique in areas including additive manufacturing and silk production, production of materials used in solar cells, printed electronics, dentistry and tissue engineering.   Edited by two leading experts, Reactive Inkjet Printing: A Chemical Synthesis Tool provides a comprehensive overview of this technique and its use in fabricating functional materials for health and energy applications. 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This popular textbook has been revised and updated to provide an overview of this exciting area of bioscience and to reflect a number of the key developments driving this expansion. Chapters on the basic methods of key technologies such as nucleic acid analysis and bioinformatics are presented, in addition to genomics and proteomics, which highlight the impact of molecular biology and biotechnology. New chapters on important and emerging methods have been introduced such as gene editing, next generation sequencing, nanobiotechnology and molecular modelling.    The first six chapters deal with the core technology used in current molecular biology and biotechnology. These primarily deal with basic molecular biology methods such as PCR, cloning genes and genomes, protein analysis techniques and recombinant protein production. Later chapters address major advances in the applications of specialist areas of molecular biotechnology. 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The aim is to provide a comprehensive overview of robotics technology applied to Healthcare, and discuss the anticipation of upcoming challenges.\u003c\/p\u003e\u003cp\u003eThe intersection of Robotics and Medicine includes socially and economically relevant areas, such as rehabilitation, therapy, and healthcare. Innovative usages of current robotics technologies are being somewhat stranded by concerns related to social dynamics. The examples covered in this volume show some of the potential societal benefits robotics can bring and how the robots are being integrated in social environments.\u003c\/p\u003e\u003cp\u003eDespite the aforementioned concerns, a fantastic range of possibilities is being opened. The current trend in social robotics adds to technology challenges and requires R\u0026amp;D to think about Robotics as an horizontal discipline, intersecting social and exact sciences. For example, robots that can act as if they have credible personalities (not necessarily similar to humans) living in social scenarios, eventually helping people. Also, robots can move inside the human body to retrieve information that otherwise is difficult to obtain. The decision autonomy of these robots raises a broad range of subjects though the immediate advantages of its use are evident.\u003c\/p\u003e\u003cp\u003eThe book presents examples of robotics technologies tested in healthcare environments or realistically close to being deployed in the field and discusses the challenges involved. Chapter 1 provides a comprehensive overview of Healthcare robotics and points to realistically expectable developments in the near future. Chapter 2 describes the challenges deploying a social robot in the Pediatrics ward of an Oncological hospital for simple edutainment activities. Chapter 3 focuses on Human-Robot Interaction techniques and their role in social robotics. Chapter 4 focus on R\u0026amp;D efforts behind an endoscopic capsule robot. Chapter 5 addresses experiments in rehabilitation with orthotics and walker robots. These examples have deep social and economic relations with the Healthcare field, and, at the same time, are representative of the R\u0026amp;D efforts the robotics community is developing.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003e\u003cb\u003eForeword\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAcknowledgements\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e--- Chapter 1 ---\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCan a Robot Bring Your Life Back?  A  Systematic Review for Robotics in Rehabilitation\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eEsyin Chew, David A. Turner\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e--- Chapter 2 ---\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSmart and Assistive Walker – ASBGo . \u003c\/b\u003e\u003cb\u003eRehabilitation robotics: a smart–walker to assist ataxic patients\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eRui Moreira, Joana Alves, Ana Matias, Cristina Santos\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e--- Chapter 3 ---\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMechanical sensing for lower limb soft exoskeletons: recent progress and challenges\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMassimo Totaro, Christian Di Natali, Irene Bernardeschi, Jesus Ortiz,  Lucia Beccai\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e --- Chapter 4 ---\u003c\/p\u003e\u003cp\u003e\u003cb\u003eA Proposed Clinical Evaluation of a Simulation Environment for Magnetically-Driven Active Endoscopic Capsules\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eYasmeen Abu-Kheil, Omar Al Trad, Lakmal Seneviratne, Jorge Dias\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e--- Chapter 5 ---\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSocial Robots as a complementary therapy in chronic, progressive diseases\u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eAna Nunes Barata\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e--- Chapter 6 ---\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDeveloping a Social Robot – A Case Study\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eJoão Silva Sequeira\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eIndex\u003c\/p\u003e\u003col\u003e\u003cli\u003e\n\u003col\u003e\u003c\/ol\u003e \u003c\/li\u003e\u003c\/ol\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743027736919,"sku":"9783030242299","price":116.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030242299.jpg?v=1791480464"},{"product_id":"near-infrared-emitting-nanoparticles-for-biomedical-applications-9783030320355","title":"Near Infrared-Emitting Nanoparticles for","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003e​This book analyzes and evaluates the growing field of light-emitting nanoprobes as contrast agents for \u003ci\u003ein vivo \u003c\/i\u003eimaging and sensing. It is a comprehensive resource that critically analyzes the state of the art in an interdisciplinary manner, with a special focus on the shift of emission wavelengths into the near-infrared (NIR) spectral region (ranging from 0.7 to 2 microns), which has greatly contributed to the latest advances in biomedical imaging and sensing. This book discusses merits of different contrast agents at nanoscale, and how their unique chemical and structural properties lead to the emission and interaction of light within the NIR window. Both the NIR-emitting materials and various surface modification strategies governing their interactions with the biological system at the “nano” level are discussed. Furthermore, different experimental techniques and protocols for NIR-light-based in vivo imaging and sensing are addressed to shed light on further understanding of the advantages and limitations of each category of these nanoprobes. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eAssembles the state of the art heretofore appearing in scientific literature into a comprehensive, multi-perspective guidebook on near infrared-emitting nanomaterials in an assortment of biomedical applications;\u003c\/li\u003e\n\u003cli\u003eExplains the physical, chemical, and biological phenomena underlying near infrared-emitting nanomaterials for biomedical applications;\u003c\/li\u003e\n\u003cli\u003ePresents conceptual and experimental approaches surrounding a unique spectral range of light emission from nanosized contrast agents, while offering a clear explanation of basic and general phenomena regarding the interaction between light and biological tissues, such as absorption, scattering and autofluorescence.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eChapter 1. Optical Properties of Tissues in the Near Infrared: Their Relevance for Optical Bioimaging.- Chapter 2. NIR autofluorescence: molecular origins and emerging clinical applications.- Chapter 3. Surface Modification of Near-Infrared-Emitting Nanoparticles for Biomedical Applications.- Chapter 4. Rare earth doped nanoparticles for advanced in vivo near infrared imaging.- Chapter 5. Recent advances in development of NIR-II fluorescent agents.- Chapter 6. Highlights on NIR Carbon Nanotubes applied to biomedical imaging sensing.- Chapter 7. NIR-Infrared Emitting Carbon Nanomaterials for Biomedical Applications.- Chapter 8. NIR-persistent luminescent nanoparticles for bio-imaging, principle and perspectives.- Chapter 9. NIR-emitting bioprobes for low-autofluorescence imaging techniques.- Chapter 10. Polymer-functionalized NIR-emitting nanoparticles: Applications in cancer theranostics and treatment of bacterial infections.- Chapter 11. Near-Infrared Ag2S Quantum Dots: Synthesis, functionalization and in vivo stem cell tracking applications.- Chapter 12. Non-plasmonic NIR activated photothermal agents.- Chapter 13. NIR-based probes and techniques for brain imaging.\u003cp\u003e\u003c\/p\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743033110871,"sku":"9783030320355","price":123.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030320355.jpg?v=1791480472"},{"product_id":"essential-current-concepts-in-stem-cell-biology-9783030339227","title":"Essential Current Concepts in Stem Cell Biology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material.\u003c\/p\u003e\u003cp\u003eBased on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge.\u003c\/p\u003e\u003cp\u003eThis textbook is a valuable complement to \u003ci\u003eConcepts and Applications of Stem Cell Biology, \u003c\/i\u003ealso published in the Learning Materials in Biosciences textbook series.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTrade Review\u003c\/h2\u003e“The books ... ‘compactly and concisely discuss a specific bio-topic based on lectures for upper-level undergraduates, master’s and graduate students’: this means that both beginners and well-trained students can benefit from reading this and other books in the same collection. ... All chapters are decorated by clear and well-designed color illustrations. I am pretty sure the book will meet the reader’s expectations.” (Manuela Monti, European Journal of Histochemistry, Vol. 64, 2020)\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e1. Hematopoietic stem cells\u003cp\u003e2. Mesenchymal stem cells \u003c\/p\u003e  \u003cp\u003e3. Cord blood stem cells  \u003c\/p\u003e  \u003cp\u003e4. Induced pluripotent stem cells \u003c\/p\u003e  \u003cp\u003e5. Epigenetic regulation in somatic cell reprogramming \u003c\/p\u003e  \u003cp\u003e6. MET in reprogramming \u003c\/p\u003e  \u003cp\u003e7. Extracellular vesicles      \u003c\/p\u003e  \u003cp\u003e8. Neural stem cells   \u003c\/p\u003e  \u003cp\u003e9. Neural stem cell niche\u003c\/p\u003e  \u003cp\u003e10. Human pluripotent stem cells and neural regeneration                                                                 \u003c\/p\u003e  \u003cp\u003e11. Organoids \u003c\/p\u003e  \u003cp\u003e12. Ethical aspects of human stem cell research                       \u003c\/p\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743033504087,"sku":"9783030339227","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030339227.jpg?v=1791480474"},{"product_id":"introduction-to-antibody-engineering-9783030546298","title":"Introduction to Antibody Engineering","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed.\u003c\/p\u003e\u003cp\u003eThe book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field.\u003c\/p\u003e\u003cp\u003e The book addresses Master- and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cbr\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743040123223,"sku":"9783030546298","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030546298.jpg?v=1791480498"},{"product_id":"a-practical-guide-to-protein-engineering-9783030568979","title":"A Practical Guide to Protein Engineering","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis textbook introduces readers in an accessible and engaging way to the nuts and bolts of protein expression and engineering. Various case studies illustrate each step from the early sequence searches in online databases over plasmid design and molecular cloning techniques to protein purification and characterization. Furthermore, readers are provided with practical tips to successfully pursue a career as a protein engineer. With protein engineering being a fundamental technique in almost all molecular biology labs, the book targets advanced undergraduates and graduate students working in molecular biology, biotechnology and related scientific fields.\u003c\/p\u003e  \u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003ePart I: Chapter 1: A brief history of protein engineeringChapter 2: From DNA to functional protein – A refresherChapter 3: Basic laboratory and computational techniques\u003cbr\u003ePart II:Chapter 4: Protein engineering strategiesChapter 5: Computational tools for protein engineeringChapter 6: Gene isolationChapter 7: Rational design Chapter 8: Directed evolutionChapter 9: Protein modification\u003cbr\u003ePart III:Chapter 10: Career prospect of a protein engineerChapter 11: Conversations with protein engineers\u003cbr\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743040713047,"sku":"9783030568979","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030568979.jpg?v=1791480501"},{"product_id":"rice-improvement-physiological-molecular-breeding-and-genetic-perspectives-9783030665326","title":"Rice Improvement: Physiological, Molecular","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eThis book is open access under a CC BY 4.0 license.\u003cbr\u003eBy 2050, human population is expected to reach 9.7 billion. The demand for increased food production needs to be met from ever reducing resources of land, water and other environmental constraints. Rice remains the staple food source for a majority of the global populations, but especially in Asia where ninety percent of rice is grown and consumed. Climate change continues to impose abiotic and biotic stresses that curtail rice quality and yields. Researchers have been challenged to provide innovative solutions to maintain, or even increase, rice production. Amongst them, the ‘green super rice’ breeding strategy has been successful for leading the development and release of multiple abiotic and biotic stress tolerant rice varieties. Recent advances in plant molecular biology and biotechnologies have led to the identification of stress responsive genes and signaling pathways, which open up new paradigms to augment rice productivity. Accordingly, transcription factors, protein kinases and enzymes for generating protective metabolites and proteins all contribute to an intricate network of events that guard and maintain cellular integrity. In addition, various quantitative trait loci associated with elevated stress tolerance have been cloned, resulting in the detection of novel genes for biotic and abiotic stress resistance. Mechanistic understanding of the genetic basis of traits, such as N and P use, is allowing rice researchers to engineer nutrient-efficient rice varieties, which would result in higher yields with lower inputs. Likewise, the research in micronutrients biosynthesis opens doors to genetic engineering of metabolic pathways to enhance micronutrients production. With third generation sequencing techniques on the horizon, exciting progress can be expected to vastly improve molecular markers for gene-trait associations forecast with increasing accuracy. \u003cbr\u003eThis book emphasizes on the areas of rice science that attempt to overcome the foremost limitations in rice production. 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There are two sections covered in this book – Ionic Liquid Related Techniques \u0026amp; Evergreen Biotechnology Techniques. A brief introduction supports each protocol to allow easy learning and implementation. The first section consists of three chapters covering studies in modern biotechnology focusing on the role of ionic liquid techniques in extracting secondary metabolites, enzyme stabilization and biomass processing. The second section covers evergreen methodologies. It comprises five chapters covering topics on microcarrier technology for cell culture; Polymerase Chain Reaction for non-halal sources detection in food; ELISA for biomarker identification; gamma ray-induced mutagenesis for enhancing microbial fuel cells; and the effect of temperature on antibacterial activity of Carica papaya seed extract. 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Elgharbawy, Md Zahangir Alam, Sharifah Shahira Syed Putra and Muhammad Moniruzzaman\u003cbr\u003eChapter 4Proliferation of rat amniotic stem cell (AFSC) on modified surface microcarrier.Nurhusna Samsudin, Yumi Zuhanis Has-Yun Hashim, Hamzah Mohd Salleh, and Azmir Ariffin.\u003cbr\u003eChapter 5Application of spectroscopic methods for the analysis of non-halal meats in food products: A narrative reviewAbdul Rohman, Nurrulhidayah Ahmad Fadzillah\u003cbr\u003eChapter 6Identification of Potential Biomarkers of Porcine GelatinNur Azira Tukiran, Amin Ismail, Haizatul Hadirah Ghazali \u0026amp; Nurul Azarima Mohd Ali\u003cbr\u003eChapter 7Gamma Ray Mutagenesis on Bacteria Isolated from Shrimp Farm Mud for Microbial Fuel Cell Enhancement and Degradation of Organic WasteAyoub Ahmed Ali, and Azura Amid, Azhar Muhammad\u003cbr\u003eChapter 8Effect of temperature on antibacterial activity and fatty acid methyl esters of Carica papaya seed extractMuhamad Shirwan Abdullah Sani, Jamilah Bakar, Russly Abdul Rahman and Faridah Abas\u003cbr\u003eChapter 9Solid-state Fermentation of Agro-industrial Waste Using Heterofermentative Lacti Acid Bacteria. 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Everyday forms of governance in Uzbekistan: the illegal, the immoral and the illegitimate (Abel Polese, Rustamjon Urinboyev, Mans Svensson, Laura Adams, Tanel Kerikmäe). - Part IV. Competing. - Chapter 9. Mixed Perceptions of State Responsibility among Informal Sector Participants (Anil Duman). - Chapter 10. State Collusion or Erosion During a Sovereign Debt Crisis: Market Dynamics Spawn Informal Practices in Lebanon (Joseph Helou). - Chapter 11. Perceived Pull and Push Factors of Healthcare Professionals Intention for Mobility: The Case Of Romania (Elena Druică and Rodica Ianole – Călin). - Chapter 12. E-nformality: Smartphones as a New Regulatory Space for Informal Exchange of Formal Resources (Aksana Ismailbekova and Gulzat Baialieva). - Chapter 13. Work, Subsistence and Distress of the Homeless in Moldova (Petru Negură)","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743052247383,"sku":"9783030825010","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030825010.jpg?v=1720063900"},{"product_id":"fundamentals-of-rna-structure-and-function-9783030902131","title":"Fundamentals of RNA Structure and Function","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis highly illustrated textbook provides an essential overview on RNA architecture and function, it offers insights into the RNA basics and also explains novel RNA technologies, such as CRISPR-Cas and their applications. In addition, the mRNA based vaccine technology, which has long been tested, also before the COVID-19 pandemic, is discussed and students receive a basic understanding of this important medical application.\u003c\/p\u003e\u003cp\u003eThe textbook is written by Prof. Grover in collaboration with her students and has an easily accessible style.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003eThe book provides a great tool for young researchers and students in biology, biomedical engineering or biochemistry, looking for a compact introduction or refresher work on RNA, including the newest findings and technologies. It is an ideal starter to learn about several RNA specific topics and to research them further.\u003cb\u003e\u003c\/b\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003e1. RNA-Composition and Base Pairing.- 2. Architecture of RNA.- 3. Small Catalytic RNA.- 4. 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Transcription.\u003c\/p\u003e\u003cbr\u003e  \u003cp\u003e\u003c\/p\u003e            \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003c\/p\u003e    \u003cp\u003e\u003c\/p\u003e                \u003cp\u003e\u003c\/p\u003e","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743056998743,"sku":"9783030902131","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030902131.jpg?v=1791480558"},{"product_id":"gender-and-migration-imiscoe-short-reader-9783030919702","title":"Gender and Migration: IMISCOE Short Reader","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eThis open access short reader offers a critical review of the debates on the transformation of migration and gendered mobilities primarily in Europe, though also engaging in wider theoretical insights. Building on empirical case studies and grounded in an analytical framework that incorporates both men and women, masculinities, sexualities and wider intersectional insights, this reader provides an accessible overview of conceptual developments and methodological shifts and their implications for a gendered understanding of migration in the past 30 years. It explores different and emerging approaches  in major areas, such as: gendered labour markets across diverse sectors beyond  domestic and care work to include skilled sectors of social reproduction; the significance of families in migration and transnational families; displacement, asylum and refugees and the incorporation of gender and sexuality in asylum determination; academic critiques and gendered discourses concerning integration often with the focus on Muslim women. The reader concludes with considerations of the potential impact of three notable developments on gendered migrations and mobilities: Black Lives Matter, Brexit and COVID-19. As such, it is a valuable resource for students, academics, policy makers, and practitioners.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eChapter 1: Gender and Migration: an Introduction.- Chapter 2: Gendered Migrations and Conceptual Approaches: Theorising and Researching Mobilities.- Chapter 3: Gendered Labour.- Chapter 4: Transnational Families, Intimate Relations, Generations.- Chapter 5: Gendering Asylum.- Chapter 6: Engendering Integration and Inclusion.- Chapter 7: Conclusion.","brand":"Springer Nature Switzerland AG","offers":[{"title":"Default Title","offer_id":48743058243927,"sku":"9783030919702","price":17.09,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783030919702.jpg?v=1720063927"},{"product_id":"novel-innovation-design-for-the-future-of-health-entrepreneurial-concepts-for-patient-empowerment-and-health-democratization-9783031081903","title":"Novel Innovation Design for the Future of Health:","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis book highlights the reasons for an urgently needed revision of the current global healthcare setup, discusses the needed mindset for a future of health, and provides a comprehensive development toolset for disruption (and for the needed incremental innovations towards disruption).\u003c\/p\u003e\u003cp\u003eToday’s biomedical and health innovation related research in universities encourages activities that lead to incremental innovations with a relatively low risk of failure. The healthcare industry on the other hand provides tools and devices for established healthcare providers to improve the diagnosis and therapy\/ treatment of the patients’ health problems. The patient is not in the center of healthcare provision however, and prevention and prediction are not core goals. The current health setup needs to be challenged and disrupted.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eDisruptions are coming from technologies or processes that lead to a significant (\u0026gt;10x) reduction in cost or price\/ performance and that also come with new business models. The need for change, effects of exponential technologies, and the needed shift to prevention and to homecare for health democratization and patient empowerment will be discussed in detail in the first parts of the book. The subsequent sections address several innovation methods with a focus on a novel meta methodology named Purpose Launchpad Health. This is followed by a comprehensive discussion on health entrepreneurship activities and needs. The final section of the book addresses how to train students to become entrepreneurial health innovators, presenting successful curricula and examples of health incubation and accelerator setups. All of the innovation tools presented and used in this book are summarized in the final chapter to help the reader get started planning an entrepreneurial venture.\u003c\/p\u003e\u003cp\u003eWritten by experts from academia and industry, the book covers important basics and best practices, as well as recent developments. Chapters are concise and enriched with key messages, learning objectives and real innovation examples to bridge theory and practice. This book aims to serve as a teaching base for health innovation design and to prepare for health-related entrepreneurial ventures.\u003c\/p\u003e\u003cp\u003eReaders with medical, biomedical, biotechnology, and health economics backgrounds - and anyone who wants to become a future oriented health innovator or who believes in disruptive approaches - will find this book a useful resource and teaching tool for developing validated products\/ services and processes for the future of health.\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003e\u003cb\u003ePart I. What Is Wrong with Health? What Should the Future of Health Be?.- \u003c\/b\u003eINNOVATION DESIGN for the FUTURE of HEALTH.- Health Innovations from an Innovators’ Perspective.- From SICKCARE to HEALTHCARE to HEALTH.- Future Look on Health: Opportunities.- Navigating Towards a Future of “One Health”.- \u003cb\u003ePart II. Exponential Medicine + Technologies + Mindset.- \u003c\/b\u003eExponential Technologies for an Exponential Medicine.- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study.- Healthy Longevity.- The Science of Health Longevity.- Space Healthtech: Innovation Base for Longevity.- \u003cb\u003ePart III. Future Health Value Propositions.- \u003c\/b\u003eHealthcare the Melting Pot of Technology, Humanity, and Confusion.- Democratize Health Delivery.- Health Innovation Process: Definitions and Short Methodology Introductions.- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health.- Digital Health Business Models: Transformation Is on the Horizon.- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable.- (Digital) Patient Journey and Empowerment: Digital Twin.- \u003cb\u003ePart IV. Innovation Methodology Basics.- \u003c\/b\u003eStanford Biodesign as Base: \u003ci\u003eEmpathy and Patient Centricity as the Main Driver\u003c\/i\u003e.- Purpose Launchpad Methodology: Introduction.- Design Thinking for Innovations in Healthcare.- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling.- Innovation Methodology I\u003csup\u003e3\u003c\/sup\u003e EME: Awareness for Biomedical Engineers.- \u003cb\u003ePart V. Ethics + Health Innovation.- \u003c\/b\u003eIntegrating Ethical Considerations into Innovation Design.- \u003cb\u003ePart VI. Health Innovation Design.- \u003c\/b\u003eCase Studies Used Throughout the Book: Innovation Categories Explained.- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities?.- Purpose Launchpad Health (PLH) Methodology Introduction.- \u003cb\u003ePart VII. Purpose Launchpad Health.- \u003c\/b\u003ePurpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies.- \u003cb\u003ePart VIII. Health Leadership, Skills and other Methodologies.- \u003c\/b\u003eSoft Skills Needed for Problem Understanding and Innovation Generation.- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches.- Future Skills Framework in Healthcare.- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry.- \u003cb\u003ePart IX. Health Entrepreneurship.- \u003c\/b\u003eGlobal Health Markets and Their Different Needs.- Patient: Health Relation and Digital Health Entrepreneurship.- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs.- Regulatory Issues for Health Innovations.- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare.- A Primer on Patents and IP for Health Innovations.- Successfully Implementing Ambidexterity in the Medical Industry.- Reverse Innovation: Circumvent Digital Health Transformation Issues.- \u003cb\u003ePart X. Health Innovation Education and Incubation.- \u003c\/b\u003eHealth Innovation Design: “CAMPing” for the Unmet Clinical Need.- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University.- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University.- Clinical Innovation at Acibadem Biodesign Center.- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program.- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology.- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator.- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe.- Leadership-Compass: “Networking and Synapting Empowered by Health Captains”.- \u003cb\u003ePart XI. Purpose Launchpad Health: Toolset Templates and Principles.- \u003c\/b\u003ePLH Templates and Principles.\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e","brand":"Springer International Publishing AG","offers":[{"title":"Default Title","offer_id":48743068172631,"sku":"9783031081903","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783031081903.jpg?v=1720063971"},{"product_id":"nanotechnological-approaches-to-the-advancement-of-innovations-in-aquaculture-9783031155185","title":"Nanotechnological Approaches to the Advancement","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eThe main practical breakthrough of this century is nanobiotechnology, an amalgamation of biology and nanotechnology based on the standards and methods of metabolism. The field mainly involves the analysis, synthesis and the links between molecular biology, nutritional science and nanotechnology. In addition, the field involves the links between other life sciences branches, since the improvement of nanotechnology strategies might be directed by considering the structure and the capability of nanoparticles present in the living cells. \u003cbr\u003eThis book is a comprehensive evaluation of the latest nanobiotechnological developments, with an emphasis on applications, especially in aquaculture. It outlines, in-depth, modern techniques, and includes a variety of important sources that make this the perfect resource for researchers in this captivating world of nanobiotechnology.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003ci\u003e​​Preface\u003c\/i\u003e\u003cbr\u003e\u003cb\u003eChapter 1: Simple Basics of Aquaculture Nanosciences Research: A Thorough Introduction\u003c\/b\u003eDr. Iddaya Karunasagar Senior Fish Safety and Quality Specialist, Fisheries and Aquaculture Department, Food \u0026amp; Agriculture Organisation of UN\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 2: Current Nanotechnology Developments in the Aquaculture Industry\u003c\/b\u003eAhmed A. Tayel, Faculty of Aquatic and Fisheries Sciences Kafrelsheikh University Kafr El Sheikh Egypt\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 3: Aquatic Nanodrug Delivery\u003c\/b\u003eWindell, D, University of Exeter, United Kingdom\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 4: Nanosensors Used in Aquaculture\u003c\/b\u003eJixiang Fang, Xi’an Jiaotong University, China\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 5: Alarming Viral Pathogens in Shrimp Industry and Nanotechnology\u003c\/b\u003eJeyachandran Sivakamavalli, Fisheries Science Institute, Chonnam National University, Yeosu 59626, South Korea\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 6: Bioenrichment of Planktons in Aquaculture through Nanotechnological Approaches\u003c\/b\u003eSivakamavalli, Fisheries Science Institute, Chonnam National University, Yeosu 59626, South KoreaKiyun Parka, Ihn-Sil Kwaka, Faculty of Marine Technology, Chonnam National University, Chonnam 550-749, Republic of Korea\u003cbr\u003e\u003cb\u003eChapter 7: Water Purification and Bioremediation Nanotechnologies\u003c\/b\u003eN. H. Rao, National Academy of Agricultural Research Management, Hyderabad, India\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 8: The Challenge of Nanotechnology-Derived Food\u003c\/b\u003eHarjinder Singh, Riddet Institute, Massey University, New Zealand\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 9: Nanoengineered Particles in Seafood: Their Concentration Level and their Kinetics\u003c\/b\u003eYing-Chou Lee, National Taiwan University, Taiwan\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 10: Harvested Fish Management and Commercialization Packaging\u003c\/b\u003eJH Han, The University of Manitoba, Canada\u003cbr\u003e\u003cbr\u003e\u003cb\u003eChapter 11: Nanotechnologies in Aquaculture Health Issues\u003c\/b\u003eMatheus D.Baldissera, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil\u003cbr\u003e\u003cbr\u003e\u003ci\u003eBibliography\u003c\/i\u003e\u003ci\u003eIndex\u003c\/i\u003e","brand":"Springer International Publishing AG","offers":[{"title":"Default Title","offer_id":48743071514967,"sku":"9783031155185","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783031155185.jpg?v=1723812629"},{"product_id":"nuclear-medicine-technology-review-questions-for-the-board-examinations-9783031267192","title":"Nuclear Medicine Technology: Review Questions for","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis textbook now published in its 6th edition prepares students and technologists for registry examinations in nuclear medicine technology by providing practice questions and answers with detailed explanations, as well as a mock registry exam. The questions are designed to test the basic knowledge required of nuclear medicine technologists, as well as the practical application of that knowledge.  The topics covered closely follow the content specifications and the components of preparedness as published by the certification boards. This new edition now includes new tracers for diagnostic imaging and therapeutic applications as well as other newly approved procedures. Coverage of positron emission tomography and hybrid multimodality imaging in the field of nuclear medicine and molecular imaging has also been expanded. \u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e1 Introduction2 Radioactivity, Radiopharmacy, and Quality Assurance3 Radiation Safety4 Instrumentation and Quality Assurance5 Image Presentation and Computers6 Skeletal System Scintigraphy7 Central Nervous System Scintigraphy8 Cardiovascular System Scintigraphy9 Respiratory System Scintigraphy 10 Gastrointestinal Tract Scintigraphy11 Genitourinary System Scintigraphy12 Oncologic Scintigraphy13 Infection Scintigraphy14 Thyroid, Parathyroid, and Salivary Gland Scintigraphy 15 Non-imaging Procedures and Radionuclide Therapy16 Patient Care17 Positron Emission Tomography18 Multimodality Imaging\u003cbr\u003e","brand":"Springer International Publishing AG","offers":[{"title":"Default Title","offer_id":48743077740887,"sku":"9783031267192","price":71.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783031267192.jpg?v=1791480657"},{"product_id":"introduction-to-insect-biotechnology-9783031267758","title":"Introduction to Insect Biotechnology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis textbook introduces to the fundamentals and applications of insect biotechnology in a concise manner. Global economically important insects such as silkworm, lac or honey bee are in the focus of this text. The book attempts to address all of the latest developments in this growing field such as application of metagenomics and proteomics in mining for genes and enzymes that could be beneficial in diverse industrial and biomedical applications. Further, insects have been established as suitable tool for the production of transgenic products which is discussed in one dedicated chapter. \u003c\/p\u003e  The book targets students and researchers in molecular biology, biotechnology or entomology who want to get familiar with the emerging field of insect biotechnology.\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Springer International Publishing AG","offers":[{"title":"Default Title","offer_id":48743077937495,"sku":"9783031267758","price":52.24,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783031267758.jpg?v=1720064014"},{"product_id":"metallomics-the-science-of-biometals-9783319901428","title":"Metallomics: The Science of Biometals","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others.\u003cbr\u003e \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThis volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eChapter1: Metallomics:  The Science of Biometals and Biometalloids.- Chapter2: Metallomics Applied to the Study of Neurodegenerative and Mental Diseases.- Chapter3: Environmental Metallomics.- Chapter4: Metallomics study in plants exposed to arsenic, mercury, selenium and sulphur.- Chapter5: Metallomics in Fish.- Chapter6: The use of Stable Isotopic Tracers in Metallomics Studies.- Chapter7: Bioimaging Metallomics.- Chapter8: Chemical speciation and Metallomics.- Chapter9: Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics.- Chapter10: New frontiers of metallomics: elemental and species specific analysis and imaging of single-cells. ","brand":"Springer International Publishing AG","offers":[{"title":"Default Title","offer_id":48743108641111,"sku":"9783319901428","price":104.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783319901428.jpg?v=1791481753"},{"product_id":"synthetic-biology-parts-devices-and-applications-9783527330751","title":"Synthetic Biology: Parts, Devices and","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003e\u003cb\u003eA review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWritten by an international panel of experts, \u003ci\u003eSynthetic Biology\u003c\/i\u003e draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy.\u003c\/p\u003e \u003cp\u003eFilled with the most recent research, compelling discussions, and unique perspectives, \u003ci\u003eSynthetic Biology\u003c\/i\u003e offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003eAbout the Series Editors xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I DNA Synthesis and Genome Engineering 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Competition and the Future of Reading and Writing DNA 3\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRobert Carlson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Productivity Improvements in Biological Technologies 3\u003c\/p\u003e \u003cp\u003e1.2 The Origin of Moore’s Law and Its Implications for Biological Technologies 5\u003c\/p\u003e \u003cp\u003e1.3 Lessons from Other Technologies 6\u003c\/p\u003e \u003cp\u003e1.4 Pricing Improvements in Biological Technologies 7\u003c\/p\u003e \u003cp\u003e1.5 Prospects for New Assembly Technologies 8\u003c\/p\u003e \u003cp\u003e1.6 Beyond Programming Genetic Instruction Sets 10\u003c\/p\u003e \u003cp\u003e1.7 Future Prospects 10\u003c\/p\u003e \u003cp\u003eReferences 11\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Trackable Multiplex Recombineering (TRMR) and Next-Generation Genome Design Technologies:\u003c\/b\u003e \u003cb\u003eModifying Gene Expression in E. coli by Inserting Synthetic DNA Cassettes and Molecular Barcodes 15\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEmily F. Freed, Gur Pines, Carrie A. Eckert, and Ryan T. Gill\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 15\u003c\/p\u003e \u003cp\u003e2.2 Current Recombineering Techniques 16\u003c\/p\u003e \u003cp\u003e2.2.1 Recombineering Systems 17\u003c\/p\u003e \u003cp\u003e2.2.2 Current Model of Recombination 17\u003c\/p\u003e \u003cp\u003e2.3 Trackable Multiplex Recombineering 19\u003c\/p\u003e \u003cp\u003e2.3.1 TRMR and T2RMR Library Design and Construction 19\u003c\/p\u003e \u003cp\u003e2.3.2 Experimental Procedure 23\u003c\/p\u003e \u003cp\u003e2.3.3 Analysis of Results 24\u003c\/p\u003e \u003cp\u003e2.4 Current Challenges 25\u003c\/p\u003e \u003cp\u003e2.4.1 TRMR and T2RMR are Currently Not Recursive 26\u003c\/p\u003e \u003cp\u003e2.4.2 Need for More Predictable Models 26\u003c\/p\u003e \u003cp\u003e2.5 Complementing Technologies 27\u003c\/p\u003e \u003cp\u003e2.5.1 MAGE 27\u003c\/p\u003e \u003cp\u003e2.5.2 CREATE 27\u003c\/p\u003e \u003cp\u003e2.6 Conclusions 28\u003c\/p\u003e \u003cp\u003eDefinitions 28\u003c\/p\u003e \u003cp\u003eReferences 29\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Site-Directed Genome Modification with Engineered Zinc Finger Proteins 33\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLauren E. Woodard, Daniel L. Galvan, and Matthew H. Wilson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction to Zinc Finger DNA-Binding Domains and Cellular Repair Mechanisms 33\u003c\/p\u003e \u003cp\u003e3.1.1 Zinc Finger Proteins 33\u003c\/p\u003e \u003cp\u003e3.1.2 Homologous Recombination 34\u003c\/p\u003e \u003cp\u003e3.1.3 Non-homologous End Joining 35\u003c\/p\u003e \u003cp\u003e3.2 Approaches for Engineering or Acquiring Zinc Finger Proteins 36\u003c\/p\u003e \u003cp\u003e3.2.1 Modular Assembly 37\u003c\/p\u003e \u003cp\u003e3.2.2 OPEN and CoDA Selection Systems 37\u003c\/p\u003e \u003cp\u003e3.2.3 Purchase via Commercial Avenues 38\u003c\/p\u003e \u003cp\u003e3.3 Genome Modification with Zinc Finger Nucleases 38\u003c\/p\u003e \u003cp\u003e3.4 Validating Zinc Finger Nuclease-Induced Genome Alteration and Specificity 40\u003c\/p\u003e \u003cp\u003e3.5 Methods for Delivering Engineered Zinc Finger Nucleases into Cells 41\u003c\/p\u003e \u003cp\u003e3.6 Zinc Finger Fusions to Transposases and Recombinases 41\u003c\/p\u003e \u003cp\u003e3.7 Conclusions 42\u003c\/p\u003e \u003cp\u003eReferences 43\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Rational Efforts to Streamline the Escherichia coli Genome 49\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eGabriella Balikó, Viktor Vernyik, Ildikó Karcagi, Zsuzsanna Györfy, Gábor Draskovits, Tamás Fehér, and\u003c\/i\u003e \u003ci\u003eGyörgy Pósfai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 49\u003c\/p\u003e \u003cp\u003e4.2 The Concept of a Streamlined Chassis 50\u003c\/p\u003e \u003cp\u003e4.3 The E. coli Genome 51\u003c\/p\u003e \u003cp\u003e4.4 Random versus Targeted Streamlining 54\u003c\/p\u003e \u003cp\u003e4.5 Selecting Deletion Targets 55\u003c\/p\u003e \u003cp\u003e4.5.1 General Considerations 55\u003c\/p\u003e \u003cp\u003e4.5.1.1 Naturally Evolved Minimal Genomes 55\u003c\/p\u003e \u003cp\u003e4.5.1.2 Gene Essentiality Studies 55\u003c\/p\u003e \u003cp\u003e4.5.1.3 Comparative Genomics 56\u003c\/p\u003e \u003cp\u003e4.5.1.4 In silico Models 56\u003c\/p\u003e \u003cp\u003e4.5.1.5 Architectural Studies 56\u003c\/p\u003e \u003cp\u003e4.5.2 Primary Deletion Targets 57\u003c\/p\u003e \u003cp\u003e4.5.2.1 Prophages 57\u003c\/p\u003e \u003cp\u003e4.5.2.2 Insertion Sequences (ISs) 57\u003c\/p\u003e \u003cp\u003e4.5.2.3 Defense Systems 57\u003c\/p\u003e \u003cp\u003e4.5.2.4 Genes of Unknown and Exotic Functions 58\u003c\/p\u003e \u003cp\u003e4.5.2.5 Repeat Sequences 58\u003c\/p\u003e \u003cp\u003e4.5.2.6 Virulence Factors and Surface Structures 58\u003c\/p\u003e \u003cp\u003e4.5.2.7 Genetic Diversity-Generating Factors 59\u003c\/p\u003e \u003cp\u003e4.5.2.8 Redundant and Overlapping Functions 59\u003c\/p\u003e \u003cp\u003e4.6 Targeted Deletion Techniques 59\u003c\/p\u003e \u003cp\u003e4.6.1 General Considerations 59\u003c\/p\u003e \u003cp\u003e4.6.2 Basic Methods and Strategies 60\u003c\/p\u003e \u003cp\u003e4.6.2.1 Circular DNA-Based Method 60\u003c\/p\u003e \u003cp\u003e4.6.2.2 Linear DNA-Based Method 62\u003c\/p\u003e \u003cp\u003e4.6.2.3 Strategy for Piling Deletions 62\u003c\/p\u003e \u003cp\u003e4.6.2.4 New Variations on Deletion Construction 63\u003c\/p\u003e \u003cp\u003e4.7 Genome-Reducing Efforts and the Impact of Streamlining 64\u003c\/p\u003e \u003cp\u003e4.7.1 Comparative Genomics-Based Genome Stabilization and Improvement 64\u003c\/p\u003e \u003cp\u003e4.7.2 Genome Reduction Based on Gene Essentiality 66\u003c\/p\u003e \u003cp\u003e4.7.3 Complex Streamlining Efforts Based on Growth Properties 67\u003c\/p\u003e \u003cp\u003e4.7.4 Additional Genome Reduction Studies 68\u003c\/p\u003e \u003cp\u003e4.8 Selected Research Applications of Streamlined-Genome E. coli 68\u003c\/p\u003e \u003cp\u003e4.8.1 Testing Genome Streamlining Hypotheses 68\u003c\/p\u003e \u003cp\u003e4.8.2 Mobile Genetic Elements, Mutations, and Evolution 69\u003c\/p\u003e \u003cp\u003e4.8.3 Gene Function and Network Regulation 69\u003c\/p\u003e \u003cp\u003e4.8.4 Codon Reassignment 70\u003c\/p\u003e \u003cp\u003e4.8.5 Genome Architecture 70\u003c\/p\u003e \u003cp\u003e4.9 Concluding Remarks, Challenges, and Future Directions 71\u003c\/p\u003e \u003cp\u003eReferences 73\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Functional Requirements in the Program and the Cell Chassis for Next-Generation Synthetic Biology 81\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAntoine Danchin, Agnieszka Sekowska, and Stanislas Noria\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 A Prerequisite to Synthetic Biology: An Engineering Definition of What Life Is 81\u003c\/p\u003e \u003cp\u003e5.2 Functional Analysis: Master Function and Helper Functions 83\u003c\/p\u003e \u003cp\u003e5.3 A Life-Specific Master Function: Building Up a Progeny 85\u003c\/p\u003e \u003cp\u003e5.4 Helper Functions 86\u003c\/p\u003e \u003cp\u003e5.4.1 Matter: Building Blocks and Structures (with Emphasis on DNA) 87\u003c\/p\u003e \u003cp\u003e5.4.2 Energy 91\u003c\/p\u003e \u003cp\u003e5.4.3 Managing Space 92\u003c\/p\u003e \u003cp\u003e5.4.4 Time 95\u003c\/p\u003e \u003cp\u003e5.4.5 Information 96\u003c\/p\u003e \u003cp\u003e5.5 Conclusion 97\u003c\/p\u003e \u003cp\u003eAcknowledgments 98\u003c\/p\u003e \u003cp\u003eReferences 98\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Parts and Devices Supporting Control of Protein Expression and Activity 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Constitutive and Regulated Promoters in Yeast: How to Design and Make Use of Promoters in S.\u003c\/b\u003e \u003cb\u003ecerevisiae 109\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDiana S. M. Ottoz and Fabian Rudolf\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 109\u003c\/p\u003e \u003cp\u003e6.2 Yeast Promoters 110\u003c\/p\u003e \u003cp\u003e6.3 Natural Yeast Promoters 113\u003c\/p\u003e \u003cp\u003e6.3.1 Regulated Promoters 113\u003c\/p\u003e \u003cp\u003e6.3.2 Constitutive Promoters 115\u003c\/p\u003e \u003cp\u003e6.4 Synthetic Yeast Promoters 116\u003c\/p\u003e \u003cp\u003e6.4.1 Modified Natural Promoters 116\u003c\/p\u003e \u003cp\u003e6.4.2 Synthetic Hybrid Promoters 117\u003c\/p\u003e \u003cp\u003e6.5 Conclusions 121\u003c\/p\u003e \u003cp\u003eDefinitions 122\u003c\/p\u003e \u003cp\u003eReferences 122\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Splicing and Alternative Splicing Impact on Gene Design 131\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBeatrix Suess, Katrin Kemmerer, and Julia E. Weigand\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 The Discovery of “Split Genes” 131\u003c\/p\u003e \u003cp\u003e7.2 Nuclear Pre-mRNA Splicing in Mammals 132\u003c\/p\u003e \u003cp\u003e7.2.1 Introns and Exons: A Definition 132\u003c\/p\u003e \u003cp\u003e7.2.2 The Catalytic Mechanism of Splicing 132\u003c\/p\u003e \u003cp\u003e7.2.3 A Complex Machinery to Remove Nuclear Introns: The Spliceosome 132\u003c\/p\u003e \u003cp\u003e7.2.4 Exon Definition 134\u003c\/p\u003e \u003cp\u003e7.3 Splicing in Yeast 135\u003c\/p\u003e \u003cp\u003e7.3.1 Organization and Distribution of Yeast Introns 135\u003c\/p\u003e \u003cp\u003e7.4 Splicing without the Spliceosome 136\u003c\/p\u003e \u003cp\u003e7.4.1 Group I and Group II Self-Splicing Introns 136\u003c\/p\u003e \u003cp\u003e7.4.2 tRNA Splicing 137\u003c\/p\u003e \u003cp\u003e7.5 Alternative Splicing in Mammals 137\u003c\/p\u003e \u003cp\u003e7.5.1 Different Mechanisms of Alternative Splicing 137\u003c\/p\u003e \u003cp\u003e7.5.2 Auxiliary Regulatory Elements 139\u003c\/p\u003e \u003cp\u003e7.5.3 Mechanisms of Splicing Regulation 140\u003c\/p\u003e \u003cp\u003e7.5.4 Transcription-Coupled Alternative Splicing 142\u003c\/p\u003e \u003cp\u003e7.5.5 Alternative Splicing and Nonsense-Mediated Decay 143\u003c\/p\u003e \u003cp\u003e7.5.6 Alternative Splicing and Disease 144\u003c\/p\u003e \u003cp\u003e7.6 Controlled Splicing in S. cerevisiae 145\u003c\/p\u003e \u003cp\u003e7.6.1 Alternative Splicing 145\u003c\/p\u003e \u003cp\u003e7.6.2 Regulated Splicing 146\u003c\/p\u003e \u003cp\u003e7.6.3 Function of Splicing in S. cerevisiae 147\u003c\/p\u003e \u003cp\u003e7.7 Splicing Regulation by Riboswitches 147\u003c\/p\u003e \u003cp\u003e7.7.1 Regulation of Group I Intron Splicing in Bacteria 148\u003c\/p\u003e \u003cp\u003e7.7.2 Regulation of Alternative Splicing by Riboswitches in Eukaryotes 148\u003c\/p\u003e \u003cp\u003e7.8 Splicing and Synthetic Biology 150\u003c\/p\u003e \u003cp\u003e7.8.1 Impact of Introns on Gene Expression 150\u003c\/p\u003e \u003cp\u003e7.8.2 Control of Splicing by Engineered RNA-Based Devices 151\u003c\/p\u003e \u003cp\u003e7.9 Conclusion 153\u003c\/p\u003e \u003cp\u003eAcknowledgments 153\u003c\/p\u003e \u003cp\u003eDefinitions 153\u003c\/p\u003e \u003cp\u003eReferences 153\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Design of Ligand-Controlled Genetic Switches Based on RNA Interference 169\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShunnichi Kashida and Hirohide Saito\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Utility of the RNAi Pathway for Application in Mammalian Cells 169\u003c\/p\u003e \u003cp\u003e8.2 Development of RNAi Switches that Respond to Trigger Molecules 170\u003c\/p\u003e \u003cp\u003e8.2.1 Small Molecule-Triggered RNAi Switches 171\u003c\/p\u003e \u003cp\u003e8.2.2 Oligonucleotide-Triggered RNAi Switches 173\u003c\/p\u003e \u003cp\u003e8.2.3 Protein-Triggered RNAi Switches 174\u003c\/p\u003e \u003cp\u003e8.3 Rational Design of Functional RNAi Switches 174\u003c\/p\u003e \u003cp\u003e8.4 Application of the RNAi Switches 175\u003c\/p\u003e \u003cp\u003e8.5 Future Perspectives 177\u003c\/p\u003e \u003cp\u003eDefinitions 178\u003c\/p\u003e \u003cp\u003eReferences 178\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Small Molecule-Responsive RNA Switches (Bacteria): Important Element of Programming Gene Expression in Response to Environmental Signals in Bacteria 181\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eYohei Yokobayashi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 181\u003c\/p\u003e \u003cp\u003e9.2 Design Strategies 181\u003c\/p\u003e \u003cp\u003e9.2.1 Aptamers 181\u003c\/p\u003e \u003cp\u003e9.2.2 Screening and Genetic Selection 182\u003c\/p\u003e \u003cp\u003e9.2.3 Rational Design 183\u003c\/p\u003e \u003cp\u003e9.3 Mechanisms 183\u003c\/p\u003e \u003cp\u003e9.3.1 Translational Regulation 183\u003c\/p\u003e \u003cp\u003e9.3.2 Transcriptional Regulation 184\u003c\/p\u003e \u003cp\u003e9.4 Complex Riboswitches 185\u003c\/p\u003e \u003cp\u003e9.5 Conclusions 185\u003c\/p\u003e \u003cp\u003eKeywords with Definitions 185\u003c\/p\u003e \u003cp\u003eReferences 186\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Programming Gene Expression by Engineering Transcript Stability Control and Processing in Bacteria\u003c\/b\u003e \u003cb\u003e189\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJason T. Stevens and James M. Carothers\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 An Introduction to Transcript Control 189\u003c\/p\u003e \u003cp\u003e10.1.1 Why Consider Transcript Control? 189\u003c\/p\u003e \u003cp\u003e10.1.2 The RNA Degradation Process in E. coli 190\u003c\/p\u003e \u003cp\u003e10.1.3 The Effects of Translation on Transcript Stability 192\u003c\/p\u003e \u003cp\u003e10.1.4 Structural and Noncoding RNA-Mediated Transcript Control 193\u003c\/p\u003e \u003cp\u003e10.1.5 Polyadenylation and Transcript Stability 195\u003c\/p\u003e \u003cp\u003e10.2 Synthetic Control of Transcript Stability 195\u003c\/p\u003e \u003cp\u003e10.2.1 Transcript Stability Control as a “Tuning Knob” 195\u003c\/p\u003e \u003cp\u003e10.2.2 Secondary Structure at the 5′ and 3′ Ends 196\u003c\/p\u003e \u003cp\u003e10.2.3 Noncoding RNA-Mediated 197\u003c\/p\u003e \u003cp\u003e10.2.4 Model-Driven Transcript Stability Control for Metabolic Pathway Engineering 198\u003c\/p\u003e \u003cp\u003e10.3 Managing Transcript Stability 201\u003c\/p\u003e \u003cp\u003e10.3.1 Transcript Stability as a Confounding Factor 201\u003c\/p\u003e \u003cp\u003e10.3.2 Anticipating Transcript Stability Issues 201\u003c\/p\u003e \u003cp\u003e10.3.3 Uniformity of 5′ and 3′ Ends 202\u003c\/p\u003e \u003cp\u003e10.3.4 RBS Sequestration by Riboregulators and Riboswitches 203\u003c\/p\u003e \u003cp\u003e10.3.5 Experimentally Probing Transcript Stability 204\u003c\/p\u003e \u003cp\u003e10.4 Potential Mechanisms for Transcript Control 205\u003c\/p\u003e \u003cp\u003e10.4.1 Leveraging New Tools 205\u003c\/p\u003e \u003cp\u003e10.4.2 Unused Mechanisms Found in Nature 206\u003c\/p\u003e \u003cp\u003e10.5 Conclusions and Discussion 207\u003c\/p\u003e \u003cp\u003eAcknowledgments 208\u003c\/p\u003e \u003cp\u003eDefinitions 208\u003c\/p\u003e \u003cp\u003eReferences 209\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Small Functional Peptides and Their Application in Superfunctionalizing Proteins 217\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSonja Billerbeck\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 217\u003c\/p\u003e \u003cp\u003e11.2 Permissive Sites and Their Identification in a Protein 218\u003c\/p\u003e \u003cp\u003e11.3 Functional Peptides 220\u003c\/p\u003e \u003cp\u003e11.3.1 Functional Peptides that Act as Binders 220\u003c\/p\u003e \u003cp\u003e11.3.2 Peptide Motifs that are Recognized by Labeling Enzymes 221\u003c\/p\u003e \u003cp\u003e11.3.3 Peptides as Protease Cleavage Sites 222\u003c\/p\u003e \u003cp\u003e11.3.4 Reactive Peptides 223\u003c\/p\u003e \u003cp\u003e11.3.5 Pharmaceutically Relevant Peptides: Peptide Epitopes, Sugar Epitope Mimics, and Antimicrobial Peptides 223\u003c\/p\u003e \u003cp\u003e11.3.5.1 Peptide Epitopes 224\u003c\/p\u003e \u003cp\u003e11.3.5.2 Peptide Mimotopes 224\u003c\/p\u003e \u003cp\u003e11.3.5.3 Antimicrobial Peptides 225\u003c\/p\u003e \u003cp\u003e11.4 Conclusions 227\u003c\/p\u003e \u003cp\u003eDefinitions 228\u003c\/p\u003e \u003cp\u003eAbbreviations 228\u003c\/p\u003e \u003cp\u003eAcknowledgment 229\u003c\/p\u003e \u003cp\u003eReferences 229\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Parts and Devices Supporting Spatial Engineering 237\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Metabolic Channeling Using DNA as a Scaffold 239\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMojca Benèina, Jerneja Mori, Rok Gaber, and Roman Jerala\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 239\u003c\/p\u003e \u003cp\u003e12.2 Biosynthetic Applications of DNA Scaffold 242\u003c\/p\u003e \u003cp\u003e12.2.1 l-Threonine 242\u003c\/p\u003e \u003cp\u003e12.2.2 trans-Resveratrol 245\u003c\/p\u003e \u003cp\u003e12.2.3 1,2-Propanediol 246\u003c\/p\u003e \u003cp\u003e12.2.4 Mevalonate 246\u003c\/p\u003e \u003cp\u003e12.3 Design of DNA-Binding Proteins and Target Sites 247\u003c\/p\u003e \u003cp\u003e12.3.1 Zinc Finger Domains 248\u003c\/p\u003e \u003cp\u003e12.3.2 TAL-DNA Binding Domains 249\u003c\/p\u003e \u003cp\u003e12.3.3 Other DNA-Binding Proteins 250\u003c\/p\u003e \u003cp\u003e12.4 DNA Program 250\u003c\/p\u003e \u003cp\u003e12.4.1 Spacers between DNA-Target Sites 250\u003c\/p\u003e \u003cp\u003e12.4.2 Number of DNA Scaffold Repeats 252\u003c\/p\u003e \u003cp\u003e12.4.3 DNA-Target Site Arrangement 253\u003c\/p\u003e \u003cp\u003e12.5 Applications of DNA-Guided Programming 254\u003c\/p\u003e \u003cp\u003eDefinitions 255\u003c\/p\u003e \u003cp\u003eReferences 256\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Synthetic RNA Scaffolds for Spatial Engineering in Cells 261\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eGairik Sachdeva, Cameron Myhrvold, Peng Yin, and Pamela A. Silver\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 261\u003c\/p\u003e \u003cp\u003e13.2 Structural Roles of Natural RNA 261\u003c\/p\u003e \u003cp\u003e13.2.1 RNA as a Natural Catalyst 262\u003c\/p\u003e \u003cp\u003e13.2.2 RNA Scaffolds in Nature 263\u003c\/p\u003e \u003cp\u003e13.3 Design Principles for RNA Are Well Understood 263\u003c\/p\u003e \u003cp\u003e13.3.1 RNA Secondary Structure is Predictable 264\u003c\/p\u003e \u003cp\u003e13.3.2 RNA can Self-Assemble into Structures 265\u003c\/p\u003e \u003cp\u003e13.3.3 Dynamic RNAs can be Rationally Designed 265\u003c\/p\u003e \u003cp\u003e13.3.4 RNA can be Selected in vitro to Enhance Its Function 266\u003c\/p\u003e \u003cp\u003e13.4 Applications of Designed RNA Scaffolds 266\u003c\/p\u003e \u003cp\u003e13.4.1 Tools for RNA Research 266\u003c\/p\u003e \u003cp\u003e13.4.2 Localizing Metabolic Enzymes on RNA 267\u003c\/p\u003e \u003cp\u003e13.4.3 Packaging Therapeutics on RNA Scaffolds 269\u003c\/p\u003e \u003cp\u003e13.4.4 Recombinant RNA Technology 269\u003c\/p\u003e \u003cp\u003e13.5 Conclusion 270\u003c\/p\u003e \u003cp\u003e13.5.1 New Applications 270\u003c\/p\u003e \u003cp\u003e13.5.2 Technological Advances 270\u003c\/p\u003e \u003cp\u003eDefinitions 271\u003c\/p\u003e \u003cp\u003eReferences 271\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Sequestered: Design and Construction of Synthetic Organelles 279\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eThawatchai Chaijarasphong and David F. Savage\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 279\u003c\/p\u003e \u003cp\u003e14.2 On Organelles 281\u003c\/p\u003e \u003cp\u003e14.3 Protein-Based Organelles 283\u003c\/p\u003e \u003cp\u003e14.3.1 Bacterial Microcompartments 283\u003c\/p\u003e \u003cp\u003e14.3.1.1 Targeting 285\u003c\/p\u003e \u003cp\u003e14.3.1.2 Permeability 287\u003c\/p\u003e \u003cp\u003e14.3.1.3 Chemical Environment 288\u003c\/p\u003e \u003cp\u003e14.3.1.4 Biogenesis 289\u003c\/p\u003e \u003cp\u003e14.3.2 Alternative Protein Organelles: A Minimal System 290\u003c\/p\u003e \u003cp\u003e14.4 Lipid-Based Organelles 292\u003c\/p\u003e \u003cp\u003e14.4.1 Repurposing Existing Organelles 293\u003c\/p\u003e \u003cp\u003e14.4.1.1 The Mitochondrion 293\u003c\/p\u003e \u003cp\u003e14.4.1.2 The Vacuole 294\u003c\/p\u003e \u003cp\u003e14.5 De novo Organelle Construction and Future Directions 295\u003c\/p\u003e \u003cp\u003eAcknowledgments 297\u003c\/p\u003e \u003cp\u003eReferences 297\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Early Applications of Synthetic Biology: Pathways, Therapies, and Cell-Free Synthesis 307\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Cell-Free Protein Synthesis: An Emerging Technology for Understanding, Harnessing, and Expanding the Capabilities of Biological Systems 309\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJennifer A. Schoborg and Michael C. Jewett\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 309\u003c\/p\u003e \u003cp\u003e15.2 Background\/Current Status 311\u003c\/p\u003e \u003cp\u003e15.2.1 Platforms 311\u003c\/p\u003e \u003cp\u003e15.2.1.1 Prokaryotic Platforms 311\u003c\/p\u003e \u003cp\u003e15.2.1.2 Eukaryotic Platforms 312\u003c\/p\u003e \u003cp\u003e15.2.2 Trends 314\u003c\/p\u003e \u003cp\u003e15.3 Products 316\u003c\/p\u003e \u003cp\u003e15.3.1 Noncanonical Amino Acids 316\u003c\/p\u003e \u003cp\u003e15.3.2 Glycosylation 316\u003c\/p\u003e \u003cp\u003e15.3.3 Antibodies 318\u003c\/p\u003e \u003cp\u003e15.3.4 Membrane Proteins 318\u003c\/p\u003e \u003cp\u003e15.4 High-Throughput Applications 320\u003c\/p\u003e \u003cp\u003e15.4.1 Protein Production and Screening 320\u003c\/p\u003e \u003cp\u003e15.4.2 Genetic Circuit Optimization 321\u003c\/p\u003e \u003cp\u003e15.5 Future of the Field 321\u003c\/p\u003e \u003cp\u003eDefinitions 322\u003c\/p\u003e \u003cp\u003eAcknowledgments 322\u003c\/p\u003e \u003cp\u003eReferences 323\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Applying Advanced DNA Assembly Methods to Generate Pathway Libraries 331\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDawn T. Eriksen, Ran Chao, and Huimin Zhao\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 331\u003c\/p\u003e \u003cp\u003e16.2 Advanced DNA Assembly Methods 333\u003c\/p\u003e \u003cp\u003e16.3 Generation of Pathway Libraries 334\u003c\/p\u003e \u003cp\u003e16.3.1 In vitro Assembly Methods 335\u003c\/p\u003e \u003cp\u003e16.3.2 In vivo Assembly Methods 339\u003c\/p\u003e \u003cp\u003e16.3.2.1 In vivo Chromosomal Integration 339\u003c\/p\u003e \u003cp\u003e16.3.2.2 In vivo Plasmid Assembly and One-Step Optimization Libraries 340\u003c\/p\u003e \u003cp\u003e16.3.2.3 In vivo Plasmid Assembly and Iterative Multi-step Optimization Libraries 341\u003c\/p\u003e \u003cp\u003e16.4 Conclusions and Prospects 343\u003c\/p\u003e \u003cp\u003eDefinitions 343\u003c\/p\u003e \u003cp\u003eReferences 344\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering 349\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePatrick Ho and Yvonne Y. Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 The Need for a New Therapeutic Paradigm 349\u003c\/p\u003e \u003cp\u003e17.2 Rationale for Cellular Therapies 350\u003c\/p\u003e \u003cp\u003e17.3 Synthetic Biology Approaches to Cellular Immunotherapy Engineering 351\u003c\/p\u003e \u003cp\u003e17.3.1 CAR Engineering for Adoptive T-Cell Therapy 352\u003c\/p\u003e \u003cp\u003e17.3.2 Genetic Engineering to Enhance T-Cell Therapeutic Function 357\u003c\/p\u003e \u003cp\u003e17.3.3 Generating Safer T-Cell Therapeutics with Synthetic Biology 359\u003c\/p\u003e \u003cp\u003e17.4 Challenges and Future Outlook 362\u003c\/p\u003e \u003cp\u003eAcknowledgment 364\u003c\/p\u003e \u003cp\u003eDefinitions 364\u003c\/p\u003e \u003cp\u003eReferences 365\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Societal Ramifications of Synthetic Biology 373\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Synthetic Biology: From Genetic Engineering 2.0 to Responsible Research and Innovation 375\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLei Pei and Markus Schmidt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 375\u003c\/p\u003e \u003cp\u003e18.2 Public Perception of the Nascent Field of Synthetic Biology 376\u003c\/p\u003e \u003cp\u003e18.2.1 Perception of Synthetic Biology in the United States 377\u003c\/p\u003e \u003cp\u003e18.2.2 Perception of Synthetic Biology in Europe 379\u003c\/p\u003e \u003cp\u003e18.2.2.1 European Union 379\u003c\/p\u003e \u003cp\u003e18.2.2.2 Austria 379\u003c\/p\u003e \u003cp\u003e18.2.2.3 Germany 381\u003c\/p\u003e \u003cp\u003e18.2.2.4 Netherlands 382\u003c\/p\u003e \u003cp\u003e18.2.2.5 United Kingdom 383\u003c\/p\u003e \u003cp\u003e18.2.3 Opinions from Concerned Civil Society Groups 384\u003c\/p\u003e \u003cp\u003e18.3 Frames and Comparators 384\u003c\/p\u003e \u003cp\u003e18.3.1 Genetic Engineering: Technology as Conflict 386\u003c\/p\u003e \u003cp\u003e18.3.2 Nanotechnology: Technology as Progress 387\u003c\/p\u003e \u003cp\u003e18.3.3 Information Technology: Technology as Gadget 387\u003c\/p\u003e \u003cp\u003e18.3.4 SB: Which Debate to Come? 388\u003c\/p\u003e \u003cp\u003e18.4 Toward Responsible Research and Innovation (RRI) in Synthetic Biology 389\u003c\/p\u003e \u003cp\u003e18.4.1 Engagement of All Societal Actors – Researchers, Industry, Policy Makers, and Civil Society – and Their Joint Participation in the Research and Innovation 390\u003c\/p\u003e \u003cp\u003e18.4.2 Gender Equality 391\u003c\/p\u003e \u003cp\u003e18.4.3 Science Education 392\u003c\/p\u003e \u003cp\u003e18.4.4 Open Access 392\u003c\/p\u003e \u003cp\u003e18.4.5 Ethics 394\u003c\/p\u003e \u003cp\u003e18.4.6 Governance 395\u003c\/p\u003e \u003cp\u003e18.5 Conclusion 396\u003c\/p\u003e \u003cp\u003eAcknowledgments 397\u003c\/p\u003e \u003cp\u003eReferences 397\u003c\/p\u003e \u003cp\u003eIndex 403\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":48743117291863,"sku":"9783527330751","price":112.16,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527330751.jpg?v=1791481932"},{"product_id":"fundamental-bioengineering-9783527336746","title":"Fundamental Bioengineering","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eA thorough introduction to the basics of bioengineering, with a focus on applications in the emerging \"white\" biotechnology industry. \u003cbr\u003eAs such, this latest volume in the \"Advanced Biotechnology\" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given.\u003cbr\u003eWith contributions from leading experts in industry and academia, this is a comprehensive source of information peer-reviewed by experts in the field.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003eAbout the Series Editors xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction and Overview 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart One Fundamentals of Bioengineering 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Experimentally Determined Rates of Bio-Reactions 5\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 5\u003c\/p\u003e \u003cp\u003e2.0 Introduction 5\u003c\/p\u003e \u003cp\u003e2.1 Mass Balances for a CSTR Operating at Steady State 7\u003c\/p\u003e \u003cp\u003e2.2 Operation of the Steady-State CSTR 13\u003c\/p\u003e \u003cp\u003eReferences 16\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Redox Balances and Consistency Check of Experiments 17\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 17\u003c\/p\u003e \u003cp\u003e3.1 Black-Box Stoichiometry Obtained in a CSTR Operated at Steady State 17\u003c\/p\u003e \u003cp\u003e3.2 Calculation of Stoichiometric Coefficients by Means of a Redox Balance 20\u003c\/p\u003e \u003cp\u003e3.3 Applications of the Redox Balance 23\u003c\/p\u003e \u003cp\u003e3.4 Composition of the BiomassX 28\u003c\/p\u003e \u003cp\u003e3.5 Combination of Black-Box Models 30\u003c\/p\u003e \u003cp\u003e3.6 Application of Carbon and Redox Balances in Bio-Remediation Processes 34\u003c\/p\u003e \u003cp\u003eReferences 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Primary Metabolic Pathways and Metabolic Flux Analysis 39\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 39\u003c\/p\u003e \u003cp\u003e4.0 Introduction 39\u003c\/p\u003e \u003cp\u003e4.1 Glycolysis 43\u003c\/p\u003e \u003cp\u003e4.2 Fermentative Metabolism: Regenerating the NAD+ Lost in Glycolysis 47\u003c\/p\u003e \u003cp\u003e4.3 The TCA Cycle: Conversion of Pyruvate to NADH + FADH2, to Precursors or Metabolic Products 50\u003c\/p\u003e \u003cp\u003e4.4 NADPH and Biomass Precursors Produced in the PP Pathway 56\u003c\/p\u003e \u003cp\u003e4.5 Oxidative Phosphorylation: Production of ATP from NADH (FADH2) in Aerobic Fermentation 57\u003c\/p\u003e \u003cp\u003e4.6 Summary of the Biochemistry of Primary Metabolic Pathways 59\u003c\/p\u003e \u003cp\u003e4.7 Metabolic Flux Analysis Discussed in Terms of Substrate to Product Pathways 61\u003c\/p\u003e \u003cp\u003e4.8 Metabolic Flux Analysis Discussed in Terms of Individual Pathway Rates in the Network 88\u003c\/p\u003e \u003cp\u003e4.9 Propagation of Experimental Errors in MFA 94\u003c\/p\u003e \u003cp\u003e4.10 Conclusions 96\u003c\/p\u003e \u003cp\u003eReferences 96\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 A Primer to 13C Metabolic Flux Analysis 97\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eWolfgang Wiechert, Sebastian Niedenführ, and Katharina Nöh Summary 97\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 97\u003c\/p\u003e \u003cp\u003e5.2 Input and Output Data of 13C MFA 99\u003c\/p\u003e \u003cp\u003e5.3 A Brief History of 13C MFA 101\u003c\/p\u003e \u003cp\u003e5.4 An Illustrative Toy Example 102\u003c\/p\u003e \u003cp\u003e5.5 The Atom Transition Network 104\u003c\/p\u003e \u003cp\u003e5.6 Isotopomers and Isotopomer Fractions 104\u003c\/p\u003e \u003cp\u003e5.7 The Isotopomer Transition Network 105\u003c\/p\u003e \u003cp\u003e5.8 Isotopomer Labeling Balances 107\u003c\/p\u003e \u003cp\u003e5.9 Simulating an Isotope Labeling Experiment 109\u003c\/p\u003e \u003cp\u003e5.10 Isotopic Steady State 110\u003c\/p\u003e \u003cp\u003e5.11 Flux Identifiability 112\u003c\/p\u003e \u003cp\u003e5.12 Measurement Models 113\u003c\/p\u003e \u003cp\u003e5.13 Statistical Considerations 114\u003c\/p\u003e \u003cp\u003e5.14 Experimental Design 115\u003c\/p\u003e \u003cp\u003e5.15 Exchange Fluxes 116\u003c\/p\u003e \u003cp\u003e5.16 Multidimensional Flux Identifiability 118\u003c\/p\u003e \u003cp\u003e5.17 Multidimensional Flux Estimation 120\u003c\/p\u003e \u003cp\u003e5.18 The General Parameter Fitting Procedure 121\u003c\/p\u003e \u003cp\u003e5.19 Multidimensional Statistics 123\u003c\/p\u003e \u003cp\u003e5.20 Multidimensional Experimental Design 124\u003c\/p\u003e \u003cp\u003e5.21 The Isotopically Nonstationary Case 127\u003c\/p\u003e \u003cp\u003e5.22 Some Final Remarks on Network Specification 130\u003c\/p\u003e \u003cp\u003e5.23 Algorithms and Software Frameworks for 13C MFA 132\u003c\/p\u003e \u003cp\u003eGlossary 135\u003c\/p\u003e \u003cp\u003eReferences 137\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Genome-Scale Models 143\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eBasti Bergdahl, Nikolaus Sonnenschein, Daniel Machado, Markus Herrgård, and Jochen Förster\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 143\u003c\/p\u003e \u003cp\u003e6.1 Introduction 143\u003c\/p\u003e \u003cp\u003e6.2 Reconstruction Process of Genome-Scale Models 144\u003c\/p\u003e \u003cp\u003e6.3 Genome-Scale Model Prediction 147\u003c\/p\u003e \u003cp\u003e6.3.1 Mathematical Description of Biochemical Reaction Systems 147\u003c\/p\u003e \u003cp\u003e6.3.2 Constraint-Based Modeling 148\u003c\/p\u003e \u003cp\u003e6.3.3 Pathway Analysis 148\u003c\/p\u003e \u003cp\u003e6.3.4 Flux Balance Analysis 150\u003c\/p\u003e \u003cp\u003e6.3.5 Engineering Applications of Constraint-Based Modeling 151\u003c\/p\u003e \u003cp\u003e6.4 Genome-Scale Models of Prokaryotes 152\u003c\/p\u003e \u003cp\u003e6.4.1 Escherichia Coli 153\u003c\/p\u003e \u003cp\u003e6.4.2 Other Prokaryotes 156\u003c\/p\u003e \u003cp\u003e6.4.3 Prokaryotic Communities 158\u003c\/p\u003e \u003cp\u003e6.5 Genome-Scale Models of Eukaryotes 159\u003c\/p\u003e \u003cp\u003e6.5.1 Saccharomyces Cerevisiae 160\u003c\/p\u003e \u003cp\u003e6.5.2 Other Unicellular Eukaryotes 164\u003c\/p\u003e \u003cp\u003e6.5.3 Other Multicellular Eukaryotes 166\u003c\/p\u003e \u003cp\u003e6.6 Integration of Polyomic Data into Genome-Scale Models 169\u003c\/p\u003e \u003cp\u003e6.6.1 Integration of Transcriptomics and Proteomics Data 170\u003c\/p\u003e \u003cp\u003e6.6.2 Metabolomics Data 171\u003c\/p\u003e \u003cp\u003e6.6.3 Integration of Multiple Omics 172\u003c\/p\u003e \u003cp\u003eAcknowledgment 172\u003c\/p\u003e \u003cp\u003eReferences 173\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Kinetics of Bio-Reactions 183\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 183\u003c\/p\u003e \u003cp\u003e7.1 Simple Models for Enzymatic Reactions and for Cell Reactions with Unstructured Biomass 184\u003c\/p\u003e \u003cp\u003e7.2 Variants of Michaelis–Menten and Monod kinetics 189\u003c\/p\u003e \u003cp\u003e7.3 Summary of Enzyme Kinetics and the Kinetics for Cell Reactions 201\u003c\/p\u003e \u003cp\u003e7.4 Cell Reactions with Unsteady State Kinetics 203\u003c\/p\u003e \u003cp\u003e7.5 Cybernetic Modeling of Cellular Kinetics 211\u003c\/p\u003e \u003cp\u003e7.6 Bioreactions with Diffusion Resistance 213\u003c\/p\u003e \u003cp\u003e7.7 Sequences of Enzymatic Reactions: Optimal Allocation of Enzyme Levels 221\u003c\/p\u003e \u003cp\u003eReferences 230\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Application of Dynamic Models for Optimal Redesign of Cell Factories 233\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMatthias Reuss\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 233\u003c\/p\u003e \u003cp\u003e8.1 Introduction 233\u003c\/p\u003e \u003cp\u003e8.2 Kinetics of Pathway Reactions: the Need to Measure in a Very Narrow Time Window 235\u003c\/p\u003e \u003cp\u003e8.2.1 Sampling 238\u003c\/p\u003e \u003cp\u003e8.2.2 Quenching and Extraction 240\u003c\/p\u003e \u003cp\u003e8.2.3 Analysis 241\u003c\/p\u003e \u003cp\u003e8.2.4 Examples for Quantitative Measurements of Metabolites in Stimulus–Response Experiments 242\u003c\/p\u003e \u003cp\u003e8.3 Tools for In Vivo Diagnosis of Pathway Reactions 245\u003c\/p\u003e \u003cp\u003e8.3.1 Modular Decomposition of the Network: the Bottom-Up Approach 247\u003c\/p\u003e \u003cp\u003e8.4 Examples: The Pentose-Phosphate Shunt and Kinetics of Phosphofructokinase 247\u003c\/p\u003e \u003cp\u003e8.4.1 Kinetics of the Irreversible Reactions of the Pentose-Phosphate Shunt 247\u003c\/p\u003e \u003cp\u003e8.4.2 Kinetics of the Phophofructokinase I (PFK1) 252\u003c\/p\u003e \u003cp\u003e8.5 Additional Approaches for Dynamic Modeling Large Metabolic Networks 256\u003c\/p\u003e \u003cp\u003e8.5.1 Generalized Mass Action 259\u003c\/p\u003e \u003cp\u003e8.5.2 S-Systems Approach 260\u003c\/p\u003e \u003cp\u003e8.5.3 Convenience Kinetics 260\u003c\/p\u003e \u003cp\u003e8.5.4 Log–Lin and Lin–Log Approaches 260\u003c\/p\u003e \u003cp\u003e8.6 Dynamic Models Used for Redesigning Cell Factories. Examples: Optimal Ethanol Production in Yeast and Optimal Production of Tryptophan in E. Coli 268\u003c\/p\u003e \u003cp\u003e8.6.1 Dynamic Model 269\u003c\/p\u003e \u003cp\u003e8.6.2 Metabolic Control (Sensitivity) Analysis 270\u003c\/p\u003e \u003cp\u003e8.6.3 Synthesis Amplification of Hexose Transporters 271\u003c\/p\u003e \u003cp\u003e8.6.4 Objective Function 273\u003c\/p\u003e \u003cp\u003e8.6.5 Optimal Solutions 275\u003c\/p\u003e \u003cp\u003e8.6.6 Flux Optimization of Tryptophan Production with E. Coli 276\u003c\/p\u003e \u003cp\u003e8.7 Target Identification for Drug Development 280\u003c\/p\u003e \u003cp\u003eReferences 285\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Chemical Thermodynamics Applied in Bioengineering 293\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 293\u003c\/p\u003e \u003cp\u003e9.0 Introduction 293\u003c\/p\u003e \u003cp\u003e9.1 Chemical Equilibrium and Thermodynamic State Functions 296\u003c\/p\u003e \u003cp\u003e9.2 Thermodynamic Properties Obtained from Galvanic Cells 305\u003c\/p\u003e \u003cp\u003e9.3 Conversion of Free Energy Harbored in NADH and FADH2 to ATP in Oxidative Phosphorylation 310\u003c\/p\u003e \u003cp\u003eReferences 317\u003c\/p\u003e \u003cp\u003ePart Two Bioreactors 319\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Design of Ideal Bioreactors 321\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 321\u003c\/p\u003e \u003cp\u003e10.0 Introduction 321\u003c\/p\u003e \u003cp\u003e10.1 The Design Basis for a Once-Through Steady-State CSTR 322\u003c\/p\u003e \u003cp\u003e10.2 Combination of Several Steady-State CSTRs in Parallel or in Series 329\u003c\/p\u003e \u003cp\u003e10.3 Recirculation of Biomass in a Single Steady-State CSTR 332\u003c\/p\u003e \u003cp\u003e10.4 A Steady-State CSTR with Uptake of Substrates from a Gas Phase 338\u003c\/p\u003e \u003cp\u003e10.5 Fed-Batch Operation of a Stirred Tank Reactor in the Bio-Industry 340\u003c\/p\u003e \u003cp\u003e10.6 Loop Reactors: a Modern Version of Airlift Reactors 349\u003c\/p\u003e \u003cp\u003eReferences 355\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Mixing and Mass Transfer in Industrial Bioreactors 357\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn Villadsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 357\u003c\/p\u003e \u003cp\u003e11.0 Introduction 357\u003c\/p\u003e \u003cp\u003e11.1 Definitions of Mixing Processes 358\u003c\/p\u003e \u003cp\u003e11.2 The Power Input P Delivered by Mechanical Stirring 362\u003c\/p\u003e \u003cp\u003e11.3 Mixing and Mass Transfer in Industrial Reactors 367\u003c\/p\u003e \u003cp\u003e11.4 Conclusions 372\u003c\/p\u003e \u003cp\u003eReferences 376\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Three Downstream Processing 379\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Product Recovery from the Cultures 381\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSunil Nath\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 381\u003c\/p\u003e \u003cp\u003e12.0 Introduction 381\u003c\/p\u003e \u003cp\u003e12.1 Steps in Downstream Processing and Product Recovery 383\u003c\/p\u003e \u003cp\u003e12.2 Baker’s Yeast 383\u003c\/p\u003e \u003cp\u003e12.3 Xanthan Gum 384\u003c\/p\u003e \u003cp\u003e12.4 Penicillin 385\u003c\/p\u003e \u003cp\u003e12.5 α-A Interferon 386\u003c\/p\u003e \u003cp\u003e12.6 Insulin 390\u003c\/p\u003e \u003cp\u003e12.7 Conclusions 391\u003c\/p\u003e \u003cp\u003eReferences 391\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Purification of Bio-Products 393\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSunil Nath\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 393\u003c\/p\u003e \u003cp\u003e13.1 Methods and Types of Separations in Chromatography 394\u003c\/p\u003e \u003cp\u003e13.2 Materials Used in Chromatographic Separations 396\u003c\/p\u003e \u003cp\u003e13.3 Chromatographic Theory 398\u003c\/p\u003e \u003cp\u003e13.4 Practical Considerations in Column Chromatographic Applications 399\u003c\/p\u003e \u003cp\u003e13.5 Scale-Up 401\u003c\/p\u003e \u003cp\u003e13.6 Industrial Applications 402\u003c\/p\u003e \u003cp\u003e13.7 Some Alternatives to Column Chromatographic Techniques 403\u003c\/p\u003e \u003cp\u003e13.8 Electrodialysis 403\u003c\/p\u003e \u003cp\u003e13.9 Electrophoresis 404\u003c\/p\u003e \u003cp\u003e13.10 Conclusions 407\u003c\/p\u003e \u003cp\u003eReferences 407\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Four Process Development, Management and Control 409\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Real-Time Measurement and Monitoring of Bioprocesses 411\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eBernhard Sonnleitner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 411\u003c\/p\u003e \u003cp\u003e14.1 Introduction 411\u003c\/p\u003e \u003cp\u003e14.2 Variables that should be Known 414\u003c\/p\u003e \u003cp\u003e14.3 Variables Easily Accessible and Standard 415\u003c\/p\u003e \u003cp\u003e14.4 Variables Requiring More Monitoring Effort and Not Yet Standard 422\u003c\/p\u003e \u003cp\u003e14.4.1 Biomass 422\u003c\/p\u003e \u003cp\u003e14.4.2 Products and Substrates 427\u003c\/p\u003e \u003cp\u003e14.5 Data Evaluation 433\u003c\/p\u003e \u003cp\u003eReferences 434\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Control of Bioprocesses 439\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJakob Kjøbsted Huusom\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 439\u003c\/p\u003e \u003cp\u003e15.1 Introduction 439\u003c\/p\u003e \u003cp\u003e15.2 Bioprocess Control 440\u003c\/p\u003e \u003cp\u003e15.2.1 Design Variables in Bioreactor Control 443\u003c\/p\u003e \u003cp\u003e15.2.2 Challenges with Respect to Control of a Bioreactor 450\u003c\/p\u003e \u003cp\u003e15.3 Principles and Basic Algorithms in Process Control 450\u003c\/p\u003e \u003cp\u003e15.3.1 Open Loop Control 450\u003c\/p\u003e \u003cp\u003e15.3.2 Feed-forward and Feedback Control 451\u003c\/p\u003e \u003cp\u003e15.3.3 Single-Loop PID Control 452\u003c\/p\u003e \u003cp\u003e15.3.4 Diagnostic Control Strategies 456\u003c\/p\u003e \u003cp\u003e15.3.5 Plant-Wide Control Design 458\u003c\/p\u003e \u003cp\u003eReferences 460\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Scale-Up and Scale-Down 463\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHenk Noorman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 463\u003c\/p\u003e \u003cp\u003e16.1 Introduction 463\u003c\/p\u003e \u003cp\u003e16.2 Description of the Large Scale 465\u003c\/p\u003e \u003cp\u003e16.2.1 Mixing 468\u003c\/p\u003e \u003cp\u003e16.2.2 Mass Transfer 472\u003c\/p\u003e \u003cp\u003e16.2.3 CO2 Removal 475\u003c\/p\u003e \u003cp\u003e16.2.4 Cooling 475\u003c\/p\u003e \u003cp\u003e16.2.5 Gas–Liquid Separation 476\u003c\/p\u003e \u003cp\u003e16.3 Scale Down 480\u003c\/p\u003e \u003cp\u003e16.3.1 One-Compartment Systems 482\u003c\/p\u003e \u003cp\u003e16.3.2 Two-Compartment Systems 484\u003c\/p\u003e \u003cp\u003e16.4 Investigations at Lab Scale 485\u003c\/p\u003e \u003cp\u003e16.4.1 Gluconic Acid 485\u003c\/p\u003e \u003cp\u003e16.4.2 Lipase 486\u003c\/p\u003e \u003cp\u003e16.4.3 Baker’s Yeast 488\u003c\/p\u003e \u003cp\u003e16.4.4 Penicillin 490\u003c\/p\u003e \u003cp\u003e16.5 Scale Up 491\u003c\/p\u003e \u003cp\u003e16.6 Outlook 494\u003c\/p\u003e \u003cp\u003eReferences 495\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Commercial Development of Fermentation Processes 499\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eThomas Grotkjær\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSummary 499\u003c\/p\u003e \u003cp\u003e17.1 Introduction 499\u003c\/p\u003e \u003cp\u003e17.2 Basic Principles of Developing New Fermentation Processes 501\u003c\/p\u003e \u003cp\u003e17.3 Techno-economic Analysis: the Link Between Science, Engineering, and Economy 506\u003c\/p\u003e \u003cp\u003e17.3.1 Value Drivers and Production Costs of Fermentation Processes 506\u003c\/p\u003e \u003cp\u003e17.3.2 Assessment of New Fermentation Technologies 519\u003c\/p\u003e \u003cp\u003e17.3.3 Assessment of Competing Petrochemical Technologies 526\u003c\/p\u003e \u003cp\u003e17.4 From Fermentation Process Development to the Market 528\u003c\/p\u003e \u003cp\u003e17.4.1 The Value Chain of the Chemical Industry 530\u003c\/p\u003e \u003cp\u003e17.4.2 Innovation and Substitution Patterns in the Chemical Industry 534\u003c\/p\u003e \u003cp\u003e17.5 The Industrial Angle and Opportunities in the Chemical Industry 537\u003c\/p\u003e \u003cp\u003e17.6 Evaluation of Business Opportunities 540\u003c\/p\u003e \u003cp\u003e17.7 Concluding Remarks and Outlook 542\u003c\/p\u003e \u003cp\u003eAcknowledgment 543\u003c\/p\u003e \u003cp\u003eReferences 543\u003c\/p\u003e \u003cp\u003eIndex 547\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":48743118602583,"sku":"9783527336746","price":135.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527336746.jpg?v=1720064191"},{"product_id":"industrial-microbiology-9783527340354","title":"Industrial Microbiology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eFocusing on current and future uses of microbes as production organisms, this practice-oriented textbook complements traditional texts on microbiology and biotechnology.\u003cbr\u003e The editors have brought together leading researchers and professionals from the entire field of industrial microbiology and together they adopt a modern approach to a well-known subject. Following a brief introduction to the technology of microbial processes, the twelve most important application areas for microbial technology are described, from crude bulk chemicals to such highly refined biomolecules as enzymes and antibodies, to the use of microbes in the leaching of minerals and for the treatment of municipal and industrial waste. In line with their application-oriented topic, the authors focus on the \"translation\" of basic research into industrial processes and cite numerous successful examples. The result is a first-hand account of the state of the industry and the future potential for microbes in industrial processes. \u003cbr\u003e Interested students of biotechnology, bioengineering, microbiology and related disciplines will find this a highly useful and much consulted companion, while instructors can use the case studies and examples to add value to their teaching.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Historical Overview and Future Perspective 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBernhard Eikmanns, Marcella Eikmanns, and Christopher J. Paddon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Use of Fermentation Procedures Before the Discovery of Microorganisms (Neolithic Era = New Stone Age Until 1850) 1\u003c\/p\u003e \u003cp\u003e1.2 Investigation of Microorganisms and Beginning of Industrial Microbiology (1850 Until 1940) 7\u003c\/p\u003e \u003cp\u003e1.3 Development of New Products and Procedures: Antibiotics and Other Biomolecules (From 1940) 11\u003c\/p\u003e \u003cp\u003e1.4 Genetic Engineering is Introduced into Industrial Microbiology (From Roughly 1980) 15\u003c\/p\u003e \u003cp\u003e1.5 Future Perspectives: Synthetic Microbiology 18\u003c\/p\u003e \u003cp\u003eReferences 20\u003c\/p\u003e \u003cp\u003eFurther Reading 21\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Bioprocess Engineering \u003c\/b\u003e\u003cb\u003e23\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMichael R. Ladisch, Eduardo Ximenes, Nathan Mosier, Abigail S. Engelberth, Kevin Solomon, and Robert Binkley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 23\u003c\/p\u003e \u003cp\u003e2.1.1 Role of Bioreactors 25\u003c\/p\u003e \u003cp\u003e2.1.2 Basic Bioreactor Configurations 26\u003c\/p\u003e \u003cp\u003e2.1.3 Types of Growth Media 27\u003c\/p\u003e \u003cp\u003e2.2 Nonstructured Models 28\u003c\/p\u003e \u003cp\u003e2.2.1 Nonstructured Growth Models 28\u003c\/p\u003e \u003cp\u003e2.2.1.1 Unstructured Models 29\u003c\/p\u003e \u003cp\u003e2.2.1.2 Biotechnical Processes 30\u003c\/p\u003e \u003cp\u003e2.2.2 Modeling Fermentations 32\u003c\/p\u003e \u003cp\u003e2.2.3 Metabolic Pathways 39\u003c\/p\u003e \u003cp\u003e2.2.4 Manipulation of Metabolic Pathways 40\u003c\/p\u003e \u003cp\u003e2.2.5 Future of Pathway Design 42\u003c\/p\u003e \u003cp\u003e2.3 Oxygen Transport 43\u003c\/p\u003e \u003cp\u003e2.3.1 Aerobic versus Anaerobic Conditions 43\u003c\/p\u003e \u003cp\u003e2.3.2 k\u003csub\u003eL\u003c\/sub\u003ea – Volumetric Mass Transfer Coefficient 44\u003c\/p\u003e \u003cp\u003e2.4 Heat Generating Aerobic Processes 46\u003c\/p\u003e \u003cp\u003e2.5 Product Recovery 49\u003c\/p\u003e \u003cp\u003e2.5.1 Basics 49\u003c\/p\u003e \u003cp\u003e2.5.2 \u003ci\u003eIn Situ \u003c\/i\u003eProduct Recovery (ISPR) 49\u003c\/p\u003e \u003cp\u003e2.6 Modeling and Simulation of Reactor Behavior 51\u003c\/p\u003e \u003cp\u003e2.6.1 Basic Approaches and Software 51\u003c\/p\u003e \u003cp\u003e2.6.2 Numerical Simulation of Bioreactor Function 51\u003c\/p\u003e \u003cp\u003e2.6.3 Contamination of Bioreactors 52\u003c\/p\u003e \u003cp\u003e2.7 Scale-up 53\u003c\/p\u003e \u003cp\u003eReferences 54\u003c\/p\u003e \u003cp\u003eFurther Reading 57\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Food \u003c\/b\u003e\u003cb\u003e59\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eGülhan Ünlü and Barbara Nielsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Fermented Foods 59\u003c\/p\u003e \u003cp\u003e3.1.1 Food Preservation 59\u003c\/p\u003e \u003cp\u003e3.1.2 Flavor and Texture 60\u003c\/p\u003e \u003cp\u003e3.1.3 Health Benefits 60\u003c\/p\u003e \u003cp\u003e3.1.4 Economic Impact 62\u003c\/p\u003e \u003cp\u003e3.2 Microorganisms and Metabolism 62\u003c\/p\u003e \u003cp\u003e3.2.1 Fermentation Processes 64\u003c\/p\u003e \u003cp\u003e3.2.2 Starter Cultures 65\u003c\/p\u003e \u003cp\u003e3.3 Yeast Fermentations – Industrial Application of \u003ci\u003eSaccharomyces \u003c\/i\u003eSpecies 65\u003c\/p\u003e \u003cp\u003e3.3.1 Grain Fermentation for Ethanol Production – Beer 66\u003c\/p\u003e \u003cp\u003e3.3.2 Grain Fermentation for CO\u003csub\u003e2\u003c\/sub\u003e Production – Bread 69\u003c\/p\u003e \u003cp\u003e3.3.2.1 Yeast Preparation 69\u003c\/p\u003e \u003cp\u003e3.3.3 Fruit Fermentation –Wines and Ciders 71\u003c\/p\u003e \u003cp\u003e3.4 Vinegar – Incomplete Ethanol Oxidation by Acetic Acid Bacteria Such as \u003ci\u003eGluconobacter oxydans \u003c\/i\u003e75\u003c\/p\u003e \u003cp\u003e3.4.1 Substrates: Wine, Cider, and Malt 75\u003c\/p\u003e \u003cp\u003e3.4.2 Distilled (White) Vinegar 77\u003c\/p\u003e \u003cp\u003e3.4.3 Balsamic and Other Specialty Vinegars 77\u003c\/p\u003e \u003cp\u003e3.5 Bacterial and Mixed Fermentations – Industrial Application of Lactic Acid Bacteria, with or without Yeast or Molds 78\u003c\/p\u003e \u003cp\u003e3.5.1 Milk – Cultured Milks – Buttermilk, Yogurt, Kefir, and Cheese 78\u003c\/p\u003e \u003cp\u003e3.5.1.1 Bacteriophage Contamination – Death of a Culture 81\u003c\/p\u003e \u003cp\u003e3.5.2 Meats – Sausages, Fish Sauces, and Pastes 82\u003c\/p\u003e \u003cp\u003e3.5.3 Vegetables – Sauerkrauts and Pickles, Olives 83\u003c\/p\u003e \u003cp\u003e3.5.4 Grains and Legumes – Soy Sauce, Miso, Natto, and Tempeh 86\u003c\/p\u003e \u003cp\u003e3.5.5 Cocoa and Coffee 87\u003c\/p\u003e \u003cp\u003e3.6 Fungi as Food 88\u003c\/p\u003e \u003cp\u003e3.6.1 Mushrooms 88\u003c\/p\u003e \u003cp\u003e3.6.2 Single-Cell Protein – \u003ci\u003eFusarium venenatum \u003c\/i\u003e90\u003c\/p\u003e \u003cp\u003e3.7 Conclusions and Outlook 91\u003c\/p\u003e \u003cp\u003eReferences 92\u003c\/p\u003e \u003cp\u003eFurther Reading 92\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Technical Alcohols and Ketones \u003c\/b\u003e\u003cb\u003e95\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePeter Dürre\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 95\u003c\/p\u003e \u003cp\u003e4.2 Ethanol Synthesis by \u003ci\u003eSaccharomyces cerevisiae \u003c\/i\u003eand \u003ci\u003eClostridium autoethanogenum \u003c\/i\u003e97\u003c\/p\u003e \u003cp\u003e4.2.1 Application 97\u003c\/p\u003e \u003cp\u003e4.2.2 Metabolic Pathways and Regulation 97\u003c\/p\u003e \u003cp\u003e4.2.3 Production Strains 98\u003c\/p\u003e \u003cp\u003e4.2.4 Production Processes 98\u003c\/p\u003e \u003cp\u003e4.2.5 Ethanol – Fuel of the Future? 100\u003c\/p\u003e \u003cp\u003e4.2.6 Alternative Substrates for Ethanol Fermentation by Cellulolytic Bacteria and \u003ci\u003eClostridium autoethanogenum \u003c\/i\u003e100\u003c\/p\u003e \u003cp\u003e4.3 1,3-Propanediol Synthesis by \u003ci\u003eEscherichia coli \u003c\/i\u003e101\u003c\/p\u003e \u003cp\u003e4.3.1 Application 101\u003c\/p\u003e \u003cp\u003e4.3.2 Metabolic Pathways and Regulation 102\u003c\/p\u003e \u003cp\u003e4.3.3 Production Strains 102\u003c\/p\u003e \u003cp\u003e4.3.4 Production Processes 104\u003c\/p\u003e \u003cp\u003e4.4 Butanol and Isobutanol Synthesis by Clostridia and Yeast 105\u003c\/p\u003e \u003cp\u003e4.4.1 History of Acetone–Butanol–Ethanol (ABE) Fermentation by \u003ci\u003eClostridium acetobutylicum \u003c\/i\u003eand \u003ci\u003eC. beijerinckii \u003c\/i\u003e105\u003c\/p\u003e \u003cp\u003e4.4.2 Application 106\u003c\/p\u003e \u003cp\u003e4.4.3 Metabolic Pathways and Regulation 107\u003c\/p\u003e \u003cp\u003e4.4.4 Production Strains 110\u003c\/p\u003e \u003cp\u003e4.4.5 Production Processes 110\u003c\/p\u003e \u003cp\u003e4.4.6 Product Toxicity 113\u003c\/p\u003e \u003cp\u003e4.5 Acetone Synthesis by Solventogenic Clostridia 113\u003c\/p\u003e \u003cp\u003e4.5.1 Application 113\u003c\/p\u003e \u003cp\u003e4.5.2 Metabolic Pathways and Regulation 113\u003c\/p\u003e \u003cp\u003e4.5.3 Production Strains 114\u003c\/p\u003e \u003cp\u003e4.5.4 Production Processes 114\u003c\/p\u003e \u003cp\u003e4.6 Outlook 115\u003c\/p\u003e \u003cp\u003eFurther Reading 115\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Organic Acids \u003c\/b\u003e\u003cb\u003e117\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMichael Sauer and Diethard Mattanovich\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 117\u003c\/p\u003e \u003cp\u003e5.2 Citric Acid 119\u003c\/p\u003e \u003cp\u003e5.2.1 Economic Impact and Applications 120\u003c\/p\u003e \u003cp\u003e5.2.2 Biochemistry of Citric Acid Accumulation 120\u003c\/p\u003e \u003cp\u003e5.2.3 Industrial Production by the Filamentous Fungus \u003ci\u003eAspergillus niger \u003c\/i\u003e122\u003c\/p\u003e \u003cp\u003e5.2.4 \u003ci\u003eYarrowia lipolytica\u003c\/i\u003e: A Yeast as an Alternative Production Platform 123\u003c\/p\u003e \u003cp\u003e5.3 Lactic Acid 124\u003c\/p\u003e \u003cp\u003e5.3.1 Economic Impact and Applications 124\u003c\/p\u003e \u003cp\u003e5.3.2 Anaerobic Bacterial Metabolism Generating Lactic Acid 125\u003c\/p\u003e \u003cp\u003e5.3.3 Lactic Acid Production by Bacteria 125\u003c\/p\u003e \u003cp\u003e5.3.4 Lactic Acid Production by Yeasts 126\u003c\/p\u003e \u003cp\u003e5.4 Gluconic Acid 127\u003c\/p\u003e \u003cp\u003e5.4.1 Economic Impact and Applications 127\u003c\/p\u003e \u003cp\u003e5.4.2 Extracellular Biotransformation of Glucose to Gluconic Acid by \u003ci\u003eAspergillus niger \u003c\/i\u003e128\u003c\/p\u003e \u003cp\u003e5.4.3 Production of Gluconic Acid by Bacteria 129\u003c\/p\u003e \u003cp\u003e5.5 Succinic Acid 129\u003c\/p\u003e \u003cp\u003e5.5.1 Economic Impact and Applications 130\u003c\/p\u003e \u003cp\u003e5.5.2 Pilot Plants for Anaerobic or Aerobic Microbes 130\u003c\/p\u003e \u003cp\u003e5.6 Itaconic Acid 132\u003c\/p\u003e \u003cp\u003e5.6.1 Economic Impact and Applications 132\u003c\/p\u003e \u003cp\u003e5.6.2 Decarboxylation as a Driver in Itaconic Acid Accumulation 132\u003c\/p\u003e \u003cp\u003e5.6.3 Production Process by \u003ci\u003eAspergillus terreus \u003c\/i\u003e132\u003c\/p\u003e \u003cp\u003e5.6.4 Metabolic Engineering for Itaconic Acid Production 132\u003c\/p\u003e \u003cp\u003e5.7 Downstream Options for Organic Acids 134\u003c\/p\u003e \u003cp\u003e5.8 Perspectives 135\u003c\/p\u003e \u003cp\u003e5.8.1 Targeting Acrylic Acid – Microbes Can Replace Chemical Process Engineering 136\u003c\/p\u003e \u003cp\u003e5.8.2 Lignocellulose-Based Biorefineries 136\u003c\/p\u003e \u003cp\u003eFurther Reading 137\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Amino Acids \u003c\/b\u003e\u003cb\u003e139\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLothar Eggeling\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 139\u003c\/p\u003e \u003cp\u003e6.1.1 Importance and Areas of Application 139\u003c\/p\u003e \u003cp\u003e6.1.2 Amino Acids in the Feed Industry 140\u003c\/p\u003e \u003cp\u003e6.1.3 Economic Significance 141\u003c\/p\u003e \u003cp\u003e6.2 Production of Amino Acids 142\u003c\/p\u003e \u003cp\u003e6.2.1 Conventional Development of Production Strains 142\u003c\/p\u003e \u003cp\u003e6.2.2 Advanced Development of Production Strains 144\u003c\/p\u003e \u003cp\u003e6.3 l-Glutamate Synthesis by \u003ci\u003eCorynebacterium glutamicum \u003c\/i\u003e145\u003c\/p\u003e \u003cp\u003e6.3.1 Synthesis Pathway and Regulation 145\u003c\/p\u003e \u003cp\u003e6.3.2 Production Process 148\u003c\/p\u003e \u003cp\u003e6.4 l-Lysine 148\u003c\/p\u003e \u003cp\u003e6.4.1 Synthesis Pathway and Regulation 148\u003c\/p\u003e \u003cp\u003e6.4.2 Production Strains 150\u003c\/p\u003e \u003cp\u003e6.4.3 Production Process 152\u003c\/p\u003e \u003cp\u003e6.5 l-Threonine Synthesis by \u003ci\u003eEscherichia coli \u003c\/i\u003e153\u003c\/p\u003e \u003cp\u003e6.5.1 Synthesis Pathway and Regulation 153\u003c\/p\u003e \u003cp\u003e6.5.2 Production Strains 154\u003c\/p\u003e \u003cp\u003e6.5.3 Production Process 155\u003c\/p\u003e \u003cp\u003e6.6 l-Phenylalanine 155\u003c\/p\u003e \u003cp\u003e6.6.1 Synthesis Pathway and Regulation 155\u003c\/p\u003e \u003cp\u003e6.6.2 Production Strains 156\u003c\/p\u003e \u003cp\u003e6.6.3 Production Process 157\u003c\/p\u003e \u003cp\u003e6.7 Outlook 158\u003c\/p\u003e \u003cp\u003eFurther Reading 159\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Vitamins, Nucleotides, and Carotenoids \u003c\/b\u003e\u003cb\u003e161\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKlaus-Peter Stahmann and Hans-Peter Hohmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Application and Economic Impact 161\u003c\/p\u003e \u003cp\u003e7.2 l-Ascorbic Acid (Vitamin C) 163\u003c\/p\u003e \u003cp\u003e7.2.1 Biochemical Significance, Application, and Biosynthesis 163\u003c\/p\u003e \u003cp\u003e7.2.2 Regioselective Oxidation with Bacteria in the Production Process 164\u003c\/p\u003e \u003cp\u003e7.3 Riboflavin (Vitamin B\u003csub\u003e2\u003c\/sub\u003e) 166\u003c\/p\u003e \u003cp\u003e7.3.1 Significance as a Precursor for Coenzymes and as a Pigment 166\u003c\/p\u003e \u003cp\u003e7.3.2 Biosynthesis by Fungi and Bacteria 167\u003c\/p\u003e \u003cp\u003e7.3.3 Production by \u003ci\u003eAshbya gossypii \u003c\/i\u003e168\u003c\/p\u003e \u003cp\u003e7.3.4 Production by \u003ci\u003eBacillus subtilis \u003c\/i\u003e171\u003c\/p\u003e \u003cp\u003e7.3.5 Downstream Processing and Environmental Compatibility 173\u003c\/p\u003e \u003cp\u003e7.4 Cobalamin (Vitamin B\u003csub\u003e12\u003c\/sub\u003e) 174\u003c\/p\u003e \u003cp\u003e7.4.1 Physiological Relevance 174\u003c\/p\u003e \u003cp\u003e7.4.2 Biosynthesis 176\u003c\/p\u003e \u003cp\u003e7.4.3 Production with \u003ci\u003ePseudomonas denitrificans \u003c\/i\u003e176\u003c\/p\u003e \u003cp\u003e7.5 Purine Nucleotides 178\u003c\/p\u003e \u003cp\u003e7.5.1 Impact as Flavor Enhancer 178\u003c\/p\u003e \u003cp\u003e7.5.2 Development of Production Strains 178\u003c\/p\u003e \u003cp\u003e7.5.3 Production of Inosine or Guanosine with Subsequent Phosphorylation 179\u003c\/p\u003e \u003cp\u003e7.6 β-Carotene 180\u003c\/p\u003e \u003cp\u003e7.6.1 Physiological Impact and Application 180\u003c\/p\u003e \u003cp\u003e7.6.2 Production with \u003ci\u003eBlakeslea trispora \u003c\/i\u003e181\u003c\/p\u003e \u003cp\u003e7.7 Perspectives 181\u003c\/p\u003e \u003cp\u003eFurther Reading 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Antibiotics and Pharmacologically Active Compounds \u003c\/b\u003e\u003cb\u003e185\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eLei Fang, Guojian Zhang, and Blaine A. Pfeifer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Microbial Substances Active Against Infectious Disease Agents or Affecting Human Cells 185\u003c\/p\u003e \u003cp\u003e8.1.1 Distribution and Impacts 185\u003c\/p\u003e \u003cp\u003e8.1.2 Diversity of Antibiotics Produced by Bacteria and Fungi 189\u003c\/p\u003e \u003cp\u003e8.2 β-Lactams 190\u003c\/p\u003e \u003cp\u003e8.2.1 History, Effect, and Application 190\u003c\/p\u003e \u003cp\u003e8.2.2 β-Lactam Biosynthesis 190\u003c\/p\u003e \u003cp\u003e8.2.3 Penicillin Production by \u003ci\u003ePenicillium chrysogenum \u003c\/i\u003e193\u003c\/p\u003e \u003cp\u003e8.2.4 Cephalosporin Production by \u003ci\u003eAcremonium chrysogenum \u003c\/i\u003e193\u003c\/p\u003e \u003cp\u003e8.3 Lipopeptides 193\u003c\/p\u003e \u003cp\u003e8.3.1 History, Effect, and Application 193\u003c\/p\u003e \u003cp\u003e8.3.2 Lipopeptide Biosynthesis 194\u003c\/p\u003e \u003cp\u003e8.3.3 Daptomycin Production by \u003ci\u003eStreptomyces roseosporus \u003c\/i\u003e194\u003c\/p\u003e \u003cp\u003e8.3.4 Cyclosporine Production by \u003ci\u003eTolypocladium inflatum \u003c\/i\u003e194\u003c\/p\u003e \u003cp\u003e8.4 Macrolides 197\u003c\/p\u003e \u003cp\u003e8.4.1 History, Effect, and Application 197\u003c\/p\u003e \u003cp\u003e8.4.2 Macrolide Biosynthesis 197\u003c\/p\u003e \u003cp\u003e8.4.3 Erythromycin Production by \u003ci\u003eSaccharopolyspora erythraea \u003c\/i\u003e197\u003c\/p\u003e \u003cp\u003e8.5 Tetracyclines 200\u003c\/p\u003e \u003cp\u003e8.5.1 History, Effect, and Application 200\u003c\/p\u003e \u003cp\u003e8.5.2 Tetracycline Biosynthesis 200\u003c\/p\u003e \u003cp\u003e8.5.3 Tetracycline Production by \u003ci\u003eStreptomyces rimosus \u003c\/i\u003e201\u003c\/p\u003e \u003cp\u003e8.6 Aminoglycosides 201\u003c\/p\u003e \u003cp\u003e8.6.1 History, Effect, and Application 201\u003c\/p\u003e \u003cp\u003e8.6.2 Aminoglycoside Biosynthesis 201\u003c\/p\u003e \u003cp\u003e8.6.3 Tobramycin Production by \u003ci\u003eStreptomyces tenebrarius \u003c\/i\u003e203\u003c\/p\u003e \u003cp\u003e8.7 Claviceps Alkaloids 203\u003c\/p\u003e \u003cp\u003e8.7.1 History, Effect, and Application 203\u003c\/p\u003e \u003cp\u003e8.7.2 Alkaloid Biosynthesis 203\u003c\/p\u003e \u003cp\u003e8.7.3 Ergotamine Production by \u003ci\u003eClaviceps purpurea \u003c\/i\u003e203\u003c\/p\u003e \u003cp\u003e8.8 Perspectives 203\u003c\/p\u003e \u003cp\u003e8.8.1 Antibiotic Resistance 203\u003c\/p\u003e \u003cp\u003e8.8.2 New Research Model for Compound Identification 206\u003c\/p\u003e \u003cp\u003e8.8.3 Future Opportunities 207\u003c\/p\u003e \u003cp\u003eFurther Reading 211\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Pharmaceutical Proteins \u003c\/b\u003e\u003cb\u003e213\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eHeinrich Decker, Susanne Dilsen, and Jan Weber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 History, Main Areas of Application, and Economic Importance 213\u003c\/p\u003e \u003cp\u003e9.2 Industrial Expression Systems, Cultivation and Protein Isolation, and Legal Framework 215\u003c\/p\u003e \u003cp\u003e9.2.1 Development of Production Strains 215\u003c\/p\u003e \u003cp\u003e9.2.2 Isolation of Pharmaceutical Proteins 221\u003c\/p\u003e \u003cp\u003e9.2.3 Regulatory Requirements for the Production of Pharmaceutical Proteins 222\u003c\/p\u003e \u003cp\u003e9.3 Insulins 223\u003c\/p\u003e \u003cp\u003e9.3.1 Application and Structures 223\u003c\/p\u003e \u003cp\u003e9.3.2 Manufacturing Processes by \u003ci\u003eEscherichia coli \u003c\/i\u003eand \u003ci\u003eSaccharomyces cerevisiae \u003c\/i\u003e225\u003c\/p\u003e \u003cp\u003e9.3.2.1 Production of a Fusion Protein in \u003ci\u003eE. coli \u003c\/i\u003e226\u003c\/p\u003e \u003cp\u003e9.3.2.2 Production of a Precursor Protein, the So-Called Mini Proinsulin with the Host Strain \u003ci\u003eS. cerevisiae \u003c\/i\u003e228\u003c\/p\u003e \u003cp\u003e9.4 Somatropin 230\u003c\/p\u003e \u003cp\u003e9.4.1 Application 230\u003c\/p\u003e \u003cp\u003e9.4.2 Manufacturing Process 231\u003c\/p\u003e \u003cp\u003e9.5 Interferons – Application and Manufacturing 232\u003c\/p\u003e \u003cp\u003e9.6 Human Granulocyte Colony-Stimulating Factor 234\u003c\/p\u003e \u003cp\u003e9.6.1 Application 234\u003c\/p\u003e \u003cp\u003e9.6.2 Manufacturing Process 235\u003c\/p\u003e \u003cp\u003e9.7 Vaccines 235\u003c\/p\u003e \u003cp\u003e9.7.1 Application 235\u003c\/p\u003e \u003cp\u003e9.7.2 Manufacturing Procedure Using the Example of Gardasil\u003csup\u003eTM\u003c\/sup\u003e 236\u003c\/p\u003e \u003cp\u003e9.7.3 Manufacturing Process Based on the Example of a Hepatitis B Vaccine 237\u003c\/p\u003e \u003cp\u003e9.8 Antibody Fragments 238\u003c\/p\u003e \u003cp\u003e9.9 Enzymes 239\u003c\/p\u003e \u003cp\u003e9.10 Peptides 240\u003c\/p\u003e \u003cp\u003e9.11 View – Future Economic Importance 240\u003c\/p\u003e \u003cp\u003eFurther Reading 242\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Enzymes \u003c\/b\u003e\u003cb\u003e243\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDavid B.Wilson, Maxim Kostylev, Karl-Heinz Maurer, Marina Schramm, Wolfgang Kronemeyer, and Klaus-Peter Stahmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Fields of Application and Economic Impacts 243\u003c\/p\u003e \u003cp\u003e10.1.1 Enzymes are Biocatalysts 243\u003c\/p\u003e \u003cp\u003e10.1.2 Advantages and Limitations of Using Enzymatic Versus Chemical Methods 244\u003c\/p\u003e \u003cp\u003e10.1.3 Brief History of Enzyme Used for the Industrial Production of Valuable Products 245\u003c\/p\u003e \u003cp\u003e10.1.4 Diverse Ways That Enzymes are Used in Industry 246\u003c\/p\u003e \u003cp\u003e10.2 Enzyme Discovery and Improvement 250\u003c\/p\u003e \u003cp\u003e10.2.1 Screening for New Enzymes and Optimization of Enzymes by Protein Engineering 250\u003c\/p\u003e \u003cp\u003e10.2.2 Classical Development of Production Strains 251\u003c\/p\u003e \u003cp\u003e10.2.3 Genetic Engineering of Producer Strains 253\u003c\/p\u003e \u003cp\u003e10.3 Production Process for Bacterial or Fungal Enzymes 255\u003c\/p\u003e \u003cp\u003e10.4 Polysaccharide-Hydrolyzing Enzymes 255\u003c\/p\u003e \u003cp\u003e10.4.1 Starch-Cleaving Enzymes Produced by \u003ci\u003eBacillus \u003c\/i\u003eand \u003ci\u003eAspergillus \u003c\/i\u003eSpecies 257\u003c\/p\u003e \u003cp\u003e10.4.2 Cellulose-Cleaving Enzymes: A Domain of \u003ci\u003eTrichoderma reesei \u003c\/i\u003e259\u003c\/p\u003e \u003cp\u003e10.4.3 Production Strains 261\u003c\/p\u003e \u003cp\u003e10.5 Enzymes Used as Cleaning Agents 263\u003c\/p\u003e \u003cp\u003e10.5.1 Subtilisin-Like Protease 264\u003c\/p\u003e \u003cp\u003e10.5.2 \u003ci\u003eBacillus \u003c\/i\u003esp. Production Strains and Production Process 265\u003c\/p\u003e \u003cp\u003e10.6 Feed Supplements – Phytases 266\u003c\/p\u003e \u003cp\u003e10.6.1 Fields of Applications of Phytase 267\u003c\/p\u003e \u003cp\u003e10.6.2 Phytase in the Animals Intestine 267\u003c\/p\u003e \u003cp\u003e10.6.3 Production of a Bacterial Phytase in \u003ci\u003eAspergillus niger \u003c\/i\u003e269\u003c\/p\u003e \u003cp\u003e10.7 Enzymes for Chemical and Pharmaceutical Industry 271\u003c\/p\u003e \u003cp\u003e10.7.1 Examples for Enzymatic Chemical Production 271\u003c\/p\u003e \u003cp\u003e10.7.2 Production of (\u003ci\u003eS\u003c\/i\u003e)-Profens by Fungal Lipase 271\u003c\/p\u003e \u003cp\u003e10.8 Enzymes as Highly Selective Tools for Research and Diagnostics 272\u003c\/p\u003e \u003cp\u003e10.8.1 Microbial Enzymes for Analysis and Engineering of Nucleic Acids 272\u003c\/p\u003e \u003cp\u003e10.8.2 Specific Enzymes for Quantitative Metabolite Assays 275\u003c\/p\u003e \u003cp\u003e10.9 Perspectives 276\u003c\/p\u003e \u003cp\u003e10.9.1 l-DOPA by Tyrosine Phenol Lyase 276\u003c\/p\u003e \u003cp\u003e10.9.2 Activation of Alkanes 276\u003c\/p\u003e \u003cp\u003e10.9.3 Enzyme Cascades 276\u003c\/p\u003e \u003cp\u003eReferences 277\u003c\/p\u003e \u003cp\u003eFurther Reading 277\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Microbial Polysaccharides \u003c\/b\u003e\u003cb\u003e279\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eVolker Sieber, Jochen Schmid, and Gerd Hublik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 279\u003c\/p\u003e \u003cp\u003e11.2 Heteropolysaccharides 282\u003c\/p\u003e \u003cp\u003e11.2.1 Xanthan: A Product of the Bacterium \u003ci\u003eXanthomonas campestris \u003c\/i\u003e282\u003c\/p\u003e \u003cp\u003e11.2.1.1 Introduction 282\u003c\/p\u003e \u003cp\u003e11.2.1.2 Regulatory Status 282\u003c\/p\u003e \u003cp\u003e11.2.1.3 Structure 282\u003c\/p\u003e \u003cp\u003e11.2.1.4 Biosynthesis 284\u003c\/p\u003e \u003cp\u003e11.2.1.5 Industrial Production of Xanthan 286\u003c\/p\u003e \u003cp\u003e11.2.1.6 Physicochemical Properties 287\u003c\/p\u003e \u003cp\u003e11.2.1.7 Applications 289\u003c\/p\u003e \u003cp\u003e11.2.2 Sphingans: Polysaccharides from \u003ci\u003eSphingomonas \u003c\/i\u003esp. 291\u003c\/p\u003e \u003cp\u003e11.2.3 Hyaluronic Acid: A High-Value Polysaccharide for Cosmetic Applications 293\u003c\/p\u003e \u003cp\u003e11.2.4 Alginate: Alternatives to Plant-Based Products by \u003ci\u003ePseudomonas \u003c\/i\u003eand \u003ci\u003eAzotobacter \u003c\/i\u003esp. 294\u003c\/p\u003e \u003cp\u003e11.2.5 Succinoglycan: Acidic Polysaccharide from \u003ci\u003eRhizobium \u003c\/i\u003esp. 294\u003c\/p\u003e \u003cp\u003e11.3 Homopolysaccharides 295\u003c\/p\u003e \u003cp\u003e11.3.1 α-Glucans 296\u003c\/p\u003e \u003cp\u003e11.3.1.1 Pullulan 296\u003c\/p\u003e \u003cp\u003e11.3.1.2 Dextran 296\u003c\/p\u003e \u003cp\u003e11.3.2 β-Glucans 297\u003c\/p\u003e \u003cp\u003e11.3.2.1 Linear β-glucans like cellulose and curdlan 297\u003c\/p\u003e \u003cp\u003e11.3.2.2 Branched β-Glucans Like Scleroglucan and Schizophyllan 297\u003c\/p\u003e \u003cp\u003e11.3.3 Fructosylpolymers like Levan 298\u003c\/p\u003e \u003cp\u003e11.4 Perspectives 298\u003c\/p\u003e \u003cp\u003eFurther Reading 299\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Steroids \u003c\/b\u003e\u003cb\u003e301\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShuvendu Das and Sridhar Gopishetty\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Fields of Applications and Economic Importance 301\u003c\/p\u003e \u003cp\u003e12.2 Advantages of Biotransformations During Production of Steroids 303\u003c\/p\u003e \u003cp\u003e12.3 Development of Production Strains and Production Processes 305\u003c\/p\u003e \u003cp\u003e12.4 Applied Types of Biotransformation 307\u003c\/p\u003e \u003cp\u003e12.5 Synthesis of Steroids in Organic – Aqueous Biphasic System 310\u003c\/p\u003e \u003cp\u003e12.6 Side-chain Degradation of Phytosterols by \u003ci\u003eMycobacterium \u003c\/i\u003eto Gain Steroid Intermediates 311\u003c\/p\u003e \u003cp\u003e12.7 Biotransformation of Cholesterol to Gain Key Steroid Intermediates 313\u003c\/p\u003e \u003cp\u003e12.8 11-Hydroxylation by Fungi During Synthesis of Corticosteroids 313\u003c\/p\u003e \u003cp\u003e12.9 Δ1-Dehydrogenation by \u003ci\u003eArthrobacter \u003c\/i\u003efor the Production of Prednisolone 316\u003c\/p\u003e \u003cp\u003e12.10 17-Keto Reduction by \u003ci\u003eSaccharomyces \u003c\/i\u003ein Testosterone Production 317\u003c\/p\u003e \u003cp\u003e12.11 Double-Bond Isomerization of Steroids 318\u003c\/p\u003e \u003cp\u003e12.12 Perspectives 319\u003c\/p\u003e \u003cp\u003eReferences 320\u003c\/p\u003e \u003cp\u003eFurther Reading 321\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Bioleaching \u003c\/b\u003e\u003cb\u003e323\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSören Bellenberg, Mario Vera Véliz, and Wolfgang Sand\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Acidophilic Microorganisms Dissolve Metals from Sulfide Ores 323\u003c\/p\u003e \u003cp\u003e13.1.1 Brief Overview on the Diversity of Acidophilic Mineral-Oxidizing Microorganisms 325\u003c\/p\u003e \u003cp\u003e13.1.2 Natural and Man-Made Habitats of Mineral-oxidizing Microorganisms 325\u003c\/p\u003e \u003cp\u003e13.1.3 Biological Catalysis of Metal Sulfide Oxidation 328\u003c\/p\u003e \u003cp\u003e13.1.4 Importance of Biofilm Formation and Extracellular Polymeric Substances for Bioleaching by \u003ci\u003eAcidithiobacillus ferrooxidans \u003c\/i\u003eand \u003ci\u003eLeptospirillum ferrooxidans \u003c\/i\u003e330\u003c\/p\u003e \u003cp\u003e13.2 Bioleaching of Copper, Nickel, Zinc, and Cobalt 334\u003c\/p\u003e \u003cp\u003e13.2.1 Economic Impact 334\u003c\/p\u003e \u003cp\u003e13.2.2 Heap, Dump, or Stirred-tank Bioleaching of Copper, Nickel, Zinc, and Cobalt 337\u003c\/p\u003e \u003cp\u003e13.3 Gold 342\u003c\/p\u003e \u003cp\u003e13.3.1 Economic Impact 343\u003c\/p\u003e \u003cp\u003e13.3.2 Unlocking Gold by Biooxidation of the Mineral Matrix 343\u003c\/p\u003e \u003cp\u003e13.4 Uranium 346\u003c\/p\u003e \u003cp\u003e13.4.1 Economic Impact 346\u003c\/p\u003e \u003cp\u003e13.4.2 \u003ci\u003eIn Situ \u003c\/i\u003eBiomining of Uranium 346\u003c\/p\u003e \u003cp\u003e13.5 Perspectives 347\u003c\/p\u003e \u003cp\u003e13.5.1 Urban Mining – Processing of Electronic Waste and Industrial Residues 347\u003c\/p\u003e \u003cp\u003e13.5.2 Microbial Iron Reduction for Dissolution of Mineral Oxides 348\u003c\/p\u003e \u003cp\u003e13.5.3 Biomining Goes Underground – \u003ci\u003eIn Situ \u003c\/i\u003eLeaching as a Green Mining Technology? 348\u003c\/p\u003e \u003cp\u003eReferences 351\u003c\/p\u003e \u003cp\u003eFurther Reading 351\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Wastewater Treatment Processes \u003c\/b\u003e\u003cb\u003e353\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eClaudia Gallert and Josef Winter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 354\u003c\/p\u003e \u003cp\u003e14.1.1 Historical Development of Sewage Treatment 354\u003c\/p\u003e \u003cp\u003e14.1.2 Resources from Wastewater Treatment 357\u003c\/p\u003e \u003cp\u003e14.1.3 Wastewater and Storm Water Drainage 358\u003c\/p\u003e \u003cp\u003e14.1.4 Wastewater Characterization and Processes for Effective Wastewater Treatment 358\u003c\/p\u003e \u003cp\u003e14.1.5 Suspended or Immobilized Bacteria as Biocatalysts for Effective Sewage Treatment 360\u003c\/p\u003e \u003cp\u003e14.2 Biological Basics of Carbon, Nitrogen, and Phosphorus Removal from Sewage 362\u003c\/p\u003e \u003cp\u003e14.2.1 Aerobic and Anaerobic Degradation of Carbon Compounds 362\u003c\/p\u003e \u003cp\u003e14.2.1.1 Mass and Energy Balance 366\u003c\/p\u003e \u003cp\u003e14.2.2 Fundamentals of Nitrification 368\u003c\/p\u003e \u003cp\u003e14.2.3 Elimination of Nitrate by Denitrification 371\u003c\/p\u003e \u003cp\u003e14.2.4 New Nitrogen Elimination Processes 371\u003c\/p\u003e \u003cp\u003e14.2.5 Microbial Phosphate Elimination 372\u003c\/p\u003e \u003cp\u003e14.3 Wastewater Treatment Processes 374\u003c\/p\u003e \u003cp\u003e14.3.1 Typical Process Sequence in Municipal Sewage Treatment Plants 374\u003c\/p\u003e \u003cp\u003e14.3.2 Activated Sludge Process 376\u003c\/p\u003e \u003cp\u003e14.3.3 Trickling Filters 378\u003c\/p\u003e \u003cp\u003e14.3.4 Technical Options for Denitrification 379\u003c\/p\u003e \u003cp\u003e14.3.5 Biological Phosphate Elimination 381\u003c\/p\u003e \u003cp\u003e14.3.6 Sewage Sludge Treatment 382\u003c\/p\u003e \u003cp\u003e14.3.6.1 Aerobic and Anaerobic Sewage Sludge Treatment 382\u003c\/p\u003e \u003cp\u003e14.3.6.2 Sanitation and Quality Assurance of Sewage Sludge 384\u003c\/p\u003e \u003cp\u003e14.4 Advanced Wastewater Treatment 384\u003c\/p\u003e \u003cp\u003e14.4.1 Elimination of Micropollutants 385\u003c\/p\u003e \u003cp\u003e14.4.2 Wastewater Disinfection 385\u003c\/p\u003e \u003cp\u003e14.5 Future Perspectives 386\u003c\/p\u003e \u003cp\u003eReferences 386\u003c\/p\u003e \u003cp\u003eFurther Reading 388\u003c\/p\u003e \u003cp\u003eIndex 389\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":48743119454551,"sku":"9783527340354","price":52.7,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527340354.jpg?v=1720064195"},{"product_id":"fundamentals-of-ionizing-radiation-dosimetry-textbook-and-solutions-9783527343539","title":"Fundamentals of Ionizing Radiation Dosimetry:","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eThe textbook \"Fundamentals of Ionizing Radition Dosimetry\" bundled with the workbook containing solutions to the exercises is the perfect pair for anyone seriously interested in radiation dosimetry.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eBackground and Essentials\u003cbr\u003e Charged-Particle Interactions with Matter\u003cbr\u003e Uncharged-Particle Interactions with Matter\u003cbr\u003e Field and Dosimetric Quantities, Radiation Equilibrium\u003cbr\u003e Elementary Aspects of the Attenuation of Uncharged Particles\u003cbr\u003e Macroscopic Aspects of the Transport of Radiation through Matter\u003cbr\u003e Characterization of Radiation Quality\u003cbr\u003e Monte Carlo Simulation of the Transport of Radiation through Matter\u003cbr\u003e Cavity Theory\u003cbr\u003e Overview of Radiation Detectors and Measurements\u003cbr\u003e Primary Radiation Standards\u003cbr\u003e Ionization Chambers\u003cbr\u003e Chemical Dosimeters\u003cbr\u003e Solid State Detector Dosimetry\u003cbr\u003e Reference Dosimetry for External Beam Radiation Therapy\u003cbr\u003e Dosimetry for Small and Composite Radiotherapy Photon Beams\u003cbr\u003e Reference Dosimetry for Diagnostic and Interventional Radiology\u003cbr\u003e Absorbed Dose Determination for Radionuclides\u003cbr\u003e Neutron Dosimetry\u003cbr\u003e \u003cbr\u003e Workbook:\u003cbr\u003e SOLUTIONS","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":48743120372055,"sku":"9783527343539","price":130.86,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527343539.jpg?v=1720064198"},{"product_id":"chemistry-and-biology-of-non-canonical-nucleic-acids-9783527345212","title":"Chemistry and Biology of Non-canonical Nucleic","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eDiscover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource\u003cbr\u003e \u003cbr\u003e Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more.\u003cbr\u003e \u003cbr\u003e An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry.\u003cbr\u003e \u003cbr\u003e Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including:\u003cbr\u003e \u003cbr\u003e * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures\u003cbr\u003e * The role played by nucleic acid structures in neurodegenerative diseases and various cancers\u003cbr\u003e * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids\u003cbr\u003e * An introduction to the history of canonical and non-canonical structures of nucleic acids\u003cbr\u003e * An analysis of the physicochemical properties of non-canonical nucleic acids\u003cbr\u003e \u003cbr\u003e Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 History for Canonical and Non-canonical Structures of Nucleic Acids \u003c\/b\u003e\u003cb\u003e1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 History of Duplex 1\u003c\/p\u003e \u003cp\u003e1.3 Non-Watson–Crick Base Pair 5\u003c\/p\u003e \u003cp\u003e1.4 Nucleic Acid Structures Including Non-Watson–Crick Base Pairs 7\u003c\/p\u003e \u003cp\u003e1.5 Perspective of the Research for Non-canonical Nucleic Acid Structures 8\u003c\/p\u003e \u003cp\u003e1.6 Conclusion and Perspective 9\u003c\/p\u003e \u003cp\u003eReferences 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Structures of Nucleic Acids Now \u003c\/b\u003e\u003cb\u003e11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 11\u003c\/p\u003e \u003cp\u003e2.2 Unusual Base Pairs in a Duplex 11\u003c\/p\u003e \u003cp\u003e2.2.1 Hoogsteen Base Pair 13\u003c\/p\u003e \u003cp\u003e2.2.2 Purine–Pyrimidine Mismatches 13\u003c\/p\u003e \u003cp\u003e2.2.3 Purine–Purine Mismatches 14\u003c\/p\u003e \u003cp\u003e2.2.4 Pyrimidine–Pyrimidine Mismatches 16\u003c\/p\u003e \u003cp\u003e2.3 Non-canonical Backbone Shapes in DNA Duplex 17\u003c\/p\u003e \u003cp\u003e2.4 Branched DNA with Junction 19\u003c\/p\u003e \u003cp\u003e2.5 Multi-stranded DNA Helices 20\u003c\/p\u003e \u003cp\u003e2.6 Structures in RNA 20\u003c\/p\u003e \u003cp\u003e2.6.1 Basic Structure Distinctions of RNA 20\u003c\/p\u003e \u003cp\u003e2.6.2 Elements in RNA Secondary Structures 21\u003c\/p\u003e \u003cp\u003e2.6.2.1 Hairpin Loop 22\u003c\/p\u003e \u003cp\u003e2.6.2.2 Bulge Loop 22\u003c\/p\u003e \u003cp\u003e2.6.2.3 Internal Loop 23\u003c\/p\u003e \u003cp\u003e2.6.3 Elements in Tertiary Interactions of RNA 24\u003c\/p\u003e \u003cp\u003e2.6.3.1 A-Minor Interactions 25\u003c\/p\u003e \u003cp\u003e2.6.3.2 Ribose Zipper 25\u003c\/p\u003e \u003cp\u003e2.6.3.3 T-Loop Motif 26\u003c\/p\u003e \u003cp\u003e2.6.3.4 Kissing-Loop Interaction 26\u003c\/p\u003e \u003cp\u003e2.6.3.5 GNRA Tetraloop Receptor Interaction 27\u003c\/p\u003e \u003cp\u003e2.6.3.6 Pseudoknot Crosslinking Distant Stem Regions 29\u003c\/p\u003e \u003cp\u003e2.7 Conclusion 29\u003c\/p\u003e \u003cp\u003eReferences 30\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Stability of Non-canonical Nucleic Acids \u003c\/b\u003e\u003cb\u003e33\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 33\u003c\/p\u003e \u003cp\u003e3.2 Factors Influencing Stabilities of the Canonical Duplexes 34\u003c\/p\u003e \u003cp\u003e3.2.1 Hydrogen Bond Formations 34\u003c\/p\u003e \u003cp\u003e3.2.2 Stacking Interactions 35\u003c\/p\u003e \u003cp\u003e3.2.3 Conformational Entropy 35\u003c\/p\u003e \u003cp\u003e3.3 Thermodynamic Analysis for the Formation of Duplex 36\u003c\/p\u003e \u003cp\u003e3.4 Factors Influencing Stabilities of the Non-canonical Nucleic Acids 39\u003c\/p\u003e \u003cp\u003e3.4.1 Factors Influencing Stability of Triplexes 39\u003c\/p\u003e \u003cp\u003e3.4.2 Factors Influencing Stability of Quadruplex 42\u003c\/p\u003e \u003cp\u003e3.4.2.1 G-Quadruplexes 42\u003c\/p\u003e \u003cp\u003e3.4.2.2 i-Motif 44\u003c\/p\u003e \u003cp\u003e3.5 Thermodynamic Analysis for the Non-canonical Nucleic Acids 45\u003c\/p\u003e \u003cp\u003e3.5.1 Thermodynamic Analysis for the Intramolecular Triplex and Tetraplex 45\u003c\/p\u003e \u003cp\u003e3.5.2 Thermodynamic Analysis for the Intermolecular Triplex 45\u003c\/p\u003e \u003cp\u003e3.5.3 Thermodynamic Analysis for the Tetraplex 46\u003c\/p\u003e \u003cp\u003e3.6 Conclusion 48\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Physicochemical Properties of Non-canonical Nucleic Acids \u003c\/b\u003e\u003cb\u003e51\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 51\u003c\/p\u003e \u003cp\u003e4.2 Spectroscopic Properties of Non-canonical Nucleic Acids 51\u003c\/p\u003e \u003cp\u003e4.2.1 Effect of Non-canonical Structure on UV Absorption 51\u003c\/p\u003e \u003cp\u003e4.2.2 Circular Dichroism of Non-canonical Nucleic Acids 53\u003c\/p\u003e \u003cp\u003e4.2.3 NMR Spectroscopy 56\u003c\/p\u003e \u003cp\u003e4.2.4 Other Spectroscopic Characteristics of Non-canonical Nucleic Acids 57\u003c\/p\u003e \u003cp\u003e4.3 Chemical Interactions on Non-canonical Nucleic Acids 59\u003c\/p\u003e \u003cp\u003e4.3.1 Hydration 59\u003c\/p\u003e \u003cp\u003e4.3.2 Cation Binding 61\u003c\/p\u003e \u003cp\u003e4.3.3 pH Effect 62\u003c\/p\u003e \u003cp\u003e4.3.4 Chemical Modification 63\u003c\/p\u003e \u003cp\u003e4.4 Chemical Platform on the Non-canonical Structures 64\u003c\/p\u003e \u003cp\u003e4.4.1 Specificity of a Ligand to Non-canonical Structures 64\u003c\/p\u003e \u003cp\u003e4.4.2 Fluorescence Platform of Non-canonical Structures 67\u003c\/p\u003e \u003cp\u003e4.4.3 Interface Between Proteins and Nucleic Acids 68\u003c\/p\u003e \u003cp\u003e4.5 Physicochemical Property of Non-canonical Nucleic Acids in Cell 69\u003c\/p\u003e \u003cp\u003e4.5.1 Molecular Crowding Condition that Reflects Cellular Environments 69\u003c\/p\u003e \u003cp\u003e4.5.2 Effects of Crowding Reagents on Non-canonical Nucleic Acid Structures 70\u003c\/p\u003e \u003cp\u003e4.5.3 Quantification of Physical Properties of Non-canonical Structures in Crowding Condition 71\u003c\/p\u003e \u003cp\u003e4.5.4 Non-canonical Structures Under Mimicking Organelle Environment 72\u003c\/p\u003e \u003cp\u003e4.5.5 Insight for the Formation of Non-canonical Nucleic Acids in Cells 73\u003c\/p\u003e \u003cp\u003e4.6 Conclusion 75\u003c\/p\u003e \u003cp\u003eReferences 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Telomere \u003c\/b\u003e\u003cb\u003e79\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 79\u003c\/p\u003e \u003cp\u003e5.2 Structural Properties of Telomere 79\u003c\/p\u003e \u003cp\u003e5.2.1 Structures of Telomere 79\u003c\/p\u003e \u003cp\u003e5.2.2 Structural Properties of Human Telomeric G4s 81\u003c\/p\u003e \u003cp\u003e5.2.3 Structure of Repeats of Human Telomeric G4s 84\u003c\/p\u003e \u003cp\u003e5.3 Biological Relevance of Telomere G4 86\u003c\/p\u003e \u003cp\u003e5.3.1 Telomerase Activity 86\u003c\/p\u003e \u003cp\u003e5.3.2 Telomerase Repeated Amplification Protocol (TRAP) Assay 89\u003c\/p\u003e \u003cp\u003e5.3.3 Alternative Lengthening of Telomere (ALT) Mechanism 89\u003c\/p\u003e \u003cp\u003e5.4 Other Non-canonical Structures Related to Telomere Region 89\u003c\/p\u003e \u003cp\u003e5.4.1 Telomere i-Motif 89\u003c\/p\u003e \u003cp\u003e5.4.2 Telomere RNA 90\u003c\/p\u003e \u003cp\u003e5.5 Conclusion 92\u003c\/p\u003e \u003cp\u003eReferences 93\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Transcription \u003c\/b\u003e\u003cb\u003e95\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 95\u003c\/p\u003e \u003cp\u003e6.2 Transcription Process 96\u003c\/p\u003e \u003cp\u003e6.2.1 Transcription Initiation 96\u003c\/p\u003e \u003cp\u003e6.2.2 Transcription Elongation 98\u003c\/p\u003e \u003cp\u003e6.2.3 Transcription Termination 99\u003c\/p\u003e \u003cp\u003e6.3 Transcription Process Perturbed by Certain Sequences of DNA and RNA 101\u003c\/p\u003e \u003cp\u003e6.4 Transcription Process Perturbed by Non-canonical Structures of DNA and RNA 103\u003c\/p\u003e \u003cp\u003e6.5 Conclusion 110\u003c\/p\u003e \u003cp\u003eReferences 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Translation \u003c\/b\u003e\u003cb\u003e113\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 113\u003c\/p\u003e \u003cp\u003e7.2 RNAs Involved in Translation Machinery 113\u003c\/p\u003e \u003cp\u003e7.3 General Process of Translation 117\u003c\/p\u003e \u003cp\u003e7.3.1 Translation Initiation 117\u003c\/p\u003e \u003cp\u003e7.3.2 Translation Elongation 119\u003c\/p\u003e \u003cp\u003e7.3.3 Translation Termination 119\u003c\/p\u003e \u003cp\u003e7.4 RNA Structures Affecting Translation Reaction 121\u003c\/p\u003e \u003cp\u003e7.4.1 Modulation of Translation Initiation in Prokaryotes 121\u003c\/p\u003e \u003cp\u003e7.4.2 Modulation of Translation Initiation in Eukaryotes 123\u003c\/p\u003e \u003cp\u003e7.4.3 RNA Structures Affecting Translation Elongation 126\u003c\/p\u003e \u003cp\u003e7.4.4 RNA Structures Affecting Translation Termination 130\u003c\/p\u003e \u003cp\u003e7.5 Conclusion 133\u003c\/p\u003e \u003cp\u003eReferences 134\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Replication \u003c\/b\u003e\u003cb\u003e137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 137\u003c\/p\u003e \u003cp\u003e8.2 Replication Machineries 137\u003c\/p\u003e \u003cp\u003e8.3 Replication Initiation 138\u003c\/p\u003e \u003cp\u003e8.3.1 Mechanism of Activation of Replication Origins 138\u003c\/p\u003e \u003cp\u003e8.3.2 Activation Control of Origins by G4s 139\u003c\/p\u003e \u003cp\u003e8.3.3 Control of Timing of Replication Initiation by G4s 142\u003c\/p\u003e \u003cp\u003e8.4 DNA Strand Elongation 142\u003c\/p\u003e \u003cp\u003e8.4.1 Mechanism of DNA Strand Elongation 142\u003c\/p\u003e \u003cp\u003e8.4.2 Impact of G4 and i-Motif Formations on DNA Strand Synthesis 144\u003c\/p\u003e \u003cp\u003e8.4.3 Relationship Between G4 and Epigenetic Modification 145\u003c\/p\u003e \u003cp\u003e8.4.4 Expansion and Contraction of Replicating Strand Induced by Hairpin Structures 147\u003c\/p\u003e \u003cp\u003e8.5 Termination of Replication 148\u003c\/p\u003e \u003cp\u003e8.6 Chemistry of the Replication and Its Regulation 148\u003c\/p\u003e \u003cp\u003e8.6.1 Cellular Environments 148\u003c\/p\u003e \u003cp\u003e8.6.2 Control of Replication by Chemical Compounds 150\u003c\/p\u003e \u003cp\u003e8.7 Conclusion 151\u003c\/p\u003e \u003cp\u003eReferences 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Helicase \u003c\/b\u003e\u003cb\u003e155\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 155\u003c\/p\u003e \u003cp\u003e9.2 Function and Structure of Helicases 155\u003c\/p\u003e \u003cp\u003e9.3 Unwinding of Non-canonical DNA Structures by Helicases 158\u003c\/p\u003e \u003cp\u003e9.4 G4 Helicases in Gene Expressions 162\u003c\/p\u003e \u003cp\u003e9.5 G4 Helicases in Replication 163\u003c\/p\u003e \u003cp\u003e9.6 G4 Helicases in Telomere Maintenance 164\u003c\/p\u003e \u003cp\u003e9.7 Relation to Diseases by Loss of G4 Helicases 165\u003c\/p\u003e \u003cp\u003e9.8 Insight into Specific Properties of Activities of G4 Helicase Under Cellular Conditions 165\u003c\/p\u003e \u003cp\u003e9.9 Conclusion 167\u003c\/p\u003e \u003cp\u003eReferences 167\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Dynamic Regulation of Biosystems by Nucleic Acids with Non-canonical Structures \u003c\/b\u003e\u003cb\u003e171\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 171\u003c\/p\u003e \u003cp\u003e10.2 Time Scale of Biological Reactions 171\u003c\/p\u003e \u003cp\u003e10.2.1 Cell Cycle 172\u003c\/p\u003e \u003cp\u003e10.2.2 Central Dogma 172\u003c\/p\u003e \u003cp\u003e10.2.3 Dynamic Structures of Nucleic Acids 174\u003c\/p\u003e \u003cp\u003e10.3 Processes in the Central Dogma Affected by Dynamics of Nucleic Acid Structures 176\u003c\/p\u003e \u003cp\u003e10.3.1 Epigenetic Regulation Caused by Chemical Modification of DNA 176\u003c\/p\u003e \u003cp\u003e10.3.2 Co-transcriptional Formation of Metastable RNA Structures 178\u003c\/p\u003e \u003cp\u003e10.3.3 Co-transcriptional Translation and Transcription Attenuation 180\u003c\/p\u003e \u003cp\u003e10.3.4 Co-transcriptional Ligand Binding and Gene Regulation 181\u003c\/p\u003e \u003cp\u003e10.3.5 Translation Elongation and Co-translational Protein Folding 183\u003c\/p\u003e \u003cp\u003e10.4 Conclusion 184\u003c\/p\u003e \u003cp\u003eReferences 185\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Cancer and Nucleic Acid Structures \u003c\/b\u003e\u003cb\u003e189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 189\u003c\/p\u003e \u003cp\u003e11.2 Detail Mechanism of Cancer 189\u003c\/p\u003e \u003cp\u003e11.2.1 Cancer Incidence 189\u003c\/p\u003e \u003cp\u003e11.2.2 The Relationship Between Genes and Cancer 192\u003c\/p\u003e \u003cp\u003e11.3 Non-canonical Structures of Nucleic Acids in Cancer Cells 192\u003c\/p\u003e \u003cp\u003e11.3.1 Structural Characteristics of Nucleic Acids in Cancer Cells 192\u003c\/p\u003e \u003cp\u003e11.3.2 Non-canonical Structures Perturb Gene Expression of Cancer-Related Genes 195\u003c\/p\u003e \u003cp\u003e11.4 Roles of Non-canonical Structures of Nucleic Acids in Cancer Cells 197\u003c\/p\u003e \u003cp\u003e11.4.1 Monitoring of Non-canonical Structures in Cancer Cells 197\u003c\/p\u003e \u003cp\u003e11.4.2 Regulation of Gene Expressions by the Non-canonical Structures in Cancer Cells 198\u003c\/p\u003e \u003cp\u003e11.5 Conclusion 199\u003c\/p\u003e \u003cp\u003eReferences 199\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Neurodegenerative Diseases and Nucleic Acid Structures \u003c\/b\u003e\u003cb\u003e203\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 203\u003c\/p\u003e \u003cp\u003e12.2 Protein Aggregation-Induced Neurodegenerative Diseases 203\u003c\/p\u003e \u003cp\u003e12.3 DNA Shows Key Role for Neurodegenerative Diseases 205\u003c\/p\u003e \u003cp\u003e12.4 RNA Toxic Plays a Key Role for Neurological Diseases 210\u003c\/p\u003e \u003cp\u003e12.5 Conclusion 212\u003c\/p\u003e \u003cp\u003eReferences 212\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Therapeutic Applications \u003c\/b\u003e\u003cb\u003e215\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 215\u003c\/p\u003e \u003cp\u003e13.2 Oligonucleotide Therapeutics 216\u003c\/p\u003e \u003cp\u003e13.2.1 Antisense Oligonucleotide 216\u003c\/p\u003e \u003cp\u003e13.2.2 Functions of Antisense Oligonucleotide Therapeutics 217\u003c\/p\u003e \u003cp\u003e13.2.3 Chemical Modifications in Therapeutic Oligonucleotides 220\u003c\/p\u003e \u003cp\u003e13.2.3.1 Backbone Modified Oligonucleotides 220\u003c\/p\u003e \u003cp\u003e13.2.3.2 Ribose Modified Oligonucleotides 221\u003c\/p\u003e \u003cp\u003e13.2.3.3 Oligonucleotides with Unnatural Backbone 221\u003c\/p\u003e \u003cp\u003e13.2.4 Oligonucleotide Therapeutics Other Than Antisense Oligonucleotide 223\u003c\/p\u003e \u003cp\u003e13.2.4.1 Oligonucleotide Therapeutics Functioning Through RNA Interference 224\u003c\/p\u003e \u003cp\u003e13.2.4.2 Oligonucleotide Therapeutics Functioning Through Binding to Protein 224\u003c\/p\u003e \u003cp\u003e13.3 Non-canonical Nucleic Acid Structures as Therapeutic Targets 224\u003c\/p\u003e \u003cp\u003e13.3.1 Traditional Antibiotics Targeting Structured Region of RNAs 225\u003c\/p\u003e \u003cp\u003e13.3.2 Strategies for Constructing Therapeutic Materials Targeting Structured Nucleic Acids 226\u003c\/p\u003e \u003cp\u003e13.4 Non-canonical Nucleic Acid Materials for Inducing Non-canonical Structures 230\u003c\/p\u003e \u003cp\u003e13.5 Conclusion 231\u003c\/p\u003e \u003cp\u003eReferences 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Materials Science and Nanotechnology of Nucleic Acids \u003c\/b\u003e\u003cb\u003e235\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 235\u003c\/p\u003e \u003cp\u003e14.2 Non-canonical Structure-Based Nanomaterials Resembling Protein Functions 235\u003c\/p\u003e \u003cp\u003e14.2.1 Aptamer 235\u003c\/p\u003e \u003cp\u003e14.2.2 DNAzyme 238\u003c\/p\u003e \u003cp\u003e14.2.3 Ion Channel 240\u003c\/p\u003e \u003cp\u003e14.3 Protein Engineering Using G4-Binding Protein 240\u003c\/p\u003e \u003cp\u003e14.4 Regulation of Gene Expression by G4-Inducing Materials 242\u003c\/p\u003e \u003cp\u003e14.5 Environmental Sensing 246\u003c\/p\u003e \u003cp\u003e14.5.1 Sensing Temperature in Cells 246\u003c\/p\u003e \u003cp\u003e14.5.2 Sensing pH in Cells 248\u003c\/p\u003e \u003cp\u003e14.5.3 Sensing K+ Ion in Cells 248\u003c\/p\u003e \u003cp\u003e14.5.4 Sensing Crowding Condition in Cells 249\u003c\/p\u003e \u003cp\u003e14.6 Conclusion 250\u003c\/p\u003e \u003cp\u003eReferences 250\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Future Outlook for Chemistry and Biology of Non-canonical Nucleic Acids \u003c\/b\u003e\u003cb\u003e253\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 253\u003c\/p\u003e \u003cp\u003e15.2 Exploring Potential: Properties of Non-canonical Structures in Unusual Media 253\u003c\/p\u003e \u003cp\u003e15.3 Systemizing Properties: Prediction of the Formation of Non-canonical Nucleic Acids Structures 259\u003c\/p\u003e \u003cp\u003e15.4 Advancing Technology: Applications of Non-canonical Structures Taking Concurrent Reactions into Account 262\u003c\/p\u003e \u003cp\u003e15.4.1 Co-transcriptional Dynamics of G-Quadruplex 263\u003c\/p\u003e \u003cp\u003e15.4.2 Co-transcriptional Functionalization of Riboswitch-Like Sensor 263\u003c\/p\u003e \u003cp\u003e15.4.3 Co-transcriptional RNA Capturing for Selection of Functional RNAs 266\u003c\/p\u003e \u003cp\u003e15.5 Conclusion 267\u003c\/p\u003e \u003cp\u003eReferences 268\u003c\/p\u003e \u003cp\u003eIndex 271\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":48743121355095,"sku":"9783527345212","price":102.56,"currency_code":"GBP","in_stock":false}]},{"product_id":"point-of-care-biosensors-for-infectious-diseases-9783527350452","title":"Point-of-Care Biosensors for Infectious Diseases","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cb\u003ePoint-of-Care Biosensors for Infectious Diseases\u003c\/b\u003e \u003cp\u003e\u003cb\u003eComprehensive resource covering key developments in biosensor-based diagnostics for infectious diseases\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eWith its overview of currently available technologies, \u003ci\u003ePoint-of-Care Biosensors for Infectious Diseases\u003c\/i\u003e serves as a starting point for the successful development and application of pathogen biosensors in a point-of-care setting. Here, expert authors review current challenges in pathogen detection and the selection of suitable biomarkers, detail currently available biosensor platforms including electrochemical, piezoelectric, magnetic, and optical sensors, and cover technology development for point-of-care biosensors for viral, bacterial, and parasitic infections. \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePoint-of-Care Biosensors for Infectious Diseases\u003c\/i\u003e covers key topics such as: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eFundamentals of biosensor detection, with a focus on optical and electrochemical techniques\u003c\/li\u003e\n\u003cli\u003eOrganic and inorganic based nanomaterials for healthcare diagnostics\u003c\/li\u003e\n\u003cli\u003eStrategies for miniaturizing biosensor devices, and state-of-the-art integrated sensing platforms\u003c\/li\u003e\n\u003cli\u003eLatest trends in point-of-care biosensing systems to detect, diagnose, and monitor infectious diseases\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eProviding comprehensive coverage of the subject, \u003ci\u003ePoint-of-Care Biosensors for Infectious Diseases\u003c\/i\u003e is an excellent reference for all developers, researchers, and technology managers in the areas of molecular diagnosis, infectious diseases, biosensors, and related fields.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Biosensors for Infectious Diseases-Fundamentals 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMaheswata Moharana, Subrat K. Pattanayak, Fahmida Khan, and Sushma Dave\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Biosensors Fundamental Aspects 2\u003c\/p\u003e \u003cp\u003e1.3 Classifications of Biosensor 3\u003c\/p\u003e \u003cp\u003e1.3.1 Biorecognition Perspective 3\u003c\/p\u003e \u003cp\u003e1.3.1.1 Nucleic Acid Biosensors 3\u003c\/p\u003e \u003cp\u003e1.3.1.2 Protein–Receptor Biosensor 5\u003c\/p\u003e \u003cp\u003e1.3.1.3 Enzymatic Biosensor 5\u003c\/p\u003e \u003cp\u003e1.3.1.4 Whole-Cells Biosensors 5\u003c\/p\u003e \u003cp\u003e1.3.1.5 Antibody-Based Biosensor 6\u003c\/p\u003e \u003cp\u003e1.4 Transduction Through Signals 6\u003c\/p\u003e \u003cp\u003e1.4.1 Electrochemical Biosensors 6\u003c\/p\u003e \u003cp\u003e1.4.2 Optical 6\u003c\/p\u003e \u003cp\u003e1.4.3 Thermometric (Calorimetric) 7\u003c\/p\u003e \u003cp\u003e1.4.4 Mass-Sensitive 7\u003c\/p\u003e \u003cp\u003e1.4.5 Electrical 8\u003c\/p\u003e \u003cp\u003e1.5 Conclusions 8\u003c\/p\u003e \u003cp\u003eReferences 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Nuts and Bolts of Modern Biosensing Technology: Smart Health Diagnostic Devices 15\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eItthipon Jeerapan, Gabriela Valdés-Ramírez, and Barbara Brunetti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 15\u003c\/p\u003e \u003cp\u003e2.2 Nuts and Bolts for Point-of-Care (POC) Biosensor-Based Testing 17\u003c\/p\u003e \u003cp\u003e2.2.1 Analytes 18\u003c\/p\u003e \u003cp\u003e2.2.2 Receptors and Sensing Elements 18\u003c\/p\u003e \u003cp\u003e2.2.3 Transducer 20\u003c\/p\u003e \u003cp\u003e2.2.4 Signal Processing Unit 21\u003c\/p\u003e \u003cp\u003e2.3 Advances in Biosensing Technology 21\u003c\/p\u003e \u003cp\u003e2.3.1 Advanced Sensors for Detecting Pathogens 21\u003c\/p\u003e \u003cp\u003e2.3.1.1 Biosensors for Bacteria Detection 22\u003c\/p\u003e \u003cp\u003e2.3.1.2 Biosensors for Detecting Viruses 26\u003c\/p\u003e \u003cp\u003e2.3.2 Advanced Biosensors for Monitoring Metabolites 33\u003c\/p\u003e \u003cp\u003e2.4 Conclusion and Prospects 40\u003c\/p\u003e \u003cp\u003eReferences 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Disease Related Detection with Electrochemical Biosensors 49\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAnulipsa Priyadarshini, Niharika Das, Saraswati Soren, Jashobanta Sahoo, Raghabendra Samantray, and Rojalin Sahu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 49\u003c\/p\u003e \u003cp\u003e3.2 Electrochemical Biosensors 50\u003c\/p\u003e \u003cp\u003e3.2.1 Materials 51\u003c\/p\u003e \u003cp\u003e3.2.2 Working Principle 53\u003c\/p\u003e \u003cp\u003e3.3 Immobilization of Different Biomolecules 54\u003c\/p\u003e \u003cp\u003e3.4 Different Types of Techniques Used in EC Biosensors for Detection of Various Diseases 55\u003c\/p\u003e \u003cp\u003e3.4.1 Voltametric Biosensor 55\u003c\/p\u003e \u003cp\u003e3.4.2 Electrochemical DNA Biosensors 56\u003c\/p\u003e \u003cp\u003e3.4.3 Impedance Biosensors 58\u003c\/p\u003e \u003cp\u003e3.4.4 Amperometric Biosensors 58\u003c\/p\u003e \u003cp\u003e3.4.5 Potentiometric Biosensors 60\u003c\/p\u003e \u003cp\u003e3.4.6 Electrochemical Immunosensor 61\u003c\/p\u003e \u003cp\u003e3.5 Conclusion and Future Direction 62\u003c\/p\u003e \u003cp\u003eReferences 63\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Biosensors for Point-of-Care (POC) Applications 69\u003cbr\u003e \u003c\/b\u003eThe Flag Bearer of the Modern Medicinal Technology to Tackle Infectious Diseases\u003cbr\u003e \u003ci\u003eSumit Kumar, Garima Rathee, Gaurav Bartwal, and Pratima R. Solanki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 69\u003c\/p\u003e \u003cp\u003e4.2 Classification of POC Biosensors for Detection of Infectious Diseases 71\u003c\/p\u003e \u003cp\u003e4.2.1 Electrochemical-Based Biosensor 71\u003c\/p\u003e \u003cp\u003e4.2.2 Fluorescence-Based Biosensor 72\u003c\/p\u003e \u003cp\u003e4.2.2.1 Direct Fluorescence Biosensors for Infectious Diseases 72\u003c\/p\u003e \u003cp\u003e4.2.2.2 Signal-on\/off Fluorescent Biosensors for Infectious Disease POC Diagnostics 73\u003c\/p\u003e \u003cp\u003e4.2.3 Surface Plasmon Resonance (SPR)-Based Biosensor 73\u003c\/p\u003e \u003cp\u003e4.2.4 Surface-Enhanced Raman Scattering (SERS)-Based Biosensor 73\u003c\/p\u003e \u003cp\u003e4.2.5 Chemiluminescence-Based Biosensor 74\u003c\/p\u003e \u003cp\u003e4.2.6 Colorimetric-Based Biosensors 74\u003c\/p\u003e \u003cp\u003e4.2.7 Magnetic-Based Biosensors 74\u003c\/p\u003e \u003cp\u003e4.3 Modern Devices for the Detection of Infectious Diseases 75\u003c\/p\u003e \u003cp\u003e4.3.1 Lab-on-a-Chip Devices and Lab-on-a-Disc Devices 75\u003c\/p\u003e \u003cp\u003e4.3.2 Microfluidic Paper-Based Analytical and Lateral Flow Devices 76\u003c\/p\u003e \u003cp\u003e4.3.3 Miniaturized PCR and Isothermal Nucleic Acid Amplification Devices 78\u003c\/p\u003e \u003cp\u003e4.4 Scope and Challenges Associated with the Next-Generation POC Devices 79\u003c\/p\u003e \u003cp\u003e4.5 Conclusion 79\u003c\/p\u003e \u003cp\u003eReferences 80\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Organic- and Inorganic-Based Nanomaterials for Healthcare Diagnostics 87\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eKomal Kashyap, Maheswata Moharana, Fahmida Khan, and Subrat K. Pattanayak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 87\u003c\/p\u003e \u003cp\u003e5.2 Nanomaterials Based on Carbon Allotropes in Healthcare 88\u003c\/p\u003e \u003cp\u003e5.3 Inorganic Nanomaterials in Health Diagnosis 91\u003c\/p\u003e \u003cp\u003e5.4 Organic Nanomaterials in Healthcare Diagnosis 92\u003c\/p\u003e \u003cp\u003e5.5 Future Prospects 95\u003c\/p\u003e \u003cp\u003eReferences 95\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 CRISPR\/Cas System 101\u003cbr\u003e \u003c\/b\u003eApplications in Diagnosis of Infectious Diseases\u003cbr\u003e \u003ci\u003eDeepak Kumar Sahel and Mohd Azhar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 101\u003c\/p\u003e \u003cp\u003e6.2 Nucleic Acids: Role in the Diagnosis 102\u003c\/p\u003e \u003cp\u003e6.2.1 Deoxyribonucleic Acids 103\u003c\/p\u003e \u003cp\u003e6.2.2 Ribonucleic Acids 103\u003c\/p\u003e \u003cp\u003e6.3 Nucleic Acid Biomarkers in Infectious Diseases 104\u003c\/p\u003e \u003cp\u003e6.4 Nucleic Acid Detection and Limitations 106\u003c\/p\u003e \u003cp\u003e6.5 CRISPR\/Cas System 108\u003c\/p\u003e \u003cp\u003e6.5.1 Characteristics Features of Different Cas Effectors 110\u003c\/p\u003e \u003cp\u003e6.5.2 CRISPR in Diagnostics 111\u003c\/p\u003e \u003cp\u003e6.5.2.1 Cas9-Based Detection 112\u003c\/p\u003e \u003cp\u003e6.5.2.2 Cas12-Based Detection 112\u003c\/p\u003e \u003cp\u003e6.5.2.3 Cas13-Based Detection 116\u003c\/p\u003e \u003cp\u003e6.5.2.4 Other Cas Effectors-Based Detection 117\u003c\/p\u003e \u003cp\u003e6.6 Conclusion and Prospects 119\u003c\/p\u003e \u003cp\u003eReferences 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Role of Piezoelectric Biosensors 129\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJaykishon Swain, Subrat Swain, Durgesh Singh, Anirudha Jena, Raghabendra Samantaray, and Rojalin Sahu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 129\u003c\/p\u003e \u003cp\u003e7.2 Types of Piezoelectric Biosensors 131\u003c\/p\u003e \u003cp\u003e7.2.1 Inorganic Piezoelectric Material 131\u003c\/p\u003e \u003cp\u003e7.2.2 Organic Piezoelectric Biosensors 133\u003c\/p\u003e \u003cp\u003e7.3 Application of Piezoelectric Biosensor Devices 135\u003c\/p\u003e \u003cp\u003e7.3.1 Immunosensors Based on Piezoelectric Material 135\u003c\/p\u003e \u003cp\u003e7.3.2 Piezoelectric Device with Molecularly Imprinted Polymers 137\u003c\/p\u003e \u003cp\u003e7.3.3 Piezoelectric Biosensors for Genetic Information 138\u003c\/p\u003e \u003cp\u003e7.4 Conclusion 139\u003c\/p\u003e \u003cp\u003eReferences 140\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Metal\/Metal Oxide Nanoparticles-Based Biosensors for Detection of Infectious Diseases 147\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDipak Maity, Gajiram Murmu, Satya R. Sahoo, Ankur Tiwari, Siddharth Ajith, and Sumit Saha\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 147\u003c\/p\u003e \u003cp\u003e8.2 Biosensors 148\u003c\/p\u003e \u003cp\u003e8.2.1 Electrochemical Biosensors 148\u003c\/p\u003e \u003cp\u003e8.2.2 Colorimetric Biosensors 150\u003c\/p\u003e \u003cp\u003e8.2.3 Fluorescence Biosensors 151\u003c\/p\u003e \u003cp\u003e8.3 Types of Infectious Diseases 153\u003c\/p\u003e \u003cp\u003e8.4 Nanoparticles-Based Biosensors 156\u003c\/p\u003e \u003cp\u003e8.4.1 Recognition of Pathogens 157\u003c\/p\u003e \u003cp\u003e8.4.2 Metal\/Metal Oxide Nanoparticles-Based Biosensors 157\u003c\/p\u003e \u003cp\u003e8.4.2.1 Gold Nanoparticles 158\u003c\/p\u003e \u003cp\u003e8.4.2.2 Magnetic Nanoparticles 158\u003c\/p\u003e \u003cp\u003e8.4.2.3 Quantum Dots 159\u003c\/p\u003e \u003cp\u003e8.4.2.4 Other Metal\/Metal Oxide Nanoparticles 160\u003c\/p\u003e \u003cp\u003e8.5 Metal\/Metal Oxide Nanoparticles-Based Biosensors used for Infectious Diseases 160\u003c\/p\u003e \u003cp\u003e8.5.1 Gold Nanoparticles (AuNPs) 161\u003c\/p\u003e \u003cp\u003e8.5.2 Silver Nanoparticles (AgNPs) 163\u003c\/p\u003e \u003cp\u003e8.5.3 Platinum Nanoparticles (PtNPs) 164\u003c\/p\u003e \u003cp\u003e8.5.4 Copper Nanoparticles (CuNPs) 165\u003c\/p\u003e \u003cp\u003e8.5.5 Zinc Oxide Nanoparticles (ZnONPs) 166\u003c\/p\u003e \u003cp\u003e8.5.6 Miscellaneous Metal Oxide Nanoparticles 167\u003c\/p\u003e \u003cp\u003e8.6 Comparative Studies of Biosensors for Infectious Diseases: Advantages and Limitations 171\u003c\/p\u003e \u003cp\u003e8.6.1 Electrochemical Biosensors 171\u003c\/p\u003e \u003cp\u003e8.6.2 Fluorescence-Based Biosensors 172\u003c\/p\u003e \u003cp\u003e8.6.3 Colorimetric Biosensors 172\u003c\/p\u003e \u003cp\u003e8.7 Conclusion and Future Prospects 173\u003c\/p\u003e \u003cp\u003eAcknowledgment 174\u003c\/p\u003e \u003cp\u003eReferences 174\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Biosensors for Point-of-Care Applications: Replacing Pathology Labs by Bedside Devices 187\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMayukh Sinha, Sayak Banerjee, Sambit Majumdar, and Arindam Kushagra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 187\u003c\/p\u003e \u003cp\u003e9.2 POCT Relevance in Healthcare 187\u003c\/p\u003e \u003cp\u003e9.3 Self-Blood Glucose Monitoring 189\u003c\/p\u003e \u003cp\u003e9.3.1 Introduction 189\u003c\/p\u003e \u003cp\u003e9.3.2 Requirements for Self-Glucose Monitoring Device 189\u003c\/p\u003e \u003cp\u003e9.3.3 Types of Sensor-Based Monitoring System 189\u003c\/p\u003e \u003cp\u003e9.3.3.1 Continuous Glucose Monitoring (CGM) 189\u003c\/p\u003e \u003cp\u003e9.3.3.2 Flash Glucose Monitoring (FGM) 190\u003c\/p\u003e \u003cp\u003e9.4 Methods of Blood Glucose Monitoring 190\u003c\/p\u003e \u003cp\u003e9.4.1 Enzymatic Assay Reaction 190\u003c\/p\u003e \u003cp\u003e9.4.2 Detection Method 191\u003c\/p\u003e \u003cp\u003e9.4.3 Errors Occuring in Blood Glucose Monitoring 191\u003c\/p\u003e \u003cp\u003e9.4.4 POCT for Blood Glucose Monitoring 191\u003c\/p\u003e \u003cp\u003e9.5 Blood Gas Analysis 192\u003c\/p\u003e \u003cp\u003e9.5.1 Introduction 192\u003c\/p\u003e \u003cp\u003e9.5.2 Methodologies 192\u003c\/p\u003e \u003cp\u003e9.5.3 Electrochemical Sensors 192\u003c\/p\u003e \u003cp\u003e9.5.4 Optical Sensors 192\u003c\/p\u003e \u003cp\u003e9.5.5 Measurement of the Blood Gas Parameters 193\u003c\/p\u003e \u003cp\u003e9.5.6 pH 193\u003c\/p\u003e \u003cp\u003e9.5.7 PaCO\u003csub\u003e2\u003c\/sub\u003e 193\u003c\/p\u003e \u003cp\u003e9.5.8 PaO\u003csub\u003e2\u003c\/sub\u003e 194\u003c\/p\u003e \u003cp\u003e9.5.9 Glucose and Lactate Metabolites 195\u003c\/p\u003e \u003cp\u003e9.5.9.1 Electrolytes 196\u003c\/p\u003e \u003cp\u003e9.5.9.2 Hemoglobin, Bilirubin 196\u003c\/p\u003e \u003cp\u003e9.5.10 POCT of Blood Gas Analysis 197\u003c\/p\u003e \u003cp\u003e9.6 Urine Analysis 197\u003c\/p\u003e \u003cp\u003e9.6.1 Introduction 197\u003c\/p\u003e \u003cp\u003e9.6.2 Methodologies 198\u003c\/p\u003e \u003cp\u003e9.6.2.1 Urine Dipsticks (Colorimetric Reagent Strip) 198\u003c\/p\u003e \u003cp\u003e9.6.2.2 Lateral Flow Immunoassay (Rapid Test) 198\u003c\/p\u003e \u003cp\u003e9.6.3 Measurement of the Parameters in the Urine Sample 200\u003c\/p\u003e \u003cp\u003e9.6.3.1 Protein 200\u003c\/p\u003e \u003cp\u003e9.6.3.2 Nitrite 201\u003c\/p\u003e \u003cp\u003e9.6.3.3 Leukocytes 201\u003c\/p\u003e \u003cp\u003e9.6.3.4 Bilirubin 201\u003c\/p\u003e \u003cp\u003e9.6.3.5 Urobilinogen 202\u003c\/p\u003e \u003cp\u003e9.6.3.6 Specific Gravity 202\u003c\/p\u003e \u003cp\u003e9.6.3.7 Hemoglobin (Hb) 203\u003c\/p\u003e \u003cp\u003e9.6.3.8 Ketone 203\u003c\/p\u003e \u003cp\u003e9.6.3.9 pH 203\u003c\/p\u003e \u003cp\u003e9.6.3.10 Glucose 203\u003c\/p\u003e \u003cp\u003e9.7 Conclusion 204\u003c\/p\u003e \u003cp\u003eReferences 204\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Strategic Synthesis of Diagnostic Novel Materials Against Infectious Diseases 209\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHardik Shyam Churi and Sushma Dave\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 209\u003c\/p\u003e \u003cp\u003e10.2 Detection Needs at the POC 211\u003c\/p\u003e \u003cp\u003e10.2.1 Nanomaterials for Malaria Parasites Detection 212\u003c\/p\u003e \u003cp\u003e10.2.2 Nanomaterials for HIV 214\u003c\/p\u003e \u003cp\u003e10.2.3 Nanomaterials for HBV 215\u003c\/p\u003e \u003cp\u003e10.2.4 Nanomaterials for HPV 216\u003c\/p\u003e \u003cp\u003e10.2.5 Nanomaterials for Dengue Virus 217\u003c\/p\u003e \u003cp\u003e10.2.6 Nanomaterials for Ebola Virus 217\u003c\/p\u003e \u003cp\u003e10.2.7 Nanomaterials for Mycobacterium Tuberculosis 218\u003c\/p\u003e \u003cp\u003e10.2.8 Nanomaterials for Zika Virus 219\u003c\/p\u003e \u003cp\u003e10.2.9 Nanomaterials for Biomarkers in Infectious Disease POCT 220\u003c\/p\u003e \u003cp\u003e10.2.10 Nanomaterials for Pathogen Nucleic Acids 221\u003c\/p\u003e \u003cp\u003e10.2.11 Nanomaterials for Antibodies and Proteins 222\u003c\/p\u003e \u003cp\u003e10.3 Technology Advancements in Infectious Disease POCT 224\u003c\/p\u003e \u003cp\u003e10.4 Futuristic Developments 224\u003c\/p\u003e \u003cp\u003eReferences 225\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Development of a Diagnostic Kit for Point-of-Care Biosensors: Fundamentals and Applications 235\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eVijay Vaishampayan, Prabir Kulabhushan, Ishita Dasgupta, Ashish Kapoor, and Sarang P. Gumfekar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 235\u003c\/p\u003e \u003cp\u003e11.2 Evolution of Biosensor 236\u003c\/p\u003e \u003cp\u003e11.3 Biosensors for Point-of-Care Sensing 237\u003c\/p\u003e \u003cp\u003e11.3.1 Fundamentals of Biosensor 237\u003c\/p\u003e \u003cp\u003e11.3.2 Bioreceptors in Biosensor 238\u003c\/p\u003e \u003cp\u003e11.3.3 Transducer in Biosensor 240\u003c\/p\u003e \u003cp\u003e11.3.3.1 Electrochemical Biosensor 240\u003c\/p\u003e \u003cp\u003e11.3.3.2 Potentiometric Biosensor 241\u003c\/p\u003e \u003cp\u003e11.3.3.3 Amperometric Biosensor 241\u003c\/p\u003e \u003cp\u003e11.3.3.4 Impedimetric Biosensors 241\u003c\/p\u003e \u003cp\u003e11.3.3.5 Voltammetric Biosensors 241\u003c\/p\u003e \u003cp\u003e11.3.3.6 Optical Biosensor 241\u003c\/p\u003e \u003cp\u003e11.3.3.7 Gravimetric Biosensor 241\u003c\/p\u003e \u003cp\u003e11.3.3.8 Acoustic Biosensors 243\u003c\/p\u003e \u003cp\u003e11.3.4 Materials Used to Fabricate Biosensors 243\u003c\/p\u003e \u003cp\u003e11.3.5 Biosensors for Infectious Diseases 243\u003c\/p\u003e \u003cp\u003e11.3.6 Biosensor for the Detection of Dengue 243\u003c\/p\u003e \u003cp\u003e11.3.7 Biosensors for Tuberculosis 246\u003c\/p\u003e \u003cp\u003e11.3.8 Future Scope 246\u003c\/p\u003e \u003cp\u003e11.4 Conclusion 247\u003c\/p\u003e \u003cp\u003eAcknowledgment 248\u003c\/p\u003e \u003cp\u003eReferences 248\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Lab-on-a-Chip Devices for Point-of-Care Infectious Diseases Diagnostics 255\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSnehal Jani, Vishakha Dave, Medha Pandya, Ranjeet Brajpuriya, and Sushma Dave\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 255\u003c\/p\u003e \u003cp\u003e12.2 Design of Lab-on-a-Chip Devices 257\u003c\/p\u003e \u003cp\u003e12.2.1 Microfluidic Paper-Based Analytical Devices (μPADs) 258\u003c\/p\u003e \u003cp\u003e12.2.1.1 Fabrication of Paper-Based Microfluidic Devices 259\u003c\/p\u003e \u003cp\u003e12.2.2 Chip-Based Microfluidic LOCs 261\u003c\/p\u003e \u003cp\u003e12.2.3 Chip-Based Microfluidic Device Substrate Materials 262\u003c\/p\u003e \u003cp\u003e12.2.4 Fundamentals of Flow of Liquid in Microchannels 262\u003c\/p\u003e \u003cp\u003e12.2.5 Sampling 263\u003c\/p\u003e \u003cp\u003e12.2.6 Diagnostics Material\/Biomarkers in Microfluidic Devices 263\u003c\/p\u003e \u003cp\u003e12.2.7 Signal Generation and Detection 264\u003c\/p\u003e \u003cp\u003e12.2.7.1 Electrochemical Method 264\u003c\/p\u003e \u003cp\u003e12.2.7.2 Magnetic Particle Labeling 265\u003c\/p\u003e \u003cp\u003e12.2.7.3 Optical Detection 265\u003c\/p\u003e \u003cp\u003e12.3 LOC for Diagnosis of Infectious Diseases 266\u003c\/p\u003e \u003cp\u003e12.3.1 LOC for Virus Detection 266\u003c\/p\u003e \u003cp\u003e12.3.2 LOC for Detection of Bacteria 267\u003c\/p\u003e \u003cp\u003e12.3.2.1 Future Perspectives and Conclusion 268\u003c\/p\u003e \u003cp\u003eReferences 270\u003c\/p\u003e \u003cp\u003eIndex 275\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":48743126303063,"sku":"9783527350452","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527350452.jpg?v=1791481956"},{"product_id":"health-physics-radiation-generating-devices-characteristics-and-hazards-9783527411833","title":"Health Physics: Radiation-Generating Devices, Characteristics, and Hazards","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eThe book bridges the gap between existing health physics textbooks and reference material needed by a practicing health physicist as the 21st century progresses. This material necessarily encompasses emerging radiation-generating technologies, advances in existing technology, and applications of existing technology to new areas. The book is written for advanced undergraduate and graduate science and engineering courses. It is also be a useful reference for scientists and engineers.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003ePreface XXI\u003c\/p\u003e \u003cp\u003eAcknowledgments XXV\u003c\/p\u003e \u003cp\u003eA Note on Units XVII\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Overview of Health Physics: Radiation-Generating Devices, Characteristics, and Hazards 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction to Twenty-First Century Health Physics 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Overview of Twenty-First Century Health Physics 3\u003c\/p\u003e \u003cp\u003e1.2 Health Physics Issues, Challenges, and Opportunities 3\u003c\/p\u003e \u003cp\u003e1.3 Forecast of Possible Future Issues 6\u003c\/p\u003e \u003cp\u003eReferences 12\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Nuclear Fuel Cycle Issues 15\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Nuclear Fuel Cycle 17\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Overview 17\u003c\/p\u003e \u003cp\u003e2.2 Basic Fuel Cycle Options 18\u003c\/p\u003e \u003cp\u003e2.3 Overview of the Twentieth-Century Nuclear Fuel Cycle 18\u003c\/p\u003e \u003cp\u003e2.3.1 Uranium Fuel Cycle 19\u003c\/p\u003e \u003cp\u003e2.4 Twenty-First-Century Changes and Innovations 31\u003c\/p\u003e \u003cp\u003e2.5 Nuclear Proliferation 75\u003c\/p\u003e \u003cp\u003e2.6 Twentieth-Century Waste Disposal Options and Solutions 81\u003c\/p\u003e \u003cp\u003e2.7 Twenty-First-Century Fuel Cycle Options 86\u003c\/p\u003e \u003cp\u003eReferences 103\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Accidents and Nuclear Events 109\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Nuclear Accidents and Radiological Emergencies 111\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Overview 111\u003c\/p\u003e \u003cp\u003e3.2 Design Considerations 111\u003c\/p\u003e \u003cp\u003e3.3 Major Reactor Accidents 131\u003c\/p\u003e \u003cp\u003e3.3.2 Chernobyl 133\u003c\/p\u003e \u003cp\u003e3.4 Emergency Preparedness Programs 142\u003c\/p\u003e \u003cp\u003e3.5 Accident Phases 151\u003c\/p\u003e \u003cp\u003e3.6 Emergency Preparedness Effectiveness 152\u003c\/p\u003e \u003cp\u003e3.7 Reprocessing Waste Tanks 162\u003c\/p\u003e \u003cp\u003e3.8 Waste Isolation Pilot Plant Accident 169\u003c\/p\u003e \u003cp\u003eReferences 180\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Nuclear Terrorist Events Including INDs and RDDs 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Overview 187\u003c\/p\u003e \u003cp\u003e4.2 Nuclear Weapons Types 188\u003c\/p\u003e \u003cp\u003e4.3 Nuclear Event Types 190\u003c\/p\u003e \u003cp\u003e4.4 Accident Assumptions 211\u003c\/p\u003e \u003cp\u003e4.5 Radiation Protection Considerations 226\u003c\/p\u003e \u003cp\u003e4.6 Mass Casualty Considerations 240\u003c\/p\u003e \u003cp\u003e4.7 Stakeholder Involvement 240\u003c\/p\u003e \u003cp\u003e4.8 Contamination Remediation 241\u003c\/p\u003e \u003cp\u003eReferences 253\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Nuclear Medicine and Public Health 259\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Nuclear Medicine 261\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Overview 261\u003c\/p\u003e \u003cp\u003e5.2 General Nuclear Medicine Categories 262\u003c\/p\u003e \u003cp\u003e5.3 Side Effects from Radiation Therapy 275\u003c\/p\u003e \u003cp\u003e5.4 Emerging Therapy Approaches 277\u003c\/p\u003e \u003cp\u003e5.6 Nanotechnology 304\u003c\/p\u003e \u003cp\u003e5.7 Other Considerations 330\u003c\/p\u003e \u003cp\u003eReferences 338\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Public Radiation Exposures and Associated Issues 345\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Overview 345\u003c\/p\u003e \u003cp\u003e6.2 Public Radiation Exposures and Associated Effects 345\u003c\/p\u003e \u003cp\u003e6.3 Summary of Doses to the US Population 370\u003c\/p\u003e \u003cp\u003e6.4 Public Dose Limits 370\u003c\/p\u003e \u003cp\u003e6.5 Risk Communication 371\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6.6 Public Involvement in Nuclear Licensing 377\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.7 Litigation 386\u003c\/p\u003e \u003cp\u003e6.8 Environmental Protection 386\u003c\/p\u003e \u003cp\u003e6.9 Unresolved Issues Associated with Major Reactor Accidents 389\u003c\/p\u003e \u003cp\u003eReferences 409\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Regulatory Issues, Limitations, and Challenges 415\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Regulatory Considerations 417\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Overview 417\u003c\/p\u003e \u003cp\u003e7.2 Twentieth-Century Regulatory Challenges 418\u003c\/p\u003e \u003cp\u003e7.3 Twenty-First-Century Regulatory Challenges 426\u003c\/p\u003e \u003cp\u003e7.4 Proactive Vice Reactive Philosophy 432\u003c\/p\u003e \u003cp\u003e7.5 Accident Analysis and Risk Assessment 433\u003c\/p\u003e \u003cp\u003e7.6 Licensing Process and Technical Basis 435\u003c\/p\u003e \u003cp\u003e7.7 National and International Standards 436\u003c\/p\u003e \u003cp\u003e7.8 Accidents Affecting Multiple Nations 439\u003c\/p\u003e \u003cp\u003e7.9 Emergency Response 448\u003c\/p\u003e \u003cp\u003e7.10 Emerging Issues 451\u003c\/p\u003e \u003cp\u003e7.11 US Regulatory Improvements 471\u003c\/p\u003e \u003cp\u003e7.12 Future Power Reactor Directions and Challenges 478\u003c\/p\u003e \u003cp\u003eReferences 490\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI Solutions to Problems 497\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSolutions 499\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VII Appendices 661\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eA Selected Data on Radionuclides of Health Physics Interest 663\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA.1 Introduction 663\u003c\/p\u003e \u003cp\u003eA.2 Alpha Decay 663\u003c\/p\u003e \u003cp\u003eA.3 Beta Decay 663\u003c\/p\u003e \u003cp\u003eA.4 Gamma Emission 668\u003c\/p\u003e \u003cp\u003eA.5 Gamma Emission 668\u003c\/p\u003e \u003cp\u003eA.6 Electron Capture 668\u003c\/p\u003e \u003cp\u003eA.7 Positron Emission 668\u003c\/p\u003e \u003cp\u003eA.8 Spontaneous Fission 668\u003c\/p\u003e \u003cp\u003eReferences 669\u003c\/p\u003e \u003cp\u003e\u003cb\u003eB Production Equations in Health Physics 671\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eB.1 Introduction 671\u003c\/p\u003e \u003cp\u003eB.2 Theory 671\u003c\/p\u003e \u003cp\u003eB.3 Examples of Production Equations 674\u003c\/p\u003e \u003cp\u003eB.3.1 Activation 674\u003c\/p\u003e \u003cp\u003eB.3.2 Demineralizer Activity 675\u003c\/p\u003e \u003cp\u003eB.3.3 Surface Deposition 675\u003c\/p\u003e \u003cp\u003eB.3.4 Release of Radioactive Material into a Room 676\u003c\/p\u003e \u003cp\u003eB.4 Alternative Derivation of the Production Equation 676\u003c\/p\u003e \u003cp\u003eB.5 Conclusions 677\u003c\/p\u003e \u003cp\u003eReferences 677\u003c\/p\u003e \u003cp\u003e\u003cb\u003eC Key Health Physics Relationships 679\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eC.1 Introduction 679\u003c\/p\u003e \u003cp\u003eC.2 Notation and Terminology 679\u003c\/p\u003e \u003cp\u003eC.3 Key Relationships 682\u003c\/p\u003e \u003cp\u003eC.3.1 Activation 682\u003c\/p\u003e \u003cp\u003eC.3.2 Activity 682\u003c\/p\u003e \u003cp\u003eC.3.3 Attenuation 683\u003c\/p\u003e \u003cp\u003eC.3.4 Duty Factor 683\u003c\/p\u003e \u003cp\u003eC.3.5 External Dosimetry 683\u003c\/p\u003e \u003cp\u003eC.3.6 Internal Dosimetry 684\u003c\/p\u003e \u003cp\u003eC.3.7 Dispersion Relationships 684\u003c\/p\u003e \u003cp\u003eC.3.8 Electromagnetic Relationships 684\u003c\/p\u003e \u003cp\u003eC.3.9 Mechanics Relationships 686\u003c\/p\u003e \u003cp\u003eC.3.10 Relationships 687\u003c\/p\u003e \u003cp\u003eC.3.11 Production Equations 687\u003c\/p\u003e \u003cp\u003eC.3.12 Quantum Mechanics 687\u003c\/p\u003e \u003cp\u003eReferences 688\u003c\/p\u003e \u003cp\u003e\u003cb\u003eD Internal Dosimetry 689\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eD.1 Introduction 689\u003c\/p\u003e \u003cp\u003eD.2 Overview of Internal Dosimetry Models 689\u003c\/p\u003e \u003cp\u003eD.3 MIRD Methodology 691\u003c\/p\u003e \u003cp\u003eD.4 ICRP Methodology 693\u003c\/p\u003e \u003cp\u003eD.5 Biological Effects 693\u003c\/p\u003e \u003cp\u003eD.6 ICRP 26\/30 and ICRP 60\/66\/30 Terminology 696\u003c\/p\u003e \u003cp\u003eD.7 ICRP 26 and ICRP 60 Recommendations 697\u003c\/p\u003e \u003cp\u003eD.7.1 Calculation of Internal Dose Equivalents Using ICRP 26\/30 698\u003c\/p\u003e \u003cp\u003eD.7.2 Calculation of Equivalent and Effective Doses Using ICRP 60\/66\/30 699\u003c\/p\u003e \u003cp\u003eD.8 ICRP 103\/66\/100 Methodology 701\u003c\/p\u003e \u003cp\u003eD.8.1 Radiation Effects, Tissue Weighting Factors, and Radiation Weighting Factors 701\u003c\/p\u003e \u003cp\u003eD.8.2 Sex Averaging 702\u003c\/p\u003e \u003cp\u003eD.8.3 Assessment of Occupational Dose 703\u003c\/p\u003e \u003cp\u003eD.9 Human Respiratory Tract Model (HRTM) 704\u003c\/p\u003e \u003cp\u003eD.9.1 Absorption 705\u003c\/p\u003e \u003cp\u003eD.9.2 Particle Sizes 705\u003c\/p\u003e \u003cp\u003eD.9.3 Additional Model Details 706\u003c\/p\u003e \u003cp\u003eD.10 Human Alimentary Tract Model (HATM) 706\u003c\/p\u003e \u003cp\u003eD.10.1 Absorption to Blood 707\u003c\/p\u003e \u003cp\u003eD.10.2 Dose Calculations 710\u003c\/p\u003e \u003cp\u003eD.10.3 Model Dependence 710\u003c\/p\u003e \u003cp\u003eReferences 710\u003c\/p\u003e \u003cp\u003e\u003cb\u003eE Health Physics-Related Computer Codes 713\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eE.1 Overview 713\u003c\/p\u003e \u003cp\u003eE.2 Code Descriptions 713\u003c\/p\u003e \u003cp\u003eE.2.1 CAP-88 (http:\/\/www.epa.gov\/radiation\/assessment\/ CAP88\/index.html) 713\u003c\/p\u003e \u003cp\u003eE.2.2 COMPASS (http:\/\/orise.orau.gov\/environmental-assessments- health physics\/resources\/marssim.aspx) 714\u003c\/p\u003e \u003cp\u003eE.2.3 COMPLY (http:\/\/www.epa.gov\/radiation\/assessment\/ comply.html#download) 714\u003c\/p\u003e \u003cp\u003eE.2.4 DCAL (http:\/\/www.epa.gov\/radiation\/assessment\/ dcal.html#download) 714\u003c\/p\u003e \u003cp\u003eE.2.5 DWUCK\/CHUCK\/MERCURY (https:\/\/rsicc.ornl.gov\/codes\/psr\/ psr5\/psr-546.html) 715\u003c\/p\u003e \u003cp\u003eE.2.6 EGS Code System (http:\/\/rcwww.kek.jp\/research\/ egs\/egs5.html) 715\u003c\/p\u003e \u003cp\u003eE.2.7 ENDF (http:\/\/www.nndc.bnl.gov\/exfor3\/endf00.htm) 715\u003c\/p\u003e \u003cp\u003eE.2.8 FLUKA (http:\/\/www.fluka.org\/) 716\u003c\/p\u003e \u003cp\u003eE.2.9 GENII-LIN (http:\/\/www-rsicc.ornl.gov\/codes\/ccc\/ccc7\/ ccc-728.html) 716\u003c\/p\u003e \u003cp\u003eE.2.10 HOTSPOT (http:\/\/www-rsicc.ornl.gov\/codes\/mis\/mis0\/ mis-009.html) 716\u003c\/p\u003e \u003cp\u003eE.2.11 IDD–SAM (www.bevelacquaresources.com) 716\u003c\/p\u003e \u003cp\u003eE.2.12 IMBA (www.hpa-radiationservices.org.uk\/services\/imba) 717\u003c\/p\u003e \u003cp\u003eE.2.13 ISO-PC (https:\/\/rsicc.ornl.gov\/codes\/ccc\/ccc6\/ccc-636.html) 717\u003c\/p\u003e \u003cp\u003eE.2.14 JENDL (http:\/\/wwwndc.tokai-sc.jaea.go.jp\/jendl\/jendl.html) 717\u003c\/p\u003e \u003cp\u003eE.2.15 LISE++ (http:\/\/lise.nscl.msu.edu\/lise.html) 718\u003c\/p\u003e \u003cp\u003eE.2.16 MACCS2 (http:\/\/www.nrc.gov\/about-nrc\/regulatory\/research\/ comp-codes.html) 718\u003c\/p\u003e \u003cp\u003eE.2.17 MARS (http:\/\/www-ap.fnal.gov\/MARS\/) 718\u003c\/p\u003e \u003cp\u003eE.2.18 MCNP (http:\/\/mcnp-green.lanl.gov\/index.html) 718\u003c\/p\u003e \u003cp\u003eE.2.19 MCNPX (http:\/\/mcnpx.lanl.gov\/) 719\u003c\/p\u003e \u003cp\u003eE.2.20 MICROSHIELD®(http:\/\/www.radiationsoftware.com\/ mshield.html) 719\u003c\/p\u003e \u003cp\u003eE.2.21 MICROSKYSHINE®(http:\/\/www.radiationsoftware.com\/mskyshine.html) 719\u003c\/p\u003e \u003cp\u003eE.2.22 MIDAS (http:\/\/www.absconsulting.com\/midas.cfm) 719\u003c\/p\u003e \u003cp\u003eE.2.23 MULTIBIODOSE (http:\/\/www.multibiodose.eu\/ software.html) 720\u003c\/p\u003e \u003cp\u003eE.2.24 OLINDA\/EXM (http:\/\/olinda.vueinnovations.com\/olinda) 720\u003c\/p\u003e \u003cp\u003eE.2.25 PRESTO (http:\/\/www.epa.gov\/radiation\/assessment\/ presto.html) 720\u003c\/p\u003e \u003cp\u003eE.2.26 RADTRAD(http:\/\/www-rsicc.ornl.gov\/codes\/ccc\/ccc8\/ ccc-800.html) 720\u003c\/p\u003e \u003cp\u003eE.2.27 RASCAL (http:\/\/www-rsicc.ornl.gov\/codes\/ccc\/ccc7\/ ccc-783.html) 721\u003c\/p\u003e \u003cp\u003eE.2.28 RESRAD (http:\/\/web.ead.anl.gov\/resrad\/home2\/) 721\u003c\/p\u003e \u003cp\u003eE.2.29 SCALE 5 (http:\/\/www-rsicc.ornl.gov\/codes\/ccc\/ ccc7\/ccc-725.html) 721\u003c\/p\u003e \u003cp\u003eE.2.30 SKYSHINE-KSU(http:\/\/www-rsicc.ornl.gov\/codes\/ccc\/ ccc6\/ccc-646.html) 722\u003c\/p\u003e \u003cp\u003eE.2.31 SPAR (http:\/\/www-rsicc.ornl.gov\/codes\/ccc\/ ccc2\/ccc-228.html) 722\u003c\/p\u003e \u003cp\u003eE.2.32 TRACE (http:\/\/www-rsicc.ornl.gov\/codes\/psr\/ psr4\/psr-481.html) 722\u003c\/p\u003e \u003cp\u003eE.2.33 VARSKIN (http:\/\/www-rsicc.ornl.gov\/codes\/ccc\/ ccc7\/ccc-781.html) 723\u003c\/p\u003e \u003cp\u003eE.2.34 VSM (http:\/\/www.doseinfo-radar.com\/RADARSoft.html) 723\u003c\/p\u003e \u003cp\u003eE.2.35 VSP (http:\/\/vsp.pnnl.gov\/) 723\u003c\/p\u003e \u003cp\u003eE.3 Code Utilization 723\u003c\/p\u003e \u003cp\u003eE.4 Code Documentation 724\u003c\/p\u003e \u003cp\u003eReferences 724\u003c\/p\u003e \u003cp\u003e\u003cb\u003eF Systematics of Charged Particle Interactions with Matter 727\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eF.1 Introduction 727\u003c\/p\u003e \u003cp\u003eF.2 Overview of External Radiation Sources 727\u003c\/p\u003e \u003cp\u003eF.2.1 Cancer Therapy 727\u003c\/p\u003e \u003cp\u003eF.2.2 Accelerator Transmutation of High-Level Waste 728\u003c\/p\u003e \u003cp\u003eF.2.3 Space Tourism 729\u003c\/p\u003e \u003cp\u003eF.3 Tissue-Absorbed Dose from a Heavy Ion or Proton Beam 730\u003c\/p\u003e \u003cp\u003eF.4 Determination of Total Reaction Cross-Section 730\u003c\/p\u003e \u003cp\u003eF.5 Calculational Considerations 731\u003c\/p\u003e \u003cp\u003eReferences 731\u003c\/p\u003e \u003cp\u003e\u003cb\u003eG Angular Absorbed Dose Dependence of Heavy Ion Interactions 733\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eG.1 Introduction 733\u003c\/p\u003e \u003cp\u003eG.2 Basic Theory 733\u003c\/p\u003e \u003cp\u003eG.3 Differential Scattering Cross-Section 734\u003c\/p\u003e \u003cp\u003eG.4 Model Calculations 735\u003c\/p\u003e \u003cp\u003eReferences 735\u003c\/p\u003e \u003cp\u003e\u003cb\u003eH Basis for Radiation Protection Regulations 737\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eH.1 Overview 737\u003c\/p\u003e \u003cp\u003eH.2 Risk 737\u003c\/p\u003e \u003cp\u003eH.3 Basic Epidemiology 739\u003c\/p\u003e \u003cp\u003eH.4 Dose–Response Relationships 740\u003c\/p\u003e \u003cp\u003eH.5 Risk Models 741\u003c\/p\u003e \u003cp\u003eH.6 BEIR VII Uncertainties 742\u003c\/p\u003e \u003cp\u003eH.7 Doubling Dose 743\u003c\/p\u003e \u003cp\u003eH.8 Probability of Causation 743\u003c\/p\u003e \u003cp\u003eH.9 Energy Employees Occupational Illness Compensation Program Act 745\u003c\/p\u003e \u003cp\u003eH.10 Future Dose Limits 746\u003c\/p\u003e \u003cp\u003eH.10.1 LNT Hypothesis 746\u003c\/p\u003e \u003cp\u003eH.10.1.1 Arguments Supporting the LNT Hypothesis 747\u003c\/p\u003e \u003cp\u003eH.10.1.2 Arguments against the LNT Hypothesis 747\u003c\/p\u003e \u003cp\u003eH.10.2 Threshold Dose limits 748\u003c\/p\u003e \u003cp\u003eH.10.3 Radiation Carcinogenesis 749\u003c\/p\u003e \u003cp\u003eH.11 Future Regulations 749\u003c\/p\u003e \u003cp\u003eReferences 749\u003c\/p\u003e \u003cp\u003eIndex 753\u003c\/p\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":48743127384407,"sku":"9783527411832","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783527411832.jpg?v=1791481964"},{"product_id":"chemistry-of-renewables-an-introduction-9783662614297","title":"Chemistry of Renewables: An Introduction","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThis textbook introduces the industrial production and processing of natural resources. It is divided into six major topics (fats and oils, carbohydrates, lignin, terpenoids, other natural products, biorefinery), which are divided into a total of 20 chapters.\u003c\/p\u003e\u003cp\u003eEach chapter is self-contained and therefore a compact learning unit, which can be worked on by students in self-study or presented by lecturers. Clear illustrations, flow diagrams, apparatus drawings and photos facilitate the understanding of the subject matter. All chapters end with a succinct summary, the \"Take Home Messages\". Each chapter is supplemented by ten short test questions, which can be solved quickly after working through the chapter; the answers are at the end of the book. All chapters contain bibliographical references that focus on essential textbooks and reference works. As a prior knowledge, only basic knowledge of chemistry is required. \u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e1 Overview\/Introduction.- I Fats and Oils.- 2 Plant Oils.- 3 Fat Products\/Oleochemicals.- 4 Reactions of fatty acid chains\/Special Oleochemical Products.- 5 The by-product of Oleochemistry\/Glycerol.- II Carbohydrate.- 6 Sugar Chemistry.- 7 From wood to pulp\/Cellulose.- 8 Starch Chemistry.- 9 Carbohydrates from the sea.- 10 Cyclodextrins.- III Lignin.- 11 Woods' essential ingredient\/Lignin.- IV Terpenoids.- 12 Tree Balm\/Terpenes.- 13 Natural rubber and its processing.- V Other Natural Products.- 14 Building blocks of life\/Amino acids and proteins.- 15 Natural Dyes.- 16 Natural Pharmaceuticals.- 17 The essential 'amines'.- 18 Natural Fragrances and Flavours.- 19 Plastics from nature\/Biopolymers.- VI Biorefineries.- 20 Smart raw materials.- Answers to the 'Quickies'.- Index.\u003cp\u003e\u003c\/p\u003e","brand":"Springer-Verlag Berlin and Heidelberg GmbH \u0026 Co. KG","offers":[{"title":"Default Title","offer_id":48743142621527,"sku":"9783662614297","price":59.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9783662614297.jpg?v=1720064297"},{"product_id":"biofilms-science-and-technology-9789401048057","title":"Biofilms - Science and Technology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cem\u003eBiofilms -- Science and Technology \u003c\/em\u003ecovers the main topics  of biofilm formation and activity, from basic science to applied  aspects in engineering and medicine. The book presents a masterly  discussion of microbial adhesion, the metabolism of microorganisms in  biofilms, modelling of mass transfer and biological reaction within  biofilms, as well as the behaviour of these microbial communities in  industry (waste water treatment, heat exchanger biofouling, membranes,  food processing) and in medicine (teeth, implants, prosthetic  devices). Laboratory techniques and industrial monitoring methods are  also presented. \u003cbr\u003e  The book is directed at readers at the postgraduate level and is  organised as a textbook, containing 11 chapters, a glossary, and a  detailed subject index. \u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eForeword. 1. Introduction. 2. Attachment.  3. Metabolism. 4. Process Analysis and Biofilm Modeling.  5. Biofilms in Medicine. 6. Biofilms in Food Processing.  7. Biofilms in Wastewater Treatment and Biodegradation of  Wastes. 8. Biofilms in Water Distribution and Industrial  Systems. 9. Biofilm Prevention and Distruction. 10.  Laboratory Methods and Industrial Monitoring. 11. Reports of  Workshop Discussions. Glossary. Subject Index.","brand":"Springer","offers":[{"title":"Default Title","offer_id":48743258980695,"sku":"9789401048057","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"applied-rna-bioscience-9789811083716","title":"Applied RNA Bioscience","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003eThe focus of this book is to introduce up-to-date information on applications and practical use of RNA for agriculture, biotechnology and medicine. It provides unique ideas, tools, and methods in detail from a variety of scientific and technical disciplines.  RNA science has progressed enormously in recent decades, and vast amounts of information on RNA functions and their regulatory mechanisms are becoming available. Such a progress opened the door to an age of practical application of RNA in many fields including agriculture, plant science, medical science, brewing and fermentation technology, and material production. This book inspires its readership and contributes to not only expansion in application of RNA but also to basic research. \u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003e\u003ci\u003eList of titles and authors (as of 24 Aug 2016)\u003c\/i\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e1. Gene expression system that can escape from translational repression caused by brewing-related stress\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Shingo IZAWA\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e2. Bacterial cellular engineering through interspecies exchange of 16S rRNA in \u003ci\u003eEscherichia coli \u003c\/i\u003eribosome.\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Kentaro MIYAZAKI\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e3. Development and application of the excellent protein synthesis technique with riboswitches in microorganisms\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Takahiro YAMAUCHI and Naoki SUGIMOTO\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e4. Cell Reprogramming by Lactic Acid Bacteria.\u003c\/b\u003e\u003c\/p\u003e    Kunimasa OHTA\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e5. \u003c\/b\u003e\u003cb\u003eNovel detection system of mycotoxin using aptamer\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Yuji MORITA\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e6. \u003c\/b\u003e\u003cb\u003eRational design of artificial riboswitches\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Atsushi OGAWA\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e7. mRNA engineering as a tool for controlling mammalian cells in medical applications\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Kei ENDO and Hirohide SAITO\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e8. \u003c\/b\u003e\u003cb\u003eModulation of abnormal splicing by small chemical compounds in RNA diseases\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Naoyuki KATAOKA\u003c\/p\u003e  \u003cb\u003e \u003c\/b\u003e\u003cb\u003e9. Protein production system by innovating mRNA export\u003c\/b\u003e\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e  Seiji MASUDA\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e10. PPR protein and the engineering\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Takahiro NAKAMURA\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e11. Long noncoding RNAs and their applications\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e  Tomohiro YAMAZAKI \u003c\/p\u003e  \u003cp\u003e \u003cb\u003e12\u003c\/b\u003e. \u003cb\u003eLong non-coding RNA as new diagnostic and therapeutic targets\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e   Eleonora LEUCCI\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e13. Riboswitches and ribozymes as RNA-based modular tools to control gene expression\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e   Yoshiya IKAWA and Shigeyoshi Matsumura\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e14.\u003c\/b\u003e\u003cb\u003e Applications of CRISPR\/Cas9 genome editing for functional characterization of RNA helicases\u003c\/b\u003e\u003c\/p\u003e     Jerry PELLETIER\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e \u003cb\u003e15. Application of systemic TGS on p\u003c\/b\u003e\u003c\/p\u003elant breeding\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e   Songling BAI\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003cb\u003e16. Theoretical and applied epigenetics in plants\u003c\/b\u003e\u003c\/p\u003e     Yuhya WAKASA, Taiji KAWAKATSU, and Fumio TAKAIWA","brand":"Springer Verlag, Singapore","offers":[{"title":"Default Title","offer_id":48743275168087,"sku":"9789811083716","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"rediscovery-of-genetic-and-genomic-resources-for-future-food-security-9789811501555","title":"Rediscovery of Genetic and Genomic Resources for","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book describes how the latest genomic resources techniques can be efficiently used in plant breeding programmes to achieve food security in the future. It also shares insights on how to utilize the untapped and unexplored genetic diversity of wild species, wild relatives and landraces for crop improvement.\u003c\/p\u003eMoreover, the book offers an impressive array of balanced analyses, fresh ideas and perspectives, and thoughtful and realistic proposals regarding the sustainable utilization of plant genetic resources with modern biotechnological techniques. The first book to address the importance of plant genetics and genomic resources for food security, it brings together a group of plant breeders and biotechnologists to investigate the use of genomic resources techniques in plant breeding programmes. Providing essential information on the efficient utilization of genomic resources in precision breeding, it offers a valuable asset for undergraduate and graduate students, teachers and professionals engaged in related fields.\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eChapter 1 Potential of genetic and genomic resources for genetic improvement of food crops.- Chapter 2 Untapped genetic diversity of wild relatives for crop improvement.- Chapter 3 Molecular approaches for harvesting natural diversity for crop improvement.- Chapter 4 Omics and plant genetic resources: Towards mining potential genes.- Chapter 5 Genetic and genomic resources and their exploitation for unlocking genetic potential from the wild relatives.-Chapter 6 Role of gene banks in maintaining crop genetic resources.- Chapter 7 Exploring genetic resources for identification of potential novel genes for crop improvement.- Chapter 8 Next-generation sequencing technologies and their implications for efficiently utilization of genetic resources.- Chapter 9 Comparative genomics for exploring new genes and traits for crop improvement.- Chapter 10 Potential of wild species in the scenario of climate change.- Chapter 11 Role of wild relatives for development of climate-resilient varieties.- Chapter 12 Strategies for conservation of genetic resources.- Chapter 13 Crop landraces: Present threats and opportunities for conservation.- Chapter 14 Future threats and opportunities facing crop wild relatives and landrace diversity.\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e","brand":"Springer Verlag, Singapore","offers":[{"title":"Default Title","offer_id":48743288045911,"sku":"9789811501555","price":151.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9789811501555.jpg?v=1791483959"},{"product_id":"a-practical-guide-to-pharmacological-biotechnology-9789811363542","title":"A Practical Guide to Pharmacological","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003ePharmacological biotechnology is applied to and used to study drug development, working mechanisms, diagnosis, and therapies. This textbook covers the whole range of experiments related to pharmacology. It also contains basic laboratory safety guidelines along with the basic calculations and formulas used in a laboratory. Each chapter starts with an introduction\/theory into the basic approach followed by detailed methods sections with easy-to-follow protocols and comprehensive troubleshooting, calculations and possible questions for examination. The target group is researchers who are studying pharmacological biotechnology in the laboratory.\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003ePart1.Introduction.- 1.1 Rules of laboratory safety in a pharmacology laboratory.- 1.2 Commom instruments and their uses used in a pharmacology laboratory.- Part2.General aspects of Pharmacology laboratory.- 2.1 Safety and Risk assessment.- 2.2 Use and Handling of laboratory animals.- 2.3 Experimental design.- 2.4 Essential statistics.- 2.5 Cumulative Dose Response Curve.- 2.6 Toxicology.- 2.7 Basic instruments and techniques in Pharmacology Laboratory .- Part3.Isolated tissues and organs.- 3.1 Basic instruments used for isolated tissue experiments.- 3.2 Organ baths.- 3.3 Smooth muscle preparations.- 3.4 Skeletal muscle preparations.- 3.5 Cardiac muscle preparations.- Part4.Isolated tissues for screening of drugs.- 4.1 Evaluation of antidiabetic agents.- 4.2 Evaluation of antidepressants.- 4.3 Evaluation of antihypertensive agents.- 4.4 Evaluation of antiulcer agents.- 4.5 Evaluation of hepatotoxicity.- 4.6 Evaluation of Antioxidant agents.- 4.7 Evaluation of local anaesthetics.- Part5.Genotoxicity and Toxicological studies.- 5.1 The Mouse Lymphoma Assay.- 5.2 The Comet Assay.- 5.3 In vitro Genotoxicity assay.- 5.4 In vitro Teratogenicity Testing.- 5.5 Histopathological studies of animal tissues.- 5.6 Drug poisoning.-  Part6.Experimental Animal studies.- 6.1 Pyrogen testing.- 6.2 Collecting blood from mice.- 6.3 Studies on different parameters of blood.- 6.4 Experiment on central nervous system.- 6.5 Evaluation on cardiovascular system.- 6.6 Experiments on GI tract.- Part7.Clinical trials.- 7.1 Clinical Pharmacology and its genesis.- 7.2 National and International agencies and their role in Clinical pharmacology.- 7.3 Stages in drug development and clinical trials.- 7.4 Ethics in Clinical research.- 7.5 Safety assessment in Clinical trials.- Part8.IPR and ethics in animal studies.- 8.1 Intellectual property rights and its different categories.- 8.2 Importance of IPR in drug development.- 8.3 Patenting cells, cell lines and animals.- 8.4 Ethics in laboratory animal studies .-  8.5 Risk assessment and management.- 8.6 Good laboratory practices.","brand":"Springer Verlag, Singapore","offers":[{"title":"Default Title","offer_id":48743288078679,"sku":"9789811363542","price":999.99,"currency_code":"GBP","in_stock":false}]},{"product_id":"a-practical-guide-to-environmental-biotechnology-9789811562518","title":"A Practical Guide to Environmental Biotechnology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis textbook provides practical guidelines on conducting experiments across the entire spectrum of environmental biotechnology. It opens with general information on laboratory safety, rules and regulations, as well as a description of various equipment commonly used in environmental laboratories. It then discusses in detail the major experiments in basic and advanced environmental studies, including the analysis of water and soil samples; the isolation, culture, and biochemical characterization of microbes; and plant tissue culture techniques and nutrient analyses. Each chapter features detailed method sections and easy-to-follow protocols, and offers guidance on calculations and formulas, as well as illustrative flow charts to assist with troubleshooting for each experiment. Given its scope, the book is an invaluable aid for laboratory researchers studying environmental biotechnology, and a rich source of information and advice for advanced undergraduates and graduates in the fields of environmental science and biotechnology.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eChapter 1: General Guidelines of Laboratory Safety, Calculations Used In Laboratory Experiments, Basic Laboratory Glassware And Instruments.-  Chapter 2: Analysis of Quality of Water and Its Nutrient Contents.-  Chapter 3: Analysis of Quality of Soil and Its Nutrient Contents.- Chapter 4: Isolation, Culture and Biochemical Characterization of Microbes.- Chapter 5: Plant Tissue Culture Techniques and Nutrient Analysis.\u003cbr\u003e","brand":"Springer Verlag, Singapore","offers":[{"title":"Default Title","offer_id":48743289815383,"sku":"9789811562518","price":58.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9789811562518.jpg?v=1791483965"},{"product_id":"artificial-intelligence-and-machine-learning-for-edge-computing-9780128240540","title":"Artificial Intelligence and Machine Learning for","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePart 1: AI and Machine Learning 1. Artificial Intelligence 2. Machine Learning 3. Regression Analysis 4. Bayesian Statistics 5. Learning Theory 6. Supervised Learning 7. Unsupervised Learning 8. Reinforcement Learning 9. Instance Based Learning and Feature Engineering    Part 2: Data Science and Predictive Analysis 10. Introduction to Data Science and Analysis  11. Linear Algebra, Statistics, Probability, Hypothesis and Inference, Gradient Descent  12. Predictive Analysis   Part 3: Edge Computing 13. Distributed Computing - Cloud to fog to Edge  14. Edge Computing 15. Integrating AI with Edge Computing  16. Machine learning integration with Edge Computing  17. Applying AI\/Ml at the edge","brand":"Elsevier Science Publishing Co Inc","offers":[{"title":"Default Title","offer_id":48864167756119,"sku":"9780128240540","price":124.45,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780128240540.jpg?v=1722270707"},{"product_id":"programmable-planet-9780231205108","title":"Programmable Planet","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003ci\u003eProgrammable Planet\u003c\/i\u003e is a grand tour through the world of synthetic biology, telling the stories of the colorful visionaries whose ideas are shaping discoveries. Ted Anton explores the field from its beginning in fighting malaria in Africa to the COVID vaccines and beyond.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTrade Review\u003c\/h2\u003e\u003ci\u003eProgrammable Planet\u003c\/i\u003e captures the passion and energy of those at the genesis of the construction of the genetically engineered world. -- Christopher Voigt, Daniel I.C. Wang Professor of Biological Engineering, Massachusetts Institute of Technology\u003cbr\u003eIf you’ve ever wondered about the promise—and the peril—of synthetic biology and its power to transform life, then \u003ci\u003eProgrammable Planet\u003c\/i\u003e is the book for you. Ted Anton’s exploration of both the history and the future of the ways we engineer life is incisive, engaging, and downright fascinating. -- Deborah Blum, Pulitzer Prize–winning author of \u003ci\u003eThe Poison Squad: One Chemist’s Single-Minded Crusade for Food Safety in the Early Twentieth Century\u003c\/i\u003e\u003cbr\u003e\u003ci\u003eProgrammable Planet\u003c\/i\u003e is a thoroughly engaging and enjoyable read. Anton is an expert storyteller who blends the human element with cutting-edge science like a synthetic biologist engineering a novel organism. Timely and at times provocative, the book provides a wonderful grounding for those interested in learning more about synthetic biology’s promise and threat. And we should all be interested in learning more. -- Aoife Brennan, president and chief executive officer, Synlogic\u003cbr\u003eIn this rollicking compendium, Anton documents a huge number of ways synthetic biology can be used in practice, embedding these examples in the experiences of the people involved. -- Drew Endy, Stanford University\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eIntroduction\u003cbr\u003e\u003cb\u003ePart I. Beginnings\u003c\/b\u003e\u003cbr\u003e1. A Glass of Absinthe: A Malaria Medicine\u003cbr\u003e2. A Radical Philosophy\u003cbr\u003e3. Pandora’s Box: The Triumph and Temptation of Gene Editing\u003cbr\u003e4. The Silk Road: Directing Evolution\u003cbr\u003e5. Wild: Remaking Life\u003cbr\u003e\u003cb\u003ePart II. Ripples in the Water\u003c\/b\u003e\u003cbr\u003e6. Rush: Biology-Made Medicines\u003cbr\u003e7. New Nature: A Do-It-Yourself Environment\u003cbr\u003e8. Hearth and Home\u003cbr\u003e9. Fantastic Voyages: Mining and the Military\u003cbr\u003e10. The Killers: Viruses as Healers\u003cbr\u003e\u003cb\u003ePart III. Bioindustrial Revolution\u003c\/b\u003e\u003cbr\u003e11. Race to a Vaccine\u003cbr\u003e12. Global Production: Perils and Profits of a New Science\u003cbr\u003e13. The Moirai’s Gift\u003cbr\u003e14. To the Planets, and Beyond: Synthetic Biology in Space\u003cbr\u003e15. Futurama\u003cbr\u003eAcknowledgments\u003cbr\u003eTimeline\u003cbr\u003eGlossary\u003cbr\u003eFurther Reading\u003cbr\u003eNotes\u003cbr\u003eIndex","brand":"Columbia University Press","offers":[{"title":"Default Title","offer_id":48864263471447,"sku":"9780231205108","price":28.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780231205108.jpg?v=1722271133"},{"product_id":"bad-blood-9780525431992","title":"Bad Blood","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003e\u003cb\u003eNATIONAL BESTSELLER • The gripping story of Elizabeth Holmes and T\u003cb\u003eheranos\u003cb\u003e—\u003c\/b\u003e\u003c\/b\u003eone of the biggest corporate frauds in history—a tale of ambition and hubris set amid the bold promises of Silicon Valley, rigorously reported by the prize-winning journalist. With a new Afterword covering her trial and sentencing, bringing the story to a close.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e“Chilling ... Reads like a thriller ... Carreyrou tells [the Theranos story] virtually to perfection.” —\u003ci\u003eThe New York Times Book Review\u003c\/i\u003e\u003c\/b\u003e\u003c\/b\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/b\u003e\u003cbr\u003eIn 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the next Steve Jobs: a brilliant Stanford dropout whose startup “unicorn” promised to revolutionize the medical industry with its breakthrough device, which performed the whole range of laboratory tests from a single drop of blood. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.5 billion. There was just one problem: The technology didn’t work. Erroneous results put patients in danger, leading to misdiagnoses and unnecessary treatments. All the while, Holmes and her partner, Sunny Balwani, worked to silence anyone who voiced misgivings—from journalists to their own employees.","brand":"Random House USA Inc","offers":[{"title":"Default Title","offer_id":48864981746007,"sku":"9780525431992","price":15.84,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780525431992.jpg?v=1722273391"},{"product_id":"earth-repair-9780865717299","title":"Earth Repair","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eA practical guide to bioremediation: natural techniques that are proven to heal land damaged by pollution.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eIn the United States and Canada alone, millions of acres have been contaminated by pesticides, chemicals, dirty energy projects, toxic waste, and other pollutants. Conventional clean-up techniques are expensive and resource-intensive and can cause further damage. Communities find themselves increasingly unable to rely on the same companies and governments that created the problems to step in and provide solutions.\u003c\/p\u003e\u003cp\u003ePacked with valuable information from visionaries in the field of bioremediation, Earth Repair empowers individuals to heal contaminated and damaged land. It encompasses everything from remediating and regenerating abandoned city lots for urban farmers and gardeners, to recovering from environmental disasters and industrial catastrophes such as oil spills and nuclear fallout.\u003c\/p\u003e\u003cp\u003eThis fertile toolbox covers various remediation methods in\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eTrade Review\u003c\/h2\u003eThe real and imagined consequences of contaminated soil and water have been some of the greatest impediments to restoration of urban wastelands for food production. Leila Darwish combines the experience of the pioneer activists and innovators with the expertise and knowledge of remediation professionals to create an empowering guide for the large numbers of citizens looking for guidance on this issue. Earth Repair includes enough technical detail and explanation to get most readers up to speed on the subject. The case studies provide empowering examples of how low cost remediation techniques that reflect permaculture design principles can be used to enhance community resilience and advance social justice. In the energy descent future, many more people will be growing food on contaminated land; out of necessity! Earth Repair offers the hope that this can be done without fear of further eroding health and well being. --David Holmgren, co-originator of permaculture and author, Permaculture: Principles and Pathways Beyond Sustainability Earth Repair, what a brilliant and useful book! Leila Darwish \u0026amp; New Society have brought forth a book for people who will not wait around to heal the world. With a broad and deep view of the historical dynamics of thoughtless upheaval and waste, Earth Repair provides thorough, local-action strategies that communities, with or without resources, can undertake to remediate their damaged landscapes. In accessible language, this book explains how to deal with a serious local issue while also shining light on where to go to deal with the source! --Mark Lakeman, cofounder, The City Repair Project, communitecture, and the Planet Repair Institute Earth Repair is a fantastic introduction to grassroots bioremediation -- an indispensible guide for citizen scientists, permaculturists, and ecological justice activists wanting to proactively address the legacy of environmental pollution which we've inherited from our industrial civilization. Within is a highly accessible toolkit of techniques and skills usable by the average person, empowering them to safely destroy or immobilize common contaminants by partnering with familiar biological allies such as microbes, worms, fungi, and plants. As we transition into a sustainable society, this book will be a key text, critical for informing communities in the process of de-toxifying our planet. --Scott Kellogg, educational director of the Radix Ecological Sustainability Center and author,Toolbox for Sustainable City Living -- A Do-It-Ourselves Guide. We are an odd, almost unique, creature that soils its own nest. As we've become more industrially and technologically muscular, our soiling has penetrated into the heart of Earth's systems, where we now pile our filth upon genetics, delicate geochemical balances, and climate. We have destabilized nature, and we won't find a way out the same way we came in. Darwish's good news is that nature WANTS to heal, and even knows how. We just have to use the tools she gives us. --Albert Bates, author, The Post-Petroleum Survival Guide and Biochar: Carbon Farming and Climate Change\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003e\u003cp\u003e Many Thanks \u003cbr\u003e Introduction: Manualfesto \u003c\/p\u003e\u003cp\u003e Chapter 1: Roots of Repair: \u003ci\u003e Decolonization and Environmental Justice \u003c\/i\u003e\u003cbr\u003e Chapter 2: Earth Repair and Grassroots Bioremediation \u003cbr\u003e Chapter 3: Getting Started \u003cbr\u003e Chapter 4: Microbial Remediation \u003cbr\u003e Chapter 5: Phytoremediation \u003cbr\u003e Chapter 6: Mycoremediation \u003cbr\u003e Chapter 7: The Art of Healing Water \u003cbr\u003e Chapter 8: Oil Spills I: \u003ci\u003e The Anatomy of an Environmental Disaster \u003c\/i\u003e\u003cbr\u003e Chapter 9: Oil Spills II: \u003ci\u003e Tools for the Grassroots Bioremediator \u003c\/i\u003e\u003cbr\u003e Chapter 10: Nuclear Energy and Remediating Radiation \u003cbr\u003e Chapter 11: Self-Care for Grassroots Remediators, Community Members and Disaster Responders \u003cbr\u003e Conclusion: Final Words for a Fertile Way Forward \u003c\/p\u003e\u003cp\u003e Appendix 1: Contaminants 101 \u003cbr\u003e Appendix 2: Conventional Remediation Techniques \u003cbr\u003e Appendix 3: Metric Conversion Table \u003cbr\u003e Endnotes \u003cbr\u003e Index \u003cbr\u003e About the Author \u003c\/p\u003e","brand":"New Society Publishers","offers":[{"title":"Default Title","offer_id":48866114568535,"sku":"9780865717299","price":20.89,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780865717299.jpg?v=1722277108"},{"product_id":"telehealthcare-9781119841760","title":"TeleHealthcare","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Machine Learning–Assisted Remote Patient Monitoring with Data Analytics 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eVinutha D. C., Kavyashree and G. T. Raju\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 2\u003c\/p\u003e \u003cp\u003e1.1.1 Traditional Patient Monitoring System 2\u003c\/p\u003e \u003cp\u003e1.1.2 Remote Monitoring System 3\u003c\/p\u003e \u003cp\u003e1.1.3 Challenges in RPM 4\u003c\/p\u003e \u003cp\u003e1.2 Literature Survey 5\u003c\/p\u003e \u003cp\u003e1.2.1 Machine Learning Approaches in Patient Monitoring 7\u003c\/p\u003e \u003cp\u003e1.3 Machine Learning in RPM 8\u003c\/p\u003e \u003cp\u003e1.3.1 Support Vector Machine 9\u003c\/p\u003e \u003cp\u003e1.3.2 Decision Tree 10\u003c\/p\u003e \u003cp\u003e1.3.3 Random Forest 11\u003c\/p\u003e \u003cp\u003e1.3.4 Logistic Regression 11\u003c\/p\u003e \u003cp\u003e1.3.5 Genetic Algorithm 12\u003c\/p\u003e \u003cp\u003e1.3.6 Simple Linear Regression 12\u003c\/p\u003e \u003cp\u003e1.3.7 KNN Algorithm 13\u003c\/p\u003e \u003cp\u003e1.3.8 Naive Bayes Algorithm 14\u003c\/p\u003e \u003cp\u003e1.4 System Architecture 15\u003c\/p\u003e \u003cp\u003e1.4.1 Data Collection 16\u003c\/p\u003e \u003cp\u003e1.4.2 Data Pre-Processing 17\u003c\/p\u003e \u003cp\u003e1.4.3 Apply Machine Learning Algorithm and Prediction 18\u003c\/p\u003e \u003cp\u003e1.5 Results 21\u003c\/p\u003e \u003cp\u003e1.6 Future Enhancement 23\u003c\/p\u003e \u003cp\u003e1.7 Conclusion 24\u003c\/p\u003e \u003cp\u003eReferences 24\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 A Survey on Recent Computer-Aided Diagnosis for Detecting Diabetic Retinopathy 27\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePriyadharsini C., Jagadeesh Kannan R. and Farookh Khadeer Hussain\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 28\u003c\/p\u003e \u003cp\u003e2.2 Diabetic Retinopathy 28\u003c\/p\u003e \u003cp\u003e2.2.1 Features of DR 28\u003c\/p\u003e \u003cp\u003e2.2.2 Stages of DR 29\u003c\/p\u003e \u003cp\u003e2.3 Overview of DL Models 31\u003c\/p\u003e \u003cp\u003e2.3.1 Convolution Neural Network 31\u003c\/p\u003e \u003cp\u003e2.3.2 Autoencoders 32\u003c\/p\u003e \u003cp\u003e2.3.3 Boltzmann Machine and Deep Belief Network 32\u003c\/p\u003e \u003cp\u003e2.4 Data Set 33\u003c\/p\u003e \u003cp\u003e2.5 Performance Metrics 34\u003c\/p\u003e \u003cp\u003e2.6 Literature Survey 36\u003c\/p\u003e \u003cp\u003e2.6.1 Segmentation of Blood Vessels 36\u003c\/p\u003e \u003cp\u003e2.6.2 Optic Disc Feature 49\u003c\/p\u003e \u003cp\u003e2.6.3 Lesion Detections 50\u003c\/p\u003e \u003cp\u003e2.6.3.1 Exudate Detection 50\u003c\/p\u003e \u003cp\u003e2.6.3.2 MA and HM 51\u003c\/p\u003e \u003cp\u003e2.6.4 DR Classification 51\u003c\/p\u003e \u003cp\u003e2.7 Discussion and Future Directions 52\u003c\/p\u003e \u003cp\u003e2.8 Conclusion 53\u003c\/p\u003e \u003cp\u003eReferences 53\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 A New Improved Cryptography Method-Based e-Health Application in Cloud Computing Environment 59\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDipesh Kumar, Nirupama Mandal and Yugal Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 60\u003c\/p\u003e \u003cp\u003e3.1.1 Contribution 61\u003c\/p\u003e \u003cp\u003e3.2 Motivation 62\u003c\/p\u003e \u003cp\u003e3.3 Related Works 62\u003c\/p\u003e \u003cp\u003e3.4 Challenges 64\u003c\/p\u003e \u003cp\u003e3.5 Proposed Work 64\u003c\/p\u003e \u003cp\u003e3.6 Proposed Algorithm for Encryption 66\u003c\/p\u003e \u003cp\u003e3.6.1 Demonstration of Encryption Algorithm 66\u003c\/p\u003e \u003cp\u003e3.6.1.1 When the Number of Columns Selected in the Table is Even 66\u003c\/p\u003e \u003cp\u003e3.6.1.2 When the Number of Columns Selected in the Table is Odd 69\u003c\/p\u003e \u003cp\u003e3.6.2 Flowchart for Encryption 72\u003c\/p\u003e \u003cp\u003e3.7 Algorithm for Decryption 73\u003c\/p\u003e \u003cp\u003e3.7.1 Demonstration of Decryption Algorithm 73\u003c\/p\u003e \u003cp\u003e3.7.1.1 When the Number of Columns Selected in the Table is Even 73\u003c\/p\u003e \u003cp\u003e3.7.1.2 When the Number of Columns Selected in the Table is Odd 75\u003c\/p\u003e \u003cp\u003e3.7.2 Flowchart of Decryption Algorithm 78\u003c\/p\u003e \u003cp\u003e3.8 Experiment and Result 78\u003c\/p\u003e \u003cp\u003e3.9 Conclusion 80\u003c\/p\u003e \u003cp\u003eReferences 80\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Cutaneous Disease Optimization Using Teledermatology Underresourced Clinics 85\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSupriya M., Murugan K., Shanmugaraja T. and Venkatesh T.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 86\u003c\/p\u003e \u003cp\u003e4.2 Materials and Methods 87\u003c\/p\u003e \u003cp\u003e4.2.1 Clinical Setting and Teledermatology Workflow 87\u003c\/p\u003e \u003cp\u003e4.2.2 Study Design, Data Collection, and Analysis 87\u003c\/p\u003e \u003cp\u003e4.3 Proposed System 88\u003c\/p\u003e \u003cp\u003e4.3.1 Teledermatology in an Underresourced Clinic 88\u003c\/p\u003e \u003cp\u003e4.3.2 Teledermatology Consultations from Uninsured Patients 89\u003c\/p\u003e \u003cp\u003e4.3.3 Teledermatology for Patients Lacking Access to Dermatologists 90\u003c\/p\u003e \u003cp\u003e4.3.4 Teledermatologist Management from Nonspecialists 92\u003c\/p\u003e \u003cp\u003e4.3.5 Segment Factors of Referring PCPs and Their Patients 93\u003c\/p\u003e \u003cp\u003e4.3.6 Teledermatology Operational Considerations 94\u003c\/p\u003e \u003cp\u003e4.3.7 Instruction of PCPs 94\u003c\/p\u003e \u003cp\u003e4.4 Challenges 95\u003c\/p\u003e \u003cp\u003e4.5 Results and Discussion 95\u003c\/p\u003e \u003cp\u003e4.5.1 Challenges of Referring to Teledermatology Services 96\u003c\/p\u003e \u003cp\u003eReferences 98\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Cognitive Assessment Based on Eye Tracking Using Device-Embedded Cameras via Tele-Neuropsychology 101\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShanmugaraja T., Venkatesh T., Supriya M. and Murugan K.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 102\u003c\/p\u003e \u003cp\u003e5.2 Materials and Methods 102\u003c\/p\u003e \u003cp\u003e5.3 Framework Elements 102\u003c\/p\u003e \u003cp\u003e5.3.1 Eye Tracker Camera 102\u003c\/p\u003e \u003cp\u003e5.3.2 Test Construction 103\u003c\/p\u003e \u003cp\u003e5.3.3 Web Camera 106\u003c\/p\u003e \u003cp\u003e5.3.4 Camera for Eye Tracking 106\u003c\/p\u003e \u003cp\u003e5.4 Proposed System 106\u003c\/p\u003e \u003cp\u003e5.4.1 Camera for Tracking Eye 106\u003c\/p\u003e \u003cp\u003e5.4.2 Web Camera 108\u003c\/p\u003e \u003cp\u003e5.4.3 Scoring 108\u003c\/p\u003e \u003cp\u003e5.4.4 Eye Tracking Camera 108\u003c\/p\u003e \u003cp\u003e5.4.5 Web Camera Human-Coded Scoring 108\u003c\/p\u003e \u003cp\u003e5.5 Subjects 109\u003c\/p\u003e \u003cp\u003e5.5.1 Characteristics of Subject 109\u003c\/p\u003e \u003cp\u003e5.6 Methodology 110\u003c\/p\u003e \u003cp\u003e5.6.1 Analysis of Data 110\u003c\/p\u003e \u003cp\u003e5.7 Results 110\u003c\/p\u003e \u003cp\u003e5.8 Discussion 112\u003c\/p\u003e \u003cp\u003e5.9 Conclusion 114\u003c\/p\u003e \u003cp\u003eReferences 115\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Fuzzy-Based Patient Health Monitoring System 117\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eVenkatesh T., Murugan K., Supriya M., Shanmugaraja T. and Rekha Chakravarthi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 118\u003c\/p\u003e \u003cp\u003e6.1.1 General Problem 119\u003c\/p\u003e \u003cp\u003e6.1.2 Existing Patient Monitoring and Diagnosis Systems 119\u003c\/p\u003e \u003cp\u003e6.1.3 Fuzzy Logic Systems 120\u003c\/p\u003e \u003cp\u003e6.2 System Design 122\u003c\/p\u003e \u003cp\u003e6.2.1 Hardware Requirements 122\u003c\/p\u003e \u003cp\u003e6.2.1.1 Functional Requirements 123\u003c\/p\u003e \u003cp\u003e6.2.1.2 Nonfunctional Specifications 125\u003c\/p\u003e \u003cp\u003e6.3 Software Architecture 125\u003c\/p\u003e \u003cp\u003e6.3.1 The Data Acquisition Unit (DAQ) Application Programmable Interface (API) 126\u003c\/p\u003e \u003cp\u003e6.3.2 Flowchart—API 128\u003c\/p\u003e \u003cp\u003e6.3.3 Foreign Tag IDs 129\u003c\/p\u003e \u003cp\u003e6.3.4 Database Manager 130\u003c\/p\u003e \u003cp\u003e6.3.5 Database Designing 130\u003c\/p\u003e \u003cp\u003e6.3.6 The Fuzzy Logic System 131\u003c\/p\u003e \u003cp\u003e6.3.6.1 Introduction to Fuzzy Logic 131\u003c\/p\u003e \u003cp\u003e6.3.6.2 The Modified Prior Alerting Score (MPAS) 132\u003c\/p\u003e \u003cp\u003e6.3.6.3 Structure of the Fuzzy Logic System 134\u003c\/p\u003e \u003cp\u003e6.3.7 Designing a System in Fuzzy 135\u003c\/p\u003e \u003cp\u003e6.3.7.1 Input Variables 135\u003c\/p\u003e \u003cp\u003e6.3.7.2 The Output Variable 138\u003c\/p\u003e \u003cp\u003e6.4 Results and Discussion 140\u003c\/p\u003e \u003cp\u003e6.4.1 Hardware Sensors Validation 140\u003c\/p\u003e \u003cp\u003e6.4.2 Implementations, Testing, and Evaluation of the Fuzzy Logic Engine 141\u003c\/p\u003e \u003cp\u003e6.4.3 Normal Group (NRM) 146\u003c\/p\u003e \u003cp\u003e6.4.4 Low Risk Group 146\u003c\/p\u003e \u003cp\u003e6.4.5 High Risk Group (HRG) 153\u003c\/p\u003e \u003cp\u003e6.5 Conclusions and Future Work 155\u003c\/p\u003e \u003cp\u003e6.5.1 Summary and Concluding Remarks 155\u003c\/p\u003e \u003cp\u003e6.5.2 Future Directions 155\u003c\/p\u003e \u003cp\u003eReferences 155\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Artificial Intelligence: A Key for Detecting COVID-19 Using Chest Radiography 159\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eC. Vinothini, P. Anitha, Priya J., Abirami A. and Akash S.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 160\u003c\/p\u003e \u003cp\u003e7.2 Related Work 162\u003c\/p\u003e \u003cp\u003e7.2.1 Traditional Approach 162\u003c\/p\u003e \u003cp\u003e7.2.2 Deep Learning–Based Approach 163\u003c\/p\u003e \u003cp\u003e7.3 Materials and Methods 163\u003c\/p\u003e \u003cp\u003e7.3.1 Data Set and Data Pre-Processing 163\u003c\/p\u003e \u003cp\u003e7.3.2 Proposed Model 165\u003c\/p\u003e \u003cp\u003e7.4 Experiment and Result 171\u003c\/p\u003e \u003cp\u003e7.4.1 Experiment Setup 171\u003c\/p\u003e \u003cp\u003e7.4.2 Comparison with Other Models 173\u003c\/p\u003e \u003cp\u003e7.5 Results 174\u003c\/p\u003e \u003cp\u003e7.6 Conclusion 175\u003c\/p\u003e \u003cp\u003eReferences 176\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 An Efficient IoT Framework for Patient Monitoring and Predicting Heart Disease Based on Machine Learning Algorithms 179\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShanthi S., Nidhya R., Uma Perumal and Manish Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 180\u003c\/p\u003e \u003cp\u003e8.2 Literature Survey 182\u003c\/p\u003e \u003cp\u003e8.3 Machine Learning Algorithms 183\u003c\/p\u003e \u003cp\u003e8.4 Problem Statement 184\u003c\/p\u003e \u003cp\u003e8.5 Proposed Work 185\u003c\/p\u003e \u003cp\u003e8.5.1 Data Set Description 185\u003c\/p\u003e \u003cp\u003e8.5.2 Collection of Values Through Sensor Nodes 186\u003c\/p\u003e \u003cp\u003e8.5.3 Storage of Data in Cloud 187\u003c\/p\u003e \u003cp\u003e8.5.4 Prediction with Machine Learning Algorithms 188\u003c\/p\u003e \u003cp\u003e8.5.4.1 Data Cleaning and Preparation 188\u003c\/p\u003e \u003cp\u003e8.5.4.2 Data Splitting 189\u003c\/p\u003e \u003cp\u003e8.5.4.3 Training and Testing 189\u003c\/p\u003e \u003cp\u003e8.5.5 Machine Learning Algorithms 189\u003c\/p\u003e \u003cp\u003e8.5.5.1 Naive Bayes Algorithm 189\u003c\/p\u003e \u003cp\u003e8.5.5.2 Decision Tree Algorithm 190\u003c\/p\u003e \u003cp\u003e8.5.5.3 K-Neighbors Classifier 191\u003c\/p\u003e \u003cp\u003e8.5.5.4 Logistic Regression 192\u003c\/p\u003e \u003cp\u003e8.6 Performance Analysis and Evaluation 192\u003c\/p\u003e \u003cp\u003e8.7 Conclusion 197\u003c\/p\u003e \u003cp\u003eReferences 197\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 BABW: Biometric-Based Authentication Using DWT and FFNN 201\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eR. Kingsy Grace, M.S. Geetha Devasena and R. Manimegalai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 202\u003c\/p\u003e \u003cp\u003e9.2 Literature Survey 203\u003c\/p\u003e \u003cp\u003e9.3 BABW: Biometric Authentication Using Brain Waves 208\u003c\/p\u003e \u003cp\u003e9.4 Results and Discussion 211\u003c\/p\u003e \u003cp\u003e9.5 Conclusion 215\u003c\/p\u003e \u003cp\u003eReferences 216\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Autism Screening Tools With Machine Learning and Deep Learning Methods: A Review 221\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePavithra D., Jayanthi A. N., Nidhya R. and Balamurugan S.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 222\u003c\/p\u003e \u003cp\u003e10.2 Autism Screening Methods 223\u003c\/p\u003e \u003cp\u003e10.2.1 Autism Screening Instrument for Educational Planning—3rd Version 224\u003c\/p\u003e \u003cp\u003e10.2.2 Quantitative Checklist for Autism in Toddlers 224\u003c\/p\u003e \u003cp\u003e10.2.3 Autism Behavior Checklist 224\u003c\/p\u003e \u003cp\u003e10.2.4 Developmental Behavior Checklist-Early Screen 225\u003c\/p\u003e \u003cp\u003e10.2.5 Childhood Autism Rating Scale Version 2 225\u003c\/p\u003e \u003cp\u003e10.2.6 Autism Spectrum Screening Questionnaire (ASSQ) 226\u003c\/p\u003e \u003cp\u003e10.2.7 Early Screening for Autistic Traits 226\u003c\/p\u003e \u003cp\u003e10.2.8 Autism Spectrum Quotient 226\u003c\/p\u003e \u003cp\u003e10.2.9 Social Communication Questionnaire 227\u003c\/p\u003e \u003cp\u003e10.2.10 Child Behavior Check List 227\u003c\/p\u003e \u003cp\u003e10.2.11 Indian Scale for Assessment of Autism 227\u003c\/p\u003e \u003cp\u003e10.3 Machine Learning in ASD Screening and Diagnosis 228\u003c\/p\u003e \u003cp\u003e10.4 DL in ASD Diagnosis 238\u003c\/p\u003e \u003cp\u003e10.5 Conclusion 242\u003c\/p\u003e \u003cp\u003eReferences 242\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Drug Target Module Mining Using Biological Multifunctional Score-Based Coclustering 249\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eR. Gowri and R. Rathipriya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 249\u003c\/p\u003e \u003cp\u003e11.2 Literature Study 250\u003c\/p\u003e \u003cp\u003e11.3 Materials and Methods 253\u003c\/p\u003e \u003cp\u003e11.3.1 Biological Terminologies 253\u003c\/p\u003e \u003cp\u003e11.3.2 Functional Coherence 256\u003c\/p\u003e \u003cp\u003e11.3.3 Biological Significances 257\u003c\/p\u003e \u003cp\u003e11.3.4 Existing Approach: MR-CoC 257\u003c\/p\u003e \u003cp\u003e11.4 Proposed Approach: MR-CoCmulti 258\u003c\/p\u003e \u003cp\u003e11.4.1 Biological Score Measures for DTM 259\u003c\/p\u003e \u003cp\u003e11.4.2 Multifunctional Score-Based Co-Clustering Approach 259\u003c\/p\u003e \u003cp\u003e11.5 Experimental Analysis 264\u003c\/p\u003e \u003cp\u003e11.5.1 Experimental Results 265\u003c\/p\u003e \u003cp\u003e11.6 Discussion 280\u003c\/p\u003e \u003cp\u003e11.7 Conclusion 280\u003c\/p\u003e \u003cp\u003eAcknowledgment 281\u003c\/p\u003e \u003cp\u003eReferences 281\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 The Ascendant Role of Machine Learning Algorithms in the Prediction of Breast Cancer and Treatment Using Telehealth 285\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJothi K.R., Oswalt Manoj S., Ananya Singhal and Suruchi Parashar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 286\u003c\/p\u003e \u003cp\u003e12.1.1 Objective 287\u003c\/p\u003e \u003cp\u003e12.1.2 Description and Goals 287\u003c\/p\u003e \u003cp\u003e12.1.2.1 Data Exploration 288\u003c\/p\u003e \u003cp\u003e12.1.2.2 Data Pre-Processing 288\u003c\/p\u003e \u003cp\u003e12.1.2.3 Feature Scaling 288\u003c\/p\u003e \u003cp\u003e12.1.2.4 Model Selection and Evaluation 288\u003c\/p\u003e \u003cp\u003e12.2 Literature Review 289\u003c\/p\u003e \u003cp\u003e12.3 Architecture Design and Implementation 304\u003c\/p\u003e \u003cp\u003e12.4 Results and Discussion 310\u003c\/p\u003e \u003cp\u003e12.5 Conclusion 312\u003c\/p\u003e \u003cp\u003e12.6 Future Work 313\u003c\/p\u003e \u003cp\u003eReferences 314\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Remote Patient Monitoring: Data Sharing and Prediction Using Machine Learning 317\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMohammed Hameed Alhameed, S. Shanthi, Uma Perumal and Fathe Jeribi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 318\u003c\/p\u003e \u003cp\u003e13.1.1 Patient Monitoring in Healthcare System 318\u003c\/p\u003e \u003cp\u003e13.2 Literature Survey 321\u003c\/p\u003e \u003cp\u003e13.3 Problem Statement 322\u003c\/p\u003e \u003cp\u003e13.4 Machine Learning 322\u003c\/p\u003e \u003cp\u003e13.4.1 Introduction 322\u003c\/p\u003e \u003cp\u003e13.4.2 Cloud Computing 324\u003c\/p\u003e \u003cp\u003e13.4.3 Design and Architecture 325\u003c\/p\u003e \u003cp\u003e13.5 Proposed System 326\u003c\/p\u003e \u003cp\u003e13.6 Results and Discussions 331\u003c\/p\u003e \u003cp\u003e13.7 Privacy and Security Challenges 333\u003c\/p\u003e \u003cp\u003e13.8 Conclusions and Future Enhancement 334\u003c\/p\u003e \u003cp\u003eReferences 335\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Investigations on Machine Learning Models to Envisage Coronavirus in Patients 339\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eR. Sabitha, J. Shanthini, R.M. Bhavadharini and S. Karthik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 340\u003c\/p\u003e \u003cp\u003e14.2 Categories of ML Algorithms in Healthcare 341\u003c\/p\u003e \u003cp\u003e14.3 Why ML to Fight COVID-19? Tools and Techniques 343\u003c\/p\u003e \u003cp\u003e14.4 Highlights of ML Algorithms Under Consideration 344\u003c\/p\u003e \u003cp\u003e14.5 Experimentation and Investigation 349\u003c\/p\u003e \u003cp\u003e14.6 Comparative Analysis of the Algorithms 353\u003c\/p\u003e \u003cp\u003e14.7 Scope of Enhancement for Better Investigation 354\u003c\/p\u003e \u003cp\u003eReferences 356\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Healthcare Informatics: Emerging Trends, Challenges, and Analysis of Medical Imaging 359\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eG. Karthick and N.S. Nithya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Emerging Trends and Challenges in Healthcare Informatics 360\u003c\/p\u003e \u003cp\u003e15.1.1 Advanced Technologies in Healthcare Informatics 360\u003c\/p\u003e \u003cp\u003e15.1.2 Intelligent Smart Healthcare Devices Using IoT With DL 361\u003c\/p\u003e \u003cp\u003e15.1.3 Cyber Security in Healthcare Informatics 362\u003c\/p\u003e \u003cp\u003e15.1.4 Trends, Challenges, and Issues in Healthcare IT Analytics 363\u003c\/p\u003e \u003cp\u003e15.2 Performance Analysis of Medical Image Compression Using Wavelet Functions 364\u003c\/p\u003e \u003cp\u003e15.2.1 Introduction 364\u003c\/p\u003e \u003cp\u003e15.2.2 Materials and Methods 366\u003c\/p\u003e \u003cp\u003e15.2.3 Wavelet Basis Functions 367\u003c\/p\u003e \u003cp\u003e15.2.3.1 Haar Wavelet 367\u003c\/p\u003e \u003cp\u003e15.2.3.2 db Wavelet 368\u003c\/p\u003e \u003cp\u003e15.2.3.3 bior Wavelet 368\u003c\/p\u003e \u003cp\u003e15.2.3.4 rbio Wavelet 368\u003c\/p\u003e \u003cp\u003e15.2.3.5 Symlets Wavelet 369\u003c\/p\u003e \u003cp\u003e15.2.3.6 coif Wavelet 369\u003c\/p\u003e \u003cp\u003e15.2.3.7 dmey Wavelet 369\u003c\/p\u003e \u003cp\u003e15.2.3.8 fk Wavelet 369\u003c\/p\u003e \u003cp\u003e15.2.4 Compression Methods 370\u003c\/p\u003e \u003cp\u003e15.2.4.1 Embedded Zero-Trees of Wavelet Transform 370\u003c\/p\u003e \u003cp\u003e15.2.4.2 Set Partitioning in Hierarchical Trees 370\u003c\/p\u003e \u003cp\u003e15.2.4.3 Adaptively Scanned Wavelet Difference Reduction 370\u003c\/p\u003e \u003cp\u003e15.2.4.4 Coefficient Thresholding 371\u003c\/p\u003e \u003cp\u003e15.3 Results and Discussion 371\u003c\/p\u003e \u003cp\u003e15.3.1 Mean Square Error 371\u003c\/p\u003e \u003cp\u003e15.3.2 Peak Signal to Noise Ratio 371\u003c\/p\u003e \u003cp\u003e15.4 Conclusion 380\u003c\/p\u003e \u003cp\u003e15.4.1 Summary 380\u003c\/p\u003e \u003cp\u003eReferences 380\u003c\/p\u003e \u003cp\u003eIndex 383\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48866419704151,"sku":"9781119841760","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119841760.jpg?v=1722278556"},{"product_id":"the-precipice-a-book-that-seems-made-for-the-present-moment-new-yorker-9781526600233","title":"The Precipice: ‘A book that seems made for the","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003e\u003cb\u003eWhat existential threats does humanity face? And how can we secure our future?\u003c\/b\u003e \u003cb\u003e ‘\u003c\/b\u003e\u003cb\u003e\u003ci\u003eThe Precipice \u003c\/i\u003eis a powerful book . . . Ord’s love for humanity and hope for its future is infectious\u003c\/b\u003e\u003cb\u003e’ \u003c\/b\u003e\u003ci\u003eSpectator\u003c\/i\u003e\u003cb\u003e ‘Ord’s analysis of the science is exemplary . . . Thrillingly written’ \u003c\/b\u003e\u003ci\u003eSunday Times\u003c\/i\u003e  We live during the most important era of human history. In the twentieth century, we developed the means to destroy ourselves – without developing the moral framework to ensure we won't. This is \u003cb\u003ethe Precipice\u003c\/b\u003e, and how we respond to it will be the most crucial decision of our time.  Oxford moral philosopher Toby Ord explores the risks to humanity's future, from the familiar man-made threats of climate change and nuclear war, to the potentially greater, more unfamiliar threats from engineered pandemics and advanced artificial intelligence.  With clear and rigorous thinking, Ord calculates the various risk levels, and shows how our own time fits within the larger story of human history. We can say with certainty that the novel coronavirus does not pose such a risk. But could the next pandemic? And what can we do, in our present moment, to face the risks head on?  A major work that brings together the disciplines of physics, biology, earth and computer science, history, anthropology, statistics, international relations, political science and moral philosophy, \u003ci\u003eThe Precipice \u003c\/i\u003eis a call for a new understanding of our age: a major reorientation in the way we see the world, our history, and the role we play in it.\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTrade Review\u003c\/h2\u003eToby Ord is today’s Carl Sagan. Clear and inspiring, this book leaves us hopeful for a flourishing human future -- Christine Peterson, co-founder of the Foresight Institute\u003cbr\u003eA powerfully argued book that alerts us to what is perhaps the most important – and yet also most neglected – problem we will ever face -- Peter Singer, author of 'Animal Liberation' and 'The Life You Can Save'\u003cbr\u003e\u003ci\u003eThe Precipice\u003c\/i\u003e separates science from hype and will remain the definitive work on existential risk for a long time to come -- Max Tegmark, author of 'Life 3.0' and 'Our Mathematical Universe'\u003cbr\u003eA fascinating and persuasive guide to the most important topic of all: how our species will survive the risks we pose to our continued existence -- Stuart Russell, author of 'Human Compatible' and 'Artificial Intelligence: A Modern Approach'\u003cbr\u003eThis book is a wake-up call to the existential threats of nuclear and biological weapons and the urgent need for action. A must-read that galvanises us to play a role in addressing these risks -- Angela Kane, former UN High Representative for Disarmament Affairs\u003cbr\u003eHumanity has never been more vulnerable – there’s now a one-in-six chance that civilisation won’t make it to the end of the century, argues a highly influential philosopher . . . Ord’s analysis of the science is exemplary . . . Thrillingly written * Sunday Times *\u003cbr\u003eMany people have recently found that they want to read books offering the grandest perspectives possible on human existence, such as \u003ci\u003eSapiens\u003c\/i\u003e . . . Toby Ord’s new book is a startling and rigorous contribution to this genre that deserves to be just as widely read * Evening Standard *\u003cbr\u003eSplendid . . . \u003ci\u003eThe Precipice \u003c\/i\u003eis a powerful book, written with a philosopher’s eye . . . Ord’s love for humanity and hope for its future is infectious * Spectator *\u003cbr\u003eUrgent and vaguely prophetic . . . In a year in which our everyday lives were upended by the unexpected (or rather the expected yet neglected), \u003ci\u003eThe Precipice \u003c\/i\u003eis a good way to put everything in perspective -- Books of the Year * WIRED *\u003cbr\u003e\u003ci\u003eThe Precipice\u003c\/i\u003e is a fascinating book, one that showcases both the knowledge of its author and his humanity * Axios *\u003cbr\u003eA book that seems made for the present moment * New Yorker *\u003cbr\u003eA story of the greatest risks to humanity’s future, from the climate crisis and nuclear war to pandemics and artificial intelligence -- Highlights for 2020 * Guardian *","brand":"Bloomsbury Publishing PLC","offers":[{"title":"Default Title","offer_id":48867472245079,"sku":"9781526600233","price":12.34,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781526600233.jpg?v=1722283439"},{"product_id":"molecular-biotechnology-principles-and-applications-of-recombinant-dna-9781683673644","title":"Molecular Biotechnology: Principles and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"American Society for Microbiology","offers":[{"title":"Default Title","offer_id":48868060168535,"sku":"9781683673644","price":96.3,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781683673644.jpg?v=1722286216"},{"product_id":"la-patrana-mas-grande-de-la-historia-9798786074797","title":"La Patraña Más Grande de la Historia","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e","brand":"Independently Published","offers":[{"title":"Default Title","offer_id":48869625266519,"sku":"9798786074797","price":17.62,"currency_code":"GBP","in_stock":true}]},{"product_id":"ethical-issues-in-biotechnology-9780742513570","title":"Ethical Issues in Biotechnology","description":"\u003ch2\u003eBook Synopsis\u003c\/h2\u003eVisit our website for sample chapters!\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTrade Review\u003c\/h2\u003eThis will be the field-defining book for the ethics of biotechnology. It is the best one-volume guide to the issues currently being debated with respect to the new genetic technologies, and the only one that illuminates the connections between medical and agricultural applications. Teachers will use it in the classroom, but beyond that it should be thought of as an indispensable read for anyone who wants to be informed about science, ethics, and public policy. -- Paul B. Thompson, Michigan State University, W.K. Kellogg Professor of Agricultural, Food, and Community Ethics\u003cbr\u003eRichard Sherlock and John Morrey have developed a timely anthology on the ethical dimensions in biotechnology that is both scientifically sound and philosophically provocative. Engaging readings as well as a compendium of cases offer many formats for teachable dialogue between instructor and students. The questions—scientific, philosophical, political, legal, moral—examined through Ethical Issues in Biotechnology illustrate the urgent need for critical ethical scholarship in this rapidly emerging field. This anthology meets that need. -- Courtney S. Campbell, Oregon State University\u003cbr\u003eThe most substantial and sophisticated treatment of biomedical ethics that I have come across recently, and a treatment that remains quite accessible to undergraduate students. -- Dr. S. N. Fratantaro, Providence College\u003cbr\u003eIt is refreshingly atypical that the book does not just focus on human cloning or human genetic screening but takes on the whole topic of biotechnology. It is enterprising and clever to have a book edited collaboratively by a biologist and a philosopher, and the result is a balanced treatment. The readings have already been proven successful with students. With diagrams, study cases, examples, and suggestions for further research, the book is a comprehensive and well-expressed introduction to the science and ethics of biotechnology. * Research News and Opportunities In Science and Theology *\u003cbr\u003eAll who are involved in ethics and biotechnology should be immensely grateful for [Sherlock and Morrey's] efforts. Balanced and teachable, Ethical Issues in Biotechnology is a valuable contribution to the field, and a must-have for those teaching either undergraduates enrolled in upper-level courses, or graduates students, across the disciplines of science and humanities. * Technology and Culture *\u003cbr\u003eSherlock and Morrey cover a fascinating and engaging set of cutting edge issues. This work covers biotechnology in the broadest sense of the word, contains masterfully selected readings, and challenges the reader to think into the future. It should be very useful to college, graduate, and professional students. -- Steven Post, Case Western Reserve University\u003cbr\u003e\u003cbr\u003e\u003ch2\u003eTable of Contents\u003c\/h2\u003eChapter 1 Introduction Part 2 I. Fundamental Issues of Ethics and Biotechnology Chapter 3 How to Assess the Consequences of Genetic Engineering Chapter 4 Redesigning the World: Ethical Questions About Genetic Engineering Chapter 5 \"Playing God\" and Invoking a Perspective Chapter 6 Genetic Trespassing and Environmental Ethics Part 7 II. Agricultural Biotechnology Chapter 8 Differing Views of the Benefits and Risks of Agricultural Biotechnology Chapter 9 Risk and Risk Management Chapter 10 Journey to the Origin: Biological Integrity and Agriculture Chapter 11 Three Concepts of Genetic Trespassing Chapter 12 Ten Reasons Why Biotechnology Will Be Important to the Developing World Chapter 13 Ten Reasons Why Biotechnology Will Not Ensure Food Security, Protect the Environment, or Reduce Poverty in the Developing World Part 14 III. Food Biotechnology Chapter 15 The Scientific and Health Aspects of Genetically Modified Foods: Rapporteurs' Summary Chapter 16 The Safety of Foods Developed by Biotechnology Chapter 17 Hazards of Genetically Engineered Foods and Crops: Why We Need a Global Moratorium Chapter 18 Why We Need Labeling of Genetically Engineered Food Chapter 19 Ethical Issues in Food Biotechnology Part 20 IV. Animal Biotechnology Chapter 21 A Critical View of the Genetic Engineering of Farm Animals Chapter 22 The \"Frankenstein Thing\": The Moral Impact of Genetic Engineering of Agricultural Animals on Society and Future Science Chapter 23 On the Ethics of Using Animals for Human Benefit Chapter 24 The Case for the Use of Animals in Biomedical Research Chapter 25 Artificial Lives: Philosophical Dimensions of Farm Animal Biotechnology Chapter 26 Genetic Engineering as Animal Slavery Chapter 27 Uncertainty in Xenotransplantation: Individual Benefit versus Collective Risk Chapter 28 Critical Ethical Issues in Clinical Trials with Xenotransplants Part 29 V. Human Genetic Testing and Therapy Chapter 30 Social, Legal, and Ethical Implications of Genetic Testing Chapter 31 Genetic Links, Family Ties, and Social Bonds: Rights and Responsibilities in the Face of Genetic Knowledge Chapter 32 Privacy and the Control of Genetic Information Chapter 33 The Ethics of Somatic Cell Gene Therapy Chapter 34 Human Inheritable Genetic Modifications: Assessing Scientific, Ethical, Religious, and Policy Issues Chapter 35 Germ-Line Genetic Engineering and Moral Diversity: Moral Controversies in a Post-Christian World Part 36 VI. Human Cloning and Stem Cell Research Chapter 37 Human Cloning: Report and Recommendations of the Natioanl Bioethics Advisory Commission Chapter 38 The Wisdom of Repugnance Chapter 39 Genetic Encores: The Ethics of Human Cloning Chapter 40 Stem Cell Research and Applications: Findings and Recommendations Chapter 41 On Human Embryos and Stem Cell Research: An Appeal for Legally and Ethically Responsible Science and Public Policy Chapter 42 Suggestions for Further Study Chapter 43 Study Cases","brand":"Rowman \u0026 Littlefield","offers":[{"title":"Default Title","offer_id":48884325482839,"sku":"9780742513570","price":112.5,"currency_code":"GBP","in_stock":false}]}],"url":"https:\/\/bookcurl.com\/collections\/biotechnology.oembed?page=31","provider":"Book Curl","version":"1.0","type":"link"}